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Old 01-12-2019, 11:13 PM #1
hunt4genetics
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The upper limits of CBD

I am very ignorant on the topic of CBD so I ask for input.

With the Farm Bill being passed and Hemp legalized, info will be able to be spread more freely in person. Intense Breeding will commence.

I assume the two paths will be: 1) to breed plants with more pulp, and fabric potential, 2) breed plants very high in CBD.

What would be the effects of consuming a plant that is high in CBD?
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Old 01-12-2019, 11:42 PM #2
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While many cannabis consumers may choose to opt for CBD-only products like CBD oil, CBD-rich flower can have better effects because of the synergy that occurs between THC and CBD. When smoking or vaping the entire cannabis flower, you get a wide breadth of therapeutic cannabinoids and fragrant terpenes that work together to influence each otherís actions. CBD, for instance, can enhance THCís pain relieving and epilepsy reducing properties. CBD also encourages THC to stay longer in the system, helpful for people with chronic conditions.
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Seeds have the power to preserve species, to enhance cultural as well as genetic diversity, to counter economic monopoly and to check the advance of conformity on all its many fronts.
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Happiness held is the seed; Happiness shared is the flower.
John Harrigan
Instant gratification takes too long.
Carrie Fisher - RIP.
afterthought autos
We are passionate breeders growing organically in the USA and offer 27 autoflowering strains, 9 photoperiods in our decades of breeding expertise. afterthought autos - we are unique quality cannabis autoflower breeders for medical conditions and recreational stimulus. Auto breeding 13 years, and running strong!

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Old 01-12-2019, 11:45 PM #3
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Here are seven health benefits of CBD oil that are backed by scientific evidence.

1. Can Relieve Pain
Marijuana has been used to treat pain as far back as 2900 B.C. (2).

More recently, scientists have discovered that certain components of marijuana, including CBD, are responsible for its pain-relieving effects.

The human body contains a specialized system called the endocannabinoid system (ECS), which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response (3).

The body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in your nervous system.

Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters (4).

For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation (5, 6).

Several human studies have found that a combination of CBD and THC is effective in treating pain related to multiple sclerosis and arthritis.

An oral spray called Sativex, which is a combination of THC and CBD, is approved in several countries to treat pain related to multiple sclerosis.

In a study of 47 people with multiple sclerosis, those treated with Sativex for one month experienced a significant improvement in pain, walking and muscle spasms, compared to the placebo group (7).

Another study found that Sativex significantly improved pain during movement, pain at rest and sleep quality in 58 people with rheumatoid arthritis (8).

CBD, especially in combination with THC, may be effective in reducing pain associated with diseases like multiple sclerosis and rheumatoid arthritis.
2. Could Reduce Anxiety and Depression
Anxiety and depression are common mental health disorders that can have devastating impacts on health and well-being.

According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth (9).

Anxiety and depression are usually treated with pharmaceutical drugs, which can cause a number of side effects including drowsiness, agitation, insomnia, sexual dysfunction and headache (10).

What’s more, medications like benzodiazepines can be addictive and may lead to substance abuse (11).

CBD oil has shown promise as a treatment for both depression and anxiety, leading many who live with these disorders to become interested in this natural approach.

In one study, 24 people with social anxiety disorder received either 600 mg of CBD or a placebo before a public speaking test.

The group that received the CBD had significantly less anxiety, cognitive impairment and discomfort in their speech performance, compared to the placebo group (12).

CBD oil has even been used to safely treat insomnia and anxiety in children with post-traumatic stress disorder (13).

CBD has also shown antidepressant-like effects in several animal studies (14, 15).

These qualities are linked to CBD’s ability to act on the brain’s receptors for serotonin, a neurotransmitter that regulates mood and social behavior.

Using CBD has been shown to reduce anxiety and depression in both human and animal studies.
3. Can Alleviate Cancer-Related Symptoms
CBD may help reduce symptoms related to cancer and side effects related to cancer treatment, like nausea, vomiting and pain.

One study looked at the effects of CBD and THC in 177 people with cancer-related pain who did not experience relief from pain medication.

Those treated with an extract containing both compounds experienced a significant reduction in pain compared to those who received only THC extract (16).

CBD may also help reduce chemotherapy-induced nausea and vomiting, which are among the most common chemotherapy-related side effects for those with cancer (17).

Though there are drugs that help with these distressing symptoms, they are sometimes ineffective, leading some people to seek alternatives.

