Oil for Cancer: Which Solvent?

[Gray Wolf]

Lots of controversy on the subject, but I think the answer is that several more readily available solvents will work, and you use the best safe one that you can get your hands on.

All should be taken out to below levels of concern afterwards anyway, regardless of what they are. Most not only have to be purged below levels of health concern, but below our more sensitive senses of taste and smell

We extract most of our cancer donations using butane, because it is effective and inexpensive if you recycle and we winterizing with ethanol because it is food grade and readily available here.

As I understand it, to be effective, we need to ingest enough cannabinoids over a 90 day period, to restore natural apoptosis to the tumor cells and starve them of additional blood supply for growth. How they were extracted, is of less importance than their presence.

Rick demonstrates using Naphtha and mentions using Iso in the video I watched, and his reported success speaks for itself, but I am troubled by using a solvent that only has a specified boiling point, instead of a specified content. If you start pulling up MSDS sheets for Light Naphtha, you will soon see that different manufacturers include different ingredients besides just Pentane and Hexane, some of them insalubrious.

Non polar simple alkane solvents like some of the ingredients in Light Naphtha work very well for the process, which is why we use simple alkanes n-Butane and n-Hexane for extraction and alchemy.

We use Ethanol for winterizing, for the reason mentioned above, and because it not only does a better job than Isopropyl for that purpose, but it has better patient acceptance when used or oral consumption.

If I could get nothing but Iso, I would most certainly extract with Iso before I would let a patient die, because I know that at the residual levels left in the oil, the Isopropyl isn't an issue, despite it being toxic at higher levels and causing auditory nerve damage.

I also know of patients experiencing miraculous results on Iso extracted oils by others, so that leads me to a bigger issue, and that is that the patient needs to be able to take enough oil to be effective.

A bigger issue for us, has been that if the THC is too high in relationship to the CBD and CBN, they will never be able to take enough to achieve the desired results without discobobulation.

We have made great inroads in that regard, by using high CBD strains like Cannatonic, and Hawaiian Bubble Gift. Heavy doses just puts them to sleep, instead of couch locking them with a racing mind.

 

[Gray Wolf]

Here is an explaination of how the cannabinoids address cancer, by a biochemist prostate cancer patient named Dennis Hill, that I scored on another forum, where it was presented by Dom

Cancer-specific Cytotoxicity of Cannabinoids

First let's look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer's aliveness.

In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the Sphingolipid Rheostat. If ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality.

Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.

The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. The purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.

Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren't enough, ceramide disrupts the cellular lysosome, the cell's digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.

The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.

How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? is endocannabinoid system exists in all animal life, just waiting for it's matched exocannabinoid activator.

This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system and the central nervous system (CNS). It is responsible for neuroprotection, and micro-manages the immune system. is is the primary control system that maintains homeostasis; our well being.

Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.

To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it's much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).

It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. us, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.

Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body's immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.

This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.

~Dennis Hill

The Human Endocannabinoid System Meets the Infammatory Cytokine Cascade

The Endocannabinoid System (ECS) started revealing itself to researchers in the 1940s and by the late ‘60s the basic structure and functionality had been laid out. Today we know the ECS is a comprehensive system of biochemical modulators that maintain homeostasis in all body systems including the central and peripheral nervous systems, all organ systems, somatic tissues, and all metabolic biochemical systems, including the immune system.

This homeostatic matrix is not a recent evolutionary twist just for humans; we find the Endo-cannabinoid System in every chordate creature for the last 500 million years. It is a fully mature biochemical technology that has maintained health and metabolic balance for most of the history of life itself.

The two major interactive systems within the ECS are (1) the cannabinoid receptors that we find on all cell surfaces and neurological junctions and (2) the endocannabinoids that fit the receptors to trigger various metabolic processes. Looking at a cannabinoid receptor distribution map we see that CB1 receptors, that are most sensitive to anandamide, are found in the brain, spinal nerves, and peripheral nerves. CB2 receptors preferred by 2-arachidonoylglycerol (2-AG) are found largely in the immune system, primarily the spleen. A mix of CB1 and CB2 receptors are found throughout the rest of the body including the skeletal system. And yes, 2-AG or CBDwill grow new trabecular bone.1 It is also useful to note that both anandamide and 2-AG can activate either CB1 or CB2 receptors.

The nature of the endocannabinoids are functionally much like neurotransmitters, but structurally are eicosanoids in the family of signaling sphingolipids. These signaling cannabinoids keep track of metabolic systems all over the body. This information is shared with the nervous system and the immune system so that any imbalance is attended to. If the body is in chronic disease or emotional stress, the immune system can fall behind and lose control of compromised systems. It is here that phytocannabinoids can pitch in to support the stressed body in a return to health. The cannabis plant provides analogues of the body’s primary signaling cannabinoids. Tetrahydrocannabinol (THC) is mimetic to anandamide, and cannabidiol (CBD) is mimetic to 2-AG, and has the same affinity to CB1 and CB2 receptors; providing the body with additional support for the immune and endocannabinoid systems.

