Announcement

Collapse
No announcement yet.

Anyone 'cured' prostate cancer with....

Collapse
This is a sticky topic.
X
X
 
  • Filter
  • Time
  • Show
Clear All
new posts

    Originally posted by trichrider View Post
    The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention

    Huzefa Vahora,1 Munawwar Ali Khan,2 Usama Alalami,2 and Arif Hussain1

    This article has been cited by other articles in PMC.

    Abstract
    Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in this regard still remains unanswered. This review summarizes the recent information on NO and its role in carcinogenesis and tumor progression, as well as dietary chemopreventive agents which have NO-modulating properties with safe cytotoxic profile. Understanding the molecular mechanisms and cross-talk modulating NO effect by these chemopreventive agents can allow us to develop better therapeutic strategies for cancer treatment.

    INTRODUCTION

    Nitric oxide (NO) is a multifunctional gaseous transmitter which is lipophilic, as well as one of the smallest molecules found in nature.13 A free radical in gaseous state functions as a messenger via cyclic GMP (cGMP).1 It was identified as a vasoactive small molecule in the 1980s and its cardiovascular activities are significant in relation to its vasorelaxation function as well as anti-thrombotic and anti-inflammatory effects. As a gasotransmitter, it regulates many physiological functions in the body, including neurotransmission, immune response, and anti-pathogenic effect,13 although NO is quite unstable and possess a half-life of 1 to 5 seconds in vivo.
    Under normal physiological conditions, NO is produced by three isoforms of nitric oxide synthase (NOS) (Fig. 1), Neuronal NOS (nNOS/NOS1) and endothelial NOS (eNOS/NOS3) form the constitutive NOS category (cNOS), activating NO production for seconds to minutes in nanomolar concentrations. Contrastingly, the third isoform, inducible NOS (iNOS/NOS2), produces greater amounts of NO, reaching micromolar concentrations and lasting hours or days. cNOS members are dependent on the calcium ion concentrations for their activity, thus they are able to produce lower amounts of NO for shorter durations, in comparison to iNOS which is independent of the calcium ion concentration.13 NOS enzymes are dimeric in nature and two distinct catalytic domains, N-terminal oxygenase domain, and C-terminal reductase domain, are present on each monomer. The substrates binding to the N-terminal are Heme-5,6,7,8- tetrahydrobiopterin (BH4), L-arginine, and oxygen and the substrates binding to the C-terminal are NADPH, flavin mononucleotide, and flavin adenine dinucleotide.1 NO production is catalyzed by NADPH and oxygen as cosubstrates of L-arginine in the presence of NOS. The process of NO synthesis takes place in two steps: (i) hydroxylation of L-arginine to N?-hydroxy-L-arginine by NOS and (ii) oxidation of N?-hydroxy-L-arginine to L-citrulline and NO. The unpaired electrons of NO impart its reactivity towards inorganic molecules (oxygen, superoxide, or transition metals), DNA structures, and prosthetic groups, thus portraying its extensive biological activity.3
    View Image
    Open in a separate window
    Figure 1.
    The pathway elucidating the production of nitric oxide (NO). NOS, NO synthase; NADP+, nicotinamide adenine dinucleotide phosphate; nNOS, neuronal NOS; iNOS, inducible NOS; eNOS, endothelial NOS.



    The actions of NO are mainly mediated through cGMP-dependent manner as well as cGMP-independent manner. The heme component of soluble guanylyl cyclase is targeted by NO, which further undergoes coupling with c-GMP-dependent protein kinase G and phosphodiesterases as well as cyclic nucleotide gated channels. In circumstances where cGMP is not available, the actions of NO are carried out independent of cGMP at low concentrations mainly in three ways, (i) interaction with proteins containing transition metal, (ii) interaction with proteins without the attached NO group, and (iii) modulation of cell signaling by posttranslational modification, mainly by forming S-nitrosothiol (SNO), which is achieved by coupling of a nitroso species to a reactive thiol group in specific cysteine residues, namely, S-nitrosylation.13
    Over many years, NO was considered to be oncogenic in nature. Evidence has shown that NO plays a variety of roles in various stages of carcinogenesis by damaging the DNA, activating oncogenes, regulating apoptosis and metastasis, and inhibiting enzymes for DNA repair and tumor suppressor genes. Pro-tumor effects of NO were linked to the expression of NO-producing enzymes in tumor progression.2 NO also portrays anti-tumor effects by utilizing the immune defense mechanisms in animal models of various human cancers.1,3
    ROLE OF NITRIC OXIDE IN CANCER BIOLOGY

