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guest3854
This is a paper that we had been given , a number of years ago written by Dr. Marion Fry M.D. Many patients have come to me asking what strains I recommend for ultimate relief , and though they are out there , oral consumption of cannabis is far more of greater value . I hope this helps alleviate some of tha pain that you folks suffer from . (This paper has been re-typed and graphs re-done (wish I had a proper graph program) by myself . Nothing has been edited or omitted .)
In tha first graph , Dr. Fry is illustrating tha duration of effect of effect smoked (represented by a backslash , \)
as apposed to oral consumption (represented by tha asterisk)
Graph 2 is in regards to tha 24 hr cycle that patients use to control pain . There is a "loading dose" and a "Maintenance dose" . Tha loading dose is represented at tha beginning of tha bandwidth , signified by tha backslash \ , and is taken 1 hr before bed The maintenance phase begins at waking hrs , signified by tha period (.) Tha maintenance dose is approximately 1/8 of tha loading dose .
Graph 3 shows tha effects of smoked cannabis in comparison to ingested cannabis . Notice tha duration of relief from orally consuming .....
I sincerely hope this helps alotta you folks out there , Dr. Fry has helped MANY folks manage their pain . Unfortunately , tha feds had her locked up , earlier this year fer doing what she was sworn to do , help tha patients .....
The Benefits Of Oral Cannabis
By Marion P. Fry M.D.
Classically , when when a drug is ingested , the stomach sends it to the liver for processing . For many years it has been known that the effectivness of all drugs consumed orally must be evaluated in terms of this affect . This is called the first pass effect . Using this information have applied the theories to the use of oral cannabis . In the use of cannabis , the liveer converts 90%of the cannais to one form , eliminating the differences between strains . This form (Hydroxy Eleven) has many advantages including the duration of action being eight hours .
Through my research in the last seven years , it has become apparent that there are two fundamentally different groups . The first group is in the minority group , representing approximatly 15% , and requires immediate and short-term relief from the drug . These patients are primarily medicating what we would consider more psychiatric issues i.e. depression , panic , anxiety ,
and anger .
The second , and much larger percentage of my patients , are primarily interested in long term relief of serious physiological problems . These patients suffer from conditions such as chronic pain , glaucoma , diabetes , and all the autoimmune disorders including lupus , rheimatoid arthritus , multiple scleroses , and chronic fatigue syndrom . I have found in my several years of research that the oral rout of administration utilizing the first pass effect of the liver is of great benefit . A many of us are aware , a tremendous percentage of the cannabinoids are converted by the liver into Hydroxy Eleven , a far more powerful and effective drug .
At the recent cannabis conference it was mentioned that Hydroxy Eleven was four times more powerful in relieving symptoms and had an effective half-life of approximatly eight hours . Utlizing the model of a loading dose combined with a maintenance dose one can afford this second group of patients a greater degree of relief .
| This graph (Graph 1) represents the larger group - chronic pain
| Negative side effects such as heavy sedation and inability to concentrate
-------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------
Level |
of |
Cannabinoids |
|
| \ \ * * * * * * * * * * * * \ \ \ \ \ \ \
| * \ \ * \
| * \ \ * \
* \ \ * \
______________*________________________\__________\____________________*_______________________________\
| | | |
0 Hr 3 Hr 6 Hr 9 Hr
Looking at the graph we can see the side effects . What may be percieved as negative side effects during waking hours , are precisely the positive effects that chronic pain patients require during the hours of sleep . Super imposing graph 1 with two ( PM loading dose , we get graph two) shows us how a patient can maintain the positive benefits of pain relief , muscle relaxation , and anti-inflammatory aspects of the drug during the day and then through a loading dose , heighten these effects during hours of sleep (See Graph 2)
Maitenance Dose
Graph 2 Evening Dose
Daytime side effects
| \ | \ \ | \ \ | \
| \ \ \ \ \ \
----------------------------------------- \---------------\------------------------------\----------------\-------------------------------\------------- \-------------------------
Level | \ \ \ \ \ \
Of | \ \ \ \ \ \
Cannabinoids |_________\ \..................\ \..................\ \...................
| _______________________________________________________________________________________________________
As the graph (Graph 3) demonstrates , patients in chronic pain never reach an unmedicated level of marijuana in the system , yet they are not plagued by over sedation . During the night however , when sleep and pain control are crucial , their levels are substantially above those obtainable by smoked marijuana . In addition the effect of the cannabinoids is extended to a full eight hours , henceforth , eliminating the need for nighttime dose . In my experience this has been disruptive to their sleep and pain control . It has been my clinical experience that many of my patients awake between 2 and 4 in the morning to reuse the smoked marijuana .
Smoked Dosage Levels Oral Dosage Levels
\ | \ * * * * * * * * * *
\ \ * *
\ * \ *
\ * \ *
\ * \ *
\ * \ *
____*\______________________ \________________________________________________*_______________________
| | | | |
9 PM 12 PM 3 AM 6 AM 9 AM
The patients who have adopted my loading and maitenance strategy no longer require dosing in the middle of the night . This greatly increases the therapeutic effect of both anti - inflammatory aspect of marijauna and it's excellent sedative qualitites . In summary , I am suggesting that both higher blood level and longer , more effective doses may be achieved by using aral cannabis in chronically ill patients . Unfortunatly , the research has never been completed and these are only relative representations of previously determined pharmacological models .
