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Old 05-15-2018, 06:56 AM #1
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All About THCV! Where To Find It? What does It Do? Research From Israel 4/22/2017

Source: Steep Hill Labs
"Steep Hill is an independently owned and operated analysis, biotechnology, and research and development facility. We seek to empower cultivators, dispensaries, manufacturers, and consumers with a transparent understanding of science."

Link To Article:
https://www.steephill.com/blogs/38

The cannabis plant makes most cannabinoids, like THC, CBD, and CBC, out of CBG-A. CBGV-A appears in the plant much more rarely, and forms similar cannabinoids, except they only have 3 carbon tails (c3), instead of the more common 5 carbon tail (c5). These 3 carbon tailed cannabinoids are referred to as ‘varins’, such that the c3 version of THC (THC-c5) is named Tetrahydrocannabivarin (THC-c3).


Being closely related to the c5 version, the c3 versions have very similar properties along with other unique qualities. For instance, THCV is more strongly psychoactive than THC, but only has about half the duration of THC. THCV is also a protagonist of THC, modifying the effects of THC. The energetic effect of THCV is more pronounced and stronger.

THCV has been found to reduce or even block panic attacks and, as a result, can be highly effective in the management of PTSD and other mental disorders involving anxiety or stress, as shown in research in places like Israel, where a great amount of cannabis research is done. THCV doesn’t appear to suppress emotions, only the ability to panic, associated with Fight or Flight response.

THCV has also been shown to reduce tremors associated with diseases such as Parkinson’s, along with ailments associated with motor control. There is also promising research demonstrating reduction of brain lesions associated with Parkinson’s.

THCV also stimulates bone cell growth, and has potential in the treatment of osteoporosis and similar ailments; possibly even in the micro gravity of space, to combat the loss of bone mass.

A side effect of THCV that requires attention is its strongly anorectic effect. If a patient is already having difficulty eating, THCVs appetite suppression can be a detriment.
Tetrahydrocannabivarinic Acid (THCV-A) is very similar to THC-A, and although it has yet to be properly studied, it is assumed to be anti-inflammatory.

Originally THCV was most commonly isolated in landrace sativas from the southern and central African continent. Until recently, THCV was only available in small concentrations in sativa strains like Durban Poison, which on average yield upwards of 0.5% THCV in a THC dominant plant. Such plants have a THC:THCV ratio of 20:1 or greater.

Several years ago, a strain named Pineapple Purps (archived test shown below) was created with a ratio of 3:1, and yielding 12% THC and 4% THCV. In the last year, a new strain, Doug’s Varin was created, with a ratio of 6:7 THC:THCV. This is the first strain we have evaluated that has more THCV than THC. All the high THCV plant strains we have observed are of the classic tall, lanky, narrow leaved sativa appearing variety.
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https://www.icmag.com/ic/showthread.php?t=358147

Drying and Cure Process Explained In Depth (Sticky Thread):

https://www.icmag.com/ic/showthread.php?t=358186

Pot Size, Root system and maximizing growth thread:

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Silicon, The Misunderstood Element:

https://www.icmag.com/ic/showthread.php?t=352413

Humic and Fulvic acid information:

https://www.icmag.com/ic/showthread.php?t=352265

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Old 05-15-2018, 08:59 AM #2
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Ah this is great!
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Old 05-15-2018, 09:17 AM #3
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Nonsense that THCV is
"THCV is more strongly psychoactive than THC, but only has about half the duration of THC. THCV is also a protagonist of THC, modifying the effects of THC. The energetic effect of THCV is more pronounced and stronger."

THCV does not get you high and is a THC CB1 antagonist.
It is obvious you have never tried pure THCV?
I did more then a decade ago when we developed THCV varieties that were only THCV over 10% by dry weight.
What I found is THCV may well have medical applications but not recreational.
This was backed up by research by Roger Pertwee and others:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189766/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/

-SamS


Quote:
Originally Posted by Ibechillin View Post
Source: Steep Hill Labs
"Steep Hill is an independently owned and operated analysis, biotechnology, and research and development facility. We seek to empower cultivators, dispensaries, manufacturers, and consumers with a transparent understanding of science."

Link To Article:
https://www.steephill.com/blogs/38

The cannabis plant makes most cannabinoids, like THC, CBD, and CBC, out of CBG-A. CBGV-A appears in the plant much more rarely, and forms similar cannabinoids, except they only have 3 carbon tails (c3), instead of the more common 5 carbon tail (c5). These 3 carbon tailed cannabinoids are referred to as ‘varins’, such that the c3 version of THC (THC-c5) is named Tetrahydrocannabivarin (THC-c3).


Being closely related to the c5 version, the c3 versions have very similar properties along with other unique qualities. For instance, THCV is more strongly psychoactive than THC, but only has about half the duration of THC. THCV is also a protagonist of THC, modifying the effects of THC. The energetic effect of THCV is more pronounced and stronger.

THCV has been found to reduce or even block panic attacks and, as a result, can be highly effective in the management of PTSD and other mental disorders involving anxiety or stress, as shown in research in places like Israel, where a great amount of cannabis research is done. THCV doesn’t appear to suppress emotions, only the ability to panic, associated with Fight or Flight response.

THCV has also been shown to reduce tremors associated with diseases such as Parkinson’s, along with ailments associated with motor control. There is also promising research demonstrating reduction of brain lesions associated with Parkinson’s.

THCV also stimulates bone cell growth, and has potential in the treatment of osteoporosis and similar ailments; possibly even in the micro gravity of space, to combat the loss of bone mass.

A side effect of THCV that requires attention is its strongly anorectic effect. If a patient is already having difficulty eating, THCVs appetite suppression can be a detriment.
Tetrahydrocannabivarinic Acid (THCV-A) is very similar to THC-A, and although it has yet to be properly studied, it is assumed to be anti-inflammatory.

Originally THCV was most commonly isolated in landrace sativas from the southern and central African continent. Until recently, THCV was only available in small concentrations in sativa strains like Durban Poison, which on average yield upwards of 0.5% THCV in a THC dominant plant. Such plants have a THC:THCV ratio of 20:1 or greater.

Several years ago, a strain named Pineapple Purps (archived test shown below) was created with a ratio of 3:1, and yielding 12% THC and 4% THCV. In the last year, a new strain, Doug’s Varin was created, with a ratio of 6:7 THC:THCV. This is the first strain we have evaluated that has more THCV than THC. All the high THCV plant strains we have observed are of the classic tall, lanky, narrow leaved sativa appearing variety.
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Old 05-15-2018, 10:12 AM #4
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The effect of appetite suppression is a great one. Developed countries have a big problem with obesity, hope this can be put into action. Got some Durban beans, I need to lose a few pounds....
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Old 05-15-2018, 10:38 AM #5
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Quote:
Originally Posted by Sam_Skunkman View Post
Nonsense that THCV is
"THCV is more strongly psychoactive than THC, but only has about half the duration of THC. THCV is also a protagonist of THC, modifying the effects of THC. The energetic effect of THCV is more pronounced and stronger."

THCV does not get you high and is a THC CB1 antagonist.
It is obvious you have never tried pure THCV?
I did more then a decade ago when we developed THCV varieties that were only THCV over 10% by dry weight.
What I found is THCV may well have medical applications but not recreational.
This was backed up by research by Roger Pertwee and others:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189766/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2219532/

-SamS
10%+ THCV by dry weight 10+ years ago even is quite an accomplishment, considering most of the recent articles ive come across reference high THCV at ~7%.

It was a direct copy from what I believed was the most credible and recent article Id found about THCV. Interestingly enough most other places ive seen also explain: "THCV At lower doses, may act as an antagonist of the cannabinoid receptor type 1 (CB1). At higher doses, however, it can switch, behaving as a CB1 agonist, much like THC." This seems to be a recurring misconception among many sources ive read. My area of focus is in the potential medical benefits, so the news that it is not psychoactive is actually welcomed news to me (and probably others), this is a start on the path to clearing up the misconception and one of the main reasons for this thread.

Im merely an enthusiast trying to share what ive learned in hopes of it benefiting someone else, (i have never had pure THCV before...lol). You by far are the most credible source, I appreciate your contributions and respect you highly.
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https://www.icmag.com/ic/showthread.php?t=352271

Science Of Lighting & Plant Reactions (Sticky Thread):

https://www.icmag.com/ic/showthread.php?t=358147

Drying and Cure Process Explained In Depth (Sticky Thread):

https://www.icmag.com/ic/showthread.php?t=358186

Pot Size, Root system and maximizing growth thread:

https://www.icmag.com/ic/showthread.php?t=344347

Silicon, The Misunderstood Element:

https://www.icmag.com/ic/showthread.php?t=352413

Humic and Fulvic acid information:

https://www.icmag.com/ic/showthread.php?t=352265


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Old 05-15-2018, 02:59 PM #6
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I've heard it's a THC antagonist, which contradicts many of the older accounts pre 1990 that say it's THC on steroids. The older reports claimed it was responsible for the extremely clear headed, psychedelic, and no body high type effects of certain African varieties. Pretty sure newer research found this to be false. Much like CBD was misrepresented.
Instead of getting the munchies, it suppresses your appetite. The Steep Hill Labs article says on the one hand it blocks panic attacks, fight or flight responses. On the other hand it's extremely psychedelic, more so then THC. I find this contradictory, when I'm exposed to high levels of THC when I have a low tolerance I've felt the flight or fight, panic response. I see it as more proof it's an antagonist.
This is not science, it's my own biased opinion but I've used cannabis to fast. It can stimulate and repress hunger. It can also stimulate panic or repress panic. At least for me. Interesting how subjectively it can draw out conflicting responses. Doesn't surprise me it can contain compounds that are agonists and antagonists.
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Old 05-15-2018, 03:38 PM #7
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Neat thread, we are surely fortunate to have Sam here.
Steeple Hill would appear to be a 'Sports Car' of cannabis info.
Thank you Sam. One of those things I should have said that many times before.
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Old 05-15-2018, 04:43 PM #8
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Different strokes for different folks,,,,,
one persons panic attack is anothers racy,stimulating high,,,,,s2
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Old 05-15-2018, 07:17 PM #9
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Now this is interesting.

This begs the question.. How linear are our Cannabinoid receptors? It is hard to imagine with the range of properties and effects that there is a 'simple fill up' from an untouched receptor to a full bound receptor.

THCv helps parkinsons? hmmm Maybe in conjunction with CBD this in theory could help with things like ALS for things like comfort.
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Old 05-15-2018, 08:51 PM #10
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I've always hated CBD, as I believed it was what made indifferent smoke indifferent...


The dreaded 'plateau' compound, if you will...?


And back in the day (70s), Rosenthal described THCv as the compound in potent grass that gave the intense electric high we all seek!


Incidentally, I find THCv described here on the page as "tetrahydrocannabiverol" rather than "tetrahydrocannabivarin"?

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