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  • Guest's Avatar
    Guest replied
    Originally posted by trichrider View Post
    https://www.mdpi.com/2072-6694/12/7/1985/htm
    Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis
    ........
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852356/
    The current state and future perspectives of cannabinoids in cancer biology
    ...........
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504989/
    Cannabidiol inhibits angiogenesis by multiple mechanisms
    ................
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791144/
    Anticancer mechanisms of cannabinoids
    .........................
    https://www.youtube.com/watch?v=Y4TW70xVkmU
    5 Hour Grateful Dead "Jam Only" Compilation 1971-1983
    Thanks again, trich.

    I'll give these a review here very shortly; this morning.

    I re-read what I replied to you and Galvano yesterday, and realized my head must've been on someone else's shoulders when I wrote some of that. I missed the initial temps you were discussing, responding to (???) instead, and failed to reply to Galvano re. the suppository approach, not replying to that until I was responding to you.

    I think that some times these days, if my head isn't really clear, I need to re-read not only what others have posted, but what I am posting, as well.

    Apologies.

    ----------------------------------

    I'll get into those and others in a moment or 2.

    Thanks again, trich.

    ----------------------------------

    Playing for Change, Song Around the World,
    featuring Stephen Marley, and live footage of Bob, nicely dubbed in.

    'Redemption Song'

    https://www.youtube.com/watch?v=55s3T7VRQSc

    Leave a comment:


  • Guest's Avatar
    Guest replied
    Originally posted by buzzmobile View Post
    I believe those tears of happy sadness and sad happiness are medicine too, moose eater. When they come on there is no resisting, no thinking, no deciding. Just tears to wash fears out of your mind. It is impossible to think, ponder, question, argue when the medicine flows from your eyes. Those tears helped me survive my chaotic brain.

    Dancing while crying is possible.


    How's about a little round of Moondog?
    Nero's Expedition
    Thanks buzz.

    Yep, incongruent affect in times of stress. Classic, to some degree. I'll take the dancing, and the fact that my legs had enough spring in them to not feel as old as I did a month or 2 ago.

    The pieces that lined up with your posted YT music, reminded me of a 'find' on YouTube television last night; black screens with a variety of meditative or sleep-inducing sounds, as well as imagery with sleep inducing sounds.

    One had us floating over the clouds, toward a giant yellow moon, with the slow orchestral/symphony music in the background. As a testament to our years, we both felt a bit motion sick. And I've not been prone to sea-sickness, typically, even when a good distance out in the Gulf of Alaska.

    Went to the 'dark screen with thunder and rain', as it seemed the most natural and calming. 'Crashing waves' just sounded like an echo of the HRV in the HRV closet, but with broken tempo. Stuff a person finds when sitting still, stoned, and prone.

    ------------------------------------------------

    Pax 3 has a label created. The email was more optimistic than that, saying it had shipped.

    ------------------------------------------------

    Still no word from the surgeon or the radio-oncologist, or their support staff.

    We'd recently told them I was cancelling my 3rd consultation with a third clinic in that region, but in light of the lack of response, Monday, when the automated call to confirm the appt. came, and we hadn't heard back from the other 2, in follow-up, I and my wife decided that for now, we should keep this door open.

    So I'll be talking with a third source today, and hoping there's no smoldering bridges.

    ----------------------------------------------

    Another day.

    Thanks for the tunes, buzz. Nice stuff, as usual.

    ---------------------------------------------

    Playing for Change, Song Around the World,
    Featuring Manu Chao

    Covering Bob Marley's 'One Love'

    https://www.youtube.com/watch?v=4xjPODksI08

    Leave a comment:


  • trichrider
    replied
    https://www.mdpi.com/2072-6694/12/7/1985/htm
    Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis
    ........
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852356/
    The current state and future perspectives of cannabinoids in cancer biology
    ...........
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504989/
    Cannabidiol inhibits angiogenesis by multiple mechanisms
    ................
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791144/
    Anticancer mechanisms of cannabinoids
    .........................
    https://www.youtube.com/watch?v=Y4TW70xVkmU
    5 Hour Grateful Dead "Jam Only" Compilation 1971-1983

    Leave a comment:


  • buzzmobile
    replied
    I believe those tears of happy sadness and sad happiness are medicine too, moose eater. When they come on there is no resisting, no thinking, no deciding. Just tears to wash fears out of your mind. It is impossible to think, ponder, question, argue when the medicine flows from your eyes. Those tears helped me survive my chaotic brain.

