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Old 10-29-2017, 01:28 AM #161
Gimpy
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Originally Posted by Douglas.Curtis View Post
I remember reading about cannabis allowing bacteria to enter deeper into the lining of the digestive system. I'm under the impression the aza is possibly increasing this effect for H.Pylori or something?

I could digest a bowling ball, before I was first poisoned with Azadirachtin 10+ years ago.
I'm almost certain that either azadirachtin is psychoactive on its own or that it binds with the THC, affecting the same parts of the endocannabinoid system and brain but with unwanted effects. This would include just about every organ, but the stomach and intestines are very susceptible. People have been posting for a while that aza weed can induce a more-paranoid-than-usual high. Often it co-occurs with body coldness or chills, and then nausea kicks in.

The hypothalamus is a peanut-sized part of the brain that controls appetite and temperature regulation. It's my suspicion that this is where azadirachtin bioaccumulates, but that's just my own theory.

Before aza, I was also able to eat anything. My GI and metabolism was in excellent condition. Now I barely eat.
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Old 11-08-2017, 08:53 PM #162
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I think there's a big difference between azadirachtin-A and azadirachtin-B. I got a half ounce of shake for fifty bucks and could smell that garlic scent that aza gives off. When I got home all of it just crumbled to bits. I rolled one up and after smoking it, got the upper back pains and stiff neck again without nausea. My "light method" didn't work this time, but thankfully I just signed up with a dispensary that is strictly pesticide free, including aza products.

A friend brought a vape pen thing from Oregon a week ago that apparently had 96% THC and it messed me and my stomach up pretty bad. I'm pretty sure they still haven't gotten a handle on their pesticides either.
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Old 11-13-2017, 10:20 AM #163
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update: CHS is caused by cannabinoids and pesticides. you become sensitive to them through the same mechanism. there is an enzyme called beta glucuronidase that is produced by e. coli bacteria (there's tons of these in your intestines that don't cause disease) the function of it is to deconjugate molecules that are coming out of your liver, such as nutrients that you need to absorb (your liver bonds molecules with glucaric acid to make them water soluble so you can excrete them) if your gut flora is imbalanced and you have too much beta glucuronidase, it starts deconjugating other things. high levels of beta glucuronidase have been linked to breast, prostate and colon cancer, because excess hormones that are being deconjugated and kept in the body are causing the cancer. so CHS sufferers are not removing cannabinoids from their body. you know how you can get sick from eating too many edibles or doing too many dabs, or how doing dabs can make you sweat? these are the main symptoms of CHS, profuse sweating and vomiting. it is possible to reach a level of cannbinoids in your intestine that makes you sick, or makes your body try to sweat out the excess toxins. a person in the prodromal phase of CHS gets sick occasionally because their body keeps running into times when the level of cannabinoids in their intestines is too high. then hyperemesis occurs when the level of cannabinoids in the fat cells becomes too high and none of it is being removed. after that, all/most of the cannabinoids in your system have been removed so you go back to normal for a while. there is only one youtube video discussing the link between beta glucuronidase, but there is plenty of reading you can do on the internet about the other effects of beta glucuronidase. this is a perfect explanation for CHS as it shows how and why it progresses, takes all the mystery out. it shouldnt even be called CHS. doctors just call it this because they only see people who are puking their guts out, not people like me who don't puke. there is a supplement you can take called calcium d glucarate that inhibits beta glucuronidase so your body can properly remove toxins. of course there's no research on using it for this purpose, but it's been shown to be effective for other applications. I've been taking it for a couple weeks and pretty quickly I noticed that i could smoke more in a day with less discomfort. I've also started taking probiotics every day. maybe I'll talk to my doctor about it as well as you can have your stool tested to see your beta glucuronidase level. I'm out of weed so I'm just going to keep taking the calcium d glucarate and smoking small amounts with friends when I get the chance. Im not good at formatting my thoughts, but I hope this information is helpful.
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Old 11-13-2017, 11:25 AM #164
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Interesting.

I've found the symptoms of aza to be more muscle tension, headaches and mild flu feeling... now that my (out of control) H.Pylori infection has been cleared up. Nausea really isn't an issue, since I'm keeping my exposure to aza/neem fairly low.

Oh, I can double up on these dirty dabs I have and after a bit that urge to puke (without accompanying nausea) starts to gather in the background. That's not cannabinoids for me though, strictly the aza, already tested it for myself and have a double blind study coming up in the spring.

