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LG Resource. links to Cannabis/Cannabinoid/Endocannabinoid research papers

dannykarey

Well-known member
http://www.advancedhealthplan.com/700_cannabis_studies_2012.pdf


**Disclaimer - I have not gone through all of the links in the above document so some might work, some might not...Please let me know so maybe we can make a list of them or delete/erase them if possible so we know what ones to avoid? Or it might be easier to list the decent ones as again some can be hit or miss.....But there is good stuff to be found!!


Trichrider already has a thread with the "granny storm crow list" which I didn't know about before I made this thread, very sorry trichrider.....Link to Trich's Thread https://www.icmag.com/ic/showthread.php?t=278827 please check it out as it has alot of great articles and information. He did an amazing job organizing everything, keep up the good work man!!




Just a few definitions...

Acetylcholine – a common neurotransmitter
Acute- sharp or severe in effect; intense
Adipose tissue - fat
Adipocyte – a fat cell
Adjunct – a medication used in conjunction with another to help it work better
2-AG- A “messenger chemical” made by your body – similar to THC
Agonist – a chemical that activates a receptor
Allodynia- pain due to a stimulus which does not normally cause pain, (ie- a light touch)
Allosteric- works through a “back door” mechanism, not the usual binding site
Analgesic – pain relieving
Analogue – a synthetic version
Anandamide/ AEA - a “messenger chemical” made by your body – similar to THC
Angiogenesis - making new blood vessels, often to feed a tumor
Anorectic - Pertaining to anorexia, a lack of appetite
Antagonist – a chemical that blocks the action of an agonist
Antigen- a substance which causes an immune response
Anti-nociception- pain relieving
Anxiolytic – calming, anti-anxiety
Apoptosis - a process that leads to the normally programmed death of a cell.
Aqueous humor – the liquid between the colored iris and the clear cornea of your eye
Ataxia - lack of muscle coordination during movements like walking, or picking up objects
Autophagy – the cell self-destructs, literally “eats itself”
Autopathic - relating to the structure and characteristics of a diseased organism. Idiopathic.

Baroreflex – the way your body uses your heart rate to control blood pressure
Beta amyloid plaque / β-amyloid/ Aβ – the stuff that gums up your brain in Alzheimer’s
Biphasic – different results for different doses, THC stops or causes nausea depending on dose
Bronchodilator – opens up the lungs

Cannabinoids –they activate CB receptors and are made in your body, cannabis or labs.
Cannabinomimetic – acting like a cannabinoid
Carcinoma - cancer
Cachexia – severe wasting away due to illness
Caveolae - little caves or pits in the cell membrane that trap fluids
CCK – an intestinal homone that tell you that you are full and satisfied
Central nervous system/CNS - the brain and spinal cord
Chemotaxis - the movement of a cell or bacteria toward, or from a stimulus (food or a poison)
Cholinergics- drugs that inhibit, enhance, or mimic the action of acetylcholine
Chondrocytes- the only kind of cells found in healthy cartilage
Chronic – long term
Cirrhosis – scarring (usually) of the liver, impairing function
Cogeners- related chemicals
Cross tolerance – tolerance to a drug causes tolerance to another, similar, drug
Cryofixed - frozen with liquid nitrogen for electron microscopic examination
Cutaneous – pertaining to the skin
Cytotoxic – poisonous to living cells

Demyelinating diseases - diseases in which the myelin on nerves is destroyed, as in MS
Dopamine - a neurotransmitter that helps control the brain's reward and pleasure centers
Dose-dependent manner – the more they got, the better it worked
Downregulation – a decrease in number
Dysregulation – malfunctioning, out of kilter

Eicosanoids – a group of bioactive compounds that include the endocannabinoids
Emesis- vomiting
Endocannabinoid – a chemical messenger made by your body- anandamide and 2-AG
Endocannabinoid System/ ECS – a system of chemical receptors on and between your cells
Endogenous – made in your own body, opposite of exogeneous
Epidermal – pertaining to the skin
Epigenetic- genes being turned on, or off, by chemical reactions, but with no change to the DNA
Epithelial cells –cells lining of your gut and surfaces of structures throughout the body
Excitotoxic- when nerve cells are damaged or killed by over-stimulation
Exogenous - from outside the body, opposite of endogenous
Extracellular – outside of the cells