    NO, a free radical and water-soluble gas produced endogenously, regulates quite a few essential biological processes.4 Since a few decades, an interest in NO has been increased as a molecule involved in carcinogenesis and tumor progression. However, a controversial facet exists in understanding its role in the biology of cancer.4 This small molecule possesses the quality to either induce cancer progression or halt cancer growth and act as therapeutic agents.4,5 In conditions where NO is at lower concentrations, it aids in angiogenesis, which stimulates tumor progression by giving blood flow access to the tumor and subsequently result in cell proliferation (Fig. 2).5 On the contrary, higher levels of NO tend to be cytotoxic to cancer cells. This is achieved by the formation of peroxynitrite, which acts as an inducer of apoptosis and other toxic species during immune surveillances.5 Interestingly, peroxynitrite plays a dual role by aiding in inflammation-related carcinogenesis through the formation of 8-nitroguanine, a DNA-damaging entity and biomarkers.37


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819660/
    .............
    https://www.youtube.com/watch?v=wV_EaHHO5KU
    [youtubeif]wV_EaHHO5KU[/youtubeif]
    Pink Floyd - MADley - Mixed Collection (Audio)
    Thanks trich.

    Watched the video, and started my way through the studies.

    (*Good tunes, as well. Thanks. And double points for Wishbone Ash!!!).

    Being quite serious, the heart arrhythmia and humming, reminded me of holding the breath to balance hiccups. Different folks have had different perceptions of this intervention, but I have thought or understood the science therein, if there is science behind it, there is the probability or possibility that the holding of the breath helps to balance the CO2 and oxygen in the body/lungs better??

    With the heart issues she addresses, that makes sense to me, at least preliminarily.

    I'll finish reading the studies, and see what they say about NO helping to stop cancer progression.

    -----------------------------------------

    I met with the 3rd clinic's Doc today. She was very patient and personable.

    I was a bit surprised to find out that, despite the ~2-month delay re scheduling to see her via Zoom, she is not the person who would likely be operating on me, and she had limited knowledge of the radio-oncology questions I have.

    That said, she had no problem acknowledging that she was limited in knowledge in that regard, and also stated that the specificity of my questions, having come this far through the consultation phase, means that the best persons to answer my questions, would likely be the gurus there, whom I had initially sent my records to; 2 surgeons.

    It's honorable to say, "I don't know that, but I can find out," or, "I know who to ask." Life doesn't require that we all be Rembrandt in our fields. It would be impossible anyway..

    So she is forwarding my current status to the radio-oncology Doc there and the urological surgeon Doc there, and believes I should hear back from them within the week.. to schedule another Zoom conference.

    I felt good about the meeting, and hope that sense of decent 'being' from earlier, before the meeting during the meeting, and currently, post meeting, lasts, but like with the cancer outcomes, there are no real guarantees. we'll just have to ride this pony, and see how far she goes.

    In any case, I'm on to the final answers, for the nitty gritty questions, and can hopefully choose between either these folks, or the others I have had more interaction with, when the time comes.. hopefully in the near future.

    ---------------------------------------

    Still no answers from the previous surgeon or the radio-oncologist, to whom I had sent several pieces of correspondence and messages. either they're THAT busy, or I'm not welcome there now. Or...????

    The best of the best often don't have to go looking for patients. And it's not like cancer went on vacation, and isn't providing any more patients for them.

    ---------------------------------------

    Snowing here lightly to moderately most of the morning, and about -18 a while ago.

    Pax 3 tracking says it's still just a label, and the shipping service is waiting for it...

    I want an end to questions, a greater sense of certainty as to who is capable of doing what, and then make a decision, though I know if it's External Beam Radiation, with or without brachy seeds, I will be away from my family, home, and pups for over (at least) 38 days on the final stint, as I will not be seeking radiation tx in Fairbanks, and likely not in Anchorage either.

    Fortunately for me, no matter which tx option, I've always viewed Seattle as a pretty cool city, as cities go. Very cool, even. And if it's radiation instead of surgery, I'll damned near be a resident by the time the dust settles.

