Yes, MM and others, using a microscope, have observed that with Seaweed, e.g., the microbes get off to a slower start, but they still take off. But is that a bad thing? It shows that they have more to process, and they are benefiting the plant by processing it. I do it both ways. Straight MO ACT, and at other times I let the herd process nutes for me, for my plants. Good luck. -granger