Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections

[h.h.]

Politicians should do the research. There’s much more trust.

3D-printed suicide pods are now legal in Switzerland

https://www.businessinsider.com/sar...ssisted-suicide-pod-booth-switzerland-2021-12

freedom

 

[h.h.]

Comparative Effectiveness of BNT162b2 and mRNA-1273 Vaccines in U.S. Veterans

https://www.nejm.org/doi/full/10.1056/NEJMoa2115463

Harvard. And who donates to Harvard? Follow the money.

 

[h.h.]

Medicago and GSK announce positive Phase 3 efficacy and safety results for adjuvanted plant-based COVID-19 vaccine candidate

https://www.gsk.com/en-gb/media/pre...positive-phase-3-efficacy-and-safety-results/

 

[gaiusmarius]

Pirates and suspicious increases in heart attacks



quite interesting....

 

[Amynamous]

Pirates and suspicious increases in heart attacks



quite interesting....

The increase in cardiovascular mortality preceded the vaccines.
SARS2 attacks the vascular system through ACE2 receptor sites which are found exclusively in vascular tissue.
I’ve been saying this for well over a year and a half now.

 

[BudToaster]

The increase in cardiovascular mortality preceded the vaccines.
SARS2 attacks the vascular system through ACE2 receptor sites which are found exclusively in vascular tissue.
I’ve been saying this for well over a year and a half now.

exclusively?

The SARS-CoV-2 virus gains entry to the epithelial cells lining the respiratory tract by way of the ACE2 (angiotensin-converting enzyme 2) receptor. This is the protein to which the viral spike proteins attach in order to gain entry into the cell.

If we knew more about this important receptor, it could be the key to unlock future therapies and preventive measures.

This ACE2 receptor is a transmembrane protein, in that it is embedded in the cell membrane. This protein is found on epithelial and endothelial cells of the upper and lower respiratory tract, heart and vasculature, kidneys, and portions of the gastrointestinal tract. It is an ectoenzyme, meaning its actions occur outside of cells. The ubiquitous nature of this receptor explains, in part, why so many different organs can be affected by SARS-CoV-2. ACE2 is a vital element in a biochemical pathway that is critical to regulating processes such as blood pressure, wound healing and inflammation, called the renin-angiotensin-aldosterone system (RAAS) pathway.

the mRNA "spike" protein can also enter/effect locations all over the body.

 

[h.h.]

exclusively?



the mRNA "spike" protein can also enter/effect locations all over the body.

The increase in cardiovascular mortality preceded the vaccines.

 

[Amynamous]

exclusively?



the mRNA "spike" protein can also enter/effect locations all over the body.

There’s lots of people here that are smarter than i am. As such, if i get any of the following wrong, please correct me.
I am not an expert, but this is my semi-educated guess:
For all intensive purposes, I am guessing that the mRNA spike protein is identical or nearly identical to the SARS2 spike protein.
As such, both should be able to freely circulate/travel throughout the body in your arteries, veins and lymphatic system and continue to do so until they find an ACE2 receptor site, or are attacked by the body’s defense system or they are rendered inert through time or environmental factors, or excreted.
The SARS2 spike protein acts as the “key” that fits into the “lock”, with the “lock” being the ACE2 receptor found throughout the vascular system. Once the key unlocks the receptor, the virus can freely enter the cell, where they use the cell’s biochemical compounds to reproduce, destroying the cell in the process. And since these are vascular cells, when the cell is destroyed, the remaining bits and pieces circulate freely throughout the vascular system. If enough cells are destroyed, they can collect and form a thrombus/clot. The destruction can also cause inflammation within arteries.

What I don’t know, is what effect, if any, the mRNA spike proteins have on ACE2 receptor sites. Another thing that I don’t know, is even if the mRNA spike protein doesn’t effect the ACE2 receptor, when the immune system attacks the mRNA spike proteins, can the resulting debris cause arterial inflammation or thrombi/clots.

However, what I do know, is that the mRNA vaccine creates a slow trickle of spike proteins, whereas an active infection creates a torrential river of spike proteins. And even a mild or non symptomatic infection can create a strong flow of spike proteins/viral particles. And if the infection bypasses the lungs, a person might never know they had covid and yet have massive amounts of spike proteins and other debris freely circulating throughout their body that can cause a variety of deleterious effects.

 

[BudToaster]

Amynamous
the mRNA version of the spike has an "anchor" attached at the bottom to allow the mRNA spike to be expressed through the cell membrane and stuck/anchored in the membrane, to be presented to the immune system. this spike is recognized as an antigen and the immune system attacks the cell where it is anchored and destroys the cell. simply processing the mRNA into spikes does not destroy the cell. however, mRNA using pseudouridine, does destroy the toll like receptors within the cell that recognize viruses - i.e. damages the innate immune system for the cell. this is theoretically okay, since the immune system was going to destroy the cell anyway. in my mind, there are a lot of loose ends in this theoretical concept.

also, each mRNA has been configured with a longer tail, so that more than one spike can be generated from the same mRNA bit.

also, the reason for the intramuscular injection is so the lymph system will sweep the lipid nanoparticles into the lymph cells, where the mRNA does its job of generating spikes to be expressed. so, in that scenario, the lymph cells are identified to the immune system as being marked for destruction. what could possibly go wrong. we simply don't know. yet.

covid enters via the upper respiratory system - that is where the antibodies should be located to identify and destroy the virions on entry. maybe an inhaled vaccine would be better.