    Edit: in an effort to help me with anxiety and so forth, during any extended or moderate absences from my home, family and pups, my wife has proposed obtaining a lap top or similar (with a remote mouse, I hope, as I HATE the tiny little control board on them), for me to travel with, so we can visually AND audibly connect, and they can take me for tours in the house, visit with the pups, plants in the shop, etc. My wife is pretty cool, very stressed, and still running her office from home. There are some circumstances and relationships in which I have been so fucking fortunate!!
    -------------------------------------------

    Valdy

    (*Canadian music from the 1970s. He hung out for a bit at the Hippie School in Carcross, Yukon Territory Canada, at 1 point. He once made a music video of himself, hitch-hiking to his own concert back then. He and Bruce Cockburn played Fall of 1977 at the Farago Folk Festival, in the now-defunct mining town of Faro, Yukon Territory, back when Faro had money (and a population). You can find dirt-cheap real estate in Faro, Yukon these days, by the way.. ;^>) ).

    'A Good Song'

    https://www.youtube.com/watch?v=CVhb...XmmRHr&index=2

    'Simple Life' ('Ode to L.A.)

    https://www.youtube.com/watch?v=mYVv...XmmRHr&index=3
    Last edited by moose eater; 02-04-2021, 00:22.

    Comment


      Still making my way through the links. Thanks again.

      ------------------------------------------

      Last night's and today's focus is, and has been, caveats in insurance coverage, to especially address, "What is medically necessary?" And yes, in the era of corporatism, your insurers will be telling your Docs what is, and isn't 'medically necessary.'

      That doesn't always mean you're stuck with the initial determination arrived at by mercenary Docs (hired by the insurer to refute claims), or by the bean counters and gate-keepers at the insurer's, but it does mean that if and when that particular draw briodge starts to go up, you may need to guard your assets by asserting yourself with energy you have to grope a bit to come up with.

      So far so good, after receiving a heads-up from the screening MD from yesterday, that was likely an automated form notification, but implored me to clarify with my insurer, that despite there being no technical caps on number of visits to primary care, or to a specialist, the 'wiggle room' that potentially benefits the insurer, and screws subscribers, is when and if someone raises a red flag, and rightly or wrongly, declares, "This is not medically necessary." at which point your pockets MIGHT become a LOT lighter, if you're not on your toes, and don't turn those sorts of determination around.

      ----------------------------------------------------

      The other focus is far more personal, and less monetary in nature, dealing more with our assessing how we came to be where we are with our 2 older children. Communication in our home has been a focus of 'things that need to change' for a long time, and despite some changes, has largely stayed where it's at.

      All of these things matter more than some might think, even, maybe, more than treating the cancer, as watching a fine young man come of age, our 3rd child, and knowing that some of the communication deficiencies that have lived here in some family members, can still be alive and well.

      Knowing that we're now rolling the dice on the future, quality of life, and more, and being angry about 1,001 things that "should've been different", I laid down another line last night, and we WILL be applying steady focus to improving these things. I'll be damned if this life will come and go, and leave things that matter to that degree, wagging in the wind, sometimes unchanged. If persons can't properly express themselves, then they are often destined for troubled relationships.

      That broadly defined issue may not seem like a priority or proper use of energy at this time, all things considered, but I can assert, confidently, that it may be more important now than anything else we're dealing with here. Because the skills of this nature, that carry forward, will affect far more lives than whether we cure this cancer or not, or how severe or minimal the residual effects of treatment end up being.

      -------------------------------------------------

      Pax 3 is on the road, headed toward me. Searched the internet for a suitable replacement battery for the Pinnacle Pro, as I hate to trash it, when all it likely needs is a new battery. Not nearly as important as changing communication style or patterns here, and a true example of a questionable use of energy, but it was a change of focus that might bring something into a better state of repair.. So...

      --------------------------------------------------

      Valdy

      'Rainmaker'

      https://www.youtube.com/watch?v=vrrq7xqr5Go
      -----------------------------------

      'Rock and Roll Song'

      https://www.youtube.com/watch?v=UpgY...T2Je_93KXmmRHr

      Comment


        https://www.youtube.com/watch?v=aEo0p29Wmz8
        [youtubeif]aEo0p29Wmz8[/youtubeif]
        ignore the first 7 minutes of social engineering.

        www.harmonicarts.ca
        ...where you can find products of coriolus versicolor
        ......
        https://www.youtube.com/watch?v=FwNv2-qNeDU
        [youtubeif]FwNv2-qNeDU[/youtubeif]
        ..........
        https://www.cancer.gov/about-cancer/.../mushrooms-pdq

        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592279/

        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277906/
        ...........

        https://www.youtube.com/watch?v=Js0u184Hhng
        [youtubeif]Js0u184Hhng[/youtubeif]

        Ben Harper & Charlie Musselwhite - Live at La Cigale, 120 Boulevard de Rochechouart, Paris France

        "when i run outta weed, i smoke match sticks...
        that first hit is FIRE!!!"


