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Old 04-02-2019, 12:07 AM #11
andl
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NO ITS NOT LOL


only if you dont know what youre doing exactly...
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Old 04-02-2019, 12:14 AM #12
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keep in mind there are 30 isomere of cbd, only 1 has been seen in nature all others not but i dont know what they sell as "CBD" a mixture, or one isomere, or maybe xxx dunno


got my point


lab analaysis is needed


everything else is not serious and not suitable
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Old 04-02-2019, 12:42 AM #13
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Quote:
Originally Posted by Cvh View Post
I'm no chemist so forgive my ignorance. But are you talking about Isomerization as written in Cannabis Alchemy by D. Gold to transform CBD into THC?
See page 21: https://calgarycmmc.com/E-books/E%20...0D.%20Gold.pdf

I was always under the impression that this was debunked and so not true.
I think Sam The Skunkman said this into the past.



i m gonna try the reaction as said and let you know next few weeks but as i see this could work properly,


keep in mind that cannabis has a lot more than one cannabinoid and you JUST ONLY GET the delta8/9 thc so.... (or diffrent delta mixtures)
(and by products ?! analysis is the way)


not the same like smoke a good 'ol BUD
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Old 04-02-2019, 10:18 AM #14
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A QUOTE from the patent at 0006 :


"Gaoni and Mechoulam (1966 , Tetrahedron 22: 1481-1488) teach methods of converting CBD to, among other compounds, Δ8-THC and Δ9-THC comprising boiling a solution of CBD (3.0 g) in absolute ethanol (100 ml) containing 0.05% HCl for 18 hours. The solution was then poured into water and extracted with ether. The ether solution was washed with water, dried (Na2SO4) and evaporated. Δ8-THC and Δ9-THC were eluted from the resulting oil and separated by chromatography. In another experiment, CBD (3.14 g) was dissolved in benzene (100 ml) containing 2 mg/ml p-toluenesulphonic acid and boiled for two hours. The reaction mixture was poured into water and the upper layer was separated, washed with 5% NaHCO3, then with water, dried and evaporated. Elution with pentane-ether (95:5) gave an oily material which was subsequently distilled. Percentage yield of Δ8-THC (Δ1(6)-THC) was given as 64% of the crude material in this paper. The crude oil product, which showed only one spot by thin layer chromatography, was purified by vacuum distillation."


this is all old chemistry !


i m suprised no1 ever tried this out


when it was postet in tetrahedron its very promising this will work!


PS: this reaction is even easier.


the second reaction is nearly the one i did suggested, but benzene isnt in use anymore you can substitute toluene for it
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Old 04-02-2019, 12:51 PM #15
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i read the chapters about isomerization and the Acetate, and i like the way he does the acetate,


because he just using the anhydride and the oil / better pure thc crystalls which makes the reaction water free whats important i suggest to dillute this in toluene because when you cook then you can get the water into the dean stark trap (and observe reaction) 1mol of thc to thc acetate should get you 1 mol of water which is 18g or 18ml 20°C removing water will drive reaction equilibrium to the side we want, when you remove the water out of the reaction.
so dont "overcook" (getting byproducts) and get sure all of the reaction is done.



some things, i disagree but all in all i think this will work.



the procedure of the cbd conversion is nearly the same i suggested with the sulfonic acid.
and i didnt even had the book before.



but he uses some acid also (Hcl, before H2SO4) and he gets delta 1 and delta 6 thc


but the procedure claimed in the patent is without acid and they claim to get delta 8 thc.....


only using the sulfonic catalyst,
(which is an lewis acid)

i dont understand why he uses the acids maybe to convert ringstructure?!



well i dont know i didnt do this reaction by myself but it all sounds promising.


thanks for sharing
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I got bills to pay
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There ain't nothing in this world for free
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Old 04-02-2019, 04:47 PM #16
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Quote:
Originally Posted by Cvh View Post
I'm no chemist so forgive my ignorance. But are you talking about Isomerization as written in Cannabis Alchemy by D. Gold to transform CBD into THC?
See page 21: https://calgarycmmc.com/E-books/E%20...0D.%20Gold.pdf

I was always under the impression that this was debunked and so not true.
I think Sam The Skunkman said this into the past.
We ran D. Golds isomerizing process before we had a GC, so were measuring the results anecdotally.

In our situation, we were unimpressed but without empirical numbers. D Gold and I’ve since discussed both his isomerizing and acetate processes, so I have a better idea where he was coming from.

I hadn’t heard the process was debunked, only put in perspective chronologically vis a vis present circumstance. There has been a huge change in available starting material during that time.

Cannabis produces CBG as a starting material, which then turns to either CBD or THC, depending on the plant genetics. Land race cannabis is typically high in CBD, with a low resin content.