A study of 16 people undergoing chemotherapy found that a one-to-one combination of CBD and THC administered via mouth spray reduced chemotherapy-related nausea and vomiting better than standard treatment alone (18).

Some test-tube and animal studies have even shown that CBD may have anticancer properties. For example, one test-tube study found that concentrated CBD induced cell death in human breast cancer cells (19).

Another study showed that CBD inhibited the spread of aggressive breast cancer cells in mice (20).

However, these are test-tube and animal studies, so they can only suggest what might work in people. More studies in humans are needed before conclusions can be made.


Though CBD has been shown to help reduce symptoms related to cancer and cancer treatment, and may even have cancer-fighting properties, more research is needed to assess its efficacy and safety.
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4. May Reduce Acne
Acne is a common skin condition that affects more than 9% of the population (21).

It is thought to be caused by a number of factors, including genetics, bacteria, underlying inflammation and the overproduction of sebum, an oily secretion made by sebaceous glands in the skin (22, 23).

Based on recent scientific studies, CBD oil may help treat acne due to its anti-inflammatory properties and ability to reduce sebum production.

One test-tube study found that CBD oil prevented sebaceous gland cells from secreting excessive sebum, exerted anti-inflammatory actions and prevented the activation of “pro-acne” agents like inflammatory cytokines (24).

Another study had similar findings, concluding that CBD may be an efficient and safe way to treat acne, thanks in part to its remarkable anti-inflammatory qualities (25).

Though these results are promising, human studies exploring the effects of CBD on acne are needed.

SUMMARY
CBD may have beneficial effects on acne due to its anti-inflammatory qualities and its ability to control the overproduction of sebum from the sebaceous glands.

5. Might Have Neuroprotective Properties
Researchers believe that CBD’s ability to act on the endocannabinoid system and other brain signaling systems may provide benefits for those with neurological disorders.

In fact, one of the most studied uses for CBD is in treating neurological disorders like epilepsy and multiple sclerosis. Though research in this area is still relatively new, several studies have shown promising results.

Sativex, an oral spray consisting of CBD and THC, has been proven to be a safe and effective way to reduce muscle spasticity in people with multiple sclerosis.

One study found that Sativex reduced spasms in 75% of 276 people with multiple sclerosis who were experiencing muscle spasticity that was resistant to medications (26).

Another study gave 214 people with severe epilepsy 0.9–2.3 grams of CBD oil per pound (2–5 g/kg) of body weight. Their seizures reduced by a median of 36.5% (27).

One more study found that CBD oil significantly reduced seizure activity in children with Dravet syndrome, a complex childhood epilepsy disorder, compared to a placebo (28).

However, it’s important to note that some people in both these studies experienced adverse reactions associated with CBD treatment, such as convulsions, fever and diarrhea.

CBD has also been researched for its potential effectiveness in treating several other neurological diseases.

For example, several studies have shown that treatment with CBD improved quality of life and sleep quality for people with Parkinson’s disease (29, 30).

Additionally, animal and test-tube studies have shown that CBD may decrease inflammation and help prevent the neurodegeneration associated with Alzheimer’s disease (31).

In one long-term study, researchers gave CBD to mice genetically predisposed to Alzheimer’s disease, finding that it helped prevent cognitive decline (32).

Though research is limited at this time, CBD has been shown to effectively treat symptoms related to epilepsy and Parkinson’s disease. CBD was also shown to reduce the progression of Alzheimer’s disease in test-tube and animal studies.
6. Could Benefit Heart Health
Recent research has linked CBD with several benefits for the heart and circulatory system, including the ability to lower high blood pressure.

High blood pressure is linked to higher risks of a number of health conditions, including stroke, heart attack and metabolic syndrome (33).

Studies indicate that CBD may be a natural and effective treatment for high blood pressure.

One recent study treated 10 healthy men with one dose of 600 mg of CBD oil and found it reduced resting blood pressure, compared to a placebo.

The same study also gave the men stress tests that normally increase blood pressure. Interestingly, the single dose of CBD led the men to experience a smaller blood pressure increase than normal in response to these tests (34).

Researchers have suggested that the stress- and anxiety-reducing properties of CBD are responsible for its ability to help lower blood pressure.

Additionally, several animal studies have demonstrated that CBD may help reduce the inflammation and cell death associated with heart disease due to its powerful antioxidant and stress-reducing properties.

For example, one study found that treatment with CBD reduced oxidative stress and prevented heart damage in diabetic mice with heart disease (35).