        "I'm not always a dick...but when I am, I drink cheap beer".

        Comment


          Thanks again, trich.

          Saw Charlie Musselwhite in Valdez, at the Community Civic Center there, 20-some years ago. Good show. Danced until I was a puddle of liquid. Got to dance with one of our more notorious Alaskan female dog mushers of yesteryear that night, with my wife's consent, of course.

          -----------------------------------------------

          Depending on the mushroom, past research has included shitake (which was not born out as effective for much other than stir-fry), reishi (spelling?) (which WebMD had stated there were varying aspects of 'success', but cautioned re. liver issues), and several times the Turkey tail mushrooms have come up, s they're next on the search function for continuing healthful changes to the diet. I'll give them a peek, shortly.
          ------------------------------------------------

          Found what I suspect is a decent vape battery to try to further revive the old Pinnacle Pro, as well as some shrink-to-fit battery cases/covers; I have issues adding to the land-fill when stuff has value and can be fixed for $10 or $15.

          ------------------------------------------------

          Radio-oncologist's scheduler phoned; one of the Docs I'd been waiting a while for, for further answers to pressing questions. They want another Zoom appt., rather than answering through the portal beyond the 1st set of answers. .Seems it was (at least) a money thing. That's well and good, though I'm now also waiting for scheduling for consultations with the oncologist and surgeon at the third clinic.

          I've made it relatively clear that I want the best of the best. For what ever reason, they noted that in my screening/intake notes from yesterday.

          I found that a bit odd. Who would not want the best of the best, when quality of life indicators/outcomes and cancer are concerned? Do they think there's folks out there who have options, thinking, "No, that's OK, give me brand X; I'm good, thanks."? Seriously??

          I apparently live in a different reality than many folks. Or... ?

          Anyway, from famine to feast, and back again.. Roller coasters have NEVER been my thing, and they especially aren't now, even if proverbial in nature.

          ----------------------------------------------------
          John Popper & Blues Traveler, October 1997, Live (shortly after the time they were also in Valdez at the Civic Center).

          Full Concert

          Shoreline Amphitheatre (mostly acoustic kids' benefit show)

          https://www.youtube.com/watch?v=omwQ5bWSAgs
          Last edited by moose eater; 02-04-2021, 21:57.

          Comment


            https://www.youtube.com/watch?v=7agK0nkiZpA
            [youtubeif]7agK0nkiZpA[/youtubeif]


            listen to a real scientist (Stamets) about the turkey tails.
            especially the part about his mom...9 min. in
            encouraging anecdote.

            edit for fungi perfecti link


            https://fungi.com/

            .....
            https://www.youtube.com/watch?v=by_qL7YHio4
            [youtubeif]by_qL7YHio4[/youtubeif]
            "when i run outta weed, i smoke match sticks...
            that first hit is FIRE!!!"


            "I'm not always a dick...but when I am, I drink cheap beer".

            Comment


              Thanks again, trich.

              At this time, I'm floating in studies and other material. I intend to go through each of them, and have already gone through some/a lot, but I have taken a bit of a break this evening, feel drained, and will read and view more later tonight or tomorrow. I think a nap is calling me right now.

              ----------------------------------------------

              Today was eventful. Seems like some other times in life, bringing to bear the old, "When it rains, it pours."

              The radiological oncologist's scheduler phoned, and set up the follow-up Zoom mtg, rather than answer through the portal system they use for secure messaging.

              Shortly after that call, the Patient Care Coordinator phoned, from the other clinic (in re. to the referrals the Doc I saw via computer yesterday, said she was starting in motion); next day service, as far as scheduling. not to shabby.

              The Coordinator scheduled me for a highly-rated, respected surgeon at the other clinic, and gave me 2 names of radiological oncologists they can offer for a consult re. that path. I have made a choice as to which radiological oncologist, though a bit uncertain initially, and will call tomorrow morning to set that up.

              So the opportunities to ask the remaining questions I have, and to compare notes to make sure everyone is talking apples to apples, so to speak.

              We're moving. And like many bureaucratic or military operations, one goes from hurry up and wait, to hurry up and move quick. But we're moving, and I hope to have the remaining crucial information provided.

              ------------------------------------------------

              I can save about $1,600 in hotel fees if I go to the one facility, rather than the other, if radiation is the winner in this. If that's the case, we're already planning to have a microwave delivered to that place for me, once I get there, as the one short-fall at that spot is the absence of kitchenettes in the rooms, though they have full size common-use kitchens on each floor.