Phytocannabinoids supercharge the body’s own Endocannabinoid System by amping up the response to demand from the immune signaling system in two modes of intervention: one, of course, is in bonding with the cannabinoid receptors; the other is in regulation of innumerable physiological processes, such as cannabinoid’s powerful neuroprotective and anti-in$ammatory actions, quite apart from the receptor system. It is interesting to note here that the phytocannabinoids and related endocannabinoids are functionally similar, but structurally different. As noted above, anandamide and 2-AG are eicosanoids while THC and CBD are tricyclic terpenes.

Let us look more closely at the two primary therapeutic cannabinoids, THC and CBD. The National Institutes of Health tell us that THC is the best known because of its signature psycho-tropic effect. is government report shows THC to be effective as an anti-cancer treatment, an appetite stimulant, analgesic, antiemetic, anxiolytic, and sedative.2

CBD (cannabidiol) is a metabolic sibling of THC, in that they are alike in many ways but are also different in important properties. First we see that CBD has no psychotropic effects and there are few CB2 receptors in the brain and peripheral nerves. There appears to be a broader therapeutic profile associated with CBD, which is listed here: anxiolytic, anticancer, antipsychotic, antidiabetic, antiepileptic, antisporiatic, neuroprotective, intestinal anti-prokinetic, vasorelaxant, analgesic, antispasmodic, bone-stimulant, anti-ishcemic, anti-inflammatory, antiproliferative, immunosupressive, antiemetic, antibacterial.

One of the most important health benefits of cannabinoids is their anti-inflammatory property. In this, they are strong modulators of the inflammatory cytokine cascade. Numerous disease states arise out of chronic inflammation; such as, depression, dementias including Alzheimer’s, cancer, arthritis and other autoimmune disorders, viral infection, HIV, brain injury, etc.

Inflammatory cytokines can be activated by oxidative stress and disease states. Cannabinoids, being immunomodulators interrupt the cytokine inflammatory cascade so that local inflammation does not result in tissue pathology. Thus we are spared morbid or terminal illnesses.4

If our own endocannabinoid system can maintain metabolic homeostasis and even cure serious disease, why are we plagued by illness? We know that the body produces only small amounts of anandamide and 2-AG; enough to maintain the body but not enough to overcome chronic stress, illness, injury, or malnutrition. Cannabis is the only plant we know of that produces phyto-cannabinoids that mimic our own endocannabinoids. One of the great benefits of this mimetic medicine is that cannabinoids are essentially natural to our biology and do no harm to our tissues and systems.

It is well known that most diseases of aging are inflammatory in origin, thus making cannabis the best anti-aging supplement we could take to avoid arthritis, dementia, hypertension, diabetes, osteoporosis, and cancer. is is our key to good health and long life.

Since it is such an important attribute, as well as being independent of the cannabinoid recep-tor system, let’s look a little deeper into the ability of cannabinoids to inhibit the inflammatory cytokine cascade. Inflammation is good for us, a little here, a little there; it brings T-cells and macrophages to infection sites. is is good. However, chronic inflammation can cause serious illness and death. How do phytocannabinoids rescue us from dreaded infirmities? When the call comes in to the immune system to send troops, the first thing to happen is that the immune system signals glial cells to produce cytokines. Once this cat is out of the bag, the process can go one of two ways.

Killer cells clean up the infection and all is well.

Cytokines can stimulate more cytokine production and cause many more cytokine receptors to awaken. Unchecked, this becomes a cytokine storm showing symptoms of swelling, redness, fatigue, and nausea; even death.

Phytocannabinoids have the ability to suppress this inflammatory cytokine cascade by inhibiting glial cell production of the cytokines interferon or interleukin. Here we see the seeds of chronic inflammation dissolved by the modulation process of cannabinoids bringing homeostasis to systems out of balance. This is a good example of how cannabinoids normalize biological processes all throughout the body and allows us to keep that glow of well-being through a long and happy lifetime.

~Dennis Hill

 

[Hundred Gram Oz]

Thank you all for the comments, good to know we have others thinking and helping us! Thank you very much!

Well we were gone today making oil deep in the Irish countryside. Our solvent of choice was ISO Alcohol 99.9% purity. I really like ISO, it's easy to work with and the quality of the oil at the end was excellent, it' was pretty dark in color.