    Dancing while crying is possible.


    How's about a little round of Moondog?
    Nero's Expedition

    Leave a comment:


  • Guest's Avatar
    Guest replied
    Every now and again, a brief period of optimism sets in, and the feeling of what I think I recall as normalcy is upon me.

    I laughed and cried, and danced, almost at the same time, while fixing my high-lycopene lunch... when this came on the screen. Our youth can haunt us as peaceful and content memories, and there's sometimes a sense of loss in that sweet nostalgia. Sometimes hard to sort out the happy tears from those of quasi-surrender, but I'm sure they're both in there at times.

    Outlaws

    'Green Grass & High Tides'

    https://www.youtube.com/watch?v=cz2CAtExXgQ

    Leave a comment:


  • Guest's Avatar
    Guest replied
    Originally posted by trichrider View Post
    ^^^at 31:35 or so in the Run from the Cure video, Simpson states "at no time should you let the temperature of the oil go over 290*F".

    i can't say whether the terpenes or whatnot work in conjunction with the thc/cbd, but more knowledgeable heads here insist on an entourage effect...which i advocate as whole plant extract...Sears catalog used to sell tinctures of cannabis, i'm curious if they knew about decarboxylation then(?)...
    .............
    https://www.youtube.com/watch?v=yTHhX1IvsIY
    [YOUTUBEIF]yTHhX1IvsIY[/YOUTUBEIF]
    Thanks trich.

    We discussed the suppository approach here (I have suppository molds, organic cacao butter chunks, and more, for their manufacturing), and at least one long-time cancer patient who has used cannabinoids to treat cancer, argued that the claims of bioavailability are not realistic, and stated they believe that the absence of a 'head high' with suppositories, is, in all likelihood, evidence that the extract isn't being absorbed into the bloodstream.

    Other sources claim a substantially greater bioavailability of cannabinoids (85% by suppository and 35% by oral ingestion).

    So I haven't yet used that method, though I have everything I need to do it; decarbed THC flowers to extract, non-decarbed THC flowers to extract, etc.

    The reduction of the solvent to THC-extract stage was mostly at just around or immediately over 200 f. It shot up for a brief second to the ~347 f. mark and was immediately addressed.

    I know there's THC in there, as I get off on it almost immediately (very short delay to effect) when dipping it straight into my mouth (minus any serious chest-tightening), and only a bit longer when ingested in capsules.

    I will note that when I was eating decarbed flowers (not having been able at that time to extract outdoors, due to temps, and we're currently -30 f +/-), and the onset of effect was LONG.. HOURS. The THC extract I have now is far faster; makes me curious as to why?

    The 75 f temps for evaporation is more or less what I was doing as 'passive evaporation' 20 years ago, leaving the solvent in Pyrex baking dishes on the enclosed back porch, nylon fine-mesh bridal veil/bug screen tightly stretched over the dishes, and held in place with linked rubber bands as a sort of wreath around the perimeter of the plates.

    I would just leave them there, check them visually through the side of the glass over a week-and-a half or 2, and when it looked like reddish crystalizing honey, I would stir it up with a safety razor, as I believed there were likely pockets of unreleased solvent trapped in the goo after it had become thick. So I'd stir and leave it another bit, then stir again. Re[peat as necessary until the probability of any solvents being present was/is reduced.

    The temps for such a season here would range from 50 to 60 f. at night, and up into the 70s, 80s or 90s+ above 0 in the summers.

    I suspect I can do a passive evap here on the back porch, even at the current temps. Or I can do a solvent extraction and try to keep the temp down to 70+ f., but the induction cook top doesn't go that low and is malfunctioning (waiting on the techs at the manufacturer to provide a replacement), and the Chinese 'laboratory' hot plate w/stir function is a total piece of unreliable dog excrement.