              If I'm staying for the duration radiation would require, or even the 12 days, if surgery is chosen, I need to be able to cook my own healthy meals, as I have been doing, and NOT be hanging out in a common area with folks waiting to cook their chow.

              ------------------------------------------------
              -32 f. on the front porch right now. They've cancelled the somewhat warmer air we were expecting this week-end.
              --------------------------------------------------

              Friend in the bush forwarded this to me. He plays guitar out in the mountains, his family gone for years. He has critters, and a guitar, among other interests, and was sitting by his wood stove, keeping warm, & practicing his guitar, when this came up on his screen, and I thought of your preference for instrumentals, trich.

              Finger-picking style on a beautiful cover of Led Zeppelin's 'Stairway to Heaven'.

              Instrumental, and well-done.

              https://www.youtube.com/watch?v=o0U3mVKLTOk

              Comment


                It sounds like you are about to see things speed up. I'm hoping your questions will be resolved and that you will be confident in your choice of treatment as a result of those answers. For me, the beginning of treatment established a routine that helped me deal with the dreamlike quality of the whole YOU HAVE CANCER diagnosis.

                You have a firm grip on the family communication problems. Hang on and work them out.

                Could you talk to the folks that cancelled the warmer air to dial back the rain? It's wet down in the grow rooms.



                Leonard sez: Live long and prosper.
                “You can disagree without being disagreeable.”
                Ruth Bader Ginsburg

                Comment


                  Originally posted by trichrider View Post
                  https://www.youtube.com/watch?v=aEo0p29Wmz8
                  [youtubeif]aEo0p29Wmz8[/youtubeif]
                  ignore the first 7 minutes of social engineering.

                  www.harmonicarts.ca
                  ...where you can find products of coriolus versicolor
                  ......
                  https://www.youtube.com/watch?v=FwNv2-qNeDU
                  [youtubeif]FwNv2-qNeDU[/youtubeif]
                  ..........
                  https://www.cancer.gov/about-cancer/.../mushrooms-pdq

                  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592279/

                  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7277906/
                  ...........

                  https://www.youtube.com/watch?v=Js0u184Hhng
                  [youtubeif]Js0u184Hhng[/youtubeif]

                  Ben Harper & Charlie Musselwhite - Live at La Cigale, 120 Boulevard de Rochechouart, Paris France

                  working my way backward through the reading and viewing.

                  Alaska has Turkey Tail mushrooms in the wild, but my initial thought is that it likely stays to more temperate climates here; South East and South Central Alaska seem to be its most likely home base.

                  http://plants.alaska.gov/pdf/Conks.pdf

                  I see there's a supplement, derived in concentrated form from the mushrooms, (or synthesized maybe??), available from a variety pf sources.

                  We're likely 4-5 months away from the season when picking mushrooms in the wild would be more practical, and while I know that many times, what is derived and stored from medically or nutritionally viable plants, often there are loses of some amount of value or vitality in the process of extraction, storing, etc.

                  But, if we don't have them near me (and I can check around to find out more about their local availability in the forests), then I can get some coming.

                  First I need to do a complete cross-referencing re. other meds, supplements, etc., and make sure I'm not crossing things that will either decrease the effectiveness, or cause greater problems.

                  Thanks.

                  -------------------------------------

                  Jimi Hendrix experience, Live, Sweden, 1969.

                  Dedicated to the American Deserters' Society, says James Marshall Hendrix. JMH died on my now-deceased younger brother's birthday (not the same year, but the same date, Sept 18).

                  https://www.youtube.com/watch?v=1nj21LhQEyE

                  Comment


                    Originally posted by buzzmobile View Post
                    It sounds like you are about to see things speed up. I'm hoping your questions will be resolved and that you will be confident in your choice of treatment as a result of those answers. For me, the beginning of treatment established a routine that helped me deal with the dreamlike quality of the whole YOU HAVE CANCER diagnosis.

                    You have a firm grip on the family communication problems. Hang on and work them out.

                    Could you talk to the folks that cancelled the warmer air to dial back the rain? It's wet down in the grow rooms.



                    Leonard sez: Live long and prosper.
                    Yes, indeed. feels a little bit like right before a ferris wheel or the giant rubber-band propelled 'slingshot' launches. Once the path is chosen, and the work begun, there's little room to say, "Hey... wait a minute!!"...
                    --------------------------------------------------------------------------
                    Some (most or all) of my family, aside from myself, have difficulty either connecting with deeper feelings, or difficulty discussing sensitive issues. On the other hand, my excess vociferousness makes up for it.. frequently.

                    I often know what persons are going to say before they say it, my mind racing ahead, and reading folks pretty clearly as a learned survival thing, decades ago.

                    With that, coupled with my control-based coping for PTSD, etc, via OCD, there have been many years that I tried to get folks to learn to communicate, while sometimes 'walking over the top' of what they MIGHT have said. Being hard of hearing, and somewhat inflexible when irritated, and I have a majority of family members that can discuss grocery lists and shit that minimally matters in the grand scheme of family intimacy, other than as logistics, but in discussing deep-rooted dreams, hurts, or what ever, there's been a major void.

                    That is a recipe that stands to perpetuate the difficulties or outcomes my 2 older children demonstrate regularly. And I have told my wife and younger son that this HAS to change, before I head off to the next astral plain, or the next clump of sod, or our youngest will potentially grow up with some of the same issues in relationships that our 2 older children have. And if this is avoidable, or repairable, to not address this and try our best to change this, rather than simply talking about it, would be a crime, as the ripples of the pattern will go forth into the future, and everybody touched by it will be left with something less than they could have had out of life..

                    I told her that in my opinion, this issue is more important than my cancer at this time. And my mixed sense of my 2 older kids has at times, for some of these reasons and more, been a greater focus in my mind than beating cancer has been..

                    I came from scattered violent insanity, but with the smell of warm pecan maple buns coming from the oven. Comfort food became the way we showed what care there was. Any wonder so many persons eat unhealthy diets? There's but one part of the issue's outcomes.

                    Anyway, the other night, with me angry about the years that I was cast into the role of disciplinarian, making me inherently into the bad guy, and the lack of clarity in assessing issues, or in communicating, I drew a HEAVY line, and stated this shit -will- change. There is no good reason for us to perpetuate issues once we've identified them, short of pretending we are helpless, and we are not.

                    ---------------------------------------

                    Like I wrote before, it occurred to me that cancer is a re-boot for life, life's needs, patterns of behavior that have bene unhelpful, and a lot more. It's all Yin & Yang, once the quaking and quivering and 'what ifs' end. We win some, we lose some, and, sometimes all at the same time.

                    I'm hoping for the best, but I can't watch train wrecks any more. They're to graphic and too expensive where quality of life is concerned.

                    --------------------------------------

                    Scheduled this AM to see the radiological oncologist next week via Zoom, and the newer surgeon the week after that.

                    ---------------------------------------

                    Local co-op got in some of the 'Beyond Meat' brand of plant-based Italian brats; none of the 'Beyond Meat' brats.

                    The Tofurkey brand sausages suck badly, now that I have had much better plant-based sausages, but I can use the Tofurkey stuff in the high-lycopene red sauce, which I need to make another batch of today, before the egg plant and fresh organic tomatoes start composting.

                    ---------------------------------------

                    In a statement of optimism, and faith in my getting some of my muscle tone back into better shape, last night I charged the satellite phone and back up batteries of various sorts, to include booster packs/portable power sources, for my younger son's and my annual trip into the mountains for our once-a-year 'church'.

                    We'll have to straight-shot it there and back, with no over-night stop on the routes, as I won't stay in a strange hotel room right now, if I can help it. Certainly not one that hasn't met CDC guidelines for such services.
                    ---------------------------------------

                    More cramping in my right and left ankles this morning, likely from the L-4 to L-5 nerve issues in the spine, and maybe a nutritional imbalance continuing to send out a bit of a signal. That will all have to take a back seat until the bigger lions and tigers are dealt with here.
                    --------------------------------------------------------------------------
                    That's about all the news that is from here. -34 f. on the porch this morning, and so far, any warm air they predicted earlier, has apparently headed elsewhere. But at least we're not -50 or -60.

                    I still have plenty of THC capsules, but it may be a bit before I can do a cold-wash extraction outdoors for the THC-a capsules. I'd like to have them done before we head to remote places, as not being able to respond to crises adequately or quickly in the middle of the night, or when ever, is a vulnerability or disability that I can't have when we're out there.

                    Take care, buzz, and know that your posts of moral and emotional support are not overlooked, and they ARE appreciated..

                    I'm back to research, reading, and maybe some chores/soilless mixes.

                    -------------------------------------

                    James Taylor, his wife, and son during COVID-19 sequestering, from their home in Montana, courtesy of Rolling Stone Mag.

                    These tunes bring nostalgic sweetness, and some tears.

                    https://www.rollingstone.com/music/m...9tFMqnOGKA3x8w
                    Last edited by moose eater; 02-05-2021, 22:45.

