What's new
  • Please note members who been with us for more than 10 years have been upgraded to "Veteran" status and will receive exclusive benefits. If you wish to find out more about this or support IcMag and get same benefits, check this thread here.
  • Important notice: ICMag's T.O.U. has been updated. Please review it here. For your convenience, it is also available in the main forum menu, under 'Quick Links"!

Can CBD with Psilocybin microdosing Treat Brain Injuries?

Vandenberg

Active member
I'm hoping this research pans out to become an effective treatment for Traumatic Brain Injury victims.
My son had a motorcycle accident and has severe "Traumatic Brain Injury" (TMI). He was in a coma for 4 months some years ago... recently an old friend tossed him a jar full of dried powdered mushrooms that is proving to be magic for him.
He has noticed an improvement in his mental clarity after recreational use so he is currently mimicking a lab mouse trying to determine what an appropriate daily microdose would be.He is doing a quarter gram daily with with balanced 1:1 cbd/thc entourage style cannabis edibles. On that note I present some hopeful information. :) Vandenberg :)
*************************

The University of Miami will begin studying if CBD and psilocybin combined can treat traumatic brain injury and post-traumatic stress disorder, two medical conditions for which there are currently no cures.

The university received a $1.64 million grant from Tassili Life Sciences to see if CBD, a non-intoxicating compound derived from cannabis, taken along with psilocybin, a psychedelic compound found in “magic mushrooms,” could reduce, or even prevent, the symptoms associated with traumatic brain injury and PTSD.

“Mild traumatic brain injury, especially concussion, is an important cause of morbidity in the United States and in the world today,” Dr. Michael E. Hoffer, MD, a professor of otolaryngology and neurological surgery, as well as one of the study’s authors, said in a press release.

According to the CDC, roughly 2.87 million Americans were either diagnosed with traumatic brain injury (TBI) during ER visits, were hospitalized for the condition, or died from it in 2014.
TBI’s symptoms usually include dizziness, memory loss, migraines, and uncontrollable mood swings. The injury often leads to PTSD, too, which brings additional complications such as social isolation, paranoia, substance abuse, an increased risk of suicide, and difficulty maintaining close relationships with others.


Currently, there are no cures for either TBI or PTSD. Conventional treatments include psychotherapy and pharmaceutical medications that can control individual symptoms, but those medications often come with dangerous side effects.
The two conditions are frequently seen in US combat veterans, though professional athletes, drivers, and abuse survivors often develop the two comorbidly, too.
With this new grant with Tassili, we have the opportunity to explore a combination therapy that might treat the traumatic brain injury as well as the PTSD,” Dr. Hoffer added.

Traumatic brain injury is associated with neurodegeneration — when the brain and nerve cells begin dying off and don’t regrow — and there is evidence that cannabis and psilocybin could restore brain cells and enhance connectivity among brain regions, respectively.
One recent study showed that psilocybin could bring people out of comas and kickstart an otherwise vegetative brain.


Dr. Hoffer and his research group were ideal for conducting this study.
He’s been investigating CBD as a potential treatment for TBI for several years, and this new study will be one of the first to see what happens when CBD is combined with psilocybin in one convenient pill. Tassili, a biotech company based in Toronto, Canada, has coordinated with other universities to investigate the medical potential of CBD and psilocybin for not only TBI and PTSD, but obsessive compulsive disorder (OCD), as well.

The University of Miami now joins Johns Hopkins Medical School and Yale University as an institution of higher learning that is researching the medicinal applications of psychedelic drugs, which are currently outlawed for recreational use in the US. Psilocybin, however, was recently decriminalized in Denver, Colorado. Two California cities, Oakland and Santa Cruz, have passed city ordinances that tolerate personal use, possession, and cultivation of psychedelic mushrooms.

