[DrJay2001]

Dear All,

As many of you know Hepatitis C is a major problem in America effecting some 8,000,000 people.

As the article below points out, the inflammation related to HCV causes the release of an immune lymphokine called Tumor Necrosis Factor (TNF) that blocks insulin receptors in the liver.

Guess what drug markedly reduces TNF? Cannabis.

Yours,
Dr. jay





Hepatitis C Virus Directly Involved in Insulin Resistance



NEW YORK (Reuters Health) Mar 09 - Hepatitis C virus (HCV) is directly involved in the development of insulin resistance, according to a report in the March issue of Gastroenterology.

HCV infection has been associated with type 2 diabetes, the authors explain, but a definite causative relationship between HCV infection and diabetes has not been established.

Dr. Kazuhiko Koike, and colleagues from University of Tokyo, studied the role of HCV in the development of diabetes using transgenic mice that carry the core gene of HCV.

"Hyperinsulinemia was observed in the core gene transgenic mice as early as 1 month old," the authors report. Insulin resistance was observed by the age of 2 months.

Administration of glucose to core gene transgenic mice revealed only mild and statistically insignificant glucose intolerance compared with control mice, the results indicate, but transgenic mice fed a high-fat diet developed overt diabetes.

Insulin resistance depended chiefly on the shortage of insulin action on the liver, the researchers note, whereas skeletal muscle contributed little to the development of insulin resistance.

Suppression of insulin action in the liver resulting from TNF-alpha-mediated suppression of tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) is at least one of the mechanisms of insulin resistance in this model, the investigators report, and TNF-alpha blockade restored insulin sensitivity.

The authors conclude, "The HCV core protein induces insulin resistance in transgenic mice without gain in body weight at young age. These results indicate a direct involvement of HCV per se in the pathogenesis of diabetes in patients with HCV infection and provide a molecular basis for insulin resistance in such a condition."

"The study makes a major contribution by showing that hepatic insulin resistance can be induced solely by expression of the HCV core protein, and that signaling abnormalities in the insulin receptor-IRS-1 pathway are present before the development of steatosis," write Dr. Steven A. Weinman and Dr. L. Maria Belalcazar from University of Texas Medical Branch, Galveston, in a related editorial.

"The article...makes an important contribution to putting the HCV-diabetes association on a mechanistic footing, thus elevating it from a curious association to an important disease process."

Gastroenterology 2004;126:840-848,917-919.

[wisc2]

Do you know of any reputable studies on the relationship of cannibis and TNF?

[DrJay2001]

Here's just one recent study that demonstrates the role of cannabinoids in reducing TNF (and other proinflammatory cytokines) in a murine (mouse) model of MS.

Yours,
Dr. Jay

J Clin Invest. 2003 Apr;111(8):1231-40. Related Articles, Links


Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212.

Croxford JL, Miller SD.

Department of Microbiology-Immunology, Interdepartmental Immunobiology Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, IL 60611, USA.

Theiler murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) is a mouse model of chronic-progressive multiple sclerosis (MS) characterized by Th1-mediated CNS demyelination and spastic hindlimb paralysis. Existing MS therapies reduce relapse rates in 30% of relapsing-remitting MS patients, but are ineffective in chronic-progressive disease, and their effects on disability progression are unclear. Experimental studies demonstrate cannabinoids are useful for symptomatic treatment of spasticity and tremor in chronic-relapsing experimental autoimmune encephalomyelitis. Cannabinoids, however, have reported immunosuppressive properties. We show that the cannabinoid receptor agonist, R+WIN55,212, ameliorates progression of clinical disease symptoms in mice with preexisting TMEV-IDD. Amelioration of clinical disease is associated with downregulation of both virus and myelin epitope-specific Th1 effector functions (delayed-type hypersensitivity and IFN-gamma production) and the inhibition of CNS mRNA expression coding for the proinflammatory cytokines, TNF-alpha, IL1-beta, and IL-6. Clinical trials investigating the therapeutic potential of cannabinoids for the symptomatic treatment of MS are ongoing, and this study demonstrates that they may also have potent immunoregulatory properties.

[wisc2]

Ty, with a medical mj bill comig up in my state, all info is great.

[DrJay2001]

You're welcome! I have both Type 1 diabetes and Hepatitis C. Even with a huge viral count, cannabis has protected my liver as evidenced by two biopsies.

Yours,
Dr. Jay

[LL84]

drjay2001-
organic coconut milk and raw coconut is really good for you and will help kill the viral count. i think it would even be more beneficial than cannabis, i dont know though. i do know that when the panama canal was being built the locals were the ones surviving from malaria because the had coconut in there diets. check it out though. i know people that eat it weekly and especially when they tell they are coming onto a cold or flu.

[KharmaGirl]

You might wanna read this LL, https://www.icmag.com/ic/showthread.php?t=11567

fuk, man... 1 in 50 people have HepC. 1 in 75 people have HIV...


I cry for those and some, I have had their blood on my hands without worry, as I am paramedic but still... I am happy to say after all of that, I am HIV and Hep C negative. I will never stop thinking and fighting a good cause.


Dr. Jay, if you can hear me in some far off place, remember me as a soldier and I will stand. I`m sure you remember me and all of us who made a stand.

reposted from over here:

https://www.icmag.com/ic/showthread.p...43#post2006043

My A1c is 6.2 I think that the max I ever hit was ~7.6
GLU 95 (that three month average one) usually ~150
CHOL 169
TRIG 131 (max reading of ~800)
bp in the doctors office was 120/78 One year ago it was 235/135

FYI that is the entire metabolic syndrome. Which is what GW pharm noted in their human studies.

The way it works is that cannabinoids lower the levels of TCF. TCF causes inflammation of the pancreas. With the lowering of the TCF levels, there is a reduction of inflammation. What is left of the pancreas moves toward normal function. In addition there is a gain in insulin sensitivity in the rest of the body.

It is a reversal of the progression of the disease.

I understand your point. I only mentioned mine because you seem to be someone of medical knowledge. Yet lacking in awareness of what cannabinoids can do for people.

Sorry folks TNF not TCF.