Yes, Spice causes it to.
It is def the cannabinoids, not anything else.
Please people, doctors are not lying. There are tons of these cases popping up now.
Here is a study of SPICE users getting diagnosed with this. I personally had HORRIBLE stomach issues when i was blending hard (using Spice).
I have smoked pure JWH's, AM-2201 and the newer ones like 5F-PB22 and and EAM-2201. The shit gets you stoned as a motherfucker, but the accompanying stomache cramps, loss of appetite and throwing up repeatedly just ain't worth it.
They all fuck up your stomach.
The cannabinoids are hitting your CB1 & CB2 receptors in your body. You body has two documented cannabinoid receptors - CB1 and CB2. CB1 is mainly found in the brain. CB2 receptors are found mostly in the body, and they regulate the way the body deals with heat, immune response and digestion. Many, many CB2 receptors are actually found in the human gut.
When you use too much cannabinoids, any kind - they can hit both the the CB1 and CB2. Overstimulation of either can bring about serious body changes
A Case of Cannabinoid Hyperemesis Syndrome Caused by Synthetic Cannabinoids
Cannabinoid hyperemesis syndrome (CHS) was initially described in 2004 and remains an under-recognized clinical entity that occurs in chronic heavy marijuana smokers.
We describe the first report of CHS in an abuser of synthetic cannabinoids. CHS is thought to be caused by over-stimulation of the cannabinoid receptors.
The synthetic cannabinoids found in K2, Spice, and other commonly abused designer cannabinoids, including those used by our patient (JWH-018, JWH-073, JWH-122, AM-2201, and AM-694), are potent agonists of the cannabinoid 1 receptor.
Our report suggests that frequent habitual smoking of synthetic cannabinoids can cause cannabinoid hyperemesis syndrome.
Case studies of cannabinoid hyperemesis describe bouts of nausea, vomiting, pain
MONDAY, Oct. 22 (HealthDay News) -- The regular use of either natural or synthetic marijuana can lead to severe nausea, vomiting and abdominal pain, according to two sets of new case studies.
This little-known condition, called cannabinoid hyperemesis, is a serious burden to the health care system because doctors often use expensive diagnostic tests and ineffective treatments in an effort to identify the cause of the patient's symptoms and treat them, the researchers said.
One telltale sign that helps pinpoint these patients: Compulsive hot bathing or showering provides temporary symptom relief.
The case studies were scheduled for presentation Monday at an American College of Gastroenterology meeting in Las Vegas.
"Most health care providers are unaware of the link between marijuana use and these episodes of cyclic nausea and vomiting, so they are not asking about natural or synthetic cannabinoid use when a patient comes to the emergency room or their doctor's office with these symptoms," Dr. Ana Maria Crissien-Martinez, of Scripps Green Hospital and Clinic in San Diego, said in an American College of Gastroenterology news release.
Cannabinoid hyperemesis was first described in 2004 in a case series of nine patients in Australia. Since then, 14 case reports and four cases series on the condition have been published.
"Patients who use cannabis -- whether natural or in a synthetic form called 'Spice' -- also don't realize their unexplained episodes of cyclic nausea and vomiting may be a result of this use, with some increasing their cannabis use because they may think it will help alleviate their symptoms -- and it actually makes them worse," Crissien-Martinez said. "The only resolution is cannabis cessation."
Crissien-Martinez co-authored a case report describing nine patients with cannabinoid hyperemesis treated at Scripps Green Hospital. The patients' average age was 30, and 88 percent of them used marijuana daily. In 80 percent of the patients, their symptoms disappeared when they stopped using marijuana.
Crissien-Martinez and her colleagues also looked at the cost of cannabinoid hyperemesis.
"We estimate $10,000 to be the minimum cost of one admission -- but on average our patients required admission to the hospital 2.8 times, a total of almost $30,000 for workup," she said.
That price does not include the added costs of primary care physician and/or gastroenterologist visits (2.5 on average) and emergency room visits (six on average).
The other case study may be the first reported case of cannabinoid hyperemesis caused by synthetic marijuana. It involved a 22-year-old man with a 10-month history of symptoms. He has been symptom-free since he stopped using synthetic marijuana.
Because this study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.