FAAH/ Fatty acid amide hydrolase – an enzyme that breaks down anandamide
Follicule - sac or cavity having excretory, secretory, or protective function: a hair follicle,

Ganglia/ ganglion – a bunch of nerves outside the CNS, or some gray matter bits in the brain
Gene expression- the body reads a gene’s info and translates it into a product (protein, etc)
Genotype - all the genetic traits of an organism, both visible and hidden
Gut microbiota - micro-organisms that live in the digestive tract

Hemp – Cannabis sativa, usually with a low level of THC
Hemoptysis – coughing up blood
Hematopoiesis – the making of new blood cells in bone marrow
Hemopressin - a hemoglobin fragment that dilates blood vessels using nitric oxide
Hepatic – pertaining to the liver
Heteromer – a group containing 2 or more different types of things.
Hippocampus – part of the brain, controls mood and memory.
Homeostasis - your body keeping everything in balance and working right
Hydrolysis - breaking down a compound using enzymes
Hyper- over, above, extreme
Hyperalgesia – severe pain
Hyperemesis – severe vomiting
Hyperphagic – over-eating
Hyperthermia – a fever
Hypo- under, or below
Hypophagic – under-eating
Hypothermia – lowered body temperature
Hypoxia – not getting enough oxygen

Idiopathic- of unknown cause
Indica - short plants, broad leaves, solid buds; “heavy” body high, good pain relief, some CBD
In silico – done on a computer
In vivo – in a live animal
In vitro – in a test tube
Infarction – damage from a lack of blood due to a blood vessel blockage
Intraocular – inside the eye
Intrathecal injection - injected under the arachnoid membrane of the brain or spinal cord
Intrauterine – inside the uterus
Inverse agonist- binds to a receptor like an agonist, but causes the opposite effect
Ischemia – damage from lack of blood to an area

Jejunum - the middle section of the small intestine in most higher animals

Koro- a fear that one’s genitals are retracting and will disappear, “genital retraction syndrome”

Lactating - producing breast milk, nursing
Leptin – a hormone that turns on hunger
Ligand - a chemical that binds to a receptor- THC is a ligand of CB1 and CB2 receptors
Lipids – fats and oils
Lysis - the destruction or decomposition of a cell

Macrophages - specialized cells that attack foreign substances, disease germs and cancer cells
MAGL - an enzyme that breaks down 2-AG
MAPK-JNK signal pathway- the way the receptor’s message gets into the nucleus’ DNA
Metabolites – what’s left over after your body breaks down a compound
Metastasis – spreading through the body
Microphage - a white blood cell capable of ingesting bacteria, etc.
Micturation – urination, peeing
Modulate – control or regulate something
Murine - mouse
Mydriasis - a disorder in which the pupil of the eye dilates abnormally, and stays dilated
Myelin – a protective covering on the axion part of a nerve cell
Myocardial – pertaining to the heart muscle
Myopericarditis - Inflammation of the heart wall and the sac around it, the pericardium

Nanomolar – a very tiny amount
Necrotic – dead or dying
Nephro – referring to the kidneys
Neurogenesis – new brain cells are being formed
Neuropathic Pain – pain due to nerve injury
Neuroprotective – protects nerves and brain cells
Neurotransmitter - a chemical messenger that carries messages between neurons and other cells
Neutrophil – the most common type of white blood cell
Nocebo- a harmless substance that creates harmful effects in a patient. Opposite of placebo.
Nociceptive –experiencing pain from a stimulus such as heat or tissue damage
Nociceptor – pain nerve
Nonpsychoactive – won’t get you high
Nonpsychotropic – won’t get you high

Occluded – blocked up, as in an occluded artery
Ocular – referring to the eye
Olfactory – pertaining to smell, odor detection
Oligodendrocytes - cells that make the myelin sheath that protects CNS nerves.
Oromucosal – pertaining to the lining inside of the mouth
Ortholog- the same gene in different species doing the same job, traceable to a common ancestor
Osteoblast – a cell that makes new bone
Osteoclast - cell that eats away and breaks down bone causing bone resorption

