Cannabidiol inhibits the reward-facilitating effect of morphine - Cannabis Botany and Advanced Growing Science - International Cannagraphic Magazine Forums

Storm Shadow · 08-10-2012, 08:45 PM

https://www.ncbi.nlm.nih.gov/pubmed/22862835

Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT(1A) receptors in the dorsal raphe nucleus.

Abstract

Cannabidiol is a non-psychotomimetic constituent of Cannabis sativa, which induces central effects in rodents. It has been shown that cannabidiol attenuates cue-induced reinstatement of heroin seeking. However, to the best of our knowledge, its effects on brain stimulation reward and the reward-facilitating effects of drugs of abuse have not yet been examined. Therefore, we investigated the effects of cannabidiol on brain reward function and on the reward-facilitating effect of morphine and cocaine using the intracranial self-stimulation (ICSS) paradigm. Rats were prepared with a stimulating electrode into the medial forebrain bundle (MFB), and a guide cannula into the dorsal raphe (microinjection experiments), and were trained to respond for electrical brain stimulation. A low dose of cannabidiol did not affect the reinforcing efficacy of brain stimulation, whereas higher doses significantly elevated the threshold frequency required for MFB ICSS. Both cocaine and morphine lowered ICSS thresholds. Cannabidiol inhibited the reward-facilitating effect of morphine, but not cocaine. This effect was reversed by pre-treatment with an intra-dorsal raphe injection of the selective 5-HT(1A) receptor antagonist WAY-100635. The present findings indicate that cannabidiol does not exhibit reinforcing properties in the ICSS paradigm at any of the doses tested, while it decreases the reward-facilitating effects of morphine. These effects were mediated by activation of 5-HT(1A) receptors in the dorsal raphe. Our results suggest that cannabidiol interferes with brain reward mechanisms responsible for the expression of the acute reinforcing properties of opioids, thus indicating that cannabidiol may be clinically useful in attenuating the rewarding effects of opioids.
© 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction

Arthritis_sucks · 08-11-2012, 04:29 AM

Ah ha, so it is not a gateway drug bitches. If anything it locks the gate and stands guard. I love you Cannabis.

guy fawkes · 08-12-2012, 01:04 PM

i wonder if its the same with other opioid painkillers

08-12-2012, 03:08 PM

All this evidence could make one sad.

There will be hopefully be a time not so far away when
people can use this plant as they see fit.

And i personally don't always need somebody in a white gown
to tell me what's good or bad for me. I'd much rather listen to my body and instincts.

Weird · 08-12-2012, 03:13 PM

Quote:

Originally Posted by loopdon

All this evidence could make one sad.

There will be hopefully be a time not so far away when
people can use this plant as they see fit.

And i personally don't always need somebody in a white gown
to tell me what's good or bad for me. I'd much rather listen to my body and instincts.

lots of testimony on this site that goes years aback about pot freeing many people from synthetic and non synthetic opiates

thats why so many people did just that, listened to their instinct and body and took another course regardless

headband 707 · 08-12-2012, 03:18 PM

This was why the study in Van BC was so effective an eye opening and perhaps why they want their greedy paws on it now headband 707

shmalphy · 08-12-2012, 05:38 PM

I have known TOO MAY people who get injuries very young, and end up addicted to opiate pain killers as a result of it, and even some that have died from subsequent overdoses. One kid was 15 when he hurt his back lifting weights, and he died of an OD at 21. It is extremely unfortunate that they are essentially the first line of defense against pain these days.

Rinse · 08-12-2012, 07:49 PM

Quote:

Originally Posted by Arthritis_sucks

Ah ha, so it is not a gateway drug bitches. If anything it locks the gate and stands guard. I love you Cannabis.

Actually it is a gateway drug...A gateway to higher consciousness

08-13-2012, 12:40 AM

some past friends of ours used to visit our hippie hideout from the city every now and then to smoke dope when they began to use too much heroin.

it was good we could help them ... but boy they had a sad life.

headband 707 · 08-13-2012, 05:22 PM

Quote:

Originally Posted by Sat X RB

some past friends of ours used to visit our hippie hideout from the city every now and then to smoke dope when they began to use too much heroin.

it was good we could help them ... but boy they had a sad life.

ppl that use heroin know they have a sad life.. This is why lots of them joined this cannabis program to stop,, headband 707

