Awesome thread! I've got a little thread on 'the entourage' on another board. We seem to have come across much of the same literature. I notice a few articles that aren't included here yet that might be interest to you.
It’s been reported that certain terpenes dilate capillaries in the lungs. Logic tells us that this would be useful in the case of smoked or vaporized cannabis. Dilated capillaries would enable beneficial cannabinoids to enter the bloodstream easier. This certainly could be useful for growers who know how their crops will be ingested, and in the production of cannabis concentrates.
Bedrocan performed a study that's interesting. They evaluate vapor vs smoked cannabis, and investigate the effects that terpenes have on the CB1 binding of cannabinoids. They anticipated monoterpenes like myrcene would increase the affinity or efficacy of THC. They didn't recognize any difference, and they suggest that terpenes elicit the majority of their effects independent of CB1.
Cannabinoid receptor 1 binding activity and quantitative analysis of Cannabis sativa L. smoke and vapor
This next one is a study that looks at 17 'mostly sativa' and 'mostly indica' terpene profiles. Myrcene was the most prominent in indicas with limonene or alpha-pinene second most prominent. Sativas we more versatile overall but often with alpha-terpinolene or alpha-pinene as the main constituent.
Variations in Terpene Profiles of Different Strains of Cannabis sativa L.
The main differences between terpene profiles of the evaluated strains belonging to the two principal biotypes were that ‘mostly indica’ strains were characterized by dominancy of β-myrcene, present in high relative contents, with limonene or α-pinene as
second most abundant terpenoid, while ‘mostly sativa’ strains were characterized by more complex terpene profiles, with some strains having α-terpinolene or α-pinene as dominant terpenoid, and some strains having β-myrcene as dominant terpenoid with α-terpinolene
or trans-β-ocimene as second most abundant terpenoid.
This wide variability in terpene composition can provide a potential tool for the characterization of Cannabis biotypes, and warrant further researches in order to evaluate the drug’s medical value and, at the same time, to select less susceptible chemotypes to the attack of herbivores and diseases. More detailed studies on the variability in monoterpenes and sesquiterpenes are needed. Breeding for specific terpenoids in plants is a fascinating research topic; in fact, the various biological activities of these compounds
make the analysis of terpenoids a valuable tool for improving a considerable number of traits in pharmaceutical and industrial cultivars of Cannabis.
Terpenoids analysis, combined with cannabinoids and flavonoids analyses, are essential for the metabolic fingerprinting of pharmaceutical cultivars. Pharmaceutical cultivars of the two principal biotypes may exhibit distinctive medicinal properties due to significant differences in relative contents of terpenoids, thus the synergy between the various secondary metabolites must be investigated in deeper details in the future in order to better elucidate the phytocomplex of Cannabis and to allow selection of chemotypes with specific medical effects.
There might be a couple other links you can find in this thread: