Research shows link - endocannabinoid system may protect the brain from aging

[CannaBunkerMan]

What, cause you wouldn't expect them thar southerners to have any idea how to do science?

The University of Mississippi is the only "Government sanctioned" facility approved to grow pot. I'd assume that the poster was suprised that the information coming from there had a positive angle to it when viewed from the cannabis perspective. I could be wrong though.

 

[john:420]

pharmaceutical company's spend billions of dollars to develop a pill for everything!!! and when that pill screws you up and causes more problems they got a pill for that as well. if they spent half as much money on research on mmj as they do on their pills maybe we would know a whole bunch more about what effect mmj has on illnesses. the medical community needs to get back to nature!!!!

 

[NOTB]

ya ever tried Not wearing cloth's? think about it.

 

[Bi0hazard]

+Medically Important

 

[AmeriSkunk]

I have always felt cannabis was an important to my health, not just physical as in uncreased body function, but mentally as well. i am sure i am not the only one who feels this way????? anyone else?????

Smoking is bad, i will say that. shwag through metal pipes when i was a teenager sucked ass... had a hacking cough then. Now im puffin good literally right now, with absolutely zero negative health effects, even lung issues. I will never believe taking in cannabis is bad for me no matter what kind of bullshit the govermnet tries to coax us into believing... I know it is a positive thing, the positives on overal quality of life outweigh any negative effects to my health to me. and i have a family and stuff, im not a selfish person, THIS IS IN NO WAY LIKE SMOKING CIGERATTES. cigeratte tobacco is crudely dried leaves of a plant. I dont know that it contains any oils that would dilute the actual smoke with oil vapor like marijuana does. that is why we love to "smoke" our buds. the smoke is not actually all smoke, i know this goes without saying to smart or educated people. But some people are stull ignorant to this little factiod. This is the part the G-men alwats happen to leave out... if they tell you its not actually all smoke its actually around a quarter to half oil vapor for some good bud. They tried to tell me in school smoking one joint was the equivalent of smoking 5 packs of cigerattes... are you fucking kidding me.... this is the shit they teach the american youth...

If someone told me cannabis wasnt bennificial i would tell them they arent using it correctly, lol. Not really i would allow them to state their opinion but i have a hard time with people saying it is bad for your health, destroys brain cells, ect... I just want to choke these idiots sometimes because when i see this its on public platforms and people are beieving this shit simply because they have never tried cannabis. this creates the demonisation of our plant. Boy would i like to put my foot knee deep in prohibition era dea guy ass....


watch in order

http://www.youtube.com/watch?v=Nr6cd44i_xI

http://www.youtube.com/watch?v=9jpYB2zvrkI&feature=related

 

[zymos]

I'm not sticking up for tobacco in any way, but:
"cigeratte tobacco is crudely dried leaves of a plant" is not really accurate- it is cured similar to how we cure our buds.
Then usually mixed with a buttload of additives with undetermined health effects...

 

[Bi0hazard]

Worth Repeating: Smoking Cannabis Does Not Cause Lung Cancer:

http://www.cannabisnews.org/united-...smoking-marijuana-does-not-cause-lung-cancer/

http://www.tokeofthetown.com/2011/01/worth_repeating_smoking_cannabis_does_not_cause_lu.php

Effects of cannabis on lung function: a population-based cohort study. (2010)
http://www.ncbi.nlm.nih.gov/pubmed/19679602

"Cannabis appears to have different effects on lung function from those of tobacco. Cannabis use was associated with higher lung volumes, suggesting hyperinflation and increased large-airways resistance, but there was little evidence for airflow obstruction or impairment of gas transfer."

 

[CannaBunkerMan]

Boy would i like to put my foot knee deep in prohibition era dea guy ass....

Blame Harry Anslinger, and Richard Nixon. Both had their pivotal roles in MJ prohibition, the first for starting it, and the second for continuing it.

 

[RollmeoneKenobi]

This is a great discussion, and a great read.

 

[Bi0hazard]

This is a great discussion, and a great read.

Ya,

There should definitely be a medical cannabis news and information location on this site.

Edit: Yes, I was informed that I am already there - who would have thought. lol. I was lost in time.

 

[CannaBunkerMan]

Ya,

There should definitely be a medical cannabis news and information location on this site.

Hey Bio, there is just such a place. Go to the home page, and scroll all of the way down, or click here:

http://www.icmag.com/ic/forumdisplay.php?f=65683

 

[Anti]

Hey Bio, there is just such a place. Go to the home page, and scroll all of the way down, or click here:

https://www.icmag.com/ic/forumdisplay.php?f=65683

Yeah... or just look up at the top of the page header above:

International Cannagraphic Magazine > Forums > IC Magazine > Marijuana News > Medical Cannabis News >

This post is *IN* that forum.

