I consider myself informed and I do not consent to being injected by this vaccine.
The reason I feel I can be so cavaliere about a treatment that is purported to be the necessary life saver, is that I am not at risk – for two reasons, first I had covid19 at the beginning of the pandemic (based on earliest described symptomology) and survived – which I perceived at the time to be a bad flu, and second I have a healthy immune system – as verified by the first reason. My immune health is my daily priority – including adequate exercise, proper nutrition, and quality food sourcing. It is not an accident that my BMI is 21. I do not think the risk of vaccination is worth the 0.7 to 1.1 absolute risk reduction offered by mRNA treatment. My health has been my priority for the last 40 years – well, I should have started resistance training before age 65, since muscles don’t grow much after that (evidently). I’m chronologically 73, biological age calculator says 53.
My rejection of the mRNA technology is in four areas of concern:
I have concerns about the polyethylene glycol used to mask the lipid nanoparticle since PEG is not biodegradable – where does it accumulate? The studies I have read indicate trouble. How is it going to be expelled from the body? Clinical studies in the past have found it to be too toxic for continued use as was desired for long term treatment.
I have concerns about the yield of the manufacturing process – it is horrendously complicated, according to the descriptions I have read. When I am offered mRNA manufacturing services there is mention of “high yield” – 70%, 80%, 90% purity? – I guess cost is the determinant. In this case, I wonder what and how much flawed mRNA is in the vial, besides the desired mRNA. Dispensary cannabis comes with a lab analysis, but not these vaccines. When the Stanford group reverse engineered the Moderna product, they used partial RNA bits from the vial – that was what CDC said was okay to do. So what is actually in the shot?
U of Mass Amherst has released a study on exactly this topic: High salt transcription of DNA co-tethered with T7 RNA polymerase to beads generates increased yields of highly pure RNA - Journal of Biological Chemistry (jbc.org) … just add salt! Who knew?
I have concerns about the cold chain – does the vial ingredient degrade with marginal parameters?, what is measured?, what is acceptable? – especially since it is a product for profit. And how well trained are the people doing injections? – it is designed to be intramuscular, and should not enter the blood stream directly – yet the needle is not aspirated to check for a vein location before injecting. Intravenous injection has been suggested as a cause of the blood clots, but I doubt that is the whole story.
I am concerned when the main stream media is so careless in their reporting of the medicine and science surrounding the pandemic. For just one example: decreasing antibody titers does not mean the immune system response was inadequate, since there are studies (preprints) that indicate T cell and B cell remodeling for the spike protein antigen. As I understand how the body evolved to function, when the antigen is gone, the antibodies will cease being produced. The body is an engineering marvel and it must, by evolution, be very efficient. Immune system proteins are only manufactured for actual threats, not as prophylaxis. As another example: the virus is said to be “sneaky” and that it “tries to evade” the immune system – I don’t think that characterizing evolutionary pressure as volition on the part of the virus is a useful message. Reality is far more scary.
I am concerned by the messaging from the medical establishment, advancing the pharmaceutical interests above the health of the people. Where are the doctors, other than on YouTube (and Mercola), who stand up and say healthy people are not at risk of covid19 (for the most part (99.4% don’t die according to WHO), based on the epidemiology to date) and here is how to lose weight and get fit? A full 70% of Americans are unfit – why not engage on this message? Pharmaceuticals are not health, they are treatment. More testing would help defining the real threat of the pandemic. This is a solved problem – Joe Rogan has been giving his guests a 15 minute covid test for over a year (Spotify must love Joe more than CDC loves me).
When I see wrong, poorly articulated and missing analysis I have to wonder, what is the agenda?. I don’t travel in the circles that can answer that question, at which point I revert to the principle that has gotten me this far – I just don’t do drugs (unless I know the chemist). I do not trust pharmaceutical companies – they have the wrong priorities, so I plan to sit this one out.
