The endogene terpenoïdsystem

Bubbleblower

Member

• Mar 10, 2015

• #1

There must be a endogene terpenoïdsystem.
And many other systems all working together and part of a bigger system.

The endogen terpenoïdsystem seems at least as important as the cannabinoïd system.
It also seems only 25% or less of the effects of cannabis are from the cannabinoïds;

[FONT=TimesNewRoman, serif]Fairbairn and Pickens (1981) detected the presence of unidentified “powerful synergists” in cannabis extracts causing 330% greater activity in mice than THC alone.​

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[FONT=TimesNewRoman, serif]Carlini et al. (1974) found cannabis produced effects up to 4 times greater than expected from their THC content.[/FONT]​

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Some terpenoids act as serotonin uptake inhibitors (as does Prozac), enhance norepinephrine activity (as do tricyclic antidepressants), increase dopamine activity (as do monoamine oxidase inhibitors and bupropion), and augment GABA (as do baclofen and the benzodiazepines). ​

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Recently, strong serotonin activity at the 5-HT1A and 5-HT2a receptors has been demonstrated that may support synergistic contributions of terpenoids on cannabis-mediated pain and mood effects.​

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Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts?​

John M. McPartland & Ethan B. Russo​

 

MJPassion

Observer

ICMag Donor

Veteran

• Mar 18, 2015

• #2

You must spread some reputation around before giving it to bubbleblower again.
K+

Thanks for the download link.

 

C

curbiechris

Member

• Mar 23, 2015

• #3

going to quote this for daaaays
thanks bubbleblower

 

Bubbleblower

Member

• Mar 30, 2015

• #4

Terpenoid components in concentrations above 0.05% are considered of pharmacological interest (Adams and Taylor, 2010).
Animal studies are certainly supportive (Buchbauer et al., 1993).
Mice exposed to terpenoid odours inhaled from ambient air for 1 h demonstrated profound effects on activity levels,
suggesting a direct pharmacological effect on the brain, even at extremely low serum concentrations
(examples: linalool with 73% reduction in motility at 4.22 ng·mL-1, pinene 13.77% increase at trace concentration, terpineol 45% reduction at 4.7 ng·mL-1).
These levels are comparable to those of THC measured in humans receiving cannabis extracts yielding therapeutic effects in pain,
or symptoms of multiple sclerosis in various randomized controlled trials

Taming THC, Ethan B. Russo

So we have all these molecules fitting in our receptors. All different shapes and sizes.
Cannabinoïds are quit big, they would be more difficult to fit in.
IMO the smaller molecules -like limonene- make them fit better/easier which would explain the synergistic effects.


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