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Old 03-17-2018, 04:05 PM #41
coldcanna
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The endocannabinoid system (ECS) is a biological system composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the mammalian central nervous system (including the brain) and peripheral nervous system. The endocannabinoid system is involved in regulating a variety of physiological and cognitive processes including fertility,[1] pregnancy,[2] during pre- and postnatal development,[3] appetite, pain-sensation, mood, and memory, and in mediating the pharmacological effects of cannabis.[4][5] The ECS is also involved in mediating some of the physiological and cognitive effects of voluntary physical exercise in humans and other animals, such as contributing to exercise-induced euphoria as well as modulating locomotor activity and motivational salience for rewards.[6][7][8][9] In humans, the plasma concentration of certain endocannabinoids (i.e., anandamide) have been found to rise during physical activity;[6][7] since endocannabinoids can effectively penetrate the blood–brain barrier, it has been suggested that anandamide, along with other euphoriant neurochemicals, contributes to the development of exercise-induced euphoria in humans, a state colloquially referred to as a runner's high.[6][7]

Two primary endocannabinoid receptors have been identified: CB1, first cloned in 1990; and CB2, cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid ligand (binding molecule), anandamide, as well as its mimetic phytocannabinoid, THC. One other main endocannabinoid is 2-arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD. 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management.[10][11][12]
Energy balance and metabolism
The endocannabinoid system has been shown to have a homeostatic role by controlling several metabolic functions, such as energy storage and nutrient transport. It acts on peripheral tissues such as adipocytes, hepatocytes, the gastrointestinal tract, the skeletal muscles and the endocrine pancreas. It has also been implied in modulating insulin sensitivity. Through all of this, the endocannabinoid system may play a role in clinical conditions, such as obesity, diabetes, and atherosclerosis, which may also give it a cardiovascular role.[52]

Stress response
While the secretion of glucocorticoids in response to stressful stimuli is an adaptive response necessary for an organism to respond appropriately to a stressor, persistent secretion may be harmful. The endocannabinoid system has been implicated in the habituation of the hypothalamic-pituitary-adrenal axis (HPA axis) to repeated exposure to restraint stress. Studies have demonstrated differential synthesis of anandamide and 2-AG during tonic stress. A decrease of anandamide was found along the axis that contributed to basal hypersecretion of corticosterone; in contrast, an increase of 2-AG was found in the amygdala after repeated stress, which was negatively correlated to magnitude of the corticosterone response. All effects were abolished by the CB1 antagonist AM251, supporting the conclusion that these effects were cannabinoid-receptor dependent.[53] These findings show that anandamide and 2-AG divergently regulate the HPA axis response to stress: while habituation of the stress-induced HPA axis via 2-AG prevents excessive secretion of glucocorticoids to non-threatening stimuli, the increase of basal corticosterone secretion resulting from decreased anandamide allows for a facilitated response of the HPA axis to novel stimuli.

Exploration, social behavior, and anxiety
.[54] These contrasting effects reveal the importance of the endocannabinoid system in regulating anxiety-dependent behavior. Results suggest that glutamatergic cannabinoid receptors are not only responsible for mediating aggression, but produce an anxiolytic-like function by inhibiting excessive arousal: excessive excitation produces anxiety that limited the mice from exploring both animate and inanimate objects. In contrast, GABAergic neurons appear to control an anxiogenic-like function by limiting inhibitory transmitter release. Taken together, these two sets of neurons appear to help regulate the organism's overall sense of arousal during novel situations.

Immune function
Evidence suggests that endocannabinoids may function as both neuromodulators and immunomodulators in the immune system. Here, they seem to serve an autoprotective role to ameliorate muscle spasms, inflammation, and other symptoms of multiple sclerosis and skeletal muscle spasms.[13] Functionally, the activation of cannabinoid receptors has been demonstrated to play a role in the activation of GTPases in macrophages, neutrophils, and BM cells. These receptors have also been implicated in the proper migration of B cells into the marginal zone (MZ) and the regulation of healthy IgM levels.[55] Interestingly, some disorders seem to trigger an upregulation of cannabinoid receptors selectively in cells or tissues related to symptom relief and inhibition of disease progression, such as in that rodent neuropathic pain model, where receptors are increased in the spinal cord microglia, dorsal root ganglion, and thalamic neurons.[24]

https://en.wikipedia.org/wiki/Endocannabinoid_system
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Old 03-17-2018, 04:12 PM #42
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The endo-cannabinoid system plays a large role in the function of our body. So like anything else, the effect of external cannabinoids on this system would be slightly different for everyone depending if your endo system is low, high, or balanced with cannabinoids. This has not been studied that I know of.

I don't have an opinion on the debate of chakras going on here. But it seems clear to me that if you are naturally lacking in cannabinoids then supplementing with phytocannabinoids (plant based) would have a positive effect on your overall well being.
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"I think myself that we have more machinery of government than is necessary, too many parasites living on the labor of the industrious." Thomas Jefferson

"One has not only a legal but a moral responsibility to obey just laws. Conversely, one has a moral responsibility to disobey unjust laws. I would agree with St. Augustine that "an unjust law is no law at all""


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Old 05-29-2018, 07:11 PM #43
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Originally Posted by Hash Zeppelin View Post
All that first paragraph says is that you have no scientific understanding of organic chemistry, and instead of learning it you hide behind spiritualism. Unfortunately most growers, organic or chemical have no understanding of chemistry or botany either. Theyíre just following instructions on a bottle and a YouTube video.