Steele
I apologize fer tha graphs , looks like it's formatting differently when pasted over here . I'll be workin on getting this together . Holler at me if you have a good graphing program ... thanks
In tha first graph , Dr. Fry is illustrating tha duration of effect of effect smoked (represented by a backslash , \)
as apposed to oral consumption (represented by tha asterisk)
Graph 2 is in regards to tha 24 hr cycle that patients use to control pain . There is a "loading dose" and a "Maintenance dose" . Tha loading dose is represented at tha beginning of tha bandwidth , signified by tha backslash \ , and is taken 1 hr before bed The maintenance phase begins at waking hrs , signified by tha period (.) Tha maintenance dose is approximately 1/8 of tha loading dose .
Graph 3 shows tha effects of smoked cannabis in comparison to ingested cannabis . Notice tha duration of relief from orally consuming .....
I sincerely hope this helps alotta you folks out there , Dr. Fry has helped MANY folks manage their pain . Unfortunately , tha feds had her locked up , earlier this year fer doing what she was sworn to do , help tha patients .....
The Benefits Of Oral Cannabis
By Marion P. Fry M.D.
Classically , when when a drug is ingested , the stomach sends it to the liver for processing . For many years it has been known that the effectivness of all drugs consumed orally must be evaluated in terms of this affect . This is called the first pass effect . Using this information have applied the theories to the use of oral cannabis . In the use of cannabis , the liveer converts 90%of the cannais to one form , eliminating the differences between strains . This form (Hydroxy Eleven) has many advantages including the duration of action being eight hours .
Through my research in the last seven years , it has become apparent that there are two fundamentally different groups . The first group is in the minority group , representing approximatly 15% , and requires immediate and short-term relief from the drug . These patients are primarily medicating what we would consider more psychiatric issues i.e. depression , panic , anxiety ,
and anger .
The second , and much larger percentage of my patients , are primarily interested in long term relief of serious physiological problems . These patients suffer from conditions such as chronic pain , glaucoma , diabetes , and all the autoimmune disorders including lupus , rheimatoid arthritus , multiple scleroses , and chronic fatigue syndrom . I have found in my several years of research that the oral rout of administration utilizing the first pass effect of the liver is of great benefit . A many of us are aware , a tremendous percentage of the cannabinoids are converted by the liver into Hydroxy Eleven , a far more powerful and effective drug .
At the recent cannabis conference it was mentioned that Hydroxy Eleven was four times more powerful in relieving symptoms and had an effective half-life of approximatly eight hours . Utlizing the model of a loading dose combined with a maintenance dose one can afford this second group of patients a greater degree of relief .
| This graph (Graph 1) represents the larger group - chronic pain
| Negative side effects such as heavy sedation and inability to concentrate
-------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------
Level |
of |
Cannabinoids |
|
| \ \ * * * * * * * * * * * * \ \ \ \ \ \ \
| * \ \ * \
| * \ \ * \
* \ \ * \
______________*________________________\__________\____________________*_______________________________\
| | | |
0 Hr 3 Hr 6 Hr 9 Hr
Looking at the graph we can see the side effects . What may be percieved as negative side effects during waking hours , are precisely the positive effects that chronic pain patients require during the hours of sleep . Super imposing graph 1 with two ( PM loading dose , we get graph two) shows us how a patient can maintain the positive benefits of pain relief , muscle relaxation , and anti-inflammatory aspects of the drug during the day and then through a loading dose , heighten these effects during hours of sleep (See Graph 2)
Maitenance Dose
Graph 2 Evening Dose
Daytime side effects
| \ | \ \ | \ \ | \
| \ \ \ \ \ \
----------------------------------------- \---------------\------------------------------\----------------\-------------------------------\------------- \-------------------------
Level | \ \ \ \ \ \
Of | \ \ \ \ \ \
Cannabinoids |_________\ \..................\ \..................\ \...................
| _______________________________________________________________________________________________________
As the graph (Graph 3) demonstrates , patients in chronic pain never reach an unmedicated level of marijuana in the system , yet they are not plagued by over sedation . During the night however , when sleep and pain control are crucial , their levels are substantially above those obtainable by smoked marijuana . In addition the effect of the cannabinoids is extended to a full eight hours , henceforth , eliminating the need for nighttime dose . In my experience this has been disruptive to their sleep and pain control . It has been my clinical experience that many of my patients awake between 2 and 4 in the morning to reuse the smoked marijuana .
Smoked Dosage Levels Oral Dosage Levels
\ | \ * * * * * * * * * *
\ \ * *
\ * \ *
\ * \ *
\ * \ *
\ * \ *
____*\______________________ \________________________________________________*_______________________
| | | | |
9 PM 12 PM 3 AM 6 AM 9 AM
The patients who have adopted my loading and maitenance strategy no longer require dosing in the middle of the night . This greatly increases the therapeutic effect of both anti - inflammatory aspect of marijauna and it's excellent sedative qualitites . In summary , I am suggesting that both higher blood level and longer , more effective doses may be achieved by using aral cannabis in chronically ill patients . Unfortunatly , the research has never been completed and these are only relative representations of previously determined pharmacological models .
Steele
I apologize fer tha graphs , looks like it's formatting differently when pasted over here . I'll be workin on getting this together . Holler at me if you have a good graphing program ... thanks