If you live near Miami and you’re wondering how you can participate in the study, you’ll need to wait several months. The initial nine to 12 months of the study will only involve animal subjects; testing for human participants will occur afterward. Until then, check out the MAPS website for more information on how to participate in psychedelics-based medical research.
Originally published Feb. 2020.
************ "" ************* """""" ************* """ **
Vandenberg :)
 
Last edited:

BudToaster

Well-known member
Veteran
I have been looking into mycology and stumbled across a lecture by Paul Stamets in two parts. In the second part, at the 30:30 point, he discusses the ability of Lion’s Mane mushrooms to stimulate nerve re-grown and repair. He proposes a three ingredient pill of dried Lion’s Mane, dried Psilocybin (microdose), and Niacin (Vitamin B3). Pretty interesting.

Here is link to second part of lecture. He is all over YouTube also.
https://www.scienceandnonduality.co...ycelium-the-mycology-of-consciousness-part-ii

Seems on point for your post.
 

Chi13

Well-known member
ICMag Donor
Very interesting. I am currently starting to grow mushrooms to try microdosing for ADHD as I read that there is some evidence around it being beneficial.

I also stumbled on the same Stamets lecture which is great. I have been taking Lions Mane for a few weeks, although can't notice any difference.

This lecture is also pretty interesting.
https://www.youtube.com/watch?v=6AfFM8pfy4s

@Vandenberg, I wish the best for your son. I work in the disability/mental health field and have a few clients with ABI's (Aquired Brain Injury). I would be interested if you could update any further improvements, or not.
 
Last edited:

mexcurandero420

See the world through a puff of smoke
Veteran
The Swiss were already far ahead with their pills.
 

Attachments

  • psilocybin_pills.jpg
    psilocybin_pills.jpg
    19 KB · Views: 76

Vandenberg

Active member
My son is still micro dosing ( as well as full Macro dosing), it and the cannabis edibles helps him keep him in a pretty good place in his head, most days...nasal spray you say...:)

On the web, a search for "magic mushroom microdosing" is for ifurther nformation, + "for sale" for offerings. ;-)

Traumatic brain injury is associated with neurodegeneration — when the brain and nerve cells begin dying off and don’t regrow — and there is evidence that cannabis and psilocybin could restore brain cells and enhance connectivity among brain regions, respectively.

Vandenberg :)
 
Last edited:

Vandenberg

Active member
So what actually is Microdosing?

Microdosing, quite simply, is taking very small, sub-perceptual, amounts of a psychedelic as part of a weekly regimen for a period of time.
What is meant by sub-perceptual would be below the threshhold of a trip.
You won't feel anything.
So no physical body high, no visual or auditory hallucinations, no mental thought changes, or anything normally associated with tripping.
You are not tripping, you are microdosing.

What are the benefits of microdosing?

People report the following:
  • Increase in creativity
  • Increase in focus
  • Better mood
  • Improvements in overall well-being
  • Clearer thinking
  • Increase in problem-solving ability

How do you start microdosing?

Although one can microdose any psychedelic substance by taking 1/20th to 1/10th of an active dose, I suggest using the psilocybin mushroom, Psilocybe cubensis, as it is very well known, easy to come by, and easy to grow. Fully dehydrate your mushrooms and grind to a powder.
The dosage would be between .05 to .15 grams with .1 gram a good starting point.

Fadiman protocol:

The Fadiman protocol is named after Dr. James Fadiman, an early researcher of hallucinogenic drugs, who literally wrote the book on microdosing, The Psychedelic Explorer's Guide.

This dosing schedule is 1 day on, 2 days off, and continue that for at least one month. What this would look like starting out:
Day 1: 1st microdosing day, take .1 grams P. cubensis mushroom
Day 2: transition day
Day 3: normal day
Day 4: 2nd microdosing day

Continue this cycle for four to eight weeks, then take a break for two to four weeks and begin again.

Stamets protocol:

The Stamets protocol is named after Paul Stamets. the well known amateur mycologist, fungi advocate, and author.
This has a slightly different dosage schedule and combines the .1 gram P. cubensis with another mushroom, Lions Mane (500mg), and niacin (Vit. B3) (100mg).