Palliative - health care focused on relieving and preventing suffering
Partial agonist- doesn’t activate receptor fully, may “hog” receptors, blocking full agonists
Pathogenesis - the origin and development of a disease
Peptide – string a bunch of peptides together, and you get a protein
Peripheral nervous system ( PNS) - the nerves and ganglia outside of the brain and spinal cord
Peritoneal – pertaining to the peritoneum that lines the walls of the abdominal cavity
Phagocyte - a “clean-up crew” cell that “eats” harmful foreign particles, bacteria, and dead cells
Phagocytosis - When a phagocyte “eats” a bacteria or other object by engulfing it
Phenotype- the genetic traits that you can see
Phytocannabinoid – a cannabinoid produced by a plant – THC and CBD are examples
Phyto - referring to plants
Phytochemical – a compound produced by a plant
Polymorphism – having more than one form, different phenotypes in genes
Porcine – pertaining to pigs
Prions – they cause Mad Cow Disease
Pruritus – chronic itchiness
Pulmonary –pertaining to the lungs

Receptors - These receive the chemical messages and send them into our cells.
Refractory pain- pain not responding to the usual treatments, stubborn pain
Renal - pertaining to the kidneys
Reperfusion damage- damage caused when blood returns to an area
Reuptake - reabsorption of a substance by the cells that originally produced it
Rhabdomyolysis - the rapid destruction of skeletal muscle.
Ruderalis – small, short-season, auto-flowering strains, potency varies

Sativa – tall plant, long skinny leaves, slow maturing; a mental/ party high, occasional paranoia
Sebaceous glands- oil glands in the skin
Seronegative - testing negative for a disease
Seropositive - testing positive for a disease
SiRNA- used to inactivate or “silence” a gene to validate the gene’s function

Teratologic – causing birth defects
Terpinoids – gives cannabis its odor, may help cannabinoids to enter cells more easily
Transgenic – genetically modified, a GMO
Trichome – in cannabis, it usually refers to tiny mushroom-shaped structures that hold THC
Trigeminal nerve – responsible for sensation in the face, and biting and chewing

Ubiquitination: The "kiss of death" for proteins. The protein is inactivated by ubiquitin.
Ubiquitin – a regulatory protein that inactivates other proteins
Upregulation – increase in number
Uveitis - infection of the middle layer of the eye involving the iris, ciliary body and/or choroid.

Vascular – referring to blood vessels
Vasodilator – expands the blood vessels
Vasoconstrictor – contracts the blood vessels
Visceral - pertaining to internal organs, guts

Xenograft - transplanting living cells, tissues or organs from one species into another


If anyone has links to other research papers or finished studies that have to do with cannabis please post them up!!!

Cheers,


Danny
 
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dannykarey

Well-known member
Cannabinoids for treatment of chronic non-cancer pain; A systematic review of randomized trials. http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2011.03970.x/epdf

Journal of Cannabis Therapeutics.
http://www.cannabis-med.org/jcant/Jcant1(1).pdf

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy.
http://mct.aacrjournals.org/content/10/7/1161.full

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.
http://mct.aacrjournals.org/content/6/11/2921.long

Effects of Smoked Cannabis and Oral ∆9-Tetrahydrocannabinol on Nausea and Emesis After Cancer Chemotherapy: A Review of State Clinical Trials.
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.337.5132&rep=rep1&type=pdf

Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538401/

Mayo Clinic: Cannabis, a valuable drug that deserves better treatment.
http://www.mayoclinicproceedings.org/article/S0025-6196(11)00027-9/pdf

Low Dose Vaporized Cannabis Significantly Improves Neuropathic Pain. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566631/

Medical Marijuana: Clearing Away the Smoke.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358713/

Plant Cannabinoids a neglected pharmacological treasure trove.
http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0706415/epdf


Danny
 
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dannykarey

Well-known member
Cannabidiol lowers incidence of diabetes in nonobese diabetic mice.
http://www.tandfonline.com/doi/pdf/10.1080/08916930500356674

