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Old 09-05-2018, 04:54 PM #31
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Originally Posted by Infinitelight5D View Post
Why sunflower lecithin over soy?
I have been trying to avoid soy lately and just wanted to know.

99% of soy, grown in the US of A, is Genetically Modified.
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Old 09-05-2018, 04:59 PM #32
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Originally Posted by Teddybrae View Post
Not-a-Scientist here.


Sugar does it for me. Eat the medible then eat two pieces of chocolate. 1 hr onset.


Or eat medible immediately before evening meal. 30 minute onset.

30 minutes to an hour is a typical onset for cannabis edibles.
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Old 09-05-2018, 07:01 PM #33
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With many pharmaceuticals, rapid onset is achieved simply by dissolving the tablet or capsule in water.
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Old 09-10-2018, 11:03 PM #34
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I have been reading some more on this. Here is a pretty sweet paper on increasing bioavailability of THC and CBD.

https://www.researchgate.net/profile...-rat-model.pdf

Also, everything I am reading points to lecithin providing a giant increase in assisting bioavailability.

It makes sense because the lecithin bonds with both water and oil so it gets into the fatty GI cells better but can also be waterborne when it gets to the bloodstream (no fat in blood, is there?)

Going to read more but so far, everything I have read says the same thing.... eating cannabis based products results in only a 6% to 8% absorption.

That's fucked up. Got to be a better way. Sublingual is only about double that. Can we fire it in our veins or snort it?


.


EDIT: Couple decent search terms..... PTL401, utilizing an advanced self-emulsifying oral drug delivery system, was designed to circumvent the “first-pass”

Nanoemulsion: an advanced mode of drug delivery system... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362737/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009397/
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Old 09-11-2018, 05:48 AM #35
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Awesome! Thanks
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Old 09-20-2018, 02:41 AM #36
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Quote:
Originally Posted by Ringodoggie View Post
I have been reading some more on this. Here is a pretty sweet paper on increasing bioavailability of THC and CBD.

https://www.researchgate.net/profile...-rat-model.pdf


That's fucked up. Got to be a better way. Sublingual is only about double that. Can we fire it in our veins or snort it?
I wonder if you could do an alcohol extraction and then process that similar to that powdered alcohol (palchoho i thinkl). When the powder booze came out i remember the people from vice snorted some, though i dont recall much other than "IT BURNS ARGHHHH."
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Old 09-21-2018, 01:48 AM #37
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I am definitely confirming the lecithin effect.

Some who know me know.... nothing gets me high. LOL Lately, edibles have been working. Even the cream I made the other day was awesome.

Tonight, I took some coconut oil I made last week and put 1.5 TBS into 2 shots of vodka. Naturally, the oil globs together on the top.

Add a tiny bit of lecithin..... watch it homogenize... add a little more. LOL This stuff is a miracle worker. I'm not sure why I am not adding a full tablespoon of lecithin. I guess I'm building up to it. I only used as much as it took to homogenize it all. Maybe 1ml, max.

I took the vodka and made a couple weak (1 shot each) pineapple and orange juice drinks. You could barely taste the cannabis. Or, the vodka for that matter. LOL

I started noticing a little effect in about a half hour. Maybe a little longer. So, nothing special about onset but I found 2 things.....

1, for sure. This lecithin will homogenize just about anything cannabis. Makes it soooo much easier to work with.

2, maybe and I'm pretty sure..... it is increasing my bioavailability. It just has to be. It is the only difference between all those times eating 10x this dose and never feeling any effect vs.... now. LOL

I have 1 TBS left (about 1 small dose). I am going to add a full TBS of lecithin to whatever I blend this with. I can do cream/milk, alcohol, butter/oil or my favorite..... beer. LOL

So, 1 TBS coconut oil, 1 TBS lecithin and 12 oz of Corona Premier.

I only have bottles so I can't make a canna beer.


..
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Old 09-21-2018, 03:06 AM #38
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Damn, I'm fucked up (yeah, yeah, I know) LOL No, really.

About 3 hours after dosing, I guess this is peaking. Not bad. Fingers are tingling. I can stay in the same room with my wife for more than 5 minutes. I feel kind of buzzed. I'm pretty sure I am off.

The thing I can't figure is why with such a low dosage? Maybe I figured something wrong.....

I used 14 grams of bud. assume the THC to be 10% to 15% THC.

I used 1/2 cup or 8 tablespoons of oil.

Basically, 1 tablespoon qualifies as a dose. Not much of one but at least I can feel some effect.

That only equates to about 2 grams of pot per dose. Nonsense. My dose is 2 grams of rosin, not bud. LMAO That's about 1/10th.

Something isn't figuring right. LOL Maybe I'm more stoned than I think.

Maybe it's the Sous Vide method I'm using. It does maintain a much better terpene profile than oven decarbing and then baking brownies in an oven again. This stuff is in a vacuum sealed package from beginning to end. And, we are learning more and more about edibles and terps.

Something is working..... I wonder what it is? Too many variables and no control or base line. Oops. LOL


EDIT: 9:30 and the ride is about over.


Beer, tomorrow.







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Old 10-12-2018, 01:03 AM #39
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I am still waiting to make the beer as I make whatever concentrate I am going to use.

I made some tincture with Everclear and I tested it last night on some friends.

However, I have a problem today.....

I mixed some tincture with a glass a Ocean Spray Cranberry Cocktail. I noticed about halfway down that the glass had oily spots of green all over. I am pretty sure the tincture somehow separated and the oil stuck top the sides of the glass.

Could this be because of the cranberry?

Didn't seem to be a problem last night when I put it in people's beer.

Cranberry does have some strange effects. But, then again, this Ocean Spray stuff is very very little, if any real cranberry.

I am not going to make the beer until I have a tincture I can bank on.

Going to try more tincture in a glass of beer, next.




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