Though more human studies are needed, CBD may benefit heart health in several ways, including by reducing blood pressure and preventing heart damage.
7. Several Other Potential Benefits
CBD has been studied for its role in treating a number of health issues other than those outlined above.

Though more studies are needed, CBD is thought to provide the following health benefits:

Antipsychotic effects: Studies suggest that CBD may help people with schizophrenia and other mental disorders by reducing psychotic symptoms (36).
Substance abuse treatment: CBD has been shown to modify circuits in the brain related to drug addiction. In rats, CBD has been shown to reduce morphine dependence and heroin-seeking behavior (37).
Anti-tumor effects: In test-tube and animal studies, CBD has demonstrated anti-tumor effects. In animals, it has been shown to prevent the spread of breast, prostate, brain, colon and lung cancer (38).
Diabetes prevention: In diabetic mice, treatment with CBD reduced the incidence of diabetes by 56% and significantly reduced inflammation (39).
SUMMARY
Some studies suggest that CBD may be an effective treatment for diabetes, substance abuse, mental disorders and certain types of cancers. However, more research in humans is needed.

Are There Any Side Effects?
Though CBD is generally well tolerated and considered safe, it may cause adverse reactions in some people.

Side effects noted in studies include:

Diarrhea
Changes in appetite
Fatigue

CBD is also known to interact with several medications. Before you start using CBD oil, discuss it with your doctor to ensure your safety and avoid potentially harmful interactions

https://www.healthline.com
__________________
Seeds have the power to preserve species, to enhance cultural as well as genetic diversity, to counter economic monopoly and to check the advance of conformity on all its many fronts.
Michael Pollan
Happiness held is the seed; Happiness shared is the flower.
John Harrigan
Instant gratification takes too long.
Carrie Fisher - RIP.
afterthought autos
We are passionate breeders growing organically in the USA and offer 27 autoflowering strains, 9 photoperiods in our decades of breeding expertise. afterthought autos - we are unique quality cannabis autoflower breeders for medical conditions and recreational stimulus. Auto breeding 13 years, and running strong!

https://www.icmag.com/ic/forumdisplay.php?f=65770
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Old 01-13-2019, 12:39 AM #4
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CBD definitely works better with some THC in it, and vice versa. I do see a lot of CBD extraction coming from hemp, and I don't see this going away. Being able to also sell the fiber materials will be a boon.

There are literally thousands of uses for the materials the hemp plant produces. Oil from the seeds can be pressed, filtered and used directly in your diesel engines. (Tractor fuel anyone?) As industry progresses, watch as breeding centers around specific needs. Long/short weak/strong fibers, soft/hard fibers, oils, terpentine, plastics, waxes and anything else industry demands.

Small scale? I'm expecting to see some crazy things over the next 10 years. lol
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Old 01-13-2019, 12:57 AM #5
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Quote:
Originally Posted by hunt4genetics View Post
I am very ignorant on the topic of CBD so I ask for input.

With the Farm Bill being passed and Hemp legalized, info will be able to be spread more freely in person. Intense Breeding will commence.

I assume the two paths will be: 1) to breed plants with more pulp, and fabric potential, 2) breed plants very high in CBD.

What would be the effects of consuming a plant that is high in CBD?
The hemp rule mandates that legal plants have less than 0.3% THC, so its not just CBD, its any cannabinoid that isn't THC. The guy who started this thread
https://www.icmag.com/ic/showthread.php?t=330712
has seeds for all sorts of other cannabinoids on the way.
One of the effects of CBD is that it inhibits certain types of drug metabolism, so the effects of consuming a plant that is high in CBD may depend on what other drugs you're on.
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Old 01-13-2019, 10:39 PM #6
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Quote:
Originally Posted by Douglas.Curtis View Post
CBD definitely works better with some THC in it, and vice versa. I do see a lot of CBD extraction coming from hemp, and I don't see this going away. Being able to also sell the fiber materials will be a boon.

There are literally thousands of uses for the materials the hemp plant produces. Oil from the seeds can be pressed, filtered and used directly in your diesel engines. (Tractor fuel anyone?) As industry progresses, watch as breeding centers around specific needs. Long/short weak/strong fibers, soft/hard fibers, oils, terpentine, plastics, waxes and anything else industry demands.

Small scale? I'm expecting to see some crazy things over the next 10 years. lol
Agreed, both minimal thc (more than what hemp is...0.3% or less) and CBD together helps me.