The dosing schedule is 4 days on, 3 days off, and continue that for at least one month. What this would look like starting out:
Day 1-4: Microdosing days, take .1 gram PC, 500mg LM, 100mg B3
Day 5-7: Transition days
Day 8-11: Microdosing days, take .1 gram PC, 500mg LM, 100mg B3
Day 12-14: Transitions days

Continue this cycle for four to eight weeks, then take a break for two to four weeks and begin again.

The effects of microdosing is subtle and may not be noticed right away. It is useful to keep a journal and take note of how you are feeling physically and mentally, your mood, and your interactions with people. You can also write out your goals with microdosing and other ways you want to improve your life.

People have been microdosing for many years, Dr. Albert Hofmann, for example, who created LSD, microdosed until late in his life, although it wasn't called microdosing in his day.
Microdosing has become very popular in the past ten years, but even so there is still some confusion as to what it is and how to go about it.
My hope is that this post may clear that up and make microdosing an easy and fun routine to incorporate into ones life.

Thanks Shroomery!,
Vandenberg :)

 
Last edited:

Vandenberg

Active member

The placebo effect? :)

Informative links to scientific studies and such embedded into this article

More People Are Microdosing for Mental Health.
But does it work?


25microdosing-effectiveness-facebookJumbo.jpg

Much of the early analysis into microdosing has been anecdotal, consisting of enthusiastic survey responses from customers who skilled enhanced consideration and cognition, emotions of well-being and reduction from nervousness and despair. Lab research of psilocybin and LSD microdoses are inclined to help these claims, exhibiting enhancements in mood, attention and creativity. But these research have usually been small, and so they didn’t examine a microdose to a placebo.
“You probably only participate at this point in a trial in microdosing if you really have a strong belief that this might help you,” stated Dr. David Erritzoe, scientific director of the Centre for Psychedelic Research at Imperial College London. And when individuals count on to learn from a drug, they usually do.
The two largest placebo-controlled trials of microdosing had been revealed final 12 months, and so they each recommend that the advantages individuals expertise are from the placebo impact. In the research, volunteers used their very own medicine to take part and, unknown to them, obtained both lively doses or a placebo packaged in equivalent capsules. At the top of a number of weeks, virtually everybody’s temper and well-being had improved, no matter what that they had taken.
“I was initially surprised but also a bit disappointed by the results, because when we set up the study we were quite optimistic that microdosing could have an effect” past a placebo, stated Michiel van Elk, an assistant professor of cognitive psychology at Leiden University within the Netherlands who led one of the trials.
Dr. Erritzoe, who ran the other study, discovered that the drug’s efficacy was tied to customers’ expectations. If they took a placebo however thought it was a microdose, they felt higher, and if that they had an lively dose however wrongly guessed it was a placebo, they didn’t.
A 3rd placebo-controlled trial, revealed earlier this month from the University of Chicago, tried to get round consumer expectations by giving individuals 4 microdoses of LSD over the course of two weeks, however with out telling them concerning the goal of the research and even what they had been taking. Once once more, there was no distinction between the LSD and placebo teams.
Still, some scientists level to proof exhibiting that microdosing has a direct influence on the mind to argue that its advantages are actual. Using neuroimaging know-how, researchers have proven adjustments in brain activity and connectivity after single small doses of LSD which might be much like what’s seen with bigger quantities of the drug. And a study in Denmark discovered {that a} microdose of psilocybin activated practically half of the particular kind of serotonin receptors that psychedelics act on to provide their hallucinogenic results.

originally published by N.Y. Times :)

Vandenberg :)
 
Last edited:

armedoldhippy

Well-known member
Veteran
i've read repeatedly about thc being a neuroprotective for the brain, with articles saying it helps esp when blood flow is interrupted via stroke, drowning, cold water immersion etc. interesting that they are testing psilocybin in combination . wow...:tiphat:
 
Top