Human Cannabinoid Pharmacokinetics

Found this an very insightful read. Thought to share the link. All credits to the author Marilyn A. Huestis.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689518/

Very interresting always thought oral has better bioavailability

Nice find ULMW!

Cannabis is one of the oldest and most commonly abused drugs in the world, and its use is associated with pathological and behavioral toxicity.

The number, duration, and spacing of puffs, hold time, and inhalation volume, or smoking topography, greatly influences the degree of drug exposure

Interesting and informative.

And, always- more research is needed. Article was published in 2009. Hoping for more recent, more relevant research.

Still, it's quite insightful!

4. Conclusions
An understanding of human cannabinoid pharmacokinetics is important for the development and monitoring of new therapeutic medications and to the interpretation of cannabinoid test results in a wide variety of biological matrices, including blood, plasma, urine, oral fluid, sweat, and hair. With the advent of new preparations containing THC, CBD, and other cannabinoids, and new administration routes, additional research is needed. Also, controlled drug-administration studies that provide the scientific database for interpreting cannabinoid concentrations in biological fluids and tissues are increasingly difficult to conduct due to safety and ethical concerns, and because of the high costs of performing human research. However, these data are essential for appropriate application of pharmacotherapies, and for drug testing in treatment, workplace, and forensic cases.

CosmicGiggle said:

Nice find ULMW!

Cannabis is one of the oldest and most commonly abused drugs in the world, and its use is associated with pathological and behavioral toxicity.

The number, duration, and spacing of puffs, hold time, and inhalation volume, or smoking topography, greatly influences the degree of drug exposure

Click to expand...

Well well well guess we know why I am fuked up, insecure,neurotic and emotional

Not smoking enough or not holding it in long enough?

We're all self-medicating here in 1 form or another!

You can find out more from Marilyn directly she has many more current articles and research. Also on LinkedIn. Good to talk directly to the authors and researchers.