[Gray Wolf]

Originally Posted by LostTribe

Didn't even think about different strain involvement. Thats what I was thinking rick's 1 gram per day....

Remind me which method do you use to extract the oil for medicinal usage? Everclear or are you using BHO and winterizing it after purge?

We've used both Everclear and butane for cancer med extraction. Typically, we extract with butane and winterize with Everclear.

[Gray Wolf]

Originally Posted by thegreenman91

Hey greywolf. Do you think there is significant difference in a winterized absolute vs. a distilled oil when it comes to cancer treatment?

We just recently started short path distilling oil, and I'm not aware of any clinical trials with patients, so have to say I don't know.

I do know the Absolute has done some amazing things, but hasn't been the great panacea, infallibly curing all ills, because not everyone survived.

A good question though, and worthy of a professional answer, so what I did, was e-mailed that question to Dr Kate, our pharmacist brain trust, to get her read, as well as Dr Melamede, whom may have already done that experimentation.

[LostTribe]

Originally Posted by Gray Wolf

We just recently started short path distilling oil, and I'm not aware of any clinical trials with patients, so have to say I don't know.

I do know the Absolute has done some amazing things, but hasn't been the great panacea, infallibly curing all ills, because not everyone survived.

A good question though, and worthy of a professional answer, so what I did, was e-mailed that question to Dr Kate, our pharmacist brain trust, to get her read, as well as Dr Melamede, whom may have already done that experimentation.

A good question for certain please report back your findings when you get time. Cheers

[Pastelero]

Originally Posted by Gray Wolf

We started with Rick's 1 gram orally per day standard, using a winterized absolute, and haven't seen reason to change it.

What Dr Robert Melamede says, is that we are simply flooding our indo-cannabinoid systems with phyto-cannabinoids that mimic their function.

different questions on this:

in my opinion, 1000mg orally per day will decrease CB1 receptor density rapidly. Consequentially you will show a higher tolerance, but also decrease the over all amount of endocannbinoids and phytocannbinoids in your system, which you want to avoid!

What about absorption capacity of CB1 receptors? How much can they uptake?
I was talking to israeli researchers, they said it does not make sense to flood your receptors with pytocannabinoids because receptors can´t absorb all of it anyway and you will decrease your receptor density!

Respect your receptors!

[Old Gold]

Originally Posted by Pastelero

different questions on this:

in my opinion, 1000mg orally per day will decrease CB1 receptor density rapidly. Consequentially you will show a higher tolerance, but also decrease the over all amount of endocannbinoids and phytocannbinoids in your system, which you want to avoid!

What about absorption capacity of CB1 receptors? How much can they uptake?
I was talking to israeli researchers, they said it does not make sense to flood your receptors with pytocannabinoids because receptors can´t absorb all of it anyway and you will decrease your receptor density!

Respect your receptors!

You seem to theorize that 1000mg is well beyond receptor capacity, but then ask "how much can they uptake?"
Perhaps 1000mg of active cannabinoids is fairly close to the "saturation" point. I agree though, and most trends in nature show us that over-use of resources effects having to put more energy in for the same output. Brain cells alike, I'd say.

[Old Gold]

I have quite the tolerance, so not the best candidate, but eating 1 g of an absolute daily is right around the point at which I still "feel something" every time. At times, sure, it's taken 2000mg to keep me asleep for 3-4 hrs...but usually, if I eat a gram, regardless of tolerance, I still retain SOME effects, and am able to eat/sleep at will (main reasons why I medicate). At 2g daily, I can legitimately say I get stoned every time (though I dab up anyways!)

[Gray Wolf]

Originally Posted by Pastelero

different questions on this:

in my opinion, 1000mg orally per day will decrease CB1 receptor density rapidly. Consequentially you will show a higher tolerance, but also decrease the over all amount of endocannbinoids and phytocannbinoids in your system, which you want to avoid!

What about absorption capacity of CB1 receptors? How much can they uptake?
I was talking to israeli researchers, they said it does not make sense to flood your receptors with pytocannabinoids because receptors can´t absorb all of it anyway and you will decrease your receptor density!

Respect your receptors!

Dr Melamede's point is that the effects of the gram a day dosage is to flood the receptors, so that they are all pulled into action.

Dr Robert Melamede's background and contribution to cannabis science is a matter of public record, so I will let him defend his position based on his own clinical research. We simply sponsored him at a seminar and I listened with rapt attention.

Certainly to remain on heavy dosage long term would have those diminishing effects, but if we are discussing the same gram a day for 90 days to address a tumor, the prima facie evidence is that it is effective against at least some cancerous tumors.

That ostensibly closes the argument that it is ineffective, but does leave open the debate as to whether it can be more effective.

I'm not a doctor, so will leave that argument to the professionals, but plan to continue with the gram a day that has proven effective for our own patients, until it can be proven that if we reduce the dosage of our life saving medication, it will save even more lives.

Certainly we would ask the buy in of the patient up front as well, since it is their lives in the balance.

[medicalmj]

Originally Posted by Old Gold

I have quite the tolerance, so not the best candidate, but eating 1 g of an absolute daily is right around the point at which I still "feel something" every time. At times, sure, it's taken 2000mg to keep me asleep for 3-4 hrs...but usually, if I eat a gram, regardless of tolerance, I still retain SOME effects, and am able to eat/sleep at will (main reasons why I medicate). At 2g daily, I can legitimately say I get stoned every time (though I dab up anyways!)

Whoa there! Are you talking about 70-90% oil? I made some for a cancer patient that tested at 70% THC and another patient that had a high tolerance ate a 150 mg pill and thought she was dead, not dying but dead. And she dabs...

[Gray Wolf]

Here is Dr Bob's response to my question of whether clear and Absolute were equally effective as a cancer med.

"I Graywolf how are you? I prefer the dark dirty oil's to Billy 75-85% THC. People like the clear ones for dabs. It seems to me you got to be losing some of the goodies with the clear ones

drbob"

[Radic]

i would love to add to what GW is saying.
THC is colorless 100% clear......
so,, the more clear, or translucent the extract is, the higher the THC content.

and Dr Bob's lost goodies are responsible for the Entourage Effect
https://www.beyondthc.com/wp-content/...rageEffect.pdf

the herbalist call it a Whole Plant Extract because it contains all three of the families of herbal therapeutics.
Terpenoids. flavanoids and cannabinoids.
you get the biggest yields from buds
Whole Plant Extracts are not about leaf or stem or roots,,, it's about Terpenoids. Flavanoids and Cannabinoids.