    So passive evap is an option, I KNOW that alcohol, gasoline, etc., WILL evaporate at cold temps, but it will likely take a fair bit longer than added heat, or a 70-80 degree f. day on the porch. Any residual water would have to be cooked inside on the stove, but most of the volatiles would be gone by then, seriously reducing the likelihood of a 'BOOM!!'

    I'll give a watch and a read to the items you left.

    And thanks for the Hendrix-Stills piece. Good stuff.

    Edit: King Weed was good stuff as well. Thanks! Never heard them before.
    ---------------------------------------
    Still nothing from the surgeon or the radio-oncologist.

    In my world, even if you're the best of the best (and these guys are among them), there's things I want to know, in detail, before I commit to a no-return kinda' therapy. No undoing this shit once it's happening.

    Hopefully they get to a place of understanding that we, as patients are entitled to have our questions answered before getting sliced and diced upon, or shaken and baked.

    All the trust in the world doesn't answer specific detailed questions.
    ---------------------------------------

    Mtg. with stand-in Doc was more or less successful. We'll go forward from there.

    --------------------------------------

    Stephen Stills

    'Treetop Flyer'

    https://www.youtube.com/watch?v=opBe5z0qwRE
    Last edited by moose eater; 02-03-2021, 02:41.

    Leave a comment:


  • trichrider
    replied
    ^^^at 31:35 or so in the Run from the Cure video, Simpson states "at no time should you let the temperature of the oil go over 290*F".

    i can't say whether the terpenes or whatnot work in conjunction with the thc/cbd, but more knowledgeable heads here insist on an entourage effect...which i advocate as whole plant extract...Sears catalog used to sell tinctures of cannabis, i'm curious if they knew about decarboxylation then(?)...
    .............
    https://www.youtube.com/watch?v=yTHhX1IvsIY
    [YOUTUBEIF]yTHhX1IvsIY[/YOUTUBEIF]

    Leave a comment:


  • trichrider
    replied
    seems to me that you could have thrown too much at the problem at once. with your dietary changes, loading up on cannabinoids, reducing physical activities, and focusing on increasingly stressful healthcare interactions as well as familial incongruity and financial implications.
    you may be camouflaging/diluting/denying what may work best.
    you stated you would never be doing a gram a day, and have yet not said whether you did or did not try suppositories. as stated prior, suppositories do not give you head highs making it the best way to approach a gram a day without the debilitating effects an oral dose gives as well as quicker action.
    one of the papers posted suggested that oral ingestion provides but 6% effect after liver metabolization. suppositories reduce this hepatic first-pass effect and acts much more quickly than oral.
    i've watched Run From the Cure ( https://www.youtube.com/watch?v=Wlk9KmGfu3E ) and i don't see him suggesting or doing any decarb other than in reducing the extract to oil by boiling (alcohol boils at 173*F) that's about 75*F lower than you would use doing it in an oven and less THCa will be converted this way.
    it may well be that decarbing is counter productive, perhaps even destroying qualities we're seeking.

    decarbing is mainly intended to increase THC for the high. this may be the nemesis of medicinal application.


    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805701/


    ..........
    https://www.youtube.com/watch?v=-3bCTC-On7g
    [youtubeif]-3bCTC-On7g[/youtubeif]


    be well

    Leave a comment:


  • Guest's Avatar
    Guest replied
    Scored a Pax 3 bundle/kit for a decent price ($200), and it ought to be here shortly; shipping out in a day or 2.

    For now, that's resolved. We'll see.

    I'll continue trying to re-generate the PP II battery. It (as stated earlier) seems to be trying to come back on line wit repeated charging.

    ---------------------------------------------------------

    Meeting with a Doc in a bit, via computer, to discuss the poor outcomes with the previous antihistamine/anti-anxiety Rx, and to see if there's a more suitable substitute.

    It bothers me that they still view liability where addictive substances are concerned, even when the track record of the patient (me) says there's NO issue with misusing the Rx's I have on-hand. I've told them many times, and they say they trust me, that IF I were a serious pill consumer, I wouldn't have 6 & 8-year-old opiate Rx's on-hand, or muscle relaxers that are at least that old, & I wouldn't have just recently finished off a 1996 Rx for Ativan .5mg.

    Obviously, the fact that these thigs are either still here, or were here, for a LONG-ASS time, says they were not being viewed as M&M's or something.

    I mean, of the fifteen .5mg Ativan they gave me 10 days ago, I still have 14-1/2!!

    Blanket policies of distrust mean that eventually, folks who need help, are turn3d away. Like paying someone else's speeding ticket, just 'cause you were nearby.

    -----------------------------------------------------

    Contacted the radio-oncologist's nurse and scheduler, both, yesterday, inquiring as to whether or not I had missed some sort of protocol re. after appointment follow-up questions via their Portal. I'd sent additional questions about 10 days ago. So far no answers.

    The one post-appt. set o f questions I sent to the surgeon, as well as the lab questions, are still both unanswered as well, and they were sent through the Portal last week.

    My wife suspects that at this time, they want to hear one of 3 things from me; "I want surgery, schedule me," "I want radiation, please schedule me," or, "I've decided to go elsewhere for treatment."

    The fact is that I want (and deserve?) the remaining questions to be answered before making what is apt to be a one-time-only choice, with some probability of follow-up treatment in the future.

    So, as I prepare to make what ever decision about which part(s) of quality-of-life, and perhaps life itself, that I'm most willing to gamble with, I'm in a holding pattern, or perhaps worse.

    So I learn to wait again. Waiting, sometimes for days on end, in one spot, as a cross-country hitch-hiker and person of the road, years ago, was often quite easy. Finding things to do, berries to eat, etc., was sometimes a plus. This circumstance is not a benefit to me..

    ------------------------------------------------------

    Paul McCartney & Wings

    'Maybe I'm Amazed'

    https://www.youtube.com/watch?v=yxTdz3hw9Xo

    Leave a comment:


  • Guest's Avatar
    Guest replied
    Originally posted by sdd420 View Post
    Look into the newvape flowerpot it’s the only vape that works for me and I’ve tried a bunch of them. You use it with your bong. I just converted a couple weeks ago and haven’t gone back. It is expensive but it really gets me high
    Thanks, sdd.

    I'll give that one a peek.

    I'd been looking at the Arizer Solo II, the PAX 3, and a couple others last night, like the Mighty. Wanted something small enough and sturdy enough, yet light-weight, to tuck into my luggage, etc.

    Had a moderate e-coupon hooked up a couple times, but had difficulty justifying pulling the trigger, thinking about the legitimacy of spending a couple hundred $$ right now. But it probably needs to happen.

    I have noticed that the last several times I've charged the battery on the PP II it has held the charge a bit longer, so it's remotely possible that it's getting re-conditioned, by charging it gradually each time, holding a bit longer and more. We've done that a time or 3 with other types of batteries that were bordering on death. But this one is over a decade old, too, and it was a slightly better than mid-grade vaporizer when it was new, in terms of function.

    Thanks again.

    Edit: I just looked at the flowerpot, and I think I need something a little more portable. I'll keep looking, but thanks for the mention..

    -------------------------------------------

    The Band

    'Live at Watkins Glen. '

    'Back to Memphis'

    https://www.youtube.com/watch?v=n1xR...5jWgNrEMDKpLsN
    Last edited by moose eater; 02-02-2021, 21:27.

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  • Guest's Avatar
    Guest replied
    Originally posted by Galvano View Post
    You're welcome.
    Indeed, thanks to you, your shared experience could help someone in the future.

    I thought it was easier in North America to find a doctor to consult for cannabinoid-based therapy.
    Here, in Italy, family and hospital doctors do not even know therapeutic uses of cannabinoids (except for pain therapy, maybe).
    However, if you cannot consult an MD or a dispensary on the CBD and drug interactions you could ask for the "grapefruit juice drug interactions", the interaction of grapefruit juice with drugs is similar to that of CBD so you can say that sometimes you drink grapefruit juice and ask if it's safe with the drugs you're taking.

