OMG!! New Dope Plant Doesn't Get People Stoned!!

headband 707 said:

The CBD's do work well for the sick but it does NOT mean you need to take the THC out of the bud lol..
As far as Isreal is concerned I would be happier with them if they were more forcoming with their reasearch and they made cannabis" LEGAL" in their country seeing as though it so fucked up there. PEACE OUT headband 707

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SourPurp said:

Just a few words about 'marijuana research'...fucking completely ridiculous...

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Not only does it leave users stone-cold sober, it also doesn't induce the munchies, the hunger pangs that the drug's smokers generally suffer.

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Suffer? I don’t know about that! (I’m quite partial to the munchies myself).

There is a very obvious problem here where is comes to wasting (appetite loss) experienced by AIDS and cancer patients – the very reason that medical marijuana was identified as a positive treatment for cancer and AIDS related Anorexia. In simple terms, where THC increases the appetite, CBD doesn’t. This probably renders Israel’s THC free cannabis ineffective as a treatment for AIDS and cancer related wasting. For instance, research by Celia JA Morgan et al (2010) demonstrates that CBD-rich Cannabis works as an appetite suppressant. The study conducted at the University College London, tested 94 subjects on two occasions. The subjects smoked their own Cannabis and "while acutely under the influence" were offered more Cannabis, other drugs, and food. Morgan et al measured the eagerness with which the subjects responded to the offerings, and found that it correlated inversely with the CBD-to-THC ratio of the Cannabis the subjects were smoking. In other words, the higher the proportion of CBD they had ingested, the less desirous they became for food. 1

On the other hand, Israel’s Raphael Mechoulam notes this re THC:

One of the symptoms of AIDS is weight loss. Many patients smoke marijuana because it is an appetite stimulant. This has been supported by clinical studies. In one such study, the effects of THC (also known as dronabinol) (2.5 mg bid) on appetite, weight and nausea were examined in 39 patients with AIDS over a six-week period. After four weeks, the patients’ weights were stable in the treated patients but lower in the placebo recipients. The data indicated that drabinol caused increased appetite in about one-third of patients. The author of this study concluded that:

Dronabinol is a safe and effective treatment for anorexia in patients with weight loss due to AIDS. By improving appetite and mood, decreasing nausea, and stabilizing weight, dronabinol may significantly improve the quality of life of patients infected with HIV.2

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Dronabinol is a synthetic THC and has been approved by the Food and Drug Administration (FDA) for the control of nausea and vomiting associated with chemotherapy and more recently for appetite stimulation of AIDS patients suffering from wasting syndrome. Synthetic dronabinol is supplied as MARINOL in the U.S. and consists of approximately 98% THC.

According to case reports of the Centre for Palliative Medicine and Paediatric Pain Therapy of the University of the Saarland (Germany) dronabinol is an effective and well-tolerated medicinal drug in the treatment of different severe illnesses in children. A scientist of a university reported of experiences from the treatment of 13 children with severe disabilities and spasticity aged 7 months to 17 years as well as of about 50 cancer patients aged three months and older.

All children in the trial received a slowly increased dose. In all children a reduction in pain, which was considerable in some of them, was observed within 48 hours after start of treatment. Efficacy with regard to spasticity set in within one to two weeks. In some patients opioid treatment could be reduced. Most cancer patients profited from an increase in appetite and weight, reduction of nausea and vomiting, as well as improved sleep and reduced anxiety. Even with long-term treatment no relevant side-effects were noted.3

A pilot study to determine if delta-9-tetrahydrocannabinol (THC) can improve taste and smell (chemosensory) perception as well as appetite, caloric intake, and quality of life for cancer patients with chemosensory alterations was undertaken by Brisbois TD et al (2011). In the study, adult advanced cancer patients, with poor appetite and chemosensory alterations, were recruited from two sites and randomized in a double-blinded manner to receive either THC (2.5 mg, Marinol(®); Solvay Pharma Inc., n = 24) or placebo oral capsules (n = 22) twice daily for 18 days. Twenty-one patients completed the trial. THC-treated patients reported improved and enhanced chemosensory perception and food 'tasted better'. Premeal appetite and proportion of calories consumed as protein increased compared with placebo. Additionally, THC-treated patients reported increased quality of sleep and relaxation.4

