Originally Posted by PDX Dopesmoker
Has there been any progress or anything interesting on the CBDV front? There are a couple active threads in other parts of the site about THCV and it reminded me that I've never really seen much at all anywhere about CBDV.
Yes, most definitely. Mark Lewis' group at Napro has a great variety that is equal parts CBD to CBDV--some of their licensed cultivators used it to win at the Emerald Cup last year. We'll have our lines out for field trials summer of 2020.
It has taken some time to develop them. Propyls (i.e. the varins) are a little more finicky than pentyls (the "regular" acid forms we are all used to); because of that, the order of operation is to isolate the pentyls first, then work to increase the propyl fraction. In other words, you have to first find good CBD, CBG, CBC, THC, etc. candidate lines, then outcross or inbreed towards the target of increasing respective CBDV, CBGV, CBCV, THCV, etc. Even with "substantially pure" propyl varieties, there is significant variation of the total "V" proportion present between siblings within seed lines. Some can be 20/80 varin/pentyl, while others are 80/20; the variation is normally distributed.
The lack of CBGVA reference standards have also been a bit of an impediment. It definitely reinforces the reality that even the best cannabis labs lose their usefulness to breeders attempting to isolate compounds rather quickly--our most interesting targets today are just unknown spikes on a chromatogram.
For what it's worth, I can also confirm what you were reading in those other threads that THCV is most definitely NOT psychoactive.