Unfortunatly we didn't have much herb, Ireland has very very little good cannabis, most of it is grown by Chinese and Viet gangs, it's very very very low quality but we managed to scrape up around 2.5oz of high quality bud, not a lot but at least we can start the treatment now while we continue to search for high quality cannabis. Out of the 2.5oz we used about 2.5-3Ltrs of ISO Alcohol and we managed to yield 8-10 grams of Oil, were very happy with that.

Here are some pics of the oil...

Lets hope we can continue this treatment.

Can any of you guys give me some recommendations on how the oil should be taken? Can it be put directly under the tongue the way it is or should we mix it with coconut oil or something first or can it be ingested directly or taken with something like coconut oil?

Any help would be greatly appreciated, thank you all and please say a prayer for us.

Peace,
HGO

 

[whiteberrieS]

If you smoke a lot of QWISO your throat will get all raspy, that's why I stopped doing QWISO. If you can find a food-grade alcohol, that's the stuff you want to use, 100% evaporative, no leftover denaturants. Brand name = Everclear. 151 proof is useable, 190 proof preferred.

edit: Didn't notice you were taking dosage suggestions at the end of your last post. If it's not being smoked, you want to bake it into cookies or brownies or something. Let the QWISO dissolve in whatever oil you're using for the baking, you should be right as rain. As for how much to use and stuff...You'll have to figure that part out, all depends on your QWISO. You said it was low-quality herb that was used so I'd start with a gram or 2 per pan of brownies or about a gram for every 20 cookies & go from there. Hope this helps. Prayers be with you.

 

[Moppel]

HGO, on a dutch website Wernard Bruining is advicing to mix it with some normal oil (like olive or coconut oil). i think 1:6. and than they put few drops under the tongue, as many times as needed p day.

hope this helps.

 

[whiteberrieS]

That's above my pay grade. Carry on fellas. Wish you and your patient the best HGO

 

[Hundred Gram Oz]

If you smoke a lot of QWISO your throat will get all raspy, that's why I stopped doing QWISO. If you can find a food-grade alcohol, that's the stuff you want to use, 100% evaporative, no leftover denaturants. Brand name = Everclear. 151 proof is useable, 190 proof preferred.

edit: Didn't notice you were taking dosage suggestions at the end of your last post. If it's not being smoked, you want to bake it into cookies or brownies or something. Let the QWISO dissolve in whatever oil you're using for the baking, you should be right as rain. As for how much to use and stuff...You'll have to figure that part out, all depends on your QWISO. You said it was low-quality herb that was used so I'd start with a gram or 2 per pan of brownies or about a gram for every 20 cookies & go from there. Hope this helps. Prayers be with you.

Hiya whiteberrieS, thank you for the post We actually used high quality weed but we only had 2.5oz of it, it's hard to get good quality over here, I'll not have another harvest in for 12 weeks and time is of the essence so were going up and down the country trying to get good quality cannabis.

I would have prefered to use Everclear, Gray Wolf suggested that I should use 190 proof Ethanol but solvents are pretty hard to get over here, ISO was the only thing available to us so we went with it. Thanks again White, we need all the help we can get

HGO, on a dutch website Wernard Bruining is advicing to mix it with some normal oil (like olive or coconut oil). i think 1:6. and than they put few drops under the tongue, as many times as needed p day.

hope this helps.

Heya Moppel! Thank you very much for that mate, I'm going to check that out now. :thumbsup:

HGO

 

[whiteberrieS]

Ok, im busted. I only read the first post Noticed Gray Wolf's post was a lot of reading. But from what I gather you guys are talking about putting the qwiso in coconut oil and dosing with drops of that? Sounds like the healthiest way to go about it. I'm not 15 anymore...the bong is pretty rough as a primary smoker.

 

[Hydro-Soil]

Can any of you guys give me some recommendations on how the oil should be taken? Can it be put directly under the tongue the way it is or should we mix it with coconut oil or something first or can it be ingested directly or taken with something like coconut oil?

You'll want to heat activate the oil first.

Try this with a gram or so first... don't do the whole batch at once, just in case.

Warm it gently and mix it with some olive oil... (or another oil you know is compatible with your digestive system). 50/50 or maybe a bit more oil... I try to use as little oil as possible.

Read up on GreyWolf's methods of using an oil bath to heat it at approximately 250F for 20 minutes... the large bubbles will have stopped.

Once it cools you'll be able to dose them with that. Couple drops under the tongue should be sufficient.

Stay Safe!

 

[Avinash.miles]

thanks for that info grey wolf!!!
good lookin extract hgo

 

[supermanlives]

everyone ^^^^ has spelled gray wolf name wrong. just sayin as there is a grey wolf if i remember right. lol carry on. good reading as i am about to make some soon too

 

[village green]

I'm assuming this method will work for CBD extraction from hemp. Does anyone know if I will need to restrict myself to only using the leaves or are there enough cannabinoids in the stalks?