However, back at another job (lab worker in material degradation lab), they do spot (and frequent) urine screens, so making my own CBD capsules from hemp.

I can attest, both together (thc/CBD and all the other components)is best, hence we developed several strains with CBD rich and high ration of CBD compared to thc. We do have a few we're watching, yet a lot of hemp are natural occurrences of monoecious plants, bearing flowers of both sexes. While some are not, that's been our experience growing several different hemp plant varieties.

Cannabis is a complex plant when it comes down to segregating all the goodness from it.

Can say taking too many CBD capsules (chronic pain), loose stools has occurred along with lower INR viscosity in blood, taking 'blood thinner'. Just have to find a happy medium.
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Seeds have the power to preserve species, to enhance cultural as well as genetic diversity, to counter economic monopoly and to check the advance of conformity on all its many fronts.
Michael Pollan
Happiness held is the seed; Happiness shared is the flower.
John Harrigan
Instant gratification takes too long.
Carrie Fisher - RIP.
afterthought autos
We are passionate breeders growing organically in the USA and offer 27 autoflowering strains, 9 photoperiods in our decades of breeding expertise. afterthought autos - we are unique quality cannabis autoflower breeders for medical conditions and recreational stimulus. Auto breeding 13 years, and running strong!

https://www.icmag.com/ic/forumdisplay.php?f=65770
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Old 01-31-2019, 09:42 PM #7
Tavish
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Quote:
Originally Posted by aridbud View Post
Here are seven health benefits of CBD oil that are backed by scientific evidence.

1. Can Relieve Pain
Marijuana has been used to treat pain as far back as 2900 B.C. (2).

More recently, scientists have discovered that certain components of marijuana, including CBD, are responsible for its pain-relieving effects.

The human body contains a specialized system called the endocannabinoid system (ECS), which is involved in regulating a variety of functions including sleep, appetite, pain and immune system response (3).

The body produces endocannabinoids, which are neurotransmitters that bind to cannabinoid receptors in your nervous system.

Studies have shown that CBD may help reduce chronic pain by impacting endocannabinoid receptor activity, reducing inflammation and interacting with neurotransmitters (4).

For example, one study in rats found that CBD injections reduced pain response to surgical incision, while another rat study found that oral CBD treatment significantly reduced sciatic nerve pain and inflammation (5, 6).

Several human studies have found that a combination of CBD and THC is effective in treating pain related to multiple sclerosis and arthritis.

An oral spray called Sativex, which is a combination of THC and CBD, is approved in several countries to treat pain related to multiple sclerosis.

In a study of 47 people with multiple sclerosis, those treated with Sativex for one month experienced a significant improvement in pain, walking and muscle spasms, compared to the placebo group (7).

Another study found that Sativex significantly improved pain during movement, pain at rest and sleep quality in 58 people with rheumatoid arthritis (8).

CBD, especially in combination with THC, may be effective in reducing pain associated with diseases like multiple sclerosis and rheumatoid arthritis.
2. Could Reduce Anxiety and Depression
Anxiety and depression are common mental health disorders that can have devastating impacts on health and well-being.

According to the World Health Organization, depression is the single largest contributor to disability worldwide, while anxiety disorders are ranked sixth (9).

Anxiety and depression are usually treated with pharmaceutical drugs, which can cause a number of side effects including drowsiness, agitation, insomnia, sexual dysfunction and headache (10).

Whatís more, medications like benzodiazepines can be addictive and may lead to substance abuse (11).

CBD oil has shown promise as a treatment for both depression and anxiety, leading many who live with these disorders to become interested in this natural approach.

In one study, 24 people with social anxiety disorder received either 600 mg of CBD or a placebo before a public speaking test.

The group that received the CBD had significantly less anxiety, cognitive impairment and discomfort in their speech performance, compared to the placebo group (12).

CBD oil has even been used to safely treat insomnia and anxiety in children with post-traumatic stress disorder (13).

CBD has also shown antidepressant-like effects in several animal studies (14, 15).

These qualities are linked to CBDís ability to act on the brainís receptors for serotonin, a neurotransmitter that regulates mood and social behavior.

Using CBD has been shown to reduce anxiety and depression in both human and animal studies.
3. Can Alleviate Cancer-Related Symptoms
CBD may help reduce symptoms related to cancer and side effects related to cancer treatment, like nausea, vomiting and pain.