Oh, I have no doubt I can tolerate and survive an mRNA treatment, but it is clear from the messaging that this is just the beginning of a sustained vaccine program. Yearly influenza shot + covid booster is already being floated in the media. A 20-valent shot that will be protecting against everything they can think of right now. As presented constantly in the media, “the platform” (lipid nanoparticle delivery vesicle carrying a reconfigurable protein-coding mRNA) is more important than health. I draw the line right here – no shot, no boosters. This is just chasing the antibiotic resistance disaster. I want to train my immune system to be effective.
If there is an immunizing vaccine – a true vaccine – I will reconsider my stand depending on the antigens floating around and my perceived risk – and I do foresee serious trouble. I think we will see that cyber hackers are nothing compared to protein hackers. The equipment is cheap, the science is fully documented, google has released the protein folding solution – what could possibly go wrong? Did I mention the “mRNA as a Service” vendors? They even put on the 5’ and 3’ caps to complete the sequence. Or maybe a DNA printer is the technology that will be preferred (with a little salt added). You should see the ad feed I get after visiting so many medical websites.
I have spent 4 to 8 hours a day since Feb 2020 studying biochem, metabolism, nutrition, exercise, fitness. Probably in excess of 2000 hours in reading peer-reviewed medical studies, preprints and watching YT lectures. There are a lot of very poor medical studies. Similarly I have studied virology, vaccine technology, and messaging, probably for 1000 hours. I am an engineer and I understand what I read. I haven’t mastered the jargon since I don’t use it much so I can’t be as articulate as I would like, but I understand the principles. My driving biochem passion is mitochondria, but I have recently started studying ribosomes, when I realized that they are really massively-parallel Turing machines. I am a software engineer by training and occupation which is why I find cellular biology to be so fascinating. mRNA is simply a software program – more like a subroutine if only one protein is coded for. I am intrigued by the possibilities.
[/rant]
That is my position about the covid19 mRNA treatment in a summary form. Thank-you for taking the time to read it. I would appreciate any comments you might care to offer.
tl;dr - my body, my choice, no jab.
The reason I feel I can be so cavaliere about a treatment that is purported to be the necessary life saver, is that I am not at risk – for two reasons, first I had covid19 at the beginning of the pandemic (based on earliest described symptomology) and survived – which I perceived at the time to be a bad flu, and second I have a healthy immune system – as verified by the first reason. My immune health is my daily priority – including adequate exercise, proper nutrition, and quality food sourcing. It is not an accident that my BMI is 21. I do not think the risk of vaccination is worth the 0.7 to 1.1 absolute risk reduction offered by mRNA treatment. My health has been my priority for the last 40 years – well, I should have started resistance training before age 65, since muscles don’t grow much after that (evidently). I’m chronologically 73, biological age calculator says 53.
My rejection of the mRNA technology is in four areas of concern:
- the technology
- the ingredients
- the manufacturing process
- the cold chain distribution and dispensing of the product
I have concerns about the polyethylene glycol used to mask the lipid nanoparticle since PEG is not biodegradable – where does it accumulate? The studies I have read indicate trouble. How is it going to be expelled from the body? Clinical studies in the past have found it to be too toxic for continued use as was desired for long term treatment.
I have concerns about the yield of the manufacturing process – it is horrendously complicated, according to the descriptions I have read. When I am offered mRNA manufacturing services there is mention of “high yield” – 70%, 80%, 90% purity? – I guess cost is the determinant. In this case, I wonder what and how much flawed mRNA is in the vial, besides the desired mRNA. Dispensary cannabis comes with a lab analysis, but not these vaccines. When the Stanford group reverse engineered the Moderna product, they used partial RNA bits from the vial – that was what CDC said was okay to do. So what is actually in the shot?
U of Mass Amherst has released a study on exactly this topic: High salt transcription of DNA co-tethered with T7 RNA polymerase to beads generates increased yields of highly pure RNA - Journal of Biological Chemistry (jbc.org) … just add salt! Who knew?
I have concerns about the cold chain – does the vial ingredient degrade with marginal parameters?, what is measured?, what is acceptable? – especially since it is a product for profit. And how well trained are the people doing injections? – it is designed to be intramuscular, and should not enter the blood stream directly – yet the needle is not aspirated to check for a vein location before injecting. Intravenous injection has been suggested as a cause of the blood clots, but I doubt that is the whole story.
I am concerned when the main stream media is so careless in their reporting of the medicine and science surrounding the pandemic. For just one example: decreasing antibody titers does not mean the immune system response was inadequate, since there are studies (preprints) that indicate T cell and B cell remodeling for the spike protein antigen. As I understand how the body evolved to function, when the antigen is gone, the antibodies will cease being produced. The body is an engineering marvel and it must, by evolution, be very efficient. Immune system proteins are only manufactured for actual threats, not as prophylaxis. As another example: the virus is said to be “sneaky” and that it “tries to evade” the immune system – I don’t think that characterizing evolutionary pressure as volition on the part of the virus is a useful message. Reality is far more scary.
I am concerned by the messaging from the medical establishment, advancing the pharmaceutical interests above the health of the people. Where are the doctors, other than on YouTube (and Mercola), who stand up and say healthy people are not at risk of covid19 (for the most part (99.4% don’t die according to WHO), based on the epidemiology to date) and here is how to lose weight and get fit? A full 70% of Americans are unfit – why not engage on this message? Pharmaceuticals are not health, they are treatment. More testing would help defining the real threat of the pandemic. This is a solved problem – Joe Rogan has been giving his guests a 15 minute covid test for over a year (Spotify must love Joe more than CDC loves me).
When I see wrong, poorly articulated and missing analysis I have to wonder, what is the agenda?. I don’t travel in the circles that can answer that question, at which point I revert to the principle that has gotten me this far – I just don’t do drugs (unless I know the chemist). I do not trust pharmaceutical companies – they have the wrong priorities, so I plan to sit this one out.
Oh, I have no doubt I can tolerate and survive an mRNA treatment, but it is clear from the messaging that this is just the beginning of a sustained vaccine program. Yearly influenza shot + covid booster is already being floated in the media. A 20-valent shot that will be protecting against everything they can think of right now. As presented constantly in the media, “the platform” (lipid nanoparticle delivery vesicle carrying a reconfigurable protein-coding mRNA) is more important than health. I draw the line right here – no shot, no boosters. This is just chasing the antibiotic resistance disaster. I want to train my immune system to be effective.
If there is an immunizing vaccine – a true vaccine – I will reconsider my stand depending on the antigens floating around and my perceived risk – and I do foresee serious trouble. I think we will see that cyber hackers are nothing compared to protein hackers. The equipment is cheap, the science is fully documented, google has released the protein folding solution – what could possibly go wrong? Did I mention the “mRNA as a Service” vendors? They even put on the 5’ and 3’ caps to complete the sequence. Or maybe a DNA printer is the technology that will be preferred (with a little salt added). You should see the ad feed I get after visiting so many medical websites.
I have spent 4 to 8 hours a day since Feb 2020 studying biochem, metabolism, nutrition, exercise, fitness. Probably in excess of 2000 hours in reading peer-reviewed medical studies, preprints and watching YT lectures. There are a lot of very poor medical studies. Similarly I have studied virology, vaccine technology, and messaging, probably for 1000 hours. I am an engineer and I understand what I read. I haven’t mastered the jargon since I don’t use it much so I can’t be as articulate as I would like, but I understand the principles. My driving biochem passion is mitochondria, but I have recently started studying ribosomes, when I realized that they are really massively-parallel Turing machines. I am a software engineer by training and occupation which is why I find cellular biology to be so fascinating. mRNA is simply a software program – more like a subroutine if only one protein is coded for. I am intrigued by the possibilities.
[/rant]
That is my position about the covid19 mRNA treatment in a summary form. Thank-you for taking the time to read it. I would appreciate any comments you might care to offer.
tl;dr - my body, my choice, no jab.