Cannabidiol,a non-psychotropic component of cannabis, attenuates vaumiting and nausea like behavior via indirect agonism of 5-HT somatodendritic autoreceptors in the dorsal raphe nucleus.
http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01621.x/epdf

The Therapeutic Potential of Cannabis and Cannabinoids.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442177/pdf/Dtsch_Arztebl_Int-109-0495.pdf

The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC16904/pdf/pq009561.pdf

A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
http://www.nature.com/bjc/journal/v95/n2/full/6603236a.html

A Population-Based Case-Control Study of Marijuana Use and Head and Neck Squamous Cell Carcinoma. http://safeaccess.ca/research/pdf/MarijuanaUse_and_Head-NeckSquamousCellCarcinoma.pdf

Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo.
http://www.nature.com/onc/journal/v27/n3/full/1210641a.html

Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
http://jpet.aspetjournals.org/content/early/2006/05/25/jpet.106.105247.full.pdf+html

Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity.
http://jpet.aspetjournals.org/content/314/2/780.full


Danny
 
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dannykarey

Well-known member
Marijuana in the management of amyotrophic lateral sclerosis.
http://ajh.sagepub.com/content/18/4/264.full.pdf

A Molecular Link between the Active Component of Marijuana and Alzheimer’s Disease Pathology.
http://www.ukcia.org/research/AlzheimersDiseasePathology.pdf

Alzheimer's disease; taking the edge off with cannabinoids?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190031/?tool=pubmed

Cannabidiol: A promising drug for neurodegenerative disorders?
http://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2008.00065.x/epdf


Danny
 

dannykarey

Well-known member
Cannabis improves symptoms of ADHD
http://www.cannabis-med.org/english/journal/en_2008_01_1.pdf

Cannabinoid facilitation of fear extinction memory recall in humans
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445738/

A Randomized, Placebo-Controlled, Crossover Trial of Cannabis
Cigarettes in Neuropathic Pain.
http://files.iowamedicalmarijuana.o...igarettes in Neuropathic Pain J Pain 2008.pdf

A historical overview of chemical research on cannabinoids
http://www.researchgate.net/profile...nnabinoids/links/02e7e52afc04ddd97a000000.pdf


Danny
 
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dannykarey

Well-known member
"Marijuana as Medicine the Science Beyond the Controversy" by ALISON MACK and JANET JOY for the Institute of Medicine

http://www.nap.edu/read/9586/chapter/2

That link is to the full book or click the red icon that says "get this book" on the top right of the screen to get the FREE pdf download version.

I haven't read the entire thing but a class mate used it as a source for one of their presentations. Figure I would throw it up.....If anyone has an issue with it for any reason please let me know and it can be taken down. Im not sure how accurate or factual ALL of the information is ....Just sayin.

Interesting read though the little of it I have read...

Cheers,

Danny
 
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dannykarey

Well-known member
Lol......Sorry man, I did a search and didn't find anything so I posted the granny storm crow thing along with a couple more of my own that I found.

You can use what ever you want man but I think Im gonna delete most of the granny storm crow stuff maybe just keep the link? Id like to go through it and see what links actually work........ to be honest a good chunk came back with page not found. Let me know what ya find bro....and again GREAT JOB!

Would it be cool if I used some info from your thread?

Cheers,

Danny
 
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dannykarey

Well-known member


Yes......NCBI is awesome but alot are links to just abstracts and I'm not cool with paying a fee to see the whole paper/text. I've used that link you posted to compile some of the papers I've mentioned but again it would be cool to have a spot that had;

A) Links to FREE, full/entire papers/documents not just the abstract.

B) Links to actual scientific research studies that can be used as a source when writing academically or when meeting with ones physician?

C) Links that actually work.

The problem with the Storm crow list, much like the NCBI data base and ones like it......Alot of them are just news reports, abstracts or quit a few of the links just don't work at all.

I find it frustrating.

Cheers,

Danny
 
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trichrider

Kiss My Ring
Veteran
Danny, the links i've saved are for public use, including mine. they don't belong to me, but i saved them to one place for memory fails at times...

use or abuse them. there is a LOT of good info, yet some are abstracts. take the good with the bad.

peace out
 
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