One study looked at the effects of CBD and THC in 177 people with cancer-related pain who did not experience relief from pain medication.

Those treated with an extract containing both compounds experienced a significant reduction in pain compared to those who received only THC extract (16).

CBD may also help reduce chemotherapy-induced nausea and vomiting, which are among the most common chemotherapy-related side effects for those with cancer (17).

Though there are drugs that help with these distressing symptoms, they are sometimes ineffective, leading some people to seek alternatives.

A study of 16 people undergoing chemotherapy found that a one-to-one combination of CBD and THC administered via mouth spray reduced chemotherapy-related nausea and vomiting better than standard treatment alone (18).

Some test-tube and animal studies have even shown that CBD may have anticancer properties. For example, one test-tube study found that concentrated CBD induced cell death in human breast cancer cells (19).

Another study showed that CBD inhibited the spread of aggressive breast cancer cells in mice (20).

However, these are test-tube and animal studies, so they can only suggest what might work in people. More studies in humans are needed before conclusions can be made.


Though CBD has been shown to help reduce symptoms related to cancer and cancer treatment, and may even have cancer-fighting properties, more research is needed to assess its efficacy and safety.
powered by Rubicon Project
4. May Reduce Acne
Acne is a common skin condition that affects more than 9% of the population (21).

It is thought to be caused by a number of factors, including genetics, bacteria, underlying inflammation and the overproduction of sebum, an oily secretion made by sebaceous glands in the skin (22, 23).

Based on recent scientific studies, CBD oil may help treat acne due to its anti-inflammatory properties and ability to reduce sebum production.

One test-tube study found that CBD oil prevented sebaceous gland cells from secreting excessive sebum, exerted anti-inflammatory actions and prevented the activation of ďpro-acneĒ agents like inflammatory cytokines (24).

Another study had similar findings, concluding that CBD may be an efficient and safe way to treat acne, thanks in part to its remarkable anti-inflammatory qualities (25).

Though these results are promising, human studies exploring the effects of CBD on acne are needed.

SUMMARY
CBD may have beneficial effects on acne due to its anti-inflammatory qualities and its ability to control the overproduction of sebum from the sebaceous glands.

5. Might Have Neuroprotective Properties
Researchers believe that CBDís ability to act on the endocannabinoid system and other brain signaling systems may provide benefits for those with neurological disorders.

In fact, one of the most studied uses for CBD is in treating neurological disorders like epilepsy and multiple sclerosis. Though research in this area is still relatively new, several studies have shown promising results.

Sativex, an oral spray consisting of CBD and THC, has been proven to be a safe and effective way to reduce muscle spasticity in people with multiple sclerosis.

One study found that Sativex reduced spasms in 75% of 276 people with multiple sclerosis who were experiencing muscle spasticity that was resistant to medications (26).

Another study gave 214 people with severe epilepsy 0.9Ė2.3 grams of CBD oil per pound (2Ė5 g/kg) of body weight. Their seizures reduced by a median of 36.5% (27).

One more study found that CBD oil significantly reduced seizure activity in children with Dravet syndrome, a complex childhood epilepsy disorder, compared to a placebo (28).

However, itís important to note that some people in both these studies experienced adverse reactions associated with CBD treatment, such as convulsions, fever and diarrhea.

CBD has also been researched for its potential effectiveness in treating several other neurological diseases.

For example, several studies have shown that treatment with CBD improved quality of life and sleep quality for people with Parkinsonís disease (29, 30).

Additionally, animal and test-tube studies have shown that CBD may decrease inflammation and help prevent the neurodegeneration associated with Alzheimerís disease (31).

In one long-term study, researchers gave CBD to mice genetically predisposed to Alzheimerís disease, finding that it helped prevent cognitive decline (32).

Though research is limited at this time, CBD has been shown to effectively treat symptoms related to epilepsy and Parkinsonís disease. CBD was also shown to reduce the progression of Alzheimerís disease in test-tube and animal studies.
6. Could Benefit Heart Health
Recent research has linked CBD with several benefits for the heart and circulatory system, including the ability to lower high blood pressure.

High blood pressure is linked to higher risks of a number of health conditions, including stroke, heart attack and metabolic syndrome (33).

Studies indicate that CBD may be a natural and effective treatment for high blood pressure.

One recent study treated 10 healthy men with one dose of 600 mg of CBD oil and found it reduced resting blood pressure, compared to a placebo.

