cannabacca
Member
It is T-cell LGLL
...You do realize that cannabinoid treatment IS chemotherapy, as opposed to radiotherapy or combination therapy?
Not only that, but there has been no real clinical studies on cannabinoid efficacy on any types of cancer, but several on animal models, and they all show that the efficacy of cannabinoid treatments is strongly dependent on the (over)expression of aforementioned cannabinoid receptors. On other studies (animal models again) show increased metastasis thanks to the immunosuppressant activity of the compounds in cell lines that do not express them.
Doctors cannot on good conscience rely on a treatment that is not proven - unlike the conventional cytostatic treatment plans, which have been proven to work times and times again. The consequences of going on a hunch, in this case prescribing cannabis, can be life-ruining for the patient and the doctor. Atleast here in Europe a doctor needs to have strong medical grounds to give a prescription, and cannabinoids do not have that yet.
Again, I might be able to give some kind of scientific insight on the subject after I've talked with the head of my study, but I suggest you consider the conventional treatments too - the remission rate of LGLL (T-cell) is near 100% with those. (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400163/)
Regards,
-mm
I do realize cannabis therapy is chemo I was speaking about conventional chemo. Current chemo causes hair to fall out, weight to drop, and many other problems. Many cancer patients don't survive it. I have witnessed this several times unfortunately. I have never seen cannabis cause this kind of destruction on an individual. And it is one plant not a cocktail that the pharmaceutical industry deems best. I am not a doctor but have seen what this plant can do. Here are some medical papers that have been written on cannabis and cancer.
http://www.collective-evolution.com...-studies-that-prove-cannabis-can-cure-cancer/
It is T-cell LGLL
And there you have it, exactly why cannabinoids are no miracle drugs.
" ...Δ9-Tetrahydrocannabinol inhibited tumour-cell proliferation in vitro and decreased tumour-cell Ki67 immunostaining when administered to two patients."
Two out of nine. Not nine out of nine. And it was applied directly to the tumors - the most direct & effective way possible. None of the other studies are clinical studies, so no conclusions on their real efficacy can be made - it's just speculation until effectiveness in humans can be shown. And none of these have anything to do with LGLL. I've read almost every single one of those papers before this discussion, and none of them prove that cannabis can "cure" cancer (which is by the way, by its very nature, incurable - there is a reason why all the papers talk about remission, not cure.)
Also, many of the cytostatic agents I have ever encountered have been either directly plant-extracted or slightly modified to better the effects/lessen their toxicity. If fungus- and bacteria-based drugs are taken to account, then it would encompass the majority of them.
If cannabis would be used as a anti-cancer drug, strict standards would be applied on the quality of the product (amount of the active compound(s), purity, way of administration, diagnostic criteria etc etc, same ones that are applied to every single drug on the market for the sake of user safety) - standards that would be almost impossible to keep up with for the ordinary cannabis user, and so the production would most probably fall to the pharmaceuticals, so blaming the companies for the lack of real research is pointless - there's still money to be made, so the lack of incentive is clearly elsewhere (clue: idiotic drug policies of western nations, inhibiting the use of many useful compounds as drugs, not only cannabis.) Bear in mind too that most of the studies you posted were funded by pharmaceutical companies.
I could go on and on about why exactly the efficacy, potency and harmful effects of the ordinary cytostatic drugs go hand to hand, and why cannabinoids are probably best used as supportive therapy in most cases, but it's the age of internet, all the information is there if you are willing to look.
Have a nice Sunday,
-mm
p.s. And oh, the absolute majority of deaths related to cancers are due to cancer, not the treatments. The treatments are harsh because of the nature of the disease, in which less harsh treatments would lead to more deaths.
Hey,Thanks for the info you posted.