Anyone with a real issue with plain cannabinoids, I feel for. At least most of us can get relief by switching to clean cannabis.
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Old 11-16-2017, 10:09 PM #165
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Originally Posted by paddyod11 View Post
update: CHS is caused by cannabinoids and pesticides. you become sensitive to them through the same mechanism. there is an enzyme called beta glucuronidase that is produced by e. coli bacteria (there's tons of these in your intestines that don't cause disease) the function of it is to deconjugate molecules that are coming out of your liver, such as nutrients that you need to absorb (your liver bonds molecules with glucaric acid to make them water soluble so you can excrete them) if your gut flora is imbalanced and you have too much beta glucuronidase, it starts deconjugating other things. high levels of beta glucuronidase have been linked to breast, prostate and colon cancer, because excess hormones that are being deconjugated and kept in the body are causing the cancer. so CHS sufferers are not removing cannabinoids from their body. you know how you can get sick from eating too many edibles or doing too many dabs, or how doing dabs can make you sweat? these are the main symptoms of CHS, profuse sweating and vomiting. it is possible to reach a level of cannbinoids in your intestine that makes you sick, or makes your body try to sweat out the excess toxins. a person in the prodromal phase of CHS gets sick occasionally because their body keeps running into times when the level of cannabinoids in their intestines is too high. then hyperemesis occurs when the level of cannabinoids in the fat cells becomes too high and none of it is being removed. after that, all/most of the cannabinoids in your system have been removed so you go back to normal for a while. there is only one youtube video discussing the link between beta glucuronidase, but there is plenty of reading you can do on the internet about the other effects of beta glucuronidase. this is a perfect explanation for CHS as it shows how and why it progresses, takes all the mystery out. it shouldnt even be called CHS. doctors just call it this because they only see people who are puking their guts out, not people like me who don't puke. there is a supplement you can take called calcium d glucarate that inhibits beta glucuronidase so your body can properly remove toxins. of course there's no research on using it for this purpose, but it's been shown to be effective for other applications. I've been taking it for a couple weeks and pretty quickly I noticed that i could smoke more in a day with less discomfort. I've also started taking probiotics every day. maybe I'll talk to my doctor about it as well as you can have your stool tested to see your beta glucuronidase level. I'm out of weed so I'm just going to keep taking the calcium d glucarate and smoking small amounts with friends when I get the chance. Im not good at formatting my thoughts, but I hope this information is helpful.
Nice work Pattyod! I considered glucorinidation but I didn't consider these factors.
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Old 11-17-2017, 06:38 AM #166
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Quote:
Originally Posted by paddyod11 View Post
update: CHS is caused by cannabinoids and pesticides. you become sensitive to them through the same mechanism. there is an enzyme called beta glucuronidase that is produced by e. coli bacteria (there's tons of these in your intestines that don't cause disease) the function of it is to deconjugate molecules that are coming out of your liver, such as nutrients that you need to absorb (your liver bonds molecules with glucaric acid to make them water soluble so you can excrete them) if your gut flora is imbalanced and you have too much beta glucuronidase, it starts deconjugating other things. high levels of beta glucuronidase have been linked to breast, prostate and colon cancer, because excess hormones that are being deconjugated and kept in the body are causing the cancer. so CHS sufferers are not removing cannabinoids from their body. you know how you can get sick from eating too many edibles or doing too many dabs, or how doing dabs can make you sweat? these are the main symptoms of CHS, profuse sweating and vomiting. it is possible to reach a level of cannbinoids in your intestine that makes you sick, or makes your body try to sweat out the excess toxins. a person in the prodromal phase of CHS gets sick occasionally because their body keeps running into times when the level of cannabinoids in their intestines is too high. then hyperemesis occurs when the level of cannabinoids in the fat cells becomes too high and none of it is being removed. after that, all/most of the cannabinoids in your system have been removed so you go back to normal for a while. there is only one youtube video discussing the link between beta glucuronidase, but there is plenty of reading you can do on the internet about the other effects of beta glucuronidase. this is a perfect explanation for CHS as it shows how and why it progresses, takes all the mystery out. it shouldnt even be called CHS. doctors just call it this because they only see people who are puking their guts out, not people like me who don't puke. there is a supplement you can take called calcium d glucarate that inhibits beta glucuronidase so your body can properly remove toxins. of course there's no research on using it for this purpose, but it's been shown to be effective for other applications. I've been taking it for a couple weeks and pretty quickly I noticed that i could smoke more in a day with less discomfort. I've also started taking probiotics every day. maybe I'll talk to my doctor about it as well as you can have your stool tested to see your beta glucuronidase level. I'm out of weed so I'm just going to keep taking the calcium d glucarate and smoking small amounts with friends when I get the chance. Im not good at formatting my thoughts, but I hope this information is helpful.
Thank you for your thoughts. this is indeed helpful
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Old 11-18-2017, 05:25 AM #167
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My Experience with Cannabinoid Hyperemesis Syndrome - looking for help

I want to make this post to tell my story with Cannabinoid Hyperemesis Syndrome.