 

[trichrider]

thnx to op...interesting fodder for this alzheimer casuality.

 

[Bi0hazard]

Yeah... or just look up at the top of the page header above:

International Cannagraphic Magazine > Forums > IC Magazine > Marijuana News > Medical Cannabis News >

This post is *IN* that forum.

Lol. Thanks for the "heads up" - it is all written out there isn't it =P

I was pretty deep into a ECSD blunt when I was writing that, didn't realize that was the forum this thread was in. I guess I would have labeled it the same thread name as the moderators obliviously.

I initially found this post on the front ICMAG page under new medical news. But I will definitely make sure a lot of my future medical cannabis discoveries gets posted there. I'm constantly browsing through the primary articles on developments with the endocannabinoid system and medical benefits of cannabis.

I'll keep you all posted on important finds along my path of research.

 

[CannaBunkerMan]

I found another article about memory that is almost a follow up to the original article at the beginning of this thread. It's not ot about cannabinoids, but about the pathway the brain uses to create memories. It could be another avenue to find a cure for alzheimers.

Neuroscientists Boost Memory in Mice Using Genetics and a New Memory-Enhancing Drug

http://www.sciencedaily.com/releases/2011/12/111208125716.htm

ScienceDaily (Dec. 8, 2011) — When the activity of a molecule that is normally elevated during viral infections is inhibited in the brain, mice learn and remember better, researchers at Baylor College of Medicine reported in a recent article in the journal Cell.


"The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown," said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM and senior author of the paper. Since the activity of PKR is altered in a variety of cognitive disorders, Costa-Mattioli and colleagues decided to take a closer look at its role in the mammalian brain.

Super memory

The authors discovered that mice lacking PKR in the brain have a kind of "super" memory. "We found that when we genetically inhibit PKR, we increased the excitability of brain cells and enhanced learning and memory, in a variety of behavioral tests," he said. For instance, when the authors assessed spatial memory (the memory for people, places and events) through a test in which mice use visual cues for finding a hidden platform in a circular pool, they found that normal mice had to repeat the task multiple times over many days in order to remember the platform's location. By contrast, mice lacking PKR learned the task after only one training session.

Costa-Mattioli and colleagues wanted to know how this molecular process actually works. They found that when PKR is inhibited, the increased synaptic activity (that is, the enhanced communication between neurons) is caused by gamma interferon, another molecule involved in immunity.

"These data are totally unexpected, and show that two molecules classically known to play a role in viral infection and the immune response regulate the kind of brain activity that leads to the formation of long-term memory in the adult brain," said Costa-Mattioli.

Drug targets PKR

Another key finding made by Costa-Mattioli and his team of researchers was the fact that this process could be mimicked by a PKR inhibitor -- a small molecule that blocks PKR activity and thus acts as a "memory-enhancing drug."

"It is indeed quite amazing that we can also enhance both memory and brain activity with a drug that specifically targets PKR." Definitely then, the next step is to use what we have learned in mice and to try to improve brain function in people suffering from memory loss, said Costa-Mattioli.

Although Costa-Mattioli's memory pill may be years away from approval by the U.S. Food and Drug Administration, its impact on society and medicine could be very profound. There are roughly 6 million Americans and 35 million people world-wide with Alzheimer's disease and more than 70 million Americans over the age of 60 who may suffer from aged-associated impairment of memory.

Costa-Mattioli said, "More investigation is undoubtedly necessary to translate these findings to effective therapies but we would be delighted if our scientific studies were to contribute in some way to this ultimate goal."

"Our identity and uniqueness is made up of our memories," Costa-Mattioli said. "This molecule could hold the key to how we can keep our memories longer, but also how we create new ones."

Others who contributed to the research include: first author Ping Jun Zhu, Wei Huang, Jong W. Yoo, Loredana Stoica, Hongyi Zhou, Jeffrey Noebels, all at BCM; Andon N. Placzek, currently with Mercer University School of Medicine; Michael J. Friedlander and Djanenkhodja Kalikulov currently with Virginia Tech; Kresimir Krnjevic, McGill University; and John C. Bell, Ottawa Health Research Institute.

The research was supported through funding from the Searle Scholars Program (award to Costa-Mattioli), the Cynthia and George Mitchell Founds (award to Costa-Mattioli), the National Institute of Neurological Diseases and Stroke, the National Institute for Child Health and Development, the BCM Intellectual and Developmental Disabilities Research Center and the National Eye Institute.