The Benefits Of Oral Cannabis By Marion P. Fry M.D.
This is a paper that we had been given , a number
of years ago written by Dr. Marion Fry M.D. Many
patients have come to me asking what strains I
recommend for ultimate relief , and though they are
out there , oral consumption of cannabis is far
more of greater value . I hope this helps alleviate
some of tha pain that you folks suffer from . (This
paper has been re-typed and graphs re-done (wish
I had a proper graph program) by myself . Nothing
has been edited or omitted .)
In tha first graph , Dr. Fry is illustrating tha duration
of effect of effect smoked (represented by a
backslash , \)
as apposed to oral consumption (represented by
tha asterisk)
Graph 2 is in regards to tha 24 hr cycle that
patients use to control pain . There is a "loading
dose" and a "Maintenance dose" . Tha loading dose
is represented at tha beginning of tha bandwidth ,
signified by tha backslash \ , and is taken 1 hr
before bed The maintenance phase begins at
waking hrs , signified by tha period (.) Tha
maintenance dose is approximately 1/8 of tha
loading dose .
Graph 3 shows tha effects of smoked cannabis in
comparison to ingested cannabis . Notice tha
duration of relief from orally consuming .....
I sincerely hope this helps alotta you folks out there
, Dr. Fry has helped MANY folks manage their pain .
Unfortunately , tha feds had her locked up , earlier
this year fer doing what she was sworn to do , help
tha patients .....
The Benefits Of Oral Cannabis
By Marion P. Fry M.D.
Classically , when when a drug is ingested , the
stomach sends it to the liver for processing . For
many years it has been known that the effectivness
of all drugs consumed orally must be evaluated in
terms of this affect . This is called the first pass
effect . Using this information have applied the
theories to the use of oral cannabis . In the use of
cannabis , the liveer converts 90%of the cannais to
one form , eliminating the differences between
strains . This form (Hydroxy Eleven) has many
advantages including the duration of action being
eight hours .
Through my research in the last seven years , it has
become apparent that there are two fundamentally
different groups . The first group is in the minority
group , representing approximatly 15% , and
requires immediate and short-term relief from the
drug . These patients are primarily medicating what
we would consider more psychiatric issues i.e.
depression , panic , anxiety ,
and anger .
The second , and much larger percentage of my
patients , are primarily interested in long term relief
of serious physiological problems . These patients
suffer from conditions such as chronic pain ,
glaucoma , diabetes , and all the autoimmune
disorders including lupus , rheimatoid arthritus ,
multiple scleroses , and chronic fatigue syndrom . I
have found in my several years of research that the
oral rout of administration utilizing the first pass
effect of the liver is of great benefit . A many of us
are aware , a tremendous percentage of the
cannabinoids are converted by the liver into
Hydroxy Eleven , a far more powerful and effective
drug .
At the recent cannabis conference it was
mentioned that Hydroxy Eleven was four times
more powerful in relieving symptoms and had an
effective half-life of approximatly eight hours .
Utlizing the model of a loading dose combined with
a maintenance dose one can afford this second
group of patients a greater degree of relief .
| This graph (Graph 1) represents the larger group -chronic pain
| Negative side effects such as heavy sedation and
inability to concentrate
-------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------Level |
of |
Cannabinoids |
|
| \ \ * * * * * * * * * * * * \ \ \ \ \ \ \| * \ \ * \| * \ \ * \* \ \ * \______________*_______________
_________\__________\_________
___________*__________________ _____________\| | | |
0 Hr 3 Hr 6 Hr 9 Hr
Looking at the graph we can see the side effects .
What may be percieved as negative side effects
during waking hours , are precisely the positive
effects that chronic pain patients require during the
hours of sleep . Super imposing graph 1 with two (
PM loading dose , we get graph two) shows us how
a patient can maintain the positive benefits of pain
relief , muscle relaxation , and anti-inflammatory
aspects of the drug during the day and then
through a loading dose , heighten these effects
during hours of sleep (See Graph 2)
Maitenance Dose
Graph 2 Evening Dose
Daytime side effects
| \ | \ \ | \ \ | \| \ \ \ \ \ \----------------------------------------- \---------------\------------------------------\----------------\-------------------------------\-------------\-------------------------Level | \ \ \ \ \ \Of | \ \ \ \ \ \Cannabinoids |_________\ \..................\ \..................\\...................
| ______________________________
______________________________
______________________________ _____________
As the graph (Graph 3) demonstrates , patients in
chronic pain never reach an unmedicated level of
marijuana in the system , yet they are not plagued
by over sedation . During the night however , when
sleep and pain control are crucial , their levels are
substantially above those obtainable by smoked
marijuana . In addition the effect of the
cannabinoids is extended to a full eight hours ,
henceforth , eliminating the need for nighttime dose
. In my experience this has been disruptive to their
sleep and pain control . It has been my clinical
experience that many of my patients awake
between 2 and 4 in the morning to reuse the
smoked marijuana .
Smoked Dosage Levels Oral Dosage Levels
\ | \ * * * * * * * * * *
\ \ * *
\ * \ *
\ * \ *
\ * \ *
\ * \ *
____*\______________________
\_____________________________
___________________*__________ _____________
| | | | |
9 PM 12 PM 3 AM 6 AM 9 AM
The patients who have adopted my loading and
maitenance strategy no longer require dosing in the
middle of the night . This greatly increases the
therapeutic effect of both anti - inflammatory
aspect of marijauna and it's excellent sedative
qualitites . In summary , I am suggesting that both
higher blood level and longer , more effective doses
may be achieved by using aral cannabis in
chronically ill patients . Unfortunatly , the research
has never been completed and these are only
relative representations of previously determined
pharmacological models .
Steele
I apologize fer tha graphs , looks like it's formatting
differently when pasted over here . I'll be workin on
getting this together . Holler at me if you have a
good graphing program ... thanks
This is a paper that we had been given , a number
of years ago written by Dr. Marion Fry M.D. Many
patients have come to me asking what strains I
recommend for ultimate relief , and though they are
out there , oral consumption of cannabis is far
more of greater value . I hope this helps alleviate
some of tha pain that you folks suffer from . (This
paper has been re-typed and graphs re-done (wish
I had a proper graph program) by myself . Nothing
has been edited or omitted .)
In tha first graph , Dr. Fry is illustrating tha duration
of effect of effect smoked (represented by a
backslash , \)
as apposed to oral consumption (represented by
tha asterisk)
Graph 2 is in regards to tha 24 hr cycle that
patients use to control pain . There is a "loading
dose" and a "Maintenance dose" . Tha loading dose
is represented at tha beginning of tha bandwidth ,
signified by tha backslash \ , and is taken 1 hr
before bed The maintenance phase begins at
waking hrs , signified by tha period (.) Tha
maintenance dose is approximately 1/8 of tha
loading dose .
Graph 3 shows tha effects of smoked cannabis in
comparison to ingested cannabis . Notice tha
duration of relief from orally consuming .....
I sincerely hope this helps alotta you folks out there
, Dr. Fry has helped MANY folks manage their pain .
Unfortunately , tha feds had her locked up , earlier
this year fer doing what she was sworn to do , help
tha patients .....
The Benefits Of Oral Cannabis
By Marion P. Fry M.D.
Classically , when when a drug is ingested , the
stomach sends it to the liver for processing . For
many years it has been known that the effectivness
of all drugs consumed orally must be evaluated in
terms of this affect . This is called the first pass
effect . Using this information have applied the
theories to the use of oral cannabis . In the use of
cannabis , the liveer converts 90%of the cannais to
one form , eliminating the differences between
strains . This form (Hydroxy Eleven) has many
advantages including the duration of action being
eight hours .
