[Sam_Skunkman]

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb.
Angelo A. Izzo1, 4, , Francesca Borrelli1, 4, Raffaele Capasso1, 4, Vincenzo Di Marzo2, 4 and Raphael Mechoulam3

D9-tetrahydrocannabinol binds cannabinoid (CB1 and
CB2) receptors, which are activated by endogenous com-
pounds (endocannabinoids) and are involved in a wide
range of physiopathological processes (e.g. modulation
of neurotransmitter release, regulation of pain percep-
tion, and of cardiovascular, gastrointestinal and liver
functions). The well-known psychotropic effects of D9-
tetrahydrocannabinol, which are mediated by activation
of brain CB1 receptors, have greatly limited its clinical
use. However, the plant Cannabis contains many can-
nabinoids with weak or no psychoactivity that, thera-
peutically, might be more promising than D9-
tetrahydrocannabinol. Here, we provide an overview
of the recent pharmacological advances, novel mechan-
isms of action, and potential therapeutic applications of
such non-psychotropic plant-derived cannabinoids.
Special emphasis is given to cannabidiol, the possible
applications of which have recently emerged in inflam-
mation, diabetes, cancer, affective and neurodegenera-
tive diseases, and to D9-tetrahydrocannabivarin, a novel
CB1 antagonist which exerts potentially useful actions in
the treatment of epilepsy and obesity

[smokesalot420]

thanks for the info!

excellent read

[pip313]

Its wierd they chose to focus on cbd, whatever benefits it has are pretty useless because the fda will never approve something so easily turned into thc.

[Sam_Skunkman]

Even if CBD was available, it would likely be more expensive then you can the price you can buy THC in good herb or resin. Then you need a lab to convert it to THC. I am not a chemist but friends in the know say it makes no economic sense. That and pure THC as produced by converting CBD to THC and then cleaning it up via HPLC is not even as good as resin that is only 50% THC, but rich in the right terpenoids. I don't think anyone will want to do this and there is zero chance of diversion of the CBD to THC. It is just an irrational fear of the DEA. It is cheaper to buy THC from your local dealer in the form of herbal Cannabis.

-SamS

[danut]

Originally Posted by pip313

Its wierd they chose to focus on cbd, whatever benefits it has are pretty useless because the fda will never approve something so easily turned into thc.

Actually it is being proven for the FDA right now.

The combination of THC and CBD in Sativex. The company is making the case of the benefits of natural cannabinoids when mixed together.

It'll be nice to be able to point out that 1. It's been proven to work and 2. GW can't make enough of it to go around .. but we can.

[danut]

Originally Posted by Sam_Skunkman

Even if CBD was available, it would likely be more expensive then you can the price you can buy THC in good herb or resin.

Ummm .. I think that industrial hemp is a little less expensive than most herb.

Right now there are tons of CBD being dumped on the ground in Canada. Right behind those machines that harvest those hemp seeds.

If those farmers knew seems that they wouldn't mind turning their trash into gold.

[Sam_Skunkman]

Industrial hemp is a poor source of CBD in fact. GW Pharmaceuticals makes CBD from a plant that gives close to 10% CBD by dry weight with little to no THC. Hemp is closer to 1% CBD and does have THC which needs to be removed via HPLC. I don't think extracting CBD from a 1% raw material source makes any sense when 10% materials are used for the same thing. Sure it can be done, but not cheaply or competitively. If you wanted to extract CBD which would you use?
-SamS

[pangolin]

Is there a seed line or cultivar currently available to the home grower that is a genuinely certified source of high% CBD? It seems hard to separate the truth and fiction of claims by seed companies...I see that plants of landrace origin may offer possibilities for this but again it seems very difficult to obtain a definitive answer...Thanks for posting the article.

[4saken]

Here's an awesome excerpt from that pdf: