Originally Posted by Cvh
I'm no chemist so forgive my ignorance. But are you talking about Isomerization as written in Cannabis Alchemy by D. Gold to transform CBD into THC?
See page 21: https://calgarycmmc.com/E-books/E%20...0D.%20Gold.pdf
I was always under the impression that this was debunked and so not true.
I think Sam The Skunkman said this into the past.
We ran D. Golds isomerizing process before we had a GC, so were measuring the results anecdotally.
In our situation, we were unimpressed but without empirical numbers. D Gold and I’ve since discussed both his isomerizing and acetate processes, so I have a better idea where he was coming from.
I hadn’t heard the process was debunked, only put in perspective chronologically vis a vis present circumstance. There has been a huge change in available starting material during that time.
Cannabis produces CBG as a starting material, which then turns to either CBD or THC, depending on the plant genetics. Land race cannabis is typically high in CBD, with a low resin content.
While there are strains that were selectively bred for high THC available in the 60’s and early 70’s, they were in short supply and expensive, with Mexican brick weed more readily available. Dave said that he was looking for a process that improved the low-grade material available at that time, which was high in CBD and low in THC.
We on the other hand were using one of the medical grades subsequently developed, which was high in THC and low in CBD, so weren’t able to discern enough gain to justify the process.
That wouldn’t be an issue starting with more readily available CBD material, and the other good news is that THC-O-A was certainly worthwhile!!
We didn’t build an inert gas chamber, and did our first run in an open field, using a process Pharmer Joe developed based on making aspirin from salicylic acid. His process worked, though the THC-O-A had a short shelf life, both literally and figuratively.
None of it was ever left over after from our cannabis alchemy classes, because we only made 10 gram samples, and the students sampled everything we made, but when we made samples our own for shits and giggles, within a few days it started to revert and took on an acrid bite.
Move forward another decade or so, and I’m currently setting up to rerun that experiment using both CBD and THCA crystals, instead of the concentrate we used in our last experiment. Pharmer Joe also believes he may have an answer to improving shelf life as well. More on that as it progresses.
Here is some data from my Sweet Mary’s Charms III article, which provides links to a more comprehensive review of multiple processes for producing the cannabinoids out of other readily available terpenes.
Not just the d9-THC and CBD that has the rapt attention of the populous, but some that are harder to acquire in large quantities and which have their own medicinal properties.
Here is a taste:
Another thank you to Dr. Justin Fischedick for the pile-o-papers and studies, in support of my quest to solve the CBN riddle, and the study done by Rak K. Rasdan titled "The Total Synthesis of Cannabinoids". Published by the Department of Chemistry, Carlton University’s “Total Synthesis of Natural Products. Available on line at:
Also (thank you SkyHighler) at:
Link to a free download via Library Genius (click on 'GET
The Total Synthesis of Cannabinoids
SISA Incorporated, Cambridge, Mass
2. Strategy in the Synthesis of (-)=d1-THC and their Metagolites
A. Synthesis of t1 and t6 THCs
B. Synthesis of cis-THCs
C. Metabolites of Tetrahydrocannabinols
D. Metabolites Functionalized in the Alicyclic Ring
E. Metabolites Functionalized in the Aromatic Ring
3. Synthesis of Otyher THCs and Related Cannabinoids
A. "Unnatural" THCs
D. Cannabinoid Acids
H. Novel Cannabinoids
4. New Cannabinoid Transformations
B. cis-+trans Conversion
5. Synthesis of THC Analogs
A. Carbocyclic Analogs
B Heterocyclic Analogs
6. Overall Structure-Activity Relationships in Cannabinoids
7. Therapeutic Indications and Potential of New Drugs from Cannabinoids