Bee's are not around in the late evening and moths and caterpillars are. Spinosad will do the trick also, it is like an A bomb going off. I use Spinosad once or twice on an outdoor crop with multiple treatments of safer brand caterpillar killer. This has worked for me for years now. I used to get horrible bud rot from those caterpillars. Not any more! I believe there is no one time answer. You have to be on top all season long.