Some people are under the impression the fungicide Eagle 20 or more specifically, the active ingredient Myclobutanil is poisonous. The issue IS NOT if there are other Powdery Mildew alternatives to Eagle or Myclobutanil (to think otherwise ignores the fact there is so many paths to the same destination)....but to clear up some misinformation, lets identify and discuss the poison.
From ALL the sources I am aware of, Myclobutanil is a known reproductive toxicant that effects males only (not females)--BUT IS NOT A POISON!
From: http://toxipedia.org/display/toxipedia/Myclobutanil
Myclobutanil is a conazole class fungicide. It is used heavily to control fungi affecting wine and table grapes, especially in California. It also has a number of other food crop and commercial or residential landscaping applications. Although it has a low acute toxicity, myclobutanil has been found to affect the reproductive abilities of test animals.
Myclobutanil is registered for use on a wide range of food and feed crops. It may also be used in greenhouses, public rights of way, turf, and in landscaping applications. Cotton seeds may be treated with myclobutanil (EPA).
California accounts for roughly 50% of all myclobutanil use in the US, using 70,000 to 90,000 lbs. annually. Grapes are the most heavily treated crop, using 60% of all myclobutanil in California. Almonds and strawberries are also account for a notable percentage of myclobutanil use in California (EPA).
Myclobutanil has a relatively low acute toxicity. The acute oral LD50 for mice is 1360 mg/kg, and ranges from 1.75 to 1.8 g/kg for rats. Myclobutanil metabolizes into 1,2,4-triazole, which has a lower acute toxicity than the parent compound (EPA).
Workers exposed to myclobutanil have reported symptoms such as skin rash, allergic dermatitis, itchiness, nausea, heachache, diarrhea, abdominal pain, vomiting, nosebleed, and eye irritation (CDPR).
In a two-generation study on rats over the effects of myclobutanil on reproduction, researchers found a decrease in pup weight gain, increased incidence of stillborns, and atrophy of the testes and prostate (EPA). Myclobutanil is listed as a developmental toxin in the Toxics Release Inventory (PANNA).
Chronic toxicity tests on rats found decreased body weight and changes to brain and spleen weight, in addition to reproductive effects (EPA).
Myclobutanil inhibits the sterol 14-demethylase enzyme, which produces ergosterol, an organic compound vital to fungal cell wall formation (EPA).
Myclobutanil is nontoxic to bees, which have an LD50 exceeding 362 ug/bee. It is moderately toxic to birds. The acute oral LD50 for bobwhite quail is 498 mg/kg. The primary metabolite, 1,2,4-triazole, is expected to be less toxic than myclobutanil (EPA).
Myclobutanil is environmentally mobile. It has been found in surface water and in rain, suggesting a potential for atmospheric transport. Due to its persistence, myclobutanil may accumulate in soil with multiple applications (EPA).
From: http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC120
PAN Bad Actor--SKULL & CROSS BONES..ooohh Prop 65
Acute Toxicity--Slight
Carcinogen--Not Likely
Cholinesterase Inhibitor--No
Ground Water Contaminant--Not likely
Developmental or Reproductive Toxin--YES
Endocrine Disruptor--Suspected
So...Myclobutanil is a PAN Bad Actor cuz it is known Reproductive Toxin for Males--at high doses (don't smear it on your chest). How many items under your kitchen sink contain this same Prop 65 warning?
Material Data Sheets (MSDS) are intended to provide workers and emergency personnel with procedures for handling or working with that substance in a safe manner, and includes information such as physical data (melting point, boiling point, flash point, etc.), toxicity, health effects, first aid, reactivity, storage, disposal, protective equipment, and spill-handling procedures. THEY ARE NOT SCIENTIFIC REPORTS OR INSTRUCTIONS and should be used according to their purpose; we all know, water in excess doses is toxic--but when used correctly, water is life--not death.
So...what is the name of the poison in Eagle 20 and at what levels is it toxic?
From ALL the sources I am aware of, Myclobutanil is a known reproductive toxicant that effects males only (not females)--BUT IS NOT A POISON!
From: http://toxipedia.org/display/toxipedia/Myclobutanil
Myclobutanil is a conazole class fungicide. It is used heavily to control fungi affecting wine and table grapes, especially in California. It also has a number of other food crop and commercial or residential landscaping applications. Although it has a low acute toxicity, myclobutanil has been found to affect the reproductive abilities of test animals.
Myclobutanil is registered for use on a wide range of food and feed crops. It may also be used in greenhouses, public rights of way, turf, and in landscaping applications. Cotton seeds may be treated with myclobutanil (EPA).
California accounts for roughly 50% of all myclobutanil use in the US, using 70,000 to 90,000 lbs. annually. Grapes are the most heavily treated crop, using 60% of all myclobutanil in California. Almonds and strawberries are also account for a notable percentage of myclobutanil use in California (EPA).
Myclobutanil has a relatively low acute toxicity. The acute oral LD50 for mice is 1360 mg/kg, and ranges from 1.75 to 1.8 g/kg for rats. Myclobutanil metabolizes into 1,2,4-triazole, which has a lower acute toxicity than the parent compound (EPA).
Workers exposed to myclobutanil have reported symptoms such as skin rash, allergic dermatitis, itchiness, nausea, heachache, diarrhea, abdominal pain, vomiting, nosebleed, and eye irritation (CDPR).
In a two-generation study on rats over the effects of myclobutanil on reproduction, researchers found a decrease in pup weight gain, increased incidence of stillborns, and atrophy of the testes and prostate (EPA). Myclobutanil is listed as a developmental toxin in the Toxics Release Inventory (PANNA).
Chronic toxicity tests on rats found decreased body weight and changes to brain and spleen weight, in addition to reproductive effects (EPA).
Myclobutanil inhibits the sterol 14-demethylase enzyme, which produces ergosterol, an organic compound vital to fungal cell wall formation (EPA).
Myclobutanil is nontoxic to bees, which have an LD50 exceeding 362 ug/bee. It is moderately toxic to birds. The acute oral LD50 for bobwhite quail is 498 mg/kg. The primary metabolite, 1,2,4-triazole, is expected to be less toxic than myclobutanil (EPA).
Myclobutanil is environmentally mobile. It has been found in surface water and in rain, suggesting a potential for atmospheric transport. Due to its persistence, myclobutanil may accumulate in soil with multiple applications (EPA).
From: http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC120
PAN Bad Actor--SKULL & CROSS BONES..ooohh Prop 65
Acute Toxicity--Slight
Carcinogen--Not Likely
Cholinesterase Inhibitor--No
Ground Water Contaminant--Not likely
Developmental or Reproductive Toxin--YES
Endocrine Disruptor--Suspected
So...Myclobutanil is a PAN Bad Actor cuz it is known Reproductive Toxin for Males--at high doses (don't smear it on your chest). How many items under your kitchen sink contain this same Prop 65 warning?
Material Data Sheets (MSDS) are intended to provide workers and emergency personnel with procedures for handling or working with that substance in a safe manner, and includes information such as physical data (melting point, boiling point, flash point, etc.), toxicity, health effects, first aid, reactivity, storage, disposal, protective equipment, and spill-handling procedures. THEY ARE NOT SCIENTIFIC REPORTS OR INSTRUCTIONS and should be used according to their purpose; we all know, water in excess doses is toxic--but when used correctly, water is life--not death.
So...what is the name of the poison in Eagle 20 and at what levels is it toxic?
term+@DOCNO+6708