The same study also gave the men stress tests that normally increase blood pressure. Interestingly, the single dose of CBD led the men to experience a smaller blood pressure increase than normal in response to these tests (34).

Researchers have suggested that the stress- and anxiety-reducing properties of CBD are responsible for its ability to help lower blood pressure.

Additionally, several animal studies have demonstrated that CBD may help reduce the inflammation and cell death associated with heart disease due to its powerful antioxidant and stress-reducing properties.

For example, one study found that treatment with CBD reduced oxidative stress and prevented heart damage in diabetic mice with heart disease (35).

Though more human studies are needed, CBD may benefit heart health in several ways, including by reducing blood pressure and preventing heart damage.
7. Several Other Potential Benefits
CBD has been studied for its role in treating a number of health issues other than those outlined above.

Though more studies are needed, CBD is thought to provide the following health benefits:

Antipsychotic effects: Studies suggest that CBD may help people with schizophrenia and other mental disorders by reducing psychotic symptoms (36).
Substance abuse treatment: CBD has been shown to modify circuits in the brain related to drug addiction. In rats, CBD has been shown to reduce morphine dependence and heroin-seeking behavior (37).
Anti-tumor effects: In test-tube and animal studies, CBD has demonstrated anti-tumor effects. In animals, it has been shown to prevent the spread of breast, prostate, brain, colon and lung cancer (38).
Diabetes prevention: In diabetic mice, treatment with CBD reduced the incidence of diabetes by 56% and significantly reduced inflammation (39).
SUMMARY
Some studies suggest that CBD may be an effective treatment for diabetes, substance abuse, mental disorders and certain types of cancers. However, more research in humans is needed.

Are There Any Side Effects?
Though CBD is generally well tolerated and considered safe, it may cause adverse reactions in some people.

Side effects noted in studies include:

Diarrhea
Changes in appetite
Fatigue

CBD is also known to interact with several medications. Before you start using CBD oil, discuss it with your doctor to ensure your safety and avoid potentially harmful interactions

https://www.healthline.com

Forgive me for my ignorance, but where are the sources?
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Old 01-31-2019, 09:56 PM #8
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Quote:
Originally Posted by Tavish View Post
Forgive me for my ignorance, but where are the sources?

Found them.



https://www.healthline.com/nutrition...efits#section1


(2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549367/


(3) https://www.ncbi.nlm.nih.gov/pubmed/19675519


(4) https://inforlife.eu/wp-content/uplo...management.pdf


(5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5478794/


(6) https://www.ncbi.nlm.nih.gov/pubmed/17157290


(7) https://www.ncbi.nlm.nih.gov/pubmed/25699191


(8) https://www.ncbi.nlm.nih.gov/pubmed/16282192


(9) https://apps.who.int/iris/bitstream/1...2017.2-eng.pdf


(10) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970636/


(11) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657308/


(12) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079847/


(13) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101100/


(14) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823358/


(15) https://www.ncbi.nlm.nih.gov/pubmed/22509273


(16) https://www.ncbi.nlm.nih.gov/pubmed/19896326


(17) https://www.ncbi.nlm.nih.gov/pubmed/16983116


(18) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2997305/


(19) https://www.ncbi.nlm.nih.gov/pubmed/21566064


(20) https://www.ncbi.nlm.nih.gov/pubmed/18025276


(21) https://www.ncbi.nlm.nih.gov/pubmed/25597339


(22) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780801/


(23) https://www.sciencedirect.com/scienc...27811715001457


(24) https://www.ncbi.nlm.nih.gov/pubmed/25061872


(25) https://www.ncbi.nlm.nih.gov/pubmed/27094344


(26) https://www.ncbi.nlm.nih.gov/pubmed/24525548


(27) https://www.ncbi.nlm.nih.gov/pubmed/26724101


(28) https://www.ncbi.nlm.nih.gov/pubmed/28538134


(29) https://www.ncbi.nlm.nih.gov/pubmed/24845114


(30) https://www.ncbi.nlm.nih.gov/pubmed/25237116


(31) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5289988/


(32) https://www.ncbi.nlm.nih.gov/pubmed/25024347


(33) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699411/


(34) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470879/


(35) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026637/


(36) https://www.ncbi.nlm.nih.gov/pubmed/25667194


(37) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444130/


(38) https://www.ncbi.nlm.nih.gov/pubmed/25916739


(39) https://www.ncbi.nlm.nih.gov/pubmed/16698671


(40) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/


(41) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4189631/
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