                    Comment


                      Ordered 3/4 lb. of turkey tail mushrooms, fresh-dried in the sun, last Fall, 2020, from a vendor on Etsy; $45 for the 3/4 lb. of 'shrooms, and another (nearly) $19 in shipping.

                      Not too bad, compared to other vendors' pricing.

                      The powdered mushrooms are available as a supplement, and I could load my own caps, or put it into food, but, again, my observation with many tings has been that the closer to the original state, and the more fresh, the better or more viable the product.

                      I'll try almost anything once, and many things twice.

                      Thanks again.

                      Comment


                        My medical advice is limited so I have to rely on my "feels memories" to pass along.

                        How do you intend to prepare the Turkey Tails?
                        “You can disagree without being disagreeable.”
                        Ruth Bader Ginsburg

                        Comment


                          Originally posted by moose eater View Post
                          Ordered 3/4 lb. of turkey tail mushrooms, fresh-dried in the sun, last Fall, 2020, from a vendor on Etsy; $45 for the 3/4 lb. of 'shrooms, and another (nearly) $19 in shipping.

                          Not too bad, compared to other vendors' pricing.

                          The powdered mushrooms are available as a supplement, and I could load my own caps, or put it into food, but, again, my observation with many tings has been that the closer to the original state, and the more fresh, the better or more viable the product.

                          I'll try almost anything once, and many things twice.

                          Thanks again.
                          yes!
                          are those whole, or powdered?
                          whole are tough as shoe leather.
                          i've tried drying and grinding in a coffee grinder...that's an ordeal.
                          i hope you get some kind of promise from their use.
                          yep, looks like things are accelerating.

                          thanks for the Hendrix link, i dig his style and the lyrics are obscure enough that they don't play in a loop over and over in my head.lol

                          this guy can play the guitar with the best of them:
                          https://www.youtube.com/watch?v=2JGb3O8ql1U
                          [youtubeif]2JGb3O8ql1U[/youtubeif]
                          "when i run outta weed, i smoke match sticks...
                          that first hit is FIRE!!!"


                          "I'm not always a dick...but when I am, I drink cheap beer".

                          Comment


                            Originally posted by buzzmobile View Post
                            My medical advice is limited so I have to rely on my "feels memories" to pass along.

                            How do you intend to prepare the Turkey Tails?
                            I've only doe a little bit or reading re. prep for them, but the seller is a person who used them for her breast cancer, and she referenced a tea soak, or alcohol extraction into a tincture (I assume she was referencing ethanol, which I still have a bit over a gallon of here)

                            The seller believes she received benefit from the TT for her cancer, and is including a free reishi mushroom, though that's the one for which WebMD (and others?) cited some potential liver issues for some persons, so I'm mildly wary. These days I tend to see skulls & cross-bones or other warnings as being 2x's larger than they often actually are.. ."Thanks, auto-immune system."

                            (I think I have a Calvinist auto-immune system, trapped in a Bohemian Jack Kerouac body. Yes, this has been a problem at times)..

                            And the emotional end of this is way important, buzz. You already know that. All of the factors within this disease have been pretty much referenced herein to one degree or another, and if anything, the wildest ride is depression, anxiety, uncertainty, gambling wit no-deposit-no-return issues where you get ONE decision at the kick-off, and the rest of the head-space issues that hold hands with cancer.

                            At this point, what ever treatment they give a person, it should come with tranquilizers; if not for the patient, for the poor bastards who have to hover, watch, help, and endure..

                            Thanks again, buzz. Knowing that someone has ridden the crests and troughs of this ride, and can say, "Yeah, I remember feeling just like that. This too shall pass, and is normal." is a huge help.

                            -----------------------------------------------
                            Had this on 8-track in a 1967 Oldsmobile 98 Luxury Sedan when I was a youngster with 4 bald tires under a 416 4-bbl, that never saw a full tank of fuel, other than for road trips to concerts (with costs shared by the numerous occupants), despite dealing and working. A 'boat with wheels' that could haul 6-8 people to a concert, but had a hellacious time stopping on glazed ice Mid-west Winter roads. Yes, I was an acid head.

                            Hot Tuna

                            'Song From the Stainless Cymbal'

                            https://www.youtube.com/watch?v=dhPPqrwrdNg

                            Comment


                              Originally posted by trichrider View Post
                              yes!
                              are those whole, or powdered?
                              whole are tough as shoe leather.
                              i've tried drying and grinding in a coffee grinder...that's an ordeal.
                              i hope you get some kind of promise from their use.
                              yep, looks like things are accelerating.