Marinol’s patent states:

Among the many problems endured by patients suffering from symptomatic HIV infection, which includes inter alia AIDS (Acquired Immune Deficiency Syndrome) and ARC (AIDS Related Complex), are loss of appetite with consequent loss of weight. This loss of appetite and loss of weight further debilitates the patients and increases the many problems associated with the HIV infection.

The compound delta-9-tetrahydrocannabinol, which is the active ingredient in marijuana and which was produced chemically as described in U.S. Pat. No. 3,668,224, has been used as an antiemetic to relieve nausea and vomiting in patients receiving cancer chemotherapy.

A number of cancer investigators have used delta-9-tetrahydrocannabinol to attempt to increase appetite and modify weight loss in cancer patients. For example, in a randomized double-blind crossover study employing oral delta-9-tetrahydrocannabinol and prochlorperazine, 50% of the subjects on delta-9-tetrahydrocannabinol reported an increased food intake while only 29% had a similar response on the prochlorperazine..sup.1 In another study of similar design and using the same medications, patients on delta-9-tetrahydrocannabinol reported feeling more hungry than patients on prochlorperazine..sup.2 Results suggestive of an appetite stimulating effect were also noted by Ekert, et al..sup.3 in groups of children and adolescents 6-19 years of age administered delta-9-tetrahydrocannabinol, prochlorperazine or metaclopramide in crossover design studies.

In a double blind study, Regelson, et al..sup.4 observed that advanced cancer patients on chemotherapy receiving delta-9-tetrahydrocannabinol maintained their weight better than those not receiving the delta-9-tetrahydrocannabinol.

In an open study, Wadleigh, et al..sup.5 observed appetite increases and a lessening of the rate of weight loss in cancer patients.

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In addition, The first cannabinoid agonist, nabilone (Cesamet), which is a synthetic analogue of Δ9- THC was specifically licensed for the suppression of nausea and vomiting produced by chemotherapy. The synthetic Δ9- THC, dronabinol (Marinol) entered clinical treatment in1985 as an anti-emetic (preventing vomiting) and in 1992 as an appetite stimulant (Pertwee, 2009). In early studies, several clinical trials compared the effectiveness of Δ9- THC with placebo or other anti-emetic drugs. Comparisons of oral Δ9- THC with existing anti-emetic agents generally indicated that Δ9- THC was at least as effective as the dopamine antagonists, such as prochlorperazine (Carey et al., 1983; Crawford & Buckman, 1986; Cunningham et al., 1988; Layeeque et al., 2006; Ungerleider et al., 1984; Tramer et al., 2001).

Prochlorperazine, a non-cannaboid drug, belongs to a group of medications called phenothiazines. It is typically used as an antipsychotic medication for schizophrenia; however, it also commonly prescribed for nausea related illnesses including pregnancy (morning sickness). What’s most concerning about the latter is there is evidence to indicate that exposure to Prochlorperazine during pregnancy may have a teratogenic effect on the fetus. A teratogen is a substance that can cause birth defects. Additionally, it is not entirely known exactly how Prochlorperazine works. However, it is known that the drug blocks or lessens the effects of dopamine, a chemical in the brain. Since dopamine can activate the part of the brain that controls nausea and vomiting, prochlorperazine can treat severe nausea and vomiting.