08-10-2012, 08:45 PM	#1
Storm Shadow Senior Member Join Date: Mar 2011 Posts: 4,639	Cannabidiol inhibits the reward-facilitating effect of morphine https://www.ncbi.nlm.nih.gov/pubmed/22862835 Cannabidiol inhibits the reward-facilitating effect of morphine: involvement of 5-HT(1A) receptors in the dorsal raphe nucleus. Abstract Cannabidiol is a non-psychotomimetic constituent of Cannabis sativa, which induces central effects in rodents. It has been shown that cannabidiol attenuates cue-induced reinstatement of heroin seeking. However, to the best of our knowledge, its effects on brain stimulation reward and the reward-facilitating effects of drugs of abuse have not yet been examined. Therefore, we investigated the effects of cannabidiol on brain reward function and on the reward-facilitating effect of morphine and cocaine using the intracranial self-stimulation (ICSS) paradigm. Rats were prepared with a stimulating electrode into the medial forebrain bundle (MFB), and a guide cannula into the dorsal raphe (microinjection experiments), and were trained to respond for electrical brain stimulation. A low dose of cannabidiol did not affect the reinforcing efficacy of brain stimulation, whereas higher doses significantly elevated the threshold frequency required for MFB ICSS. Both cocaine and morphine lowered ICSS thresholds. Cannabidiol inhibited the reward-facilitating effect of morphine, but not cocaine. This effect was reversed by pre-treatment with an intra-dorsal raphe injection of the selective 5-HT(1A) receptor antagonist WAY-100635. The present findings indicate that cannabidiol does not exhibit reinforcing properties in the ICSS paradigm at any of the doses tested, while it decreases the reward-facilitating effects of morphine. These effects were mediated by activation of 5-HT(1A) receptors in the dorsal raphe. Our results suggest that cannabidiol interferes with brain reward mechanisms responsible for the expression of the acute reinforcing properties of opioids, thus indicating that cannabidiol may be clinically useful in attenuating the rewarding effects of opioids. © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction __________________ Hall Of Fame
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08-11-2012, 04:29 AM	#2
Arthritis_sucks The Dude Join Date: Dec 2009 Posts: 5,147	Ah ha, so it is not a gateway drug bitches. If anything it locks the gate and stands guard. I love you Cannabis. __________________ "Drawing is the honesty of art. There is no possibility of cheating. It is either good or bad." Salvador Dali Oahu Daze episode 1 https://www.icmag.com/ic/showthread.php?t=288836 Finished Irie Tiki Farm 2017 Outdoor https://www.icmag.com/ic/showthread.php?t=344729
	Quote 1 members found this post helpful.

08-12-2012, 01:04 PM	#3
guy fawkes Senior Member Join Date: Aug 2012 Location: shit britain Posts: 1,785	i wonder if its the same with other opioid painkillers __________________ the eyes are useless if the mind is blind!
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08-12-2012, 03:08 PM	#4
Guest 209445 Guest Posts: n/a	All this evidence could make one sad. There will be hopefully be a time not so far away when people can use this plant as they see fit. And i personally don't always need somebody in a white gown to tell me what's good or bad for me. I'd much rather listen to my body and instincts.
	Quote 1 members found this post helpful.

08-12-2012, 03:18 PM	#6
headband 707 Plant whisperer Join Date: Jul 2009 Location: who wants to know? Posts: 4,017	This was why the study in Van BC was so effective an eye opening and perhaps why they want their greedy paws on it now headband 707 __________________ Any man that knows a thing knows he knows not a damn thing at all. https://www.icmag.com/viewarticle.ph...id=1422&page=2 "WEED be everywhere" Are we growing wiser or are we just growing taller? When everyone is going left it's important to look right.. Never follow the crowd they are usually WRONG! Headband707 The more I see the less I know LOL... Micheal Faranti What we do for ourselves dies with us. What we do for others and the world remains and is immortal. Albert Pine Somthing that drives me Hazy ,, I'm I or the other's crazy?Albert Einstien Free Gypsy ffs!! Nas& Damian Marley " Friends" https://www.youtube.com/watch?v=OO18F4aKGzQ https://www.youtube.com/watch?v=MrC-yum82MI Nas&Damian Marley "Patience" https://www.youtube.com/watch?v=01FE9cPXE3M https://www.youtube.com/watch?v=17FZIncZi8Q https://www.youtube.com/watch?v=XSbZidsgMfw now you should listen to it loud...
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08-12-2012, 05:38 PM	#7
shmalphy Banned Join Date: Nov 2011 Posts: 950	I have known TOO MAY people who get injuries very young, and end up addicted to opiate pain killers as a result of it, and even some that have died from subsequent overdoses. One kid was 15 when he hurt his back lifting weights, and he died of an OD at 21. It is extremely unfortunate that they are essentially the first line of defense against pain these days.
	Quote

08-13-2012, 12:40 AM	#9
Sat X RB Guest Posts: n/a	some past friends of ours used to visit our hippie hideout from the city every now and then to smoke dope when they began to use too much heroin. it was good we could help them ... but boy they had a sad life.
	Quote