Chemical fertilizers donít have to be used to the detriment of the environment, and organic growing isnít always good for the environment either. Itís all about understanding the science behind it. Chemical and organic growing are not much different. On a chemical level itís all pretty much the same stuff. A chemical is a chemical. Nitrogen is nitrogen. Potassium is potassium. There is no real difference on a chemical level. Organic potassium is still a chemical. Itís just that synthetic chemicals are more concentrated and dumb people over use the shit out of them instead of using them sparingly and building a living soil with them. They also use stupid poisons like plant growth regulators, which are illegal because they are proven to be detrimental to the environment and peopleís health. They also spray stuff like myclobutanil, which is not safe to burn because it creates small amounts of hydrogen cyanide gas that build up in your system and cause damage to your body over time.

The scientific method is a key part of discovering how to do things responsibly and efficiently. You can be as thoughtful as you want, but if you donít understand science, youíre just as likely to fuck up the environment as anyone else because you donít understand the effects of what youíre doing. Just ask the people that lived through the dust bowl. Their crops were all organic. They still fucked up entire farming regions in the United States and caused famine just because they were too dumb to rotate their crops.

As far as terps and quality go, I have grown with chemicals, organic, and even veganic. They all turn out the same because I know what Iím doing on a scientific level. My grows are environmentally responsible. My buds taste and smell amazing and burn to a clean white ash. Almost every person that gets ahold of my nugs immediately comments on the terps, and wonders how I get them so nice. Itís simple. I do not overfeed. I flush a lot. I do not let any salt build up occur. I build a living soil with microbes. I feed my microbes with short and long chain carbohydrates. I check every plant everyday. I never spray anything in flower, not even organic preventatives. Instead I build my room to have a controlled, pressurized environment, with massive amounts of filtered air exchange. And soon my entire indoor grow will be solar powered.

Taking the time to learn the science behind responsible growing is caring. Thatís whats going to stop people from hurting the environment, not spiritualism. I donít care if you want to believe in chakras, but donít try to apply it growing. I donít care if you always want to grow all organic either, but Iím not going to support your bullshit claims that its automatically the only ethical way to grow, or the only way to grow and reach maximum quality because thatís factually false, and Iíve been proving it for almost two decades.

you seem sensible. i dont disagree, just want to say that the whole is bigger than the sum of its parts.

there is one fundamental question-what is real? science measure mass and particles. this is far from the entirety of reality. you can weave a carpet out of strands of wool that you have shorn, spun, and stitched together but it will never equal the original coat of the sheep.
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Old 05-30-2018, 12:58 AM #44
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Yeah. Look ... I mean Listen ... it doesn't matter how many words we use to describe ... WHAT?



We go round and round in our thoughts and waffle and waffle with our mouths and take positions and we're talking about ... WHAT?


all we say here is NOTIONAL.


we have Notions that things are real. the Presidency, the U. S. of A. all Notional. Chakras? Notional!



the Sanyassins smoke chillums to help become enlightened. I bet the figures for success are about the same as non-smokers who reach enlightenment.


don't use it for imagining Chakras. keep it STILL ...


breathing in ... breathing out ... I am ALIVE!
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Old 05-30-2018, 03:20 AM #45
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The explanation is that weed does something to clog the energy channels. I don't know about the channels, inner winds and drops that the the Tibetan Buddhists use to explain the why's. I do know that the ability to stabilize the mind, rest in it's innate peace and have that peace and stability remain post meditation is profoundly enhanced after weeks and months of non smoking.

...Exhaustion is a greater cause of mental dullness/ distraction than weed.

I can relate to this post, and largely agree. I find ordinary exhaustion to be the biggest burden, and see it as the most common reason why pilots and surgeons mess up. In the same way that alcohol and most other drugs are "worse" than weed, exhaustion is worse as well, about like a hangover minus the sickness.


The Tibetan components are talking about prana (life force) and karma. The karma exists mentally. Even with meditation experience, karmic winds can still blow the mind this way and that, and throw the life-force off center. This prevents the subtle drops from operating, those drops being of the nature of combined insight and bliss. You feed them those energies, and when they activate, it produces transcendent experience.


Weed is very "borderline" here; it may help get started, but, in the long run, yes, it can reduce mindfulness. I am not sure if this is automatically so because it directly interferes with the channels, or if it is just a sensation tempting us to laziness, which could be overcome. Probably will experiment with this fine point for a few decades. If anything produces sluggishness, concentration is to be placed in the ajna or center between the eyebrows. And so if this technique works on "everything", it should work on "weed fog" as well.
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Old 05-31-2018, 12:43 AM #46
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Originally Posted by Easy7 View Post
Ego exhaustion. There must be some greater design to things. Attachments can be a lot of fun, but they do get old at times. There needs some refreshment.

There must be 'greater design' because I need to justify my Ego and Self Importance!
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