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Old 08-30-2011, 02:11 PM #1
StRa
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Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxioly
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

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The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory capacity of the potent synthetic cannabinoid HU210 on hippocampal neurogenesis and its possible correlation with behavioral change. We show that both embryonic and adult rat hippocampal NS/PCs are immunoreactive for CB1 cannabinoid receptors, indicating that cannabinoids could act on CB1 receptors to regulate neurogenesis. This hypothesis is supported by further findings that HU210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal NS/PCs likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. Chronic, but not acute, HU210 treatment promoted neurogenesis in the hippocampal dentate gyrus of adult rats and exerted anxiolytic- and antidepressant-like effects. X-irradiation of the hippocampus blocked both the neurogenic and behavioral effects of chronic HU210 treatment, suggesting that chronic HU210 treatment produces anxiolytic- and antidepressant-like effects likely via promotion of hippocampal neurogenesis.

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https://www.jci.org/articles/view/25509
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Old 09-09-2011, 06:32 PM #2
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WOW! GOOD READ BUT, I HAD TO GET MY DICTIONARY OUT.
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Old 09-09-2011, 06:41 PM #3
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yeah i suspected that it does

smoking repairs the brain
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Old 09-14-2011, 01:05 PM #4
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Natural selection has conserved cannabinoid receptors in various vertebrates and invertebrates that have been evolutionarily separate for 500 million years (33), indicating the importance of cannabinoid receptors to life...
I really like the term neurogenesis, it makes my brain feel all warm and tingly when I hit the bowl.
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When it comes to a drug that is currently listed in schedule I, if it is undisputed that such drug has no currently accepted medical use in treatment in the United States and a lack of accepted safety for use of the drug or other substance under medical supervision.."

No accepted safety of use under medical supervision? How medically supervised are all the patients in all the medical states?

Excerpt from US Govt Cannabinoid Patent 6,630,507
Cannabinoids have been found to have important properties...cannabinoids useful in the treatment... stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease...
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Old 09-14-2011, 01:32 PM #5
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In case anyone missed it, HU210 is a synthetic cannabinoid (ie Spice, etc...).
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Old 09-14-2011, 01:41 PM #6
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Any bets on whether natural cannabinoids have a more powerful effect? I would put money on it.
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Old 09-14-2011, 02:22 PM #7
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why not? i read in some article, where they tested on lab rats, one group got only alcohol (in certain doses), and the other groupe alcohol and cannabinodol, guess what,... after some time only the alcohol group showed brain damage induced by the toxicity of alcohol... the other group showed near to or zero degenerative signs -> could be that the destroyed braincells got "regenerated" by the cbd... or at least, the cbd counteracted the degeneration...

blessss
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Old 09-14-2011, 02:30 PM #8
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Quote:
Originally Posted by purple_man View Post
why not? i read in some article, where they tested on lab rats, one group got only alcohol (in certain doses), and the other groupe alcohol and cannabinodol, guess what,... after some time only the alcohol group showed brain damage induced by the toxicity of alcohol... the other group showed near to or zero degenerative signs -> could be that the destroyed braincells got "regenerated" by the cbd... or at least, the cbd counteracted the degeneration...

blessss

I just realized Cannabis may be a Smart Drug or Nootropic. It is neuroprotective, promotes neurogenesis, fosters long term memory and increases awareness.
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Old 09-14-2011, 02:37 PM #9
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Originally Posted by purple_man View Post
why not? i read in some article, where they tested on lab rats,
hey Purple, maybe was this one???

https://www.icmag.com/ic/showthread.php?t=133855
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Old 09-14-2011, 02:38 PM #10
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I just realized Cannabis may be a Smart Drug or Nootropic. It is neuroprotective, promotes neurogenesis, fosters long term memory and increases awareness.

i put a post in as my old user name when i joined in 08 saying how i feel like charlie from the book flowers for Algernon (or robert dinero int he movie awakenings)

it was as if i was coming out a fog where i could not properly focus and think

pot fixed neurological dysfunction in my brain

took years but fuck here i am

i think big alcohol big tobacco and big pharma know their drugs and propaganda fuck up cognitive reasoning

big reason pot is a threat
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Quote:
The shape it takes could be yours to choose

What you may win, what you may lose
Sativa is manna from heaven - BLueGrassToker

Ounce of prevention is worth a pound of cured - Ureapwhatusow

nobody every told me i found out for myself, you've got to believe in foolish miracles - o. osborne

Although the masters make the rules
For the wise men and the fools
I got nothing, Ma, to live up to - b. Dylan
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