                              thanks for the Hendrix link, i dig his style and the lyrics are obscure enough that they don't play in a loop over and over in my head.lol

                              this guy can play the guitar with the best of them:
                              https://www.youtube.com/watch?v=2JGb3O8ql1U
                              [youtubeif]2JGb3O8ql1U[/youtubeif]
                              Thanks trich.

                              Yes, looking at them, and knowing they are a form of shelf mushroom from (mostly/often) dead or dying trees, my assumption was that they're softer than chaga or some other tree-bark medicines, but dried, I assumed they are going to be at least as tough as dried whole peyote buttons; like shoe leather, as you say. Hopefully without the conditioned response of nausea that I used to get, while chewing the buttons (the power of the memory of puking after chewing dried, tough, cactus buttons)..

                              We have a variety of potential apparatus for pulverizing, but these are, indeed, whole and dried.

                              I haven't yet done proper research re. poor or unsafe interactions with other drugs or meds sources, but the biggest wild card right now, as stated to buzz, is the seemingly independent nature of my auto-immune system lately.

                              There's recipes online, and the seller recommends either a tea soak, or alcohol extraction. I want to find some recipes that might entertain rehydration in warm (not hot) H2O, and maybe using them like shitake in stir-fries or vegan lo mein, or similar. But I have no reference at the moment for taste, and if they taste strictly like medicine, then I'll have to figure something else out.

                              My greatest focus, aside from getting them into a state where I can keep them down, is to maximize the ingesting and processing of the most beneficial components (PSK and PSP).

                              By the way, from the herbalist researcher author in Whitehorse, whose book I got for my wife's birthday, dandelion root, which I referenced earlier as being looked at as aiding diabetes (2011), also promotes production of bile (as in, working to dissolve gall stones), and are high in potassium and Vit A, among other stuff.

                              We used to make dandelion wine 40-50 years ago, but our recent bumper crops are now likely headed to other uses. The author recommends roasting them like carrots, but I suspect keeping the heat lower is a safer way of preserving the components that are being sought.
                              -----------------------------------
                              Yeah, I think I have parts of that Sweden Hendrix concert from '69 here, on other tapes.

                              The Rainbow Bridge Lp (still here on 33-1/3 vinyl) was awesome as well.

                              JH is one among many who went astoundingly early in their lives (Tommy Bolin, Lowell George, Janis, and many more), as Gracie Slick pointed out, lots of these folks didn't necessarily want to die; they simply partied to hard, and maybe forgot how much dope had been ingested. Pure speculation, but I tend to believe that perspective.

                              Not from Rainbow Bridge, but from a 1970 show at the LA Forum.

                              'Hey Baby'

                              https://www.youtube.com/watch?v=bki0ScmXiH0

                              And, originally (in the case of my collection) from the 'Axis Bold as Love' Lp, (also still here on vinyl) what I believe was -the- most beautiful Hendrix tune ever put to ears. My deceased younger brother's guitar teacher used to do this very nicely.

                              'Little Wing'

                              Live from Winterland October 1968

                              https://www.youtube.com/watch?v=0YDB...ygUhG&index=23

                              *Not an ear worm, per se', but it has stuck with me for close to 50 years as a thing of beauty.

                              Comment


                                A quick heads-up re. alternative plant-based sausages, for those either entertaining sampling such things, or for those more serious about pursuing a plant-based diet for health concerns, whether they be general concerns, or specific to a diagnosis that such a diet would/might benefit.

                                The Beyond Meat (brand) of spicy Italian brats, or regular brats, are PHENOMENAL. I'm sold. I love decently done meat, whether steaks or sausages, or ???? And switching over to the plant-based diet for health reasons, I was finding a lot of substandard stuff that made me wonder if the folks making these products had ever actually eaten sausage, or meats in general?

                                I also found some vegan ham, and the BM brats. Picked up a container of vegan parmesan cheese, and have some on a salad as I type right now.

                                Being able to like and/or appreciate a new diet matters. sticking to the new diet would have been made more difficult, had we not found stuff that was tasty and enjoyable.

                                A good trip, though maybe 4 days before I wanted to go in. we're headed into a week with lows down near -40 to -55 f., and aside from having a blood draw on Tuesday AM, for lipids, PSA, A1C, and various other functions of the body, I'm planning to "stay the fuck at home", and engage in Telehealth/Zoom meetings with Docs.

                                Comment

                                Working...
                                X