What's new
  • Please note members who been with us for more than 10 years have been upgraded to "Veteran" status and will receive exclusive benefits. If you wish to find out more about this or support IcMag and get same benefits, check this thread here.
  • Important notice: ICMag's T.O.U. has been updated. Please review it here. For your convenience, it is also available in the main forum menu, under 'Quick Links"!

Cannabis cures psoriasis (with pics)

G.O. Joe

Active member
Veteran
Someone has surely patented cannabinoids for psoriasis in every way possible. With all the iffy patents and the highly regulated drug system, you may have to make oils for whatever ailment yourself for some time to come, regardless of the legal situation. Where the "science" is now:

Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis
Jonathan D. Wilkinson, Elizabeth M. Williamson
Journal of Dermatological Science
Volume 45, Issue 2, February 2007, Pages 87–92

Abstract
BACKGROUND: Cannabinoids from cannabis (Cannabis sativa) are anti-inflammatory and have inhibitory effects on the proliferation of a number of tumorigenic cell lines, some of which are mediated via cannabinoid receptors. Cannabinoid (CB) receptors are present in human skin and anandamide, an endogenous CB receptor ligand, inhibits epidermal keratinocyte differentiation. Psoriasis is an inflammatory disease also characterised in part by epidermal keratinocyte hyper-proliferation.

OBJECTIVE: We investigated the plant cannabinoids Delta-9 tetrahydrocannabinol, cannabidiol, cannabinol and cannabigerol for their ability to inhibit the proliferation of a hyper-proliferating human keratinocyte cell line and for any involvement of cannabinoid receptors.

METHODS: A keratinocyte proliferation assay was used to assess the effect of treatment with cannabinoids. Cell integrity and metabolic competence confirmed using lactate-dehydrogenase and adenosine tri-phosphate assays. To determine the involvement of the receptors, specific agonist and antagonist were used in conjunction with some phytocannabinoids. Western blot and RT-PCR analysis confirmed presence of CB1 and CB2 receptors.

RESULTS: The cannabinoids tested all inhibited keratinocyte proliferation in a concentration-dependent manner. The selective CB2 receptor agonists JWH015 and BML190 elicited only partial inhibition, the non-selective CB agonist HU210 produced a concentration-dependent response, the activity of theses agonists were not blocked by either CB1/CB2 antagonists.

CONCLUSION: The results indicate that while CB receptors may have a circumstantial role in keratinocyte proliferation, they do not contribute significantly to this process. Our results show that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for cannabinoids in the treatment of psoriasis.


Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
E. Gaffal, M. Cron, N. Glodde, T. Tüting
Allergy
Volume 68, Issue 8, pages 994–1000, August 2013

Abstract
BACKGROUND: ∆(9) -Tetrahydrocannabinol (THC), the active constituent of Cannabis sativa, exerts its biological effects in part through the G-protein-coupled CB1 and CB2 receptors, which were initially discovered in brain and spleen tissue, respectively. However, THC also has CB1/2 receptor-independent effects. Because of its immune-inhibitory potential, THC and related cannabinoids are being considered for the treatment of inflammatory skin diseases. Here we investigated the mechanism of the anti-inflammatory activity of THC and the role of CB1 and CB2 receptors.

METHODS: We evaluated the impact of topically applied THC on DNFB-mediated allergic contact dermatitis in wild-type and CB1/2 receptor-deficient mice. We performed immunohistochemical analyses for infiltrating immune cells and studied the influence of THC on the interaction between T cells, keratinocytes and myeloid immune cells in vitro.

RESULTS: Topical THC application effectively decreased contact allergic ear swelling and myeloid immune cell infiltration not only in wild-type but also in CB1/2 receptor-deficient mice. We found that THC (1) inhibited the production of IFNγ by T cells, (2) decreased the production of CCL2 and of IFNγ-induced CCL8 and CXL10 by epidermal keratinocytes and (3) thereby limited the recruitment of myeloid immune cells in vitro in a CB1/2 receptor-independent manner.

CONCLUSIONS: Topically applied THC can effectively attenuate contact allergic inflammation by decreasing keratinocyte-derived pro-inflammatory mediators that orchestrate myeloid immune cell infiltration independent of CB1/2 receptors. This has important implications for the future development of strategies to harness cannabinoids for the treatment of inflammatory skin diseases.