 

[high life 45]

I have not been "activating" my oil after watching videos on juicing raw cannabis. Your body absorbs 60x more cannabinoids "unactivated" vs activated. You wil not get stoned from it though..

I have been gently warming oil into raw og coconut oil w og raw cacao butter. Keeping it under 110'f with a candy thermometer.

 

[MissKittyKat]

I am cancer free now after 8 years of bullshit with the Canadian and American medical systems.

I started to use the cannabis oil and within 2 months my cancer started to retreat. I am now cancer free and it only took 4 months with the oil and no chemo, radiation or other shit from the doctors.

I use naphtha for the solvent. Its expensive but the best. You can also use 99% ISO but I find that naphtha comes out more honey color.

http://ricksimpsonhempoil.blogspot.ca/2010/08/how-to-make-hemp-oil-by-rick-simpson.html

Here is a good link on how to make it. It works, if you want to save your friend then tell them to stay away from the medical system. They want to make profit and not save anyone. They scare people into taking chemo and radiation saying "you got 2 months to live" if you don't take chemo. BULLSHIT!

My husband and I have now given oil to 4 people we know. Stomach cancer, breast cancer, brain tumors, prostate cancer, all gone and cancer free!

Don't take chemo, it kills more then saves. If you want my medical records I can show you the pictures of the cancer and it shrinking every month I was taking oil. I was taking about a half gram a day all at once. Sometimes a gram depending on how much I could tollerate it. The idea is to consume/ingest as much as you can within 90 days

good luck and it works don't let the doctors touch your friend!

MissKittyKat

 

[high life 45]

Thanks so much for sharing mkk.
My friend/patient with cancer loves to hear other people's testimony. He has prostate cancer, previously I helped him use Chlorine dioxide, the cancer went into remission within a month and four months later they couldn't find it and actually fired a VA doctor for a misdiagnosis, they didn't want to hear about mms/chlorine dioxide.
A couple years later the cancer returned and now we are using oil. I feel better using the oil than the mms, however mms is easier to get for people who aren't around medical cannabis. I have lost friends and family from cancer in my life when I was young. I feel empowered and pleased that I can take action and help people suffering regain health.
One thing I must plug again is Juicing Raw cannabis and the Gerson method or gerson diet.
Raw organic foods is another way to empower your body to battle any illness. A friends of mines uncle is one of a handful if people clinically proven to have beaten AIDS. They were told they had 6months to live. They Stopped taking all medications and started eating a 100% raw food diet. That was years ago and that person is alive and aids free.

Never underestimate the power of your body.

Nature has the answers.

Peace love and happy healing to all.
HL45

 

[high life 45]

Thanks so much for sharing mkk.
My friend/patient with cancer loves to hear other people's testimony. He has prostate cancer, previously I helped him use Chlorine dioxide, the cancer went into remission within a month and four months later they couldn't find it and actually fired a VA doctor for a misdiagnosis, they didn't want to hear about mms/chlorine dioxide.
A couple years later the cancer returned and now we are using oil. I feel better using the oil than the mms, however mms is easier to get for people who aren't around medical cannabis. I have lost friends and family from cancer in my life when I was young. I feel empowered and pleased that I can take action and help people suffering regain health.
One thing I must plug again is Juicing Raw cannabis and the Gerson method or gerson diet.
Raw organic foods is another way to empower your body to battle any illness. A friends of mines uncle is one of a handful if people clinically proven to have beaten AIDS. They were told they had 6months to live. They Stopped taking all medications and started eating a 100% raw food diet. That was years ago and that person is alive and aids free.

Never underestimate the power of your body.

Nature has the answers.

Peace love and happy healing to all.
HL45

 

[MissKittyKat]

get him eating as much oil as possible. Make sure you decarboxulate it if you use Butane. You need to heat that up to activate it.

The doctors will want to give him those shots that will shrink everything including his prostate. So get him on the oil asap and it will be gone in 4 months if he take is properly.

BTW I used only bud when I made it. I would use a half pound to a pound of bud to ensure that it was a potent as possible.

hope this helps!

 

[high life 45]

I use alchohol, double boiled. Mixed with raw virgin og coconut oil and raw og cacao butter. I have several pounds of extremely high grade trim mixed with small nuggets that a kind outdoor grower gifted me. Have you looked into juicing raw cannabis MKK?

 

[eurasian_farmer]

even without the herb, coconut oil is awesome!

mixed with indica oil might well be the closest thing to an elixir of life

 

[MissKittyKat]

Yes juicing raw cannabis is good for children and toddlers with cancer. I find that the oil is to strong for children but juicing cannabis leaf seems to work well for fighting cancer in children.
With the active ingredients being low in the leafs i can not see it being affective for adults with aggressive cancer.