[jeanj]

My boxer was diagnosed with a grade 3 mast cell tumor after a lump was removed from his ear July 1st. It was the only lump and they got clean margins. He was put on Benadryl then taken off even tho she said there was a good chance it could spread. We put him back on two weeks ago when he developed another lump. And then added Tagamet a week ago. It continued to increase in size so I researched cannabis and made some RSO Monday. They say if you stop the Benadryl/Tagamet it may make things worse. Can he be on the RSO with the Benadryl/Tagamet or should he taper off those and only use the RSO? He started RSO Monday night has had three doses and seems to be tolerating it well.

[Weezard]

Benadryl and Tagamet do not treat cancer, just pain, inflamation and allergic reaction.
They are "comfort" meds.
There is no conflict with RSO and their effect should be additive.

Be very careful when ramping up the dosage.
Our "poi" dog loses her appetite if she gets too much too soon.

Carry on and please keep us posted.

[jeanj]

Thank you for the quick reply! there are numerous forums where people talk about shrinking mast cell tumors with the benadryl/tagament combo. Chemo was our only other option from the vet and we did not want to poison him. I may just stop those and stick with the RSO--they dont really seem to be helping anyway. Do you have experience with mast cell tumors specifically? The one he has now is under the skin, so a topical application wouldnt help or would it? thanks again!

[Weezard]

Shrinking?! I'll have to research that.

I know that the combination helps prevent metastasis, as does Prednisone.

As dogs evolved, the mast cells job was to deter parasites.
In modern times they are under-worked.

When they go cancerous any irritation kicks them into gear and they grow and spread.
That is why surgery can be counterproductive.

It does seem that topical application can be effective, but if it's in place the dog can reach to lick, the risk of overdosage is high.
Will it be effective? A lot depends on the age of the dog.
For a young dog, it is a good bet.
However, once a dog nears the end of it's normal lifespan treatment gets more difficult and prognosis is not good.

Good luck and Aloha,
Weeze

[sadpanda]

Originally Posted by Weezard

It does seem that topical application can be effective, but if it's in place the dog can reach to lick, the risk of overdosage is high.

perhaps mix in something that the dog doesn't like. I know nothing about this so had to google it, but I had heard a long time ago of "Bitrex" (actual non-brand name Denatonium) as being "the most bitter compound known", which is added to things to prevent people eating them. It has a good safety profile and no known long term health risks... it just tastes really, really bad! Which is great cos doggy will only lick that once! and then you can get maximal topical use.

https://en.wikipedia.org/wiki/Denatonium

In 1995, the U.S. state of Oregon required that denatonium benzoate be added to products containing sweet-tasting ethylene glycol and methanol such as antifreeze and windshield washer fluid to prevent poisonings of children and animals.

Im sure there are other things you could add to deter a dog but i've got no idea, so if you could source some Bitrex it seems the way to go, just search ebay or whatever for either "bitrex" or "Denatonium". Looks like you can get 5gms denatonium benzoate salt off ebay for about $15, and 5 grams would probably last a lifetime lol, you don't need much!!!

ITS PROBABLY A GOOD IDEA TO HAVE PLENTY OF WATER AT HAND FOR WHEN THE DOG FIRST (and only time!) LICKS IT!!

For example here's a doggy paw "Antibacterial spray with Bitrex®":

[Weezard]

Good idea!
I use "Granny's bitter apple spray". to stop them from chewing their hair off of hot spots.

With my big dog I measure out an oral dose, then smear it on her mammary tumors.
She licks it off.
Two birds. . .

[jeanj]

thanks for those tips, it is on the back of his head under his ear, so he cant lick it. He just scratched it tho. it bled a little and I tried some oil but it seems to bother him, he doesnt like anything in his fur. husband wants to take him to the vet to have it removed Monday. It can take a few weeks to decrease in size? Should it at least stop growing now? He's only 4 years old. Still eats, plays--no signs of sickness except a lump.

[Weezard]

If not removed, at least biopsied.
Best to know exactly what you are dealing with before attempting any treatment.

Aloha,
Weeze

[jeanj]

it is cancer, they thought it may be an abscess, but now he has another one that is ulcerating. We switched to a higher CBD oil (Swiss-Tsu = THC 5.3%/CBD 52.4%), but they only had one gram and it's almost gone.

They have a 1:1 at 26% oil, would that be too high in THC?

Another dispensary has Sour Tsunami Rosin (2.58 THC/64 CBD). Can you melt rosin to ingest like the oil or is that completely different?

[Weezard]

They have a 1:1 at 26% oil, would that be too high in THC?.

No. It would be about right.
I avoid butane extractions altogether. I find them to be ineffective for surface cancers where solvent derived oil works well.
Just my experience, I could be wrong.