Endocannabinoids Modulate Human Epidermal Keratinocyte Proliferation and Survival via the Sequential Engagement of Cannabinoid Receptor-1 and Transient Receptor Potential Vanilloid-1
Balázs I Tóth, Nóra Dobrosi, Angéla Dajnoki, Gabriella Czifra, Attila Oláh, Attila G Szöllősi, István Juhász, Koji Sugawara, Ralf Paus and Tamás Bíró
Journal of Investigative Dermatology (2011) 131, 1095–1104

Abstract
We have recently shown that lipid mediators of the emerging endocannabinoid system (ECS) are key players of growth control of the human pilosebaceous unit. In this study, we asked whether the prototypic endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) has a role in growth and survival of epidermal keratinocytes (KCs). Using human cultured KCs and skin organ-culture models, and by employing combined pharmacological and molecular approaches, we provide early evidence that AEA markedly suppresses KC proliferation and induces cell death, both in vitro and in situ. Moreover, we present that these cellular actions are mediated by a most probably constitutively active signaling mechanism that involves the activation of the metabotropic cannabinoid receptor CB(1) and a sequential engagement of the "ionotropic cannabinoid receptor" transient receptor potential vanilloid-1 (TRPV1). Finally, we demonstrate that the cellular effects of AEA are most probably due to a Ca(2+) influx via the non-selective, highly Ca(2+)-permeable ion channel TRPV1, and the concomitant elevation of intracellular Ca(2+) concentration. The data reported here may encourage one to explore whether the targeted manipulation of the above signaling pathway of the cutaneous ECS could become a useful adjunct treatment strategy for hyperproliferative human dermatoses such as psoriasis or KC-derived skin tumors.
 

mttam510

New member
@ Jabba. Thanks for that info. I will definitely be trying that method out after this next harvest. I have been suffering from psoriasis for the last seven years. I have recently been vaporizing a steady bit of 9-11% CBD flowers over the last six weeks and have definitely noticed a reduction of inflamation and redness. I have tried a bunch of different flowers. So far, 'Pennywise' (Harlequin x Jack the Ripper) is my fav, very tasty excellent daytime med.
 

mttam510

New member
I have also tried cannatonic, cannatonic x tsunami, harlem blues and dancehall....all of which i've picked up through two of the SF Bay Areas better dispensaries (Harborside and Organicann). I am about 4 weeks into my first CBD rich strains at home, have a Harlequin in with some others. I have a cannatonic mom that I will be taking cuts from shortly for my next cyclye....which will be predominantly CBD. But by far, the Pennywise is the best CBD rich strain I have had thus far, it's REALLY nice.
 
S

Sat X RB

@ Jabba. Thanks for that info. I will definitely be trying that method out after this next harvest. I have been suffering from psoriasis for the last seven years. I have recently been vaporizing a steady bit of 9-11% CBD flowers over the last six weeks and have definitely noticed a reduction of inflamation and redness. I have tried a bunch of different flowers. So far, 'Pennywise' (Harlequin x Jack the Ripper) is my fav, very tasty excellent daytime med.

smoking cannabis, even with a vapouriser, has no effect on psoriasis.
 

mttam510

New member
smoking cannabis, even with a vapouriser, has no effect on psoriasis.

whatever, maybe for you. I can only speak from my own experience. I have noticed big improvements since I have been vaping high CBD meds on a regular basis over the last month and a half.

seems to be a different opinion here: http://www.ncbi.nlm.nih.gov/pubmed/17157480http://www.ncbi.nlm.nih.gov/pubmed/17157480

...plus there are many other compounds within the cannabis plant that are possibly contributing as well. Anyways,to make a statement like that is pretty silly.
 

normaltype

New member
I'm very interested in this. I have had psoriasis for the last 26 years. I control it with topical steroids, tars, immune-suppressants, and I have a tanning bed (all of which long term side effects are bad). I am extremely knowledgeable about psoriasis.

I was prescribed cannabis this year to treat PTSD and insomnia (i've had for the last 7 years) and its the only thing that has worked...no joke. Antidepressants, narcotics and CBT all failed. THC is the only thing that works for me.

When I asked my doctor about cannabis and psoriasis she said there is no evidence to show benefits or harm either way.

I have smoked off and on for years, but scientifically and technically, I am a cannabis noob.

I would argue that mild doses of cannabis (orally or inhaled) are relaxing and thus reduce stress which is one of the causes of psoriasis. So I see that as a definite benefit but would agree that alone is not a significant benefit.

I'm interested in making a topical ointment if it seriously works...I don't care if its greasy. I use high quality bud (24% THC) and am very good at decarb and extraction. I prefer coconut oil as it has the highest fat content so best absorption of THC. Coconut oil itself is very good for you and helps with psoriasis when applied topically or orally.

My concern is that my extractions are very potent and I don't know much about absorption. I suppose I could experiment and/or dilute an extraction for topical use.

