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Magic Mushroom Nasal Spray for PTSD and depression

Vandenberg

Well-known member

PTSD and depression are two conditions that are being trialed for treatment with psilocybin.​

A ‘magic mushroom’ nasal spray has been designed to make microdosing easier for people trying to treat their PTSD or depression.

Silo Wellness, an Oregon company with a team with roots in cannabis delivery modalities, has developed a magic mushroom nasal spray in Jamaica – where psilocybin is legal – for controlled, metered-dosing known as ‘microdosing’.

Magic mushroom nasal spray​

The psilocybin nasal spray passes the gut, going directly to the bloodstream through the nasal mucus membranes and eventually the liver for metabolising. This saves the patient from feeling nauseous, as commonly experienced when taking psilocybin.

Board Advisor and Silo Wellness investor Becky Rotterman, a Missouri pharmacist, stated: “Many psilocybin patients, particularly women, complain of upset stomach or vomiting when taking high-doses of mushrooms.

“We want to bring this wonderful natural medicine first to Oregon and then the flyover states – to those who would be afraid to eat a handful of fungi and who feel more comfortable seeing their medicine in a familiar delivery modality, such as a metered-dose nasal spray.”

The correct dose​

When a patient takes psilocybin the dosage is vital. Many people end up ‘stacking’, whereby the first dose takes some time to take effect so the patient consumes more, only to find they have taken too much later on. Microdosing alternatives with faster uptake speed are important in order to prevent accidental high-dosage experiences.

Silo Wellness founder, Mike Arnold, said he created the medicine dispenser after his first experience with psilocybin after he was advised by a doctor to try it.

He said: “I couldn’t help to think how fortunate I was to have an actual physician take me on my first trip rather than ‘some guy’ I know, but I realised that most first-time users don’t have that luxury.

“I reached out to my long-time colleague from the marijuana space, brilliant inventor Michael Hartman, and we agreed that we need to be able to give patients predictable dosing so they can self-titrate into the desired levels of sub-psychedelic or psychedelic treatment.”

“We solved the age-old problem with plant- and fungus-based medicine: How do you know how much is a dose?” Hartman explained. “How do you avoid taking too much, like the cannabis edibles dilemma? We also managed to solve one of the common complaints of some mushroom users: taste and upset stomach.”

Healing trauma with magic mushrooms​

Psilocybin is being trialed for the treatment of a number of physical and mental conditions, two of which are PTSD and depression.
The psychoactive component is thought to stimulate receptors in the brain and potentially ‘rewire the brain’ by increasing neuro connectivity – helping to heal trauma from physical or psychological events.


COO, Scott Slay, said: “We are so grateful for the opportunity to have an actual and real first-to-market consumer product in magic mushrooms.

“I found mushrooms after returning from Iraq working in IED demolition and combat. The war changed me and the VA was ill equipped to help me transition and deal with my PTSD.

“I was heavily medicated. Mushrooms and DMT saved me. My life was renewed. I now have peace and purpose, and I can’t wait to share this opportunity with the world.”

Since psilocybin and other psychoactive compounds are found in nearly 200 known-species of mushrooms, humans have evolved around these beneficial chemical compounds.

Users of psychedelics have known for many years that small “micro doses” of mushrooms can give the user spiritual, medical, and therapeutic benefits without sending the user into a psychedelic ’trip’ as with high doses of mushroom biomass.

Psilocybin for depression has recently been given its second ‘Breakthrough Therapy’ designation by the FDA.

Silo wellness hosts all inclusive, luxury psychedelic retreats in Jamaica and Canada.

Vandenberg :)
 
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Vandenberg

Well-known member

A company exploring the efficacy of psychedelic treatments for PTSD in veterans has announced the international expansion of its Phase 2A clinical trials.​

The Mydecine trials are exploring psilocybin-assisted psychotherapy to treat chronic post-traumatic stress disorder (PTSD) in veterans and Emergency Medical Services (EMS) personnel. The purpose of the trials is to explore how the brain responds to psychedelics and to develop a better understanding of the biological underpinnings created by the psychedelic experience.

The research will take place at Leiden University Medical Centre in the Netherlands; the University of Western Ontario; and the University of Alberta, with other clinical sites on the horizon in the USA, Europe, and Australia.

Psychedelic psychotherapy
Mydecine hopes the trials will help to establish the safety and efficacy of psychedelic administered psychotherapy in a safe and supervised setting.

Chief Medical Officer, Dr Jetly, a prominent voice in the fight against PTSD and other mental health issues facing vulnerable populations like veterans and first responders, said: “The choice of working with veterans as our first subjects in our clinical trials was made for a variety of reasons. Along with my experience, and that of our Scientific Advisory Board, we have devoted our professional lives to the treatment of soldiers and veterans suffering from a variety of mental health conditions including PTSD.

“Those who have treated veterans and connected research in the same group have come to the realisation that, although many evidence-based treatments exist for PTSD, they are built largely on the ‘fear-based model,’ and sadly a significant proportion of those suffering do not respond positively. In fact, veterans tend to respond less often to the evidence-based therapies compared to other types of trauma.”


Moral injury​

Psychedelic-assisted psychotherapy also allows for exploration of an important growing concept that appears to be particularly relevant in military populations known as ‘Moral Injury’.

Moral Injury describes persistent psychological difficulties that include guilt, shame, and anger that may become amplified when one perceives moral transgression of highly held values.
It is hoped that after the psychedelic experience the internal reflection may allow therapists to influence these difficult-to-treat emotions.


Jetly added: “When we review the literature, we see psychedelics and psychotherapy being used effectively to treat a variety of conditions from depression and PTSD to chronic pain and addictions. When a treatment works in such varied conditions, we must wonder about a common underlying mechanism. We hope to study the brain and body via neuroimaging, electrophysiology and blood-based biomarkers in order to identify the key characteristics that lead to patients fundamentally changing to accept psychotherapy that they would not otherwise be receptive to.”

In addition to the sites in the Netherlands, Ontario, and Alberta, Mydecine is exploring additional trial sites across North America including Ottawa, Los Angeles, New York, and Boston.

Vandenberg :)
 
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St. Phatty

Well-known member
How is it different than eating a partial dose of Shrooms, and waiting an hour ?

I'd be afraid of too much drug too fast. Like mainlining THC or something.
 

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