Treating Cancer with Concentrates Thread
- Thread starter LostTribe
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LostTribe
Well-known member
So is the 200mg of absolute combined with coco oil what you would recommend for most cancer patients?
Coco butter. It is stiff enough to insert, where coconut oil is not.
We worked our cancer patients up to 300 mg doses. I only tested the 200 mg.
Ummmm, how easy is it to insert? Maybe a little like shooting pool with a cotton rope for a cue?
live resin
Member
Does conversion to the ester make it more water soluble?
Would this same prodrug work orally or is it completely different mechanisms of absorption and metabolization?
Currently have a friend with pancreatic cancer w/ metastasis into liver, 2nd round of chemo. Made some oil using ethanol/rice cooker and 20 cc syringe. He felt it was too 'druggy' (his term) not being a cannabis user. We experimented with dose, but he didn't like the sensation orally.
Then, I made suppositories from the remaining oil (size 1#). He's taking 3x a day, larger dose at night (00#). Reports less pain, a bit more energy, ability to eat after chemo.
Made another batch finely ground herb heated in coconut oil, then cooled before filling capsules. He seems to tolerate that better, again, 3x a day (size 1# gel capsule) and 00# at night. Cannot accurately measure g/ml and mg, but ratios for ground herb into oil 3:1.5, similar to a paste.
Any added suggestions would be welcome.
Then, I made suppositories from the remaining oil (size 1#). He's taking 3x a day, larger dose at night (00#). Reports less pain, a bit more energy, ability to eat after chemo.
Made another batch finely ground herb heated in coconut oil, then cooled before filling capsules. He seems to tolerate that better, again, 3x a day (size 1# gel capsule) and 00# at night. Cannot accurately measure g/ml and mg, but ratios for ground herb into oil 3:1.5, similar to a paste.
Any added suggestions would be welcome.
G.O. Joe
Well-known member
I assume it's easily hydrolyzed regardless - it can be injected as well - so measuring solubility could be a problem.
We bought disposable suppository molds off the internet, and mixed warm coco butter and the dosage, blended them well, and poured them in the molds, before sticking them in the freezer to set.
When they cool down, they are solid enough at room temperature to insert, after the disposable mold is torn away. Coco butter way stiffer than coconut oil.
Here is a mold link as an example, but if you google suppository molds you will be offered a panoply of choices.
http://www.cureyourowncancer.org/suppository-molds.html
We've used the same dosages and gone through the same issues with building tolerance before administering 330 mg dosages three times a day.
GrowGoddess
Member
I would have to agree. Three doses per day. Building up a tolerance can be difficult, but well worth the effort.
The most difficult thing in treating a couple of my patients was building up a tolerance. It took three months before we could start increasing the doses, but it went more smoothly from that point.
Dosing three times a day was problematic for one patient I'm currently working with.
Lack of tolerance was making it too hard for her to function/ up the dose.
Switching to four times a day helped her deal better and she got up to her target dose per day within a couple of weeks of switching to 4 daily doses.
Lack of tolerance was making it too hard for her to function/ up the dose.
Switching to four times a day helped her deal better and she got up to her target dose per day within a couple of weeks of switching to 4 daily doses.
Thank you, Gray Wolf!!
Friend (like my little brother, 4 decades of friendship) is tolerating lower dose orally (packing less in smaller capsule).
Plus, he uses olive oil to lubricate capsule before inserting rectally. We may explore suppository molds, however he says upon evacuation of capsule, it's absorbed.
Had capsules on hand.
Appreciate your invaluable input.
Friend (like my little brother, 4 decades of friendship) is tolerating lower dose orally (packing less in smaller capsule).
Plus, he uses olive oil to lubricate capsule before inserting rectally. We may explore suppository molds, however he says upon evacuation of capsule, it's absorbed.
Had capsules on hand.
Appreciate your invaluable input.
LostTribe
Well-known member
Hey GW!
So you are recommending 1 gram orally per day? 90 days or longer? And what kind of oil? BHO? percentage thc?
We started with Rick's 1 gram orally per day standard, using a winterized absolute, and haven't seen reason to change it.
What Dr Robert Melamede says, is that we are simply flooding our indo-cannabinoid systems with phyto-cannabinoids that mimic their function.
More a matter of returning the indo-cannabinoid system to its normal balance and function, so that it cures the problem, just like it normally would.
He says THC is the main actor in restoring apoptosis, and CBD in pain and seizure control, so recreational strains are effective.
The biggest stumbling block is getting the average patient up to 1 gram a day dosage without discombobulation, and CBD also helps ameliorate THC's psychoactive effects, so we typically start patients out with a Cannatonic or Maui Bubblegift 50/50% strain, and wean them to higher THC strains.
A winterized recreational strain, in Absolute state, has no wax or monoterpenes left, so THC is typically in the 90 percentile range.
Dr Melamede also turned us on to administering 3X the oil dose in Citicolene, 20 minutes before dosing, to help mollify the psychoactive effects of the THC.
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thegreenman91
Member
Hey greywolf. Do you think there is significant difference in a winterized absolute vs. a distilled oil when it comes to cancer treatment?