While there are strains that were selectively bred for high THC available in the 60’s and early 70’s, they were in short supply and expensive, with Mexican brick weed more readily available. Dave said that he was looking for a process that improved the low-grade material available at that time, which was high in CBD and low in THC.

We on the other hand were using one of the medical grades subsequently developed, which was high in THC and low in CBD, so weren’t able to discern enough gain to justify the process.

That wouldn’t be an issue starting with more readily available CBD material, and the other good news is that THC-O-A was certainly worthwhile!!

We didn’t build an inert gas chamber, and did our first run in an open field, using a process Pharmer Joe developed based on making aspirin from salicylic acid. His process worked, though the THC-O-A had a short shelf life, both literally and figuratively.

None of it was ever left over after from our cannabis alchemy classes, because we only made 10 gram samples, and the students sampled everything we made, but when we made samples our own for shits and giggles, within a few days it started to revert and took on an acrid bite.

Move forward another decade or so, and I’m currently setting up to rerun that experiment using both CBD and THCA crystals, instead of the concentrate we used in our last experiment. Pharmer Joe also believes he may have an answer to improving shelf life as well. More on that as it progresses.

Here is some data from my Sweet Mary’s Charms III article, which provides links to a more comprehensive review of multiple processes for producing the cannabinoids out of other readily available terpenes.

Not just the d9-THC and CBD that has the rapt attention of the populous, but some that are harder to acquire in large quantities and which have their own medicinal properties.

Here is a taste:

Sweet Mary’s Charms III

Another thank you to Dr. Justin Fischedick for the pile-o-papers and studies, in support of my quest to solve the CBN riddle, and the study done by Rak K. Rasdan titled "The Total Synthesis of Cannabinoids". Published by the Department of Chemistry, Carlton University’s “Total Synthesis of Natural Products. Available on line at:


https://onlinelibrary.wiley.com/doi/1...78.ch2/summary


Also (thank you SkyHighler) at:


Link to a free download via Library Genius (click on 'GET')
https://libgen.io/scimag/ads.php?doi...&downloadname=


The Total Synthesis of Cannabinoids
by
Rajk. Razdan,
SISA Incorporated, Cambridge, Mass
1. Introduction
2. Strategy in the Synthesis of (-)=d1-THC and their Metagolites
A. Synthesis of t1 and t6 THCs
B. Synthesis of cis-THCs
C. Metabolites of Tetrahydrocannabinols
D. Metabolites Functionalized in the Alicyclic Ring
E. Metabolites Functionalized in the Aromatic Ring
3. Synthesis of Otyher THCs and Related Cannabinoids
A. "Unnatural" THCs
B. Cannabidiols
C. Cammabinols
D. Cannabinoid Acids
E. Cannabigerol
F. Cannabichromene
G. Cannabicyclol
H. Novel Cannabinoids
4. New Cannabinoid Transformations
A. Photochemical
B. cis-+trans Conversion
C. Pyrolysis
5. Synthesis of THC Analogs
A. Carbocyclic Analogs
B Heterocyclic Analogs
6. Overall Structure-Activity Relationships in Cannabinoids
7. Therapeutic Indications and Potential of New Drugs from Cannabinoids
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Old 04-02-2019, 05:00 PM #17
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Here is an archive link to our THC-O-A article on Skunk Pharm Research.


https://web.archive.org/web/20150709...om/thc-acetate
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Believing is seeing and ignorance is bliss until it bites you in the ass!

Fervor is the weapon of the impotent. The harder the sell, the poorer the product.

Alas, my ignorance abounds; the more I've learned, the less I know that I know..........

Thou shalt seek and respect the opinions of operators, even unto the third helper, for theirs is a wisdom unknown to technicrats.

Wise men learn more from fools, than fools from wise men.

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Old 04-02-2019, 05:16 PM #18
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I found the post from Skunkman what made me confused.
https://www.icmag.com/ic/showpost.ph...5&postcount=10

I think I misunderstood him, I think he meant naturally synthesized in the plant as a comment on a posted article into that thread.
The thread is however about Isomerization.

Very interesting thread to read:
https://www.icmag.com/ic/showthread.php?p=3511035
@Op, be sure to check this thread out.
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Old 04-02-2019, 09:16 PM #19
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@ wolf and Cvh

youre great i will have a look into that.

sharing is caring so really, thanks a lot!



will take some time
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Money don't grow on trees
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There ain't nothing in this world for free
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Though you know, I wish I couldOh no there ain't no rest for the wicked
Until we close our eyes for good"

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Old 05-29-2019, 05:20 PM #20
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Quote:
Originally Posted by andl View Post
i got all chemicals and equiptment needed to try this but i need to get others things done before
I plan on trying this out too.

Just have to purify my Toluene and prepare Toluene p-Sulfonic Acid.
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