Marijuana use may cause severe cyclic nausea, vomiting, a little-known, but costly effect
Effect researchers suggest is a serious burden to the health care system
Las Vegas, NV (October 22, 2012) – Marijuana use—both natural and synthetic—may cause cannabinoid hyperemesis (CH) a little-known but costly effect that researchers suggest is a serious burden to the health care system as it often leads to expensive diagnostic tests and ineffective treatments in an effort to find the cause of a patient's symptoms and provide relief, according to two separate case reports unveiled today at the American College of Gastroenterology's (ACG) 77th Annual Scientific meeting in Las Vegas. Cannabinoid hyperemesis is characterized by a history of chronic cannabis use followed by a cyclic pattern of nausea, vomiting and colicky abdominal pain. Interestingly, compulsive hot baths or showers temporarily relieve symptoms, another characteristic which aids clinicians in diagnosis.
"Patients who use cannabis whether natural or in synthetic form called 'Spice' also don't realize their unexplained episodes of cyclic nausea and vomiting may be a result of this use, with some increasing their cannabis use because they may think it will help alleviate their symptoms—and it actually makes them worse," said Dr. Crissien-Martinez . "The only resolution is cannabis cessation."
Dr. Crissien-Martinez co-authored the case report, "Marijuana: Anti-Emetic or Pro-Emetic" which described a series of 9 patients with cannabinoid hyperemesis at Scripps Green Hospital with average age at diagnosis 30 years-old; 88 percent male; onset of cannabis use during teen years; 88 percent used cannabis daily; 56 percent compulsive bathing behavior; and 80 percent symptom resolution with cannabis cessation.
The other case report, "Spicing Up the Differential for Cyclic Vomiting: A Case of Synthetic-Cannabinoid Induced Hyperemesis Syndrome (CHS)," may be the first reported case of CH attributed to synthetic cannabinoid, according to Fong-Kuei Cheng, M.D. and his research team from Walter Reed Walter Reed National Military Medical Center/Uniformed Services University of the Health Sciences in Bethesda, MD.
"Legal synthetic cannabinoids became available in the United States by 2009 with widespread usage among military personnel due to its ability to elude standard drug testing. It is important to recognize that routine urine drug testing does not include JWH-018 and JWH 073, which are the primary components in synthetic cannabinoids," said Dr. Cheng.
The case report described a 22-year active duty military male who was admitted with a 10-month history of progressive, intermittent abdominal pain, nausea and vomiting, with episodes occurring every two months and lasting up to a week. He underwent several diagnostic tests before a urine synthetic cannabinoid test confirmed the diagnosis of cannabinoid hyperemesis syndrome (CHS). Since discontinuing these drugs, the patient has remained symptom-free, according to the case report.
"This case illustrates that CHS should be in the differential diagnosis of unexplained, episodic abdominal pain with nausea and vomiting, particularly if relieved with compulsive hot showers. Recognition of this syndrome is important to prevent unnecessary testing and to reduce health care expenditures," said Dr. Cheng. "We have also noted, particularly in the active duty population where drug testing for cannabis usage is done routinely, that there appears to be an increased usage instead of the synthetic cannabinoids, so we would advocate routine additional testing for them when the clinical suspicion is high."
Patients frequently have multiple hospital, clinic and emergency room visits with extensive negative work-up to include imaging studies, endoscopies, and laboratory testing before they are finally diagnosed with cannabinoid hyperemesis, according to the researchers of both case reports.
"We estimate $10,000 to be the minimum cost of one admission—but on average our patients required admission to the hospital 2.8 times, a total of almost $30,000 for workup," said Dr. Crissien-Martinez, who added that that cost does not include the added costs of primary care physician and/or gastroenterologist and emergency room visits, which averaged 2.5 and 6 times respectively.
Dr. Crissien-Martinez said that 80 percent of the Scripps Green patients who stopped cannabis experienced symptom resolution; however, only one of them remained abstinent and consequently symptom-free.
"As health care providers, we must be aware of the potential side effects of chronic cannabis use and understand that cannabinoid hyperemesis is diagnosed clinically to avoid expensive diagnostic and therapeutic modalities," said Dr. Crissien-Martinez. "Instead the focus should be shifted towards counseling and resources allocated towards marijuana cessation."
About the American College of Gastroenterology
Founded in 1932, the American College of Gastroenterology (ACG) is an organization with an international membership of more than 12,000 individuals from 80 countries. The College is committed to serving the clinically oriented digestive disease specialist through its emphasis on scholarly practice, teaching and research. The mission of the College is to serve the evolving needs of physicians in the delivery of high quality, scientifically sound, humanistic, ethical, and cost-effective health care to gastroenterology patients. www.gi.org
View releases on other research breaking at the ACG meeting at https://gi.org/media/press-releases-f...tific-meeting/
The reason I mention this is because on another forum I am on (A Spice forum) people are having these symptoms and their doctors have diagnosed them with this, so i figured i would ask here on a pot forum.