I would like to know if CBD is better? I have access to 8% CBD bud. Also wondering if strain makes a difference (indica or sativa).

Next year I intend to grow a few plants so I will also have access to shake. Again, I'm new to growing also so we'll see how that goes.

Please PM me your experiences/knowledge.

Thanks!
 

diffusing

Active member
I'm very interested in this. I have had psoriasis for the last 26 years. I control it with topical steroids, tars, immune-suppressants, and I have a tanning bed (all of which long term side effects are bad). I am extremely knowledgeable about psoriasis.

I was prescribed cannabis this year to treat PTSD and insomnia (i've had for the last 7 years) and its the only thing that has worked...no joke. Antidepressants, narcotics and CBT all failed. THC is the only thing that works for me.

When I asked my doctor about cannabis and psoriasis she said there is no evidence to show benefits or harm either way.

I have smoked off and on for years, but scientifically and technically, I am a cannabis noob.

I would argue that mild doses of cannabis (orally or inhaled) are relaxing and thus reduce stress which is one of the causes of psoriasis. So I see that as a definite benefit but would agree that alone is not a significant benefit.

I'm interested in making a topical ointment if it seriously works...I don't care if its greasy. I use high quality bud (24% THC) and am very good at decarb and extraction. I prefer coconut oil as it has the highest fat content so best absorption of THC. Coconut oil itself is very good for you and helps with psoriasis when applied topically or orally.

My concern is that my extractions are very potent and I don't know much about absorption. I suppose I could experiment and/or dilute an extraction for topical use.

I would like to know if CBD is better? I have access to 8% CBD bud. Also wondering if strain makes a difference (indica or sativa).

Next year I intend to grow a few plants so I will also have access to shake. Again, I'm new to growing also so we'll see how that goes.

Please PM me your experiences/knowledge.

Thanks!

hey, from what i've read, skunkpharms topical "holy annointing oil" cures the symptoms of psoriasis amongst other things. (http://skunkpharmresearch.com/holy-anointing-oil-and-holy-shit/) They use decarbed BHO and coconut oil, with a few other ingredients. may be worth a try. Im looking to make a batch myself for the same reason... not heard different experiences using high CBD strains.. yet anyway.

good luck, and let us know.
 

Chunkypigs

passing the gas
Veteran
I found a mixture of high CBD and thc to be useful for symptoms of PA but didn't help my plaque type P. you may be different so give it a shot. my oil was decarbed and about 40% coconut oil added in to make it spread well. good luck!
 

Albertine

Member
I developed a type of eczema plus some psoriasis several years ago...dry callous like patches that fissure on my palms and soles, and a couple classic psoriasis patches on my elbows. These days it s starting to sound like a cliche, but I stopped eating gluten and dairy, and it got way better, right now there are no patches on elbows and minor palm sole issues.The integrative medicine doc in town says that gluten dairy kind of works in a pair. As an autoimmune disease, approaching it from the point of what is causing the inflammation rather than treating the symptoms seems like a more fruitful approach. There is research coming out now about gut bacteria tied into these type of reactions.
i am also eating a lot of fresh nettles, and I think they help with inflammation, but removing the inflammation producing items in the first place seems most important. I have a friend with rheumatoid arthritis, and she sees a huge difference with and without gluten.
i definitely do not mean to diss the cannabis aspect, and am sure it works, but personally feel one is much healthier if not ingesting inflammatory foods on a regular basis, and if one has any kind of inflammation based condition, it is worth manipulating one's diet to see if it affects those conditions.
 

IndoGorilla

Member
My wife has extreme eczema and/or psoriasis. First they said eczema, then it was psoriasis. After a lab analysis after many years of fuckery they landed back on eczema. I don't trust them. We have been to several dermatologists, family doctors, allergy specialists, tried everything from every kind of cream, and oil, hydrating and bathing techniques, dietary changes(no gluten and diary particularly), chinese herbal medicines, chinese herbal doctor special recommended diets, detoxs and cleanses and all kinds of nasty pharma like methotrexate, prednisone and some other wild shit I can't even remember. She's still on some nasty pharma. She even works in a medical clinic around some very good, caring doctors which are very very hard to find.

I need to read through this whole thread as I just found it but if anyone has a specific recipe of something using cannabis oil I would be very grateful! This gives me a glimmer of hope to give my wife some relief from her daily suffering. Cheers!
 
S

Sat X RB

whatever, maybe for you. I can only speak from my own experience. I have noticed big improvements since I have been vaping high CBD meds on a regular basis over the last month and a half.

seems to be a different opinion here: http://www.ncbi.nlm.nih.gov/pubmed/17157480http://www.ncbi.nlm.nih.gov/pubmed/17157480

...plus there are many other compounds within the cannabis plant that are possibly contributing as well. Anyways,to make a statement like that is pretty silly.

well, I need to qualify my statement: Tony Bower (Mullaway), Australia's Cannabis medicine-man ... and the producer of a variety of effective cannabis tinctures told me that the medicine needs to be ingested. ie, eaten. (previous to his advice vaping made no difference to my symptoms.)

Mullaway's tinctures cured my Erythrodermic Psoriasis (which included p.arthritis) in a little over a fortnight after suffering near death for ten months. my story is recounted earlier in this thread.

So my statement was not silly ... I simply omitted references and now the 'silly' claim looks like an anxious value judgement.
 

brat11

New member
Hi Sat,
Can you please share details of your cure scheme? You have mentioned ingesting of cannabis. How did you proceed? Would be good to here your feedback and to start treatment, I'm also psoriasis positive and now got an arthritis additional to skin issue.
Tx!
 

minde2348

New member
Hi guys!
First, to all of you who got this psoriasis - hang in there!we can beat this!
I have been diagnosed with it few weeks ago. At first i had a patch on my belly, GP told me it was a fungus - ringworm to be exact. Then I went to a dermatologist, was told it's a psoriasis.
Now I feel so broken and faulty, that i can't stop thinking about it. I have it for about a year now, and its gotten worse - head, elbows, belly, feet, legs oh my god...
I've tried mixing 100% pure hemp oil with coconut oil, to get a mixture. Thought it would help, cuz someone here mentioned that it helps.
Why isn't it working for me? Maybe i've done something wrong? I heated the oil up to 100 degrees and then added coconut oil. I have been using it for a week or two, but i can't see any improvements. I'm getting really desperate here. So uncomfortable, so different now, nothing is the same anymore damn..
I seek for an advice, please help me i don't want to use that dovobet - which has steroids in it.After reading here how bad the steroids are, I am afraid it might damage my body even more.
 

Lila

New member
Hi guys!
First, to all of you who got this psoriasis - hang in there!we can beat this!
I have been diagnosed with it few weeks ago. At first i had a patch on my belly, GP told me it was a fungus - ringworm to be exact. Then I went to a dermatologist, was told it's a psoriasis.
Now I feel so broken and faulty, that i can't stop thinking about it. I have it for about a year now, and its gotten worse - head, elbows, belly, feet, legs oh my god...
I've tried mixing 100% pure hemp oil with coconut oil, to get a mixture. Thought it would help, cuz someone here mentioned that it helps.
Why isn't it working for me? Maybe i've done something wrong? I heated the oil up to 100 degrees and then added coconut oil. I have been using it for a week or two, but i can't see any improvements. I'm getting really desperate here. So uncomfortable, so different now, nothing is the same anymore damn..
I seek for an advice, please help me i don't want to use that dovobet - which has steroids in it.After reading here how bad the steroids are, I amid it might damage my body even more.
Hi Mindy,
I'm new to the cannabis oil treatment for psoriasis, but had the skin problem for 30 years. I am taking cold pressed hemp oil internally. Hemp oil cannot stand heating to high temperatures. I also apply it topically, but have not found any relief. I came across the following article on the internet, from a guy in Wales:.
The batch of oil in this case was made by adding 1 ml of 80% cannabinoid oil to 99 ml of cold pressed hemp seed oil, gentle heat helps the two oils to mix thoroughly

I appreciate that not everyone has access to concentrated cannabinoid oil so a similar strength topical lotion can be made in your kitchen

Break up 7 grams of decarboxylated (completely dry) bud and place in a cafetierre, add 100ml of cold pressed hemp seed oil and put cafetierre in a pan of simmering water. Leave on the heat for 2 hours, stir the oil/bud every 20 mins or so (top up the simmering water as required)

After a few hours, remove from heat, press plunger and oil is ready to use (when cooled)

The oil sodden bud at the bottom of the cafetierre can be used as a poultice. "
He Made this solution for a 9 year old girl with terrible psoriasis, and it worked!

I am looking at anything that help for this disease! I have now mixed some cannabis oil (about 6 drops) as it burns my skin, with coconut oil, olive oil, hemp oil. I have been using this for 3 days, and the first layers of skin is starting to come off! I hope that you have found something in the meantime that works. But for me I will proceed with this mixture for a while. I do believe the cannabis oil is the answer to getting rid of psoriasis. I have been on topical steriods for many years. All it does is suppress the psoriasis. I stopped 3 months ago, and now my spots are really flaring up everywhere! I will revert back at a later stage! 😀
 

Latest posts

Latest posts

Top