Common side effects of prochlorperazine include, drowsiness, dizziness, unusual body movements, shakes or twitches, blurred vision, sexual problems and a dry mouth.
While more severe side effects are listed as:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue; unusual hoarseness; wheezing); chest pain; confusion; decreased coordination; drooling; fainting; fast, slow, or irregular heartbeat; mask-like face; muscle spasms of the face, neck, or back; muscle weakness; new or worsening mental or mood problems; numbness of an arm or leg; prolonged or painful erection; restlessness; seizures; severe or persistent constipation; severe or persistent dizziness, drowsiness, or headache; shuffling walk; sleeplessness; stiff or rigid muscles; sudden shortness of breath or vomiting; swelling of the hands, ankles, or feet; symptoms of infection (eg, fever, chills, persistent sore throat); symptoms of liver problems (eg, yellowing of the skin or eyes; dark urine; pale stools; severe or persistent nausea, stomach pain, or loss of appetite); tremor; trouble urinating; twisting or twitching movements; uncontrolled muscle movements (eg, twitching of the face or tongue; loss of balance; uncontrolled movements of arms or legs; trouble speaking, breathing, or swallowing); unusual bruising or bleeding; unusual eye movements or inability to move eyes; unusual or excessive sweating; unusual tiredness or weakness; unusually pale skin; vision changes (eg. blurred vision).3

Sounds like great stuff! I.e. comparing cannabis to prochlorperazine is like comparing shit to shinola! And yet one is legal and the other is not. Go figure!

End to that. All I'm saying is the more options med users have the better. Each to their own. Take for example my condition which is PTSD. If I smoke very high THC to very low CBD medicine it pretty much creates massive anxiety which is exactly what PTSD is - so magnify this 10 fold and I am literally emotionally crippled and have panic attacks which in a worst case scenario results in a form of psychosis. On the other hand, some conditions require high THC for optimal treatment.

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cchem said:

Peace back. No one is saying otherwise. THC low pot is absolutely useless to treat anorexia wasting in cancer and AIDS patients - full stop! And yep 100% agree re Israel legalizing but then in a perfect world the sun would come up everyday and all would be smiling. Haha - SourPurp what more can be said mate?

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SeaMaiden said:

I'll use my mom as an example here. She's in her 70s and is no stranger to weed, but she honestly prefers her white wine. She just doesn't do well with the high, and the higher the THC levels the worse off she is. She works in a demanding field where she *must* be on her game, always.

But! When she developed high blood pressure (surprising considering her size and weight, she's rather petite and has never been overweight), her docs put her on several drugs to help drop it. Those drugs were making her feel awful, so she decided to try a different route. That route became hot yoga and sparingly used medibles, and through that she was able to drive her BP down and get off three of the four meds she was on.

If someone wants to chime in that she should have changed her diet, that's all well and good, but as a dietitian who's very well-known in her profession, it's a foregone conclusion that diet was the first technique she tried.

She also talks a lot about the men she hires who come from deep in the heart of Mexico and all the traditional medicine they practice using cannabis in many forms. How they will use low-THC fan leaves in a poultice for an old person's arthritic joints. A trick taught to us by an old woman who was, for all intents and purposes, a walking botanico, to deal with my very colicky nephew was a stick of celery, 3" long, boiled in a cup of water and given to him--worked like a CHARM. So that is to say that the old peoples' methods often hold great wisdom that we have yet to tap.

We have a funeral service to attend this Saturday. Our neighbor, Colette, succumbed to her metastatic breast cancer three weeks ago. I honestly don't know if *any* cannabis would have helped her with much of anything except perhaps the chemo and radiation 'therapies'. Rest in peace, Colette, I truly hope you do.

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headband 707 said:

Awww perhaps you brought up what doctors have been worried about right there ppl with cancer....
Now that I come to think about it. For example if I have a patient that is had cancer and I want him/her to be treated with cannabis I don't want this person to feel" euphoria " I simply want them to eat or enjoy the side effects of the drugs not "get high" so to speak... which is why there are so many ppl that like the low thc in cannbis or atleast this is what I hear. I have a few friends that get this for their parents and they always ask for very low thc etc.
I don't know any doctor that wants anyone to feel euphoria period.. headband 707

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ZippyThePinhead said:

What fun is pot that doesnt get you high?

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