Let me preface this thread with the fact I am not anti cannabis. I am 59 years old and have been growing for the last 14 years and have been smoking since my teens.
Over the last few years I have been experiencing intermittent bouts of severe morning nausea getting progressivly more frequent with no relief from smoking, as well as bouts of constipation. I would feel better as the day wore on. I stopped wake and baking a long time ago and don't smoke during work hours. Nights are usually 2 j's, weekends and vacations I smoked like a fiend I have lost almost 15lbs in this time frame. As I normally weighed 149lbs at 5'9" this is a drastic loss of weight. My family freaked out when they saw me last Thanksgiving.
I have been through upper and lower GI scopes, EKG, chest x ray and even an MRI of my brain to determine what could be causing it. All my blood work ups and the above procedures indicate I am a very healthy 59.
Research on the internet has led me to many articles regarding CHS, the following is about the easiest to understand,
here are a few other links
In general there is a paradox of the anti-emetic properties of cannabis as it affects the CB1 receptors. If THC crosses the gut barrier it cancels the brain receptors ability to provide anti-emetic effects and causes a slowdown/shutdown of the peristalsis action of the gut. Morning are the worst, I would assume increased nighttime smoking and munchies.
As the articles indicate, the first indicator is chronic long term use. It is noted that hot showers are the only relief of the symptoms during the hyperemtic stage with medicines usually used for hyper emesis having no effect on symptom reduction.
I have been in the prodromal phase for all this time, with an occasional bout of morning vomiting in which it looked as if nothing digested (gastroparisis). I have stopped smoking for the last three days and my morning nausea has decreased. I am confident as the THC level in my body decreases so will my illness.
The only cure is to stop smoking. None of the Drs. I have seen have associated my illness to my marijuana use. I live in a non MM state in an area predominated with senior citizens.
My GP had prescribed Zofran for the nausea and Xanax for the anxiety this undiagnosed illness has cause. I no longer use the Zofran everyday and take .5 mg of Xanax at bedtime ( to help with the insomnia from going cold turkey), .25mg in the morning and .25mg in the afternoon to give me an effective blood level of .5-.75mg during the day. Still have fear of vomiting.
I really enjoy smoking and hope a dry out will lower my THC levels to below toxic in this case so I may enjoy an occasional toke.
If you are struggling with constant nausea not related to other issues such as chemo or other illness, or you are and smoking to alleviate the nausea of these issues, high concentrations of THC may be countering the anti-emetic effects of your prescribed medicines.
And don't be mislead regarding no withdrawal symptoms of MJ. You will experience vivid dreams, possible anxiety and if you are suffering from CHS, digestive issues as your gut returns to normal, (mine is very loose stools). I prefer loose vs. the agony of constipation.
I hope this post helps someone else dealing with this issue.