    In addition to ingesting and vaporizing I'd do some research about suppository administration, it seems that rectally administered cannobinoids have a greater bioavailability:

    https://pubmed.ncbi.nlm.nih.gov/8383856/
    https://pubmed.ncbi.nlm.nih.gov/8897084/

    Moreover they are delivered directly near the affected organ
    so they don't have to travel long through lungs or stomach and bloodstream.

    Best wishes
    You're correct. There are many Docs in the US who might agree with formal discussion re. CBD/THC/THC-a therapies. But at the moment, the clinic my primary care Doc works at, forbids formal discussion of such, so anything stated in those meetings is informal and brief.

    Her nurse, just a couple weeks ago, stated they were not permitted to discuss 'home remedies' when I was attempting to discuss some of the traditional 'treatments' for gall stones posted on-line, such as the vinegar and oil regimens.

    In that regard, I think it becomes not only a way of banning any discussion of cannabinoid therapies, but a way of preventing liability in the event there's any counter-indications or poor reactions between therapies.

    Likely the same/similar reason the reference was placed in my chart at the one clinic, after I'd asked for it to be not formally mentioned in writing, for a variety of continuing issues in our society where such references can still carry some negative results.

    And thank you again.

    ---------------------------------------------

    Graham Nash

    'Immigration Man'

    https://www.youtube.com/watch?v=d9hpmJH2m0k

    Leave a comment:


  • Galvano
    replied
    Originally posted by moose eater View Post
    Thank you.
    You're welcome.
    Indeed, thanks to you, your shared experience could help someone in the future.

    But your insight re. the possible issues with CBD are very helpful.

    Unfortunately, I can't formally discuss this with any of my healthcare providers at this time; some due to indiscretions, and some due to clinic policies.
    I thought it was easier in North America to find a doctor to consult for cannabinoid-based therapy.
    Here, in Italy, family and hospital doctors do not even know therapeutic uses of cannabinoids (except for pain therapy, maybe).
    However, if you cannot consult an MD or a dispensary on the CBD and drug interactions you could ask for the "grapefruit juice drug interactions", the interaction of grapefruit juice with drugs is similar to that of CBD so you can say that sometimes you drink grapefruit juice and ask if it's safe with the drugs you're taking.

    In addition to ingesting and vaporizing I'd do some research about suppository administration, it seems that rectally administered cannobinoids have a greater bioavailability:

    https://pubmed.ncbi.nlm.nih.gov/8383856/
    https://pubmed.ncbi.nlm.nih.gov/8897084/

    Moreover they are delivered directly near the affected organ
    so they don't have to travel long through lungs or stomach and bloodstream.

    Best wishes

    Leave a comment:


  • sdd420
    replied
    Originally posted by moose eater View Post
    Some discussion of inflammation as an issue that works to invite cancer cells, and efforts to decrease inflammation, aside from THC as an anti-inflammatory. Smoke seems to be an irritant that leads to such negatives.

    With al the extract ingestion, and auto-immune issues, I'd quite smoking joints or pipes a week or 2 ago, and am trying to not interfere with the CBD's potential action with any more THC during day time, so smoking a bit less (I had been a mostly afternoon and bed-time smoker for a long while, anyway, occasionally imbibing during the day time).

    In line with these changes/thoughts, I pulled out my old Pinnacle Pro II and plugged it in to charge. I had used it routinely after spine surgery, partly to protect the lungs at a time of vulnerability/healing, and because the hospital-affiliated hotel we used has a very strict policy on smoking.

    The Pinnacle Pro is having some battery issues, and being over 10 years old (maybe more than 10 yrs.) the fact that it holds any charge, even for a couple days, is impressive. But I will be needing a replacement.

    So.... Best prices/sources on a PAX 3, a Mighty, a Crafty, more portable Arizer, or something of at least GOOD quality, pocket-able, preferably with a glass air-tube and chamber, and no truly hot sensations when holding or toking on the thing (the PPII gets hot at times).

    And, if possible, no Blue Tooth. If we've come to a place where we need a smart phone to program or adjust a smoking device, then....

    So, if anyone has any input re. a GOOD, to EXCELLENT, higher-quality, reliable, well-warrantied vaporizer, please chime in.

    Ideally, it would function with hash and flowers, and maybe even dabs, but at least effective with flowers and hash.

    Thanks.
    ----------------------------------------------------

    George Harrison

    'What is Life'

    https://www.youtube.com/watch?v=773tS353yPQ
    Look into the newvape flowerpot it’s the only vape that works for me and I’ve tried a bunch of them. You use it with your bong. I just converted a couple weeks ago and haven’t gone back. It is expensive but it really gets me high

    Leave a comment:


  • Guest's Avatar
    Guest replied
    Some discussion of inflammation as an issue that works to invite cancer cells, and efforts to decrease inflammation, aside from THC as an anti-inflammatory. Smoke seems to be an irritant that leads to such negatives.

    With al the extract ingestion, and auto-immune issues, I'd quite smoking joints or pipes a week or 2 ago, and am trying to not interfere with the CBD's potential action with any more THC during day time, so smoking a bit less (I had been a mostly afternoon and bed-time smoker for a long while, anyway, occasionally imbibing during the day time).

    In line with these changes/thoughts, I pulled out my old Pinnacle Pro II and plugged it in to charge. I had used it routinely after spine surgery, partly to protect the lungs at a time of vulnerability/healing, and because the hospital-affiliated hotel we used has a very strict policy on smoking.

    The Pinnacle Pro is having some battery issues, and being over 10 years old (maybe more than 10 yrs.) the fact that it holds any charge, even for a couple days, is impressive. But I will be needing a replacement.

    So.... Best prices/sources on a PAX 3, a Mighty, a Crafty, more portable Arizer, or something of at least GOOD quality, pocket-able, preferably with a glass air-tube and chamber, and no truly hot sensations when holding or toking on the thing (the PPII gets hot at times).

    And, if possible, no Blue Tooth. If we've come to a place where we need a smart phone to program or adjust a smoking device, then....

    So, if anyone has any input re. a GOOD, to EXCELLENT, higher-quality, reliable, well-warrantied vaporizer, please chime in.

    Ideally, it would function with hash and flowers, and maybe even dabs, but at least effective with flowers and hash.

    Thanks.
    ----------------------------------------------------

    George Harrison

    'What is Life'

    https://www.youtube.com/watch?v=773tS353yPQ

    Leave a comment:


  • Guest's Avatar
    Guest replied
    With some degree of confusion over efficacy, and which cannabinoids do what, for how long, for whom, I am temporarily deciding to undertake a specific regimen, pending an informal review of the idea, by another forum member.

    25-30mg of full-spectrum CBD tincture 3 x's/day, AM, Noon, and mid-PM, followed by 120-160mg of decarbed THC extract at bed time.

    My hope is to not inundate the body with too much of either, but trying to maintain an effective dose (time will/may tell re. that issue, but there will be some built-in subjectivity to those assessments, period). The above study re. epilepsy (I THINK it was in that one) referenced finding greater efficacy with somewhat lower doses, and this echoes Weez's experience to some degree, when he had dialed back the THC dose, but added CBD, and it had, for a time, done its work.

    My additional hope is that a regimen as I have described it, will help to avoid any tolerance or resistance to any one cannabinoid; vary the ammunition.

    Clear as mud, right? Like much of the research in this area.

    So, on that note, it's been over a month-and-a-half since my last blood draw for PSA, A1C and lipids (cholesterol, etc., and longer since a more thorough lab work-up, so I'm scheduled to do a complete lab set at bargain basement prices (albeit out of pocket), the middle of next week.

    Let the tracking continue...

    ---------------------------------------------------

    Ringo Starr

    'It Don't Come Easy'

    https://www.youtube.com/watch?v=uCD0fPSsdBA

    Leave a comment:

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