 

[gaiusmarius]

The increase in cardiovascular mortality preceded the vaccines.
SARS2 attacks the vascular system through ACE2 receptor sites which are found exclusively in vascular tissue.
I’ve been saying this for well over a year and a half now.

according to the heart specialist in the clip, this study indicated that the heavy increase in heart attacks started in July.

 

[Amynamous]

BudToaster
Thanks.

Although the respiratory system is the primary entryway for the virus, i am not convinced that it is the only entryway. Other corona viruses and influenza viruses are known to enter the body through the eyes and mouth and i believe that SARS2 is capable of entering the body the same way. It may account for a small percentage of infections, but that doesn’t preclude it from happening. And it could possibly explain why some people do not develop lung infections.

I agree that an inhaled vaccine could very well be better.

 

[h.h.]

Logic should be mandatory in grade school.

https://www.usnews.com/news/us/arti...heart-disease-and-diabetes-climbed-amid-covid

 

[armedoldhippy]

Logic should be mandatory in grade school.

https://www.usnews.com/news/us/arti...heart-disease-and-diabetes-climbed-amid-covid

logic & common sense in seriously short supply.

 

[BudToaster]

logic & common sense in seriously short supply.

well said, in fact, from the article:

Many patients stopped taking care of themselves during the crisis, gaining weight or cutting back on taking high blood pressure medications, he said. Experts said the stress of the crisis, the lockdown-related disappearance of exercise options, and the loss of jobs and the accompanying health insurance were all factors, too.

not too smart. somebody should have told them.

 

[armedoldhippy]

quite a few of the so-called "bonus" deaths, over what is expected yearly, are believed to be folks that did not seek treatment because of their fear of catching the virus in a medical facility. of course, some hospitals etc stopped doing routine surgeries etc because of work overload as well. they really pushed "telehealth" around here the last year or so...

 

[gaiusmarius]

if its only the fat and lazy, why the sudden increase in young athletes with heart conditions?

 

[h.h.]

COVID May Trigger Heart Condition in Young Athletes

https://www.bjsph.org/Health-Library/View-Content?contentTypeId=6&contentId=1655783066

 

[BudToaster]

COVID May Trigger Heart Condition in Young Athletes

https://www.bjsph.org/Health-Library...tId=1655783066

lots of opinion, limited facts ...

Myocarditis has also been linked in some young people to the COVID vaccine. But the odds are far greater that this inflammation of the heart muscle will occur in those who get COVID infection itself, experts said.

that's just a guess/opinion, because ...

Twenty of these patients with COVID-19 myocarditis (54%) had no cardiac symptoms or heart abnormalities seen on other tests. Only MRIs found the problem.

and

MRIs are expensive, and most patients hospitalized for COVID-19 don't get them, so it's likely that many cases of myocarditis go undiagnosed, he said.

so, probably jabbed folks don't get MRIs either, so how rare is myocarditis in the jabbed? is there a study?

 

[h.h.]

lots of opinion, limited facts ...



that's just a guess/opinion, because ...



and



so, probably jabbed folks don't get MRIs either, so how rare is myocarditis in the jabbed? is there a study?

Are you asking if claims that the jab causes the heart condition are unfounded? Is there a study?

 

[Chi13]

Some exerts from articles about Vaccines, Covid and heart issues.

Fact Check-No evidence COVID-19 vaccines are linked to athletes collapsing or dying from myocarditis

By Reuters Fact Check

There is no evidence currently that COVID-19 vaccines are linked to an increase in sportspeople collapsing or dying due to heart issues such as myocarditis.
...
Moreover, the Cardiac Risk in the Young (CRY) organisation, a British charity that funds medical research and supports families of young people affected by heart conditions, told Reuters they were “not aware” of any published or peer-reviewed researched into alleged links between sudden cardiac arrests in athletes and COVID-19 vaccines. “It’s important to understand that young sudden cardiac death (in both sportspeople and the general population) is tragically not a new phenomenon,” they said.

CRY also pointed Reuters toward data published in 2008, which showed 12 ‘apparently fit and healthy’ young people (aged 35 and under) die in the United Kingdom every week from previously undiagnosed heart conditions (www.c-r-y.org.uk/statistics/ and here).

In 2018, prior to the pandemic, CRY announced the findings of a 10-year study, which concluded sudden cardiac death in elite footballers was more common than initially thought.
https://www.reuters.com/article/fact...-idUSL1N2SK160

Heart Problems after COVID-19

COVID-19, the disease caused by the SARS-CoV-2 coronavirus, can damage heart muscle and affect heart function.

There are several reasons for this. The cells in the heart have angiotensin converting enzyme-2 (ACE-2) receptors where the coronavirus attaches before entering cells. Heart damage can also be due to high levels of inflammation circulating in the body. As the body’s immune system fights off the virus, the inflammatory process can damage some healthy tissues, including the heart.

Coronavirus infection also affects the inner surfaces of veins and arteries, which can cause blood vessel inflammation, damage to very small vessels and blood clots, all of which can compromise blood flow to the heart or other parts of the body. “Severe COVID-19 is a disease that affects endothelial cells, which form the lining of the blood vessels,” Post says.
https://www.hopkinsmedicine.org/heal...-after-covid19