jamesbrownghost
Member
I made a batch of canna butter and the first time I used it on some pancakes I was high all day, but after that I could never get high again on it.....WHY????
Yes, you can have a tolorance to edibles, but probably not after one day. Of course, people are different. I swear by edibles and won't do anything else, but I talk to people who say it does nothing for them.
^^^^ yes. And people who say they do nothin haven't tried Mine -
Drink a glass of grapefruit juice 30-45 mins before eating the edibles. More active ingredients will get into your bloodstream via the GF juice inhibiting the CYP450 enzyme. DISCLAIMER: If you are on prescriptions or any other pharmaceuticals, DO NOT DO THIS as it can result in an overdose and possibly death.
Edibles have never done much of anything for me. I make a batch of cookies or brownies and everyone else turns to jello (especially my dog), but they do nothing for me. Do you have to stop smoking for awhile to feel the effects or something?
Drink a glass of grapefruit juice 30-45 mins before eating the edibles. More active ingredients will get into your bloodstream via the GF juice inhibiting the CYP450 enzyme. DISCLAIMER: If you are on prescriptions or any other pharmaceuticals, DO NOT DO THIS as it can result in an overdose and possibly death.
CYPs are the major enzymes involved in drug metabolism, accounting for about 75% of the total metabolism.[1] Most drugs undergo deactivation by CYPs, either directly or by facilitated excretion from the body. Also, many substances are bioactivated by CYPs to form their active compounds.
Naturally occurring compounds may also induce or inhibit CYP activity. For example, bioactive compounds found in grapefruit juice and some other fruit juices, including bergamottin, dihydroxybergamottin, and paradicin-A, have been found to inhibit CYP3A4-mediated metabolism of certain medications, leading to increased bioavailability and, thus, the strong possibility of overdosing.[15] Because of this risk, avoiding grapefruit juice and fresh grapefruits entirely while on drugs is usually advised.[16]