Through my research in the last seven years , it has
become apparent that there are two fundamentally
different groups . The first group is in the minority
group , representing approximatly 15% , and
requires immediate and short-term relief from the
drug . These patients are primarily medicating what
we would consider more psychiatric issues i.e.
depression , panic , anxiety ,
and anger .
The second , and much larger percentage of my
patients , are primarily interested in long term relief
of serious physiological problems . These patients
suffer from conditions such as chronic pain ,
glaucoma , diabetes , and all the autoimmune
disorders including lupus , rheimatoid arthritus ,
multiple scleroses , and chronic fatigue syndrom . I
have found in my several years of research that the
oral rout of administration utilizing the first pass
effect of the liver is of great benefit . A many of us
are aware , a tremendous percentage of the
cannabinoids are converted by the liver into
Hydroxy Eleven , a far more powerful and effective
drug .
At the recent cannabis conference it was
mentioned that Hydroxy Eleven was four times
more powerful in relieving symptoms and had an
effective half-life of approximatly eight hours .
Utlizing the model of a loading dose combined with
a maintenance dose one can afford this second
group of patients a greater degree of relief .
| This graph (Graph 1) represents the larger group -chronic pain
| Negative side effects such as heavy sedation and
inability to concentrate
-------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------Level |
of |
Cannabinoids |
|
| \ \ * * * * * * * * * * * * \ \ \ \ \ \ \| * \ \ * \| * \ \ * \* \ \ * \______________*_______________
_________\__________\_________
___________*__________________ _____________\| | | |
0 Hr 3 Hr 6 Hr 9 Hr
Looking at the graph we can see the side effects .
What may be percieved as negative side effects
during waking hours , are precisely the positive
effects that chronic pain patients require during the
hours of sleep . Super imposing graph 1 with two (
PM loading dose , we get graph two) shows us how
a patient can maintain the positive benefits of pain
relief , muscle relaxation , and anti-inflammatory
aspects of the drug during the day and then
through a loading dose , heighten these effects
during hours of sleep (See Graph 2)
Maitenance Dose
Graph 2 Evening Dose
Daytime side effects
| \ | \ \ | \ \ | \| \ \ \ \ \ \----------------------------------------- \---------------\------------------------------\----------------\-------------------------------\-------------\-------------------------Level | \ \ \ \ \ \Of | \ \ \ \ \ \Cannabinoids |_________\ \..................\ \..................\\...................
| ______________________________
______________________________
______________________________ _____________
As the graph (Graph 3) demonstrates , patients in
chronic pain never reach an unmedicated level of
marijuana in the system , yet they are not plagued
by over sedation . During the night however , when
sleep and pain control are crucial , their levels are
substantially above those obtainable by smoked
marijuana . In addition the effect of the
cannabinoids is extended to a full eight hours ,
henceforth , eliminating the need for nighttime dose
. In my experience this has been disruptive to their
sleep and pain control . It has been my clinical
experience that many of my patients awake
between 2 and 4 in the morning to reuse the
smoked marijuana .
Smoked Dosage Levels Oral Dosage Levels
\ | \ * * * * * * * * * *
\ \ * *
\ * \ *
\ * \ *
\ * \ *
\ * \ *
____*\______________________
\_____________________________
___________________*__________ _____________
| | | | |
9 PM 12 PM 3 AM 6 AM 9 AM
The patients who have adopted my loading and
maitenance strategy no longer require dosing in the
middle of the night . This greatly increases the
therapeutic effect of both anti - inflammatory
aspect of marijauna and it's excellent sedative
qualitites . In summary , I am suggesting that both
higher blood level and longer , more effective doses
may be achieved by using aral cannabis in
chronically ill patients . Unfortunatly , the research
has never been completed and these are only
relative representations of previously determined
pharmacological models .
Steele
I apologize fer tha graphs , looks like it's formatting
differently when pasted over here . I'll be workin on
getting this together . Holler at me if you have a
good graphing program ... thanks
