Is someone getting quotes on the sort of shiny new industrial gel chromatography system you guys would want? We won't tell.
The patent specified a column 1.5 meters tall filled to an unspecified height with 400 g. of the Sephadex, loaded with the dissolved extract of 100 grams of something. Let's say it was 20 grams of extract - 1:20 column loading is not bad at all. But, the LH-20 product instructions suggest a flow rate of 1-10 cm./hr. Compare this to the level of detail in El-Sohly's 6,730,519.
There are faster, dirtier, much, much cheaper methods that scale up well.