Hey GW!
So you are recommending 1 gram orally per day? 90 days or longer? And what kind of oil? BHO? percentage thc?
We started with Rick's 1 gram orally per day standard, using a winterized absolute, and haven't seen reason to change it.
What Dr Robert Melamede says, is that we are simply flooding our indo-cannabinoid systems with phyto-cannabinoids that mimic their function.
More a matter of returning the indo-cannabinoid system to its normal balance and function, so that it cures the problem, just like it normally would.
He says THC is the main actor in restoring apoptosis, and CBD in pain and seizure control, so recreational strains are effective.
The biggest stumbling block is getting the average patient up to 1 gram a day dosage without discombobulation, and CBD also helps ameliorate THC's psychoactive effects, so we typically start patients out with a Cannatonic or Maui Bubblegift 50/50% strain, and wean them to higher THC strains.
A winterized recreational strain, in Absolute state, has no wax or monoterpenes left, so THC is typically in the 90 percentile range.
Dr Melamede also turned us on to administering 3X the oil dose in Citicolene, 20 minutes before dosing, to help mollify the psychoactive effects of the THC.