I have smoked weed for almost 2 years now (started smoking regularly around January 2016). My friends and I started smoking daily through a bong and joints/blunts. This continued through summer of 2016. During summer 2016, my friends and I smoked heavily (I would guess I was smoking around an 8th of weed per week). We also were taking chops (weed and tobacco) consistently. I never experienced any negative side effects from smoking until about august of 2016. I was just moving into the dorms for my first year of college when I woke up one morning feeling nauseas. I started to throw up and developed a very sharp, constant pain in my lower abdomen that would not go away. I was vomiting uncontrollably and the pain in my abdomen was unbearable. I could not stop throwing up and eventually was in so much pain that my parents had to take me to the ER. I could not keep any liquids or food down so I was very dehydrated and in pain. The doctors ran many tests (blood, urine, CT scans) but everything showed that I was healthy. I am a very healthy person and have never had any prior medical conditions/history. I am about 5’11 165 lbs. They suggested that I had Cannabinoid Hyperemesis Syndrome, something I had never heard about. I read up about CHS and concluded that it was ridiculous I could have such a thing considering that weed had always been super beneficial and something that I could count on to relax myself. It was also a very social thing amongst my friend group. Thus, my stubborn self continued to consume marijuana pretty much daily, usually smoking a joint or two at night. At this time I was in the dorms for college and did not have access to a bong, so I would only smoke bong if I was at a friends house. My parents obviously were very concerned and seemed to think that I did actually have CHS, but the doctors could not officially “diagnose” me with it. It was not until about 2 months later when one night, I had the same nausea from the start of school. I began to throw up again and the excruciating pain returned. Having experienced this before, I attempted to “tough it out”. I stayed up all night in my dorm bathroom, constantly taking hot baths to try and subside the pain. Eventually the morning came and I could not bear it anymore, I was also so dehydrated that I thought I would pass out. I returned to the ER and the same thing happened again. The doctors gave me some anti-nausea medicine, fluids, and eventually painkillers to stop the stomach pain. My parents were understandably pissed, knowing that I had still been smoking. again the doctors said they thought it was CHS and said I needed to stop smoking. (P.S. after both visits to the ER I generally felt fine the next couple days and did not have recurring symptoms besides my stomach being weak from throwing up so much) Once again, I did not want to give up smoking so I continued again. I smoked daily for about 11months with no visit to the hospital and no signs of CHS. Thinking I was in the clear, I had another incident very recently, this time being worse. I had to visit the ER 3 days in a row, each morning repeating the same cycle of vomiting, pain, etc. As of now, I have stopped smoking because I have finally realized that CHS is real and unfortunately I have developed it. Along with the excruciating pain, going to the ER every so often is not something I want to be doing.

It has been about 5 days since my last ER visit and I have not smoked weed since then, nor do I plan on starting. But, it kills me to think that weed will forever be something I must abstain from. Speaking to any of you who have CHS, is there any chance I will be able to consume marijuana every so often, maybe a joint or bong hit every week or two? I have accepted the possibility that I will never be able to smoke weed again, but I also was curious to try using only CBD? I have heard of the benefits of CBD and I think it would be something very helpful to me. Am I able to consume strictly CBD without instigating another hyperemesis breakout? I am worried to try anything because I really do not want to experience it again. If you have any insight - please respond with your experience with CHS. Thanks
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Old 11-18-2017, 07:04 AM #168
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As stated in the other thread, please read this thread.

I understand you're in crisis and though it sucks horribly you're going to be ok. Take some benadryl or other strong anti-histamine and start taking an activated charcoal pill each day.
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Old 01-09-2018, 09:45 PM #169
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I want to make this post to tell my story with Cannabinoid Hyperemesis Syndrome.

but the doctors could not officially “diagnose” me with it
because its not an actual thing
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Old 02-26-2018, 08:46 AM #170
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I'm back, after having switched to a dispensary that claimed they didn't use pesticides. I became way too comfortable with the fact that my bud didn't have aza, and so I was smoking more. Suddenly the bud started to look more colorful and have more crystals, but I kept smoking, putting faith in another grower. It's true, the only way to know for sure is to grow it yourself.

@Douglas, I now know what you are talking about when you say stiffness and back pain. I can't find a comfortable position, and Another forum post you were just on, someone said something about permethrin and bifenthrin being in aza products (which I hope is BS). Worse than this is the headache, which kind of feels like it moves around. You CANNOT detect this stuff, regardless of what it smells like or looks like--especially if it's systemic.

Did anyone else ever get jerks and spasms? This game simply isn't worth it anymore.
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