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THC's Effects on Endocrine System, etc.

H

Helps Me

Member
Hi all:

I thought I'd start a Thread with articles pertaining to research, (some articles may have negative slants, some positive. I don't mind reading both sides in order to make my decision) info, etc. about how THC effects the various systems I'm interested in: (The Endocrine Systems, Neurotransmitters, etc.).

So far, here is some:

http://www.ukcia.org/research/EndocrineEffects.pdf

http://www.ukcia.org/research/EndocrineAndReproductiveSystems.pdf

http://www.cannabishealth.com/site/content/view/58/47/

I'll keep posting as I find them.

Hope this is of interest to you, too! :)
 
H

Helps Me

Member
Thanks for the additions, Storm Crow! :)

I know that personally mj does something positive hormonally for me, because so far every single time I medicate, the next day, I rely on my soy milk, and natural female hormone pills less. So it HELPS somehow, just not sure how, yet. (scientifically, I mean). But am enjoying the journey discovering the answer :)
 
H

Helps Me

Member
That was an interesting article, thanks! :)

Also really enjoying your MMJ medical studies Thread/links you've provided in your sig!
 
DoobieDuck

DoobieDuck

Senior Member
ICMag Donor
Veteran
HelpsMe interesting topic and thread..thanks for posting the links and Granny for your research as well...DD
 
H

Helps Me

Member
While doing a search for endocannabinoid system..

While doing a search for endocannabinoid system..

Found this interesting article:

http://endo.endojournals.org/cgi/content/full/150/1/98

This part of that article is particularly interesting~

Although exogenous administration of the plant cannabinoid
Dgr.gif
9THC decreases serum TSH and thyroid hormone levels (11), and the endocannabinoids can inhibit the glutamatergic input of TRH neurons (12), it is currently unclear how and under which circumstances endocannabinoids regulate TRH neurons.
An interesting observation in the study is the electron microscopic demonstration that CB1 axons in contact with hypophysiotropic TRH neurons establish both symmetric and asymmetric type synapses. Because symmetric synapses are generally associated with inhibitory and asymmetric synapses with a stimulatory action (21) and the hypophysiotropic neurons are densely innervated by axons containing either
ggr.gif
-aminobutyric acid (GABA), the main inhibitory transmitter, or glutamate, the main excitatory transmitter, the above observation suggests that CB1 triggered regulatory mechanisms are capable of interacting with both GABAergic and glutamatergic inputs of TRH neurons. This is not unusual for CB1, because both GABAergic and glutamatergic axons contain CB1 in the hippocampus (22, 23). Therefore,
Dgr.gif
9THC should suppress simultaneously a portion of both the inhibitory and excitatory input of the TRH neurons that contain CB1. The inhibitory effect of
Dgr.gif
9THC on the HPT axis is, therefore, the net effect of this substance on the excitatory and inhibitory inputs of TRH neurons. This would suggest that the CB1-containing excitatory input of TRH neurons is more active under basal conditions than the CB1-containing inhibitory input of these cells.
 
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