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Old 10-18-2018, 07:07 AM #301
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If a hemp farmer has a crop test a little too high in thc could this cannabinoid free variety be used to remediate that down to a usable number? Is that allowed?
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Old 10-18-2018, 09:22 AM #302
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Originally Posted by socioecologist View Post
The main uses of cannabinoid-free plants: (1) smoking for flavor without a cannabinoid experience (terpenes also alter mood); (2) using as a blending material to maintain federal legality (0.3% THC) without losing flavor; (3) an actual placebo that looks and tastes like the "real thing" in the use of clinical studies. Most importantly though...

We are replacing hops with a plant that is much easier to grow, harvest, and breed, while increasing the total relative oil yield per acre. Cannabis for the win.
Thanks, I couldn't think up a decent reason myself, but you seemed excited about it, so I knew it was something special. Its kinda hilarious that you bred a workaround for a regulatory burden.
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Old 10-18-2018, 10:44 AM #303
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Is this industry or government sponsored?

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Old 10-25-2018, 05:54 PM #304
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Cannabis pain relief without the 'high'

Canadian researchers pinpoint the mechanism of cannabidiol for safe pain relief without side effects
McGill University Health Centre


In the wake of cannabis legalization, a team of scientists at the Research Institute of the McGill University Health Centre (MUHC) and McGill University have delivered encouraging news for chronic pain sufferers by pinpointing the effective dose of marijuana plant extract cannabidiol (CBD) for safe pain relief without the typical "high" or euphoria produced by the THC. The findings of their study have been published in the journal PAIN (The Journal of the International Association for the Study of Pain).
Cannabis indica and sativa are the two main cannabis strains that produce the pharmacological principles known as tetrahydrocannabinol (THC) and cannabidiol (CBD). Dr. Gabriella Gobbi's team demonstrated that CBD does not act on the CB1 cannabinoid receptors like THC but through the mechanism that binds specific receptors involved in anxiety (serotonin 5-HT1A) and pain (vanilloid TRPV1). Researchers were able to extrapolate the exact dosage of CBD displaying analgesic and antianxiety properties without the risk of addiction and euphoria classically produced by the THC.
"We found in animal models of chronic pain that low doses of CBD administered for seven days alleviate both pain and anxiety, two symptoms often associated in neuropathic or chronic pain," says first author of the study Danilo De Gregorio, a post-doctoral fellow at McGill University in Dr. Gobbi's laboratory.
Lead author Dr. Gobbi, a researcher in the Brain Repair and Integrative Neuroscience (BRaIN) Program of the RI-MUHC, sees this as advancement for the evidence-based application of cannabis in medicine with CBD offering a safe alternative to THC and opioids for chronic pain, such as back pain, sciatica, diabetic, cancer and post-trauma pain.
"Our findings elucidate the mechanism of action of CBD and show that it can be used as medicine without the dangerous side effects of the THC," says Dr. Gobbi, who is also Professor of Psychiatry at the Faculty of Medicine at McGill University and staff psychiatrist at the MUHC. "This research is a new advancement for an evidence-based application of cannabis in medicine."
Despite widespread public usage, little clinical studies exist on CBD, which became legal in Canada on October 17, 2018, following the passage of Canada's Cannabis Act.
"There is some data showing that CBD provides pain relief for humans but more robust clinical trials are needed ," says Dr. Gobbi, a recent grant recipient for her study of the pharmalogical effects of CBD.
###
About the Study
The study 'Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain' was co-authored by Danilo De Gregorio (First author); Ryan McLaughlin; Luca Posa; Rafael Ochoa Sanchez; Justine Enns; Martha Lopez Canul; Matthew Aboud; Sabatino Maione; Stefano Comai et Gabriella Gobbi (Corresponding author).
DOI: 10.1097/j.pain.0000000000001386
This work was supported by a matching grant (PSR-SIIRI) from the Ministère de l'Économie Science et Innovation du Québec (MESI, Program PSR-SIIRI) and Aurora Cannabis Inc.



https://www.eurekalert.org/pub_relea...-cpr102418.php
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Old 10-26-2018, 02:42 AM #305
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THC is a "dangerous side effect"? Guess I have my doubts about this research.
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Old 10-26-2018, 06:53 AM #306
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socioecologist, You seem to be having fantastic success in targeting specific cannabinoids in breeding, including eliminating them completely. Have you tried aiming at specific terpenes yet and is that process similar to targeting specific cannabinoids?
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Old 10-27-2018, 07:12 PM #307
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What are hemp prices going for in Oregon? Per pound? I would imagine its based of off test results of the finished material. What is demanding the highest price? High CBD? CBG? CBN?

Also, I have heard that California/FDA will require any Hemp/CBD etc for human consumption will have to be grown indoors/greenhouses. What say you?

Thank you!
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Old 10-28-2018, 12:37 AM #308
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Quote:
Originally Posted by PDX Dopesmoker View Post
socioecologist, You seem to be having fantastic success in targeting specific cannabinoids in breeding, including eliminating them completely. Have you tried aiming at specific terpenes yet and is that process similar to targeting specific cannabinoids?
Great question, and yes, we target specific terpene combinations in our work as well. Many of the mother plants we use to create our CBD lines are farnesene dominant--I haven't seen any other commercially available varieties carrying this trait. We are shifting towards qPCR for early screening of terpene synthases in our hops-replacement breeding program.

Locking in general terpene profiles is attainable. Locking in really specific terpene profiles is difficult, if not impossible. The main problem is that terpene synthases have been found to produce multiple compounds (research done by Jon Page's group at Anandia labs). This helps to explain why environment and nutrition seem to alter flavors so dramatically, even in identical clones. The paper describing these behaviors is publicly available and a really cool read.

https://journals.plos.org/plosone/art...l.pone.0173911
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Old 10-28-2018, 02:16 AM #309
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Thanks, thats a lot of enzymes I never even heard of before in there. Seems potentially interesting.
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Old 11-02-2018, 06:59 AM #310
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Anyone who is interested in this thread might enjoy this podcast
https://media.blubrry.com/shapingfir...s_and_Hemp.mp3
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