I do understand what you are saying but you have to understand you and other medical professionals keep saying we need clinical trials for a plant that has been used medicinally longer then anything else. Meanwhile big pharma and doctors overmedicate society with drugs that have horrible side effects. Many pharma companies used to give incentives to push their drugs, not heal patients. This is part of the reason we have an oc problem in America. I am very against the modern medicine practice of pumping our bodies full of various medicines that it takes half of a commercial to tell all of the side effects of a drug. Cannabis is all I use to stay healthy. I consider it a miracle drug since it not only works with cancer but aids, ms, and many other diseases without the dangerous side effects. Even if it only works for 2 out of 9 it is working. Also if you have not seen the patents big pharma and the us government has been making on cannabis. Their are a lot of claims made in them. While they tell us we need to wait and make sure everything is safe, they are getting as many patents as possible. Here is one
http://www.google.com/patents/CA2726258A1
This is one of hundreds!!
I stopped by to visit my elderly uncle a few years ago, big mean man in his day WW2 vet 50 years as a Grizzly bear hunting guide & Logger ect. just tough as nails. While talking with the man he started telling me that god damn marijuana is a miracle plant he said in that gravel grizzled voice !! Well this statement by this tough old guy seemed so odd I nearly fell off my chair I laughed so hard, years later I realized the man is right ! Yes marijuana is a miracle plant ! There is no drug I know of that has such a positive affect on so many ailments ! Is marijuana a powerful drug like say morphine for example ? no it's not, morphine by comparison can relieve mild pain all the way through to put you in a coma and even kill you if you receive enough, yes marijuana is a miracle plant ! monkman your help has been extremely valuable thank you, at this point things don't look nearly as grim as they did last week thank god for that. The Oncologist plan at this point is to leave my wife on cyclosporine 500 ( don't know the unit of measurement ) and do nothing else but monitor her until running into complications. It sounds to me like fludarabine and if this cancer is over expressed at receptors CB1 and CB2 cannabis just might put this Genie back in the bottle maybe even permanently !
I realized it really was a miracle plant in hindsight after my wife nearly died once before due to the long term affects from Hemodialysis, those affects include starvation because at end stage renal failure everything the person smells and tastes smells and taste rotten especially meat. Also pain and restless legs can be a problem especially restless legs, marijuana aleviated all these problems along with insomnia and nausea, .. No I had to rethink the idea about marijuana that marijuana was a miracle plant yes it is simply because it can work so well on so many different ailments. monkman can you give us some details on the study you work at you seem to have a really good understanding on how cannabis works in regards to cancer which at this time is of interest to a lot of people stricken with this desease.
~~ This is good advice! monkey5Look into reishi and other anti cancer mushrooms also..
This is good advice too! monkey5cannabacca, google Granny Storm Crow's List and try to contact her on a site she is actually signing into. You may not have a great deal of time for research and reading, you can probably contact her via/ another site/ internet and get better results quicker. She is often at GrassC...if that is helpful.
My experience from reading as much as I possibly can is, the more rare the disease or cancer, it seems the more risk simpson oil (concentrated cannabis oil) and especially cannabinoids and thc are performing miracles. Hopefully, you'll be able to get the medicine and proper research asap and get on with making what time your wife has left...last as long as you expected. At least, that is my wish for you both. jpt
LGLL is one of the rarer forms of leukemia, but 100 cases worldwide is definitely on the very low side. T-cell LGLL is the more common of the two (NK-cell LGLL being the other) and apparently responds better to treatment. Based on the studies I've read, I'd trust your oncologist - the mean survival rate and progression-free time seems quite high with proper treatment. However, there are no curative treatments as far as I'm aware of.
I'd say your best bet lies in conventional therapies, maybe combined with the cannabinoid treatment if needed. I'd consult your oncologist on the possibility of having fludarabine and cyclophosphamide therapy (FC treatment) as these are significantly better tolerated and have much lower toxicity than the methotrexate, and shown to have very positive effects specifically on T-cell LGLL. Still, 50/50 chance of remission/dying with methotrexate treatment is an crude exaggeration from your hematologist. With proper oversight methotrexate is a very useful and effective treatment method (despite having quite high toxicity.)
Have a nice day,
-mm