CBD and memory protection

[Jeff Johnson]

You all probably noticed today that international news headline on health and weed. I think it was CBS news...better get the link:

http://www.cbsnews.com/8301-501465_162-20018594-501465.html

The serious research says that strains high in CBD can actually protect memory loss from weed smoking. To me, this is great news since I am older than many of you.

My example is strain whose hype I fell for: guerilla gold. I grew that out when Greenz and Mr. Clone were hyping that to smithereens. It was early, and it was strong, but the high was not interesting, and destroyed memory. Must have been minimal CBD.

Which strains have high CBD? These days I am trimming my newly harvested strains...ak48, DNA lemon skunk, Maple Leaf Indica, Hashberry, and Mandala Safari Mix. Do I have any winners?

 

[Thule]

99,9 of all commercial strains are low in CBD, probably the number is even higher. Basically hemp has more. CBD is no miracle drug though, definitely not for recreational users but for severe anxiety and cancer it goes well.

 

[englishrick]

Canna can do fab things when you know what your injesting

 

[bakelite]

You all probably noticed today that international news headline on health and weed. I think it was CBS news...better get the link:

http://www.cbsnews.com/8301-501465_162-20018594-501465.html

The serious research says that strains high in CBD can actually protect memory loss from weed smoking. To me, this is great news since I am older than many of you.

My example is strain whose hype I fell for: guerilla gold. I grew that out when Greenz and Mr. Clone were hyping that to smithereens. It was early, and it was strong, but the high was not interesting, and destroyed memory. Must have been minimal CBD.

Which strains have high CBD? These days I am trimming my newly harvested strains...ak48, DNA lemon skunk, Maple Leaf Indica, Hashberry, and Mandala Safari Mix. Do I have any winners?

JJ, For CBD you probably want to look into Indica dominant or pure indicas. There are people here at ICMag that know specifics better than I could tell you, but there are some specific strains kicking around that are high in CBD. BTW, CBD production is regulated by the genes and not the environment. Also High CBD plants are often pheno specific. I tried Sensi's Hindu Kush to be the only strain/cross (out of 20+ that I have tried) that eliminates my lower back pain. HK is a pure indica. Since CBD has anti inflammatory properties I have good reason to believe that there is a fair amount of it in HK. Others to look for Cannabiogen Sand Storm, Soma's A+(Rock Bud), White Rhino/Medicine man, Leb27, Salmon Creek Big Bud (if you can find it let me know). It seems that most commercial genetics will only have small amounts of CBD (0.1-4.0%), but some phenos can be higher. From what i've read, strains very high in CBD won't get you high. Again, look towards the pure indicas (Afghani', Pakistani, Hash Plants, Hindu Kush etc.) especially landrace Indicas that haven't been worked over for potency yet.

 

[eexpee]

I'm no expert but, as others say, there are very very few strains out there high in CBD. As for the strains you have which are most likely to be high in (or higher than average) CBD I would safely say Madala's seeds are your best bet. A lot of his strains contain landrace genetics which seem to be the only hope in finding high CBD cannabis anywhere. So, hopefully out a pack of the safari mix or even Hashberry which I believe has genetics from North India you will find a keeper

Good luck!

 

[mage]

I the strains i grow must be pretty low in CBD, because im forgetful as fk when im smoking xD

I used to do alls sorts of shit when i was sober but during periods of heavy smoking. Like forget to put the handbrake on and see the car roll down the hill in neutral xD and another time when i was at the shops and drove the car forward into the carpark in front to exit not reallizing there were some big ass conc block things (kinda like a kerb) inbetween. funny thing is i had walked over them and everything to get to the door. the wife wasnt too impressed lol

 

[GrinStick]

???
doesn't THC degrade into CBD (with oxidative indication apparent in amber trichomes), so harvest timing and light intensity are variables?
Later harvesting allows THC to begin oxidation, light intensity increases oxidation.
or have I confused the chemical process?

 

[love?]

???
doesn't THC degrade into CBD (with oxidative indication apparent in amber trichomes), so harvest timing and light intensity are variables?
Later harvesting allows THC to begin oxidation, light intensity increases oxidation.
or have I confused the chemical process?

THC degrades into CBN, not CBD.

The CBS News article was surprisingly good. Here's a link to the original for those interested: http://bjp.rcpsych.org/cgi/content/abstract/197/4/285

 

[Dr. Purpur]

Is that CBDs that GDP has? Or CBNs?

 

[Jeff Johnson]

Thanks for the interest in this thread. As someone who makes a living with my memory, I have a keen interest in its preservation.

I grow mostly indicas year after year; