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CBD is a major component of flax seed

danut

Member
http://www.examiner.com/article/getting-the-flax-straight-about-cannabidiol

A research team based in Poland may have discovered that CBD is a major component of the flax plant. The Cannabis plant also makes CBD (Cannabidiol), a miraculous plant compound that demonstrates the potential to treat a wide range of diseases with virtually no side effects.
Interestingly, the researchers discovered the presence of CBD in flax accidently. They were analyzing genetically modified flax plants and comparing them to natural flax plants.

More at the link.

Does that mean that flax is now a schedule one drug?
 

hush

Señor Member
Veteran
So... does that mean we can isomerize flax seed extracts and get high?
 

stihgnobevoli

Active member
Veteran
i wonder how many more plants contain all the same compounds in weed which we now call cannabinoids? what if weed was the first plant and all plants came from it?
 

hush

Señor Member
Veteran
Or, what if all plants are still evolving, and some of them have just learned how to produce cannabinoids because they saw how well we treat cannabis and they want in on that action?
 

Hydro-Soil

Active member
Veteran
Watch it turn out that the sample was tainted with cannabis. lol

CBD does NOT get you high... I'll keep repeating that until other people start it as well.

Stay Safe! :blowbubbles:
 

hush

Señor Member
Veteran
CBD does NOT get you high...

Yeah, but, doesn't something happen to the CBD when you isomerize it that converts it to THC? I admit I don't know, but I always thought there were procedures that did this, so that hempy low quality bud could produce an effective oil?

Edit: I found something on another forum that said it's not isomerization that would convert CBD to THC, but refluxing the material in an acidic aqueous solution that would do it. It has something to do with this picture, which is way over my head, but maybe some of the chemists among us can verify:

4temp.jpg


So, from what I understand, if flax seed does in fact contain CBD, one should be able to reflux flax seed oil with appropriately measured amounts of sulfuric acid and create THC in there somewhere. That's the extent of my knowledge on the subject.
 

Skip

Active member
Veteran
THC-A converts to THC.
CBD-A converts to CBD.

At least that's how I understand it.
Now if you eat your cannabis, it converts into different metabolites.
 

hush

Señor Member
Veteran
I found this:

http://www.patentstorm.us/patents/7399872/fulltext.html said:
Gaoni and Mechoulam (1966, Tetrahedron 22: 1481-1488) teach methods of converting CBD to, among other compounds, Δ8-THC and Δ9-THC comprising boiling a solution of CBD (3.0 g) in absolute ethanol (100 ml) containing 0.05%HCl for 18 hours. The solution was then poured into water and extracted with ether. The ether solution was washed with water, dried (Na2SO.sub.4) and evaporated. Δ8-THC and Δ9-THC were eluted from the resulting oil andseparated by chromatography. In another experiment, CBD (3.14 g) was dissolved in benzene (100 ml) containing 2 mg/ml p-toluenesulphonic acid and boiled for two hours. The reaction mixture was poured into water and the upper layer was separated, washedwith 5% NaHCO3, then with water, dried and evaporated. Elution with pentane-ether (95:5) gave an oily material which was subsequently distilled. Percentage yield of Δ8-THC (Δ1(6)-THC) was given as 64% of the crude material inthis paper. The crude oil product, which showed only one spot by thin layer chromatography, was purified by vacuum distillation.

Gaoni and Mechoulam (1964, J Amer Chem Soc 86: 1646) also described a method for converting CBD to Δ9-THC comprising boiling a mixture of CBD in ethanol containing 0.05% hydrogen chloride for 2 hours. Percentage yield ofΔ9-THC (Δ1-THC) was 2% (Mechoulam et al, 1972, J Amer Chem Soc 94: 6159-6165; Mechoulam and Gaoni, 1965, J Amer Chem Soc 87: 3273). Using boron trifluoride, the yield was 70% (Gaoni and Mechoulam, 1971, J Amer Chem Soc 93: 217-224)although purity was not given.

Clearly, as the cannabinoids are of potential medicinal value, improved methods of converting CBD to Δ9-THC or Δ8-THC are needed.


The reason why eaten cannabis converts into different metabolites is that gastric juice is acidic. It would stand to reason that the process could be duplicated in a laboratory using acidic aqueous solution. Here is an article citing proof of that:

http://micannalytics.com/articles/CBD-Gastric-Juice.pdf said:
For better understanding of whether CBD is converted to other cannabinoids, it is important to investigate the cyclization of CBD under conditions similar to those in biological systems. In the
present study, we describe the conversion of CBD to ∆9-THC, cannabinol (CBN), and hexahydrocannabinols (HHCs) in artificial gastric juice and their pharmacological effects in mice.
 
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