i read OG has CBN and THC but little or no CBD.
it is weird because, little to no CBD or CBN in lanrace sativas gives no burnout, even though THC is said to metabolize to CBN.
but the initial CBN in the hit of an OG would cause couchlock tiredness.
also, i've been gathering that himilayan charas strains, have little to no CBN but are CBD rich, and these can be euphoric i gather, but not paranoia like, like a thai type is reported to be like, before it mellows out to an effect that ACE green haze is like to start at, according to someone on the "zamaldelica, the search for trip weed" thread.
CBD is also a 5HT1a receptor, partial agonist
i noticed that if i take alot of CBD tincture, maybe 25 or 35 to 50 mg orally, i don't remember, with about a pot of coffee, (and i don't remember if it was in between or after the coffee, which was brewed with "bold" setting using single serve side of dual type coffee machine, using a full scoop of coffee divided into cups as i made them) i got some unease, watching TV, like when i smoke a pure sativa
(i mean it shouldn't have had any CBD, CBN, i dont remember which strain type specifically)
and watch TV. the kind of unease was existential or something, where i would find subject matter unsettling, drama and problems and it would have me feeling like i need to breathe in deep breaths, and stop watching TV, which i did (i assume it was as much set and setting, as internal, well i don't know, it wasn't a revelating teaching of the cosmos and .
(also i had given myself acute and chronic mercury poisoning the prior year or so, which is reportedly a tricyclic re-uptake inhibiter and even though i dealt with the situation, i read it stays in the brain for 27 years. i thought i had increased response to coffee, but now i'm not sure anymore. increased with more pronounced negative effects. if i drink alot it wears off with a funny feeling and lethargy and head pressure, but sometimes, even a teabag, gives me a bit of feel good energy and than a tired feeling and headache. i don't know how my myelin sheathing is doing, so i figured i could use some anti-inflammatory type stuff like pot
i could always work with a sativa in me, as long as i was busy, i felt happy. when i was out of work, like setting up, repotting plants and stuff, i felt bad. watching a show was unbearable and i took a shower and kind of curled up in bed after watching some star trek.
about CBD, from wiki to look at sources about receptors, is "Pharmacodynamics
Cannabidiol has very low affinity
for the cannabinoid CB1
and CB2 receptors
but acts as an indirect antagonist
of these receptors.
It may potentiate THC's effects by increasing CB1 receptor density or through another CB1 receptor-related mechanism.
Cannabidiol may also extend the duration of the effects of THC via inhibition of the cytochrome P450
and CYP2C enzymes
Cannabidiol has been found to act as an antagonist of GPR55
, a G protein-coupled receptor
and putative cannabinoid receptor that is expressed in the caudate nucleus
in the brain.
It has also been shown to act as a 5-HT1A receptor partial agonist
and this action may be involved in the antidepressant
effects of cannabidiol. It is an allosteric modulator
of the μ-
and δ-opioid receptors
Cannabidiol's pharmacological effects have additionally been attributed to PPARγ agonism
and intracellular calcium release
Research suggests that CBD may exert some of its pharmacological action through its inhibition of fatty acid amide hydrolase
(FAAH), which may in turn increase the levels of endocannabinoids
, such as anandamide
, produced by the body.
It has also been speculated that some of the metabolites of CBD have pharmacological effects that contribute to the biological activity of CBD.
Recently, cannabidiol has been identified as a novel inverse agonist
of the GPR12
the intracellular calcium release part, is giving me the thought of it being related to glial cells. albert einstein had alot of glial cells, reportedly. glial cells don't send electrical signals like neurons, supposedly. they control the amount of calcium released on the brain, supposedly.
if the cbd oil was CBD in glycerin, not medium chain tryglycerides, i might try vaping it. i don't really like nicotine as much as i try to use it. i might try anyway
5HT1a is a serotonin (5HT, 5 hydroxy tryptomine) receptor. if you look at it like a puzzle, you just know you don't know but some stuff makes some sense, and you get more parts put together eventually. wikipedia is good. for example, psychedelics go to the 5HT2a receptor and MGlu2 receptors, is what i've gathered. the 1a receptor is encoded on a different chromosome (the 5th?) the 2a is on the 13th
"5-HT1A receptor agonists like buspirone
show efficacy in relieving anxiety
are currently approved for these indications in various parts of the world. Others such as gepirone
have also been investigated, though none have been fully developed and approved yet. Some of the atypical antipsychotics
are also partial agonists
at the 5-HT1A receptor and are sometimes used in low doses as augmentations to standard antidepressants
like the selective serotonin reuptake inhibitors
"5-HT1A autoreceptor desensitization and increased 5-HT1A receptor postsynaptic activation via general increases in serotonin levels by serotonin precursor supplementation
, serotonin reuptake inhibition
, or monoamine oxidase inhibition
has been shown to be a major mediator in the therapeutic benefits of most mainstream antidepressant supplements
, including serotonin precursors like L-tryptophan
, selective serotonin reuptake inhibitors
(SSRIs), serotonin-norepinephrine reuptake inhibitors
(SNRIs), tricyclic antidepressants
(TCAs), tetracyclic antidepressants
(TeCAs), and monoamine oxidase inhibitors
5-HT1A receptor activation likely plays a significant role in the positive effects of serotonin releasing agents
(SRAs) like MDMA
") as well.