When I'm starting a new room all I think about is:
Lights-up high and as bright as can be, hps all the way.
Air-follow the vpd chart and point your fans away from the plants. Co2 only works in elevated vpd areas IMO.
Water-keep it under 70, always check your ppms,EC, and pH in hydro and often in soil. What you feed and the runoff. Organics this is not so important as biological life is..
Nutrients- keep it simple and balanced. Start by only using a base and add boosters as you go. Less is more. Again EC,ppms,pH is super important and all solely dependent on your medium. Look into jacks hydro 5-12-26.
Substrate-pick the type of smoke you wish and the medium will give it to you. Every substrate gives a diff product and so far organic soils are the best when it comes to getting medicine. Hydro mediums are fantastic for commercial production but you really cannot unlock what a plant has to offer in this type of lifeform.