Just effectively used Spinosad to treat thrips during flower. While researching I happened upon conflicting data, gathered from studies. One states that Spinosad nearly tripled the mutagen rate of chromosomes in test mice (I disagree with testing chems on non-consenting animals).
http://en.wikipedia.org/wiki/Spinosad#cite_note-
http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022408lbl.pdf
http://www.fspublishers.org/ijab/past-issues/IJABVOL_10_NO_1/2.pdf
Taken from the third link:
According to EPA (1997), spinosad has no mutagenic activity and the literature offers no additional data in this respect. Recently, Mansour et al. (2007) found that spinosad at 9.0; 37.38 mg a.i. kg-1 b.w. reduced the total number of erythrocytes and inhibited serum ChE in male rats. In the light of our findings study, we suggest that cytogenetic activity of spinosad may refer to the spinosad’s chemical structure and/or certain impurities in the commercial formulation; a matter, which needs further elucidation.
Generally, cytogenetic and reproductive effects, as well as alteration in testosterone level, were observed in a dose-dependent manner and malathion exhibited more pronounced effect than spinosad.
Taken from wikipedia:
However, most tests ignore the cytotoxic(toxicity within the cell) aspects. One study,"Cytogenetic and Hormonal Alteration in Rats Exposed to Recommended “Safe Doses” of Spinosad and Malathion Insecticides", by S.A. MANSOUR1, A.H. MOSSA AND T.M. HEIKAL, found significant markers for long term mutagenic effects in mammals.[13]
Now of course, the doses we're being exposed to, even in a commercial grow using a pump-sprayer are at most standard manual agricultural doses similar to, if not less than citrus farmers and other agricultural farmers. In addition, spinosad is largely considered a selective insecticide and one of the safer, yet still highly effective insecticides that can be used.
That said, anyone have any additional information to add about the possible mutagenic effects of spinosad? I might even be interpreting "found significant markers for long term mutagenic effects in mammals." quote incorrectly.
That does in fact mean that there was evidence of mutagenic activity, correct?
http://en.wikipedia.org/wiki/Spinosad#cite_note-
http://www.accessdata.fda.gov/drugsatfda_docs/label/2011/022408lbl.pdf
http://www.fspublishers.org/ijab/past-issues/IJABVOL_10_NO_1/2.pdf
Taken from the third link:
According to EPA (1997), spinosad has no mutagenic activity and the literature offers no additional data in this respect. Recently, Mansour et al. (2007) found that spinosad at 9.0; 37.38 mg a.i. kg-1 b.w. reduced the total number of erythrocytes and inhibited serum ChE in male rats. In the light of our findings study, we suggest that cytogenetic activity of spinosad may refer to the spinosad’s chemical structure and/or certain impurities in the commercial formulation; a matter, which needs further elucidation.
Generally, cytogenetic and reproductive effects, as well as alteration in testosterone level, were observed in a dose-dependent manner and malathion exhibited more pronounced effect than spinosad.
Taken from wikipedia:
However, most tests ignore the cytotoxic(toxicity within the cell) aspects. One study,"Cytogenetic and Hormonal Alteration in Rats Exposed to Recommended “Safe Doses” of Spinosad and Malathion Insecticides", by S.A. MANSOUR1, A.H. MOSSA AND T.M. HEIKAL, found significant markers for long term mutagenic effects in mammals.[13]
Now of course, the doses we're being exposed to, even in a commercial grow using a pump-sprayer are at most standard manual agricultural doses similar to, if not less than citrus farmers and other agricultural farmers. In addition, spinosad is largely considered a selective insecticide and one of the safer, yet still highly effective insecticides that can be used.
That said, anyone have any additional information to add about the possible mutagenic effects of spinosad? I might even be interpreting "found significant markers for long term mutagenic effects in mammals." quote incorrectly.
That does in fact mean that there was evidence of mutagenic activity, correct?
