Learn How Cannabis Kills Cancer! Part 1: VEGF -Backed up by National Cancer Institute

[maryjaneismyfre]

Let them do what they want...Keep your seeds, including heirloom vegetable seed, on cold store. Make and grow your own medicine and for others. It will not matter. The more people that realize that there IS a conspiracy, that THC outright cures cancer, the better for us and the worse for Monsanto and the likes of their skummy corporate circle.

Thank you Bio for sharing the information...

Om namah Shivaia!

 

[pink.lovebud]

Thank you Bi0hazard for the enlightment of information. This is one of the most amazing posts that I have read so far on this forum! Please post more

 

[Bi0hazard]

" Cancer-specific Cytotoxicity of Cannabinoids (How Cannabinoids kill Cancer continued...)

By: Dennis Hill

First let's look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer's aliveness.

In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the "Sphingolipid Rheostat." If ceramide (a signaling metabolite of sphingosine-1- phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality.

Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. the purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.

Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren't enough, ceramide disrupts the cellular lysosome, the cell's digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.

How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for it's matched exocannabinoid activator.
This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system andthe central nervous system (CNS). It is responsible for neuroprotection, and micro- manages the immune system. This is the primary control system that maintains homeostasis; our well being.

Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.

To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it's much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).

It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.

Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body's immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.

This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.

~Dennis Hill

Bibliography
1. http://cancerres.aacrjournals.org/content/65/5/1635.abstract
Sami Sarfaraz, Farrukh Afaq, Vaqar M. Adhami, and Hasan Mukhtar + Author Affiliations. Department of Dermatology, University of Wisconsin, Madison, Wisconsin

2. http://www.ncbi.nlm.nih.gov/sites/pubmed
J Neuroimmunol. 2007 Mar;184(1-2):127-35. Epub 2006 Dec 28. Immune control by endocannabinoids - new mechanisms of neuroprotection? Ullrich O, Merker K, Timm J, Tauber S. Institute of Immunology, Medical Faculty, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. oliver.ullrich@medizine.uni-magdeburg.de

3. http://en.wikipedia.org/wiki/Endocannabinoid_system
Endocannabinoid synthesis & release.

4. http://en.wikipedia.org/wiki/Cannabinoids
Cannabinoid receptor type 1.

5. http://www3.interscience.wiley.com/journal/121381780/abstract? CRETRY=1&SRETRY=0
Journal of Neurochemistry, Volume 104 Issue 4, Pages 1091 - 1100 Published Online: 18 Aug 2008

6. http://leavesofgrass.info/info/Non-Psychoactive-Cannabinoids.pdf
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Angelo A. Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, and Raphael Mechoulam. Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy. Institute of Biomolecular Chemistry, National Research Council, Pozzuoli (NA), Italy. Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem, Israel, Endocannabinoid Research Group, Italy

7. http://sciencenews.org/view/feature/id/59872/title/Not_just_a_high
Scientists test medicinal marijuana against MS, inflammation and cancer By Nathan Seppa June 19th, 2010; Vol.177 #13 (p. 16)

8. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766198/
NIH Public Access: A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death Tarek A. Taha, Thomas D. Mullen, and Lina M. Obeid Division of General Internal Medicine, Ralph H. Johnson Veterans Administration Hospital, Charleston, South Carolina 29401; and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425 Corresponding author: Lina M. Obeid, M.D., Department of Medicine, Medical University of South Carolina, 114 Doughty St., P.O.Box 250779, Charleston, South Carolina 29425. E-mail: obeidl@musc.edu
"

 

[Beetlepumpr]

Documentary Run From The Cure

Documentary Run From The Cure

website www.pheonixtears.ca All ppl in the documentary had diff. forms of cancer. one man was days away from worm food. all were healed. by using one pound of quaility bud and making a resin, makes about 6 - 5-7 CC syringes. All resin must be used for a cure. all have been cleared as being cancer free. one girl 16 years old had leukemia. she took ALL the resin in 31 days. The ppl associated with this recipe say they do not know how she did it in 31 days. But she was given an all clear after the end of 31 days. youtube other vids by Rick Simpson and other involved with him. Great! go to youtube and watch the full length version of Run From the Cure.

 

[DryNobBob]

Is Rick still on the run?

 

[HUGE]

Pure awesome

 

[Duckhunter-DK]

Thank you so much for this thread. Will spread it to every bio/med nerd I know.

 

[idiit]

It turns out, THC when ingested in highly concentrated forms (such as EATING CANNABIS OIL) will attack any mutated cells in your body while strengthening and rejuvenating the healthy cells.

The PERFECT Cure for Cancer: it works fast, it works well, it works on many different forms of Cancer in ALL stages and it has ZERO harmful side effects. (Unlike Chemo which deteriorates your entire body and kills 1 in 5 patients). Not only that, but it dissolves ALL forms of tumors and can even combat superbugs like MRSA.

Intelligent people realize that the scientific method does not work by *disproving* information or people. Cannabinoids are listed on the National Cancer Institute website and once you see how fast the cure works, the cognitive dissonance wears off pretty quickly. One needs to remember that *ignore* is the root word of "ignorance"...
Scientific evidence for the use of cannabis in curing cancer:

http://fengshuiserenity.blogspot.com/2013/01/cannabis-cures-wide-spectrum-of.html

^article just published today with a lot of links to the scientific studies the assertions re "cannabis cures cancer and so much more" derive.

 

[Agaricus]

A couple days ago I accompanied a friend to her chemo appointment. While we were talking to her oncologist I mentioned cannabis' anti-cancer properties. The doc didn't seem to have heard of this, though the clinic is very pot-friendly. At least in prescribing dronabinol etc. and encouraging smoked and eaten pot to help alleviate pain and making the side effects of chemo more valuable.

Anyway, to get to the point, I plan to send the url of this thread to the doc. The info needs to get to the mainstream medical community.

 

[Bi0hazard]

Agaricus,

Yes! I've seen this so many places I've talked to doctors.

The research and results are already there, the information just needs to be brought to their attention..

Make sure you show the doctor this Review of Key Studies @ http://cancerres.aacrjournals.org/content/68/2/339.full#ref-2

Also I put together a tread of all the cancer/cannabis studies organized by Cancer Type, so you can show the doctor studies for the specific cancer as well as the review that goes over the basics of how it works.

Thread with Cancer Cure Studies Organized by Type of Cancer @ https://www.icmag.com/ic/showthread.php?t=243468

 

[Bi0hazard]

Also this thread, has links to studies for each type of cancer. So you can also show the doctor specific studies on that type of cancer, along with the review article.

Cannabis and Cancer Article Organized by Type of Cancer: https://www.icmag.com/ic/showthread.php?t=243468

Private message me if you need a list of all the links together, if you copy and paste from this site, it might not grab all the links corretly.