I'd say CO2 ends up being way for trouble than it's worth 90% of the time, especially when aircooling lights. It doesn't even increase yields that much, it just makes plants ripen a little quicker. Just run more lights for more yield. C02 is just a hydro shop scam in my opinion. I find it funny how many people with unsealed rooms think that adding CO2 is going to give them better yields right off the bat...wasting money trying to maintain ppm's in an unsealed area or wasting money on electricity running 3 ton air conditioners to keep temps in check without aircooling. Take the grand that you were gunna spend on CO2 bullshit and buy a couple more lights.
20% increase from CO2... LOL maybe 5% at the MOST and thats WITH A SEALED ROOM ONLY. You would end up running 5 lights worth of juice with the A/C needed to cool the room during lights on and another light worth for the dehumidifier which would be constantly running during lights off.
And just how many 4000w sealed CO2 grows have you run? Sorry but I don't correlate a 250W grower with something 8X the size. 20% is a commonly accepted increase with CO2, I've had that myself on a 3KW.
Of course the room has to be sealed, and yes it requires a good handful of expensive equipment. But lots of guys are maxing out their spaces and want to get better yields, adding more lights isn't often practical so adding CO2 to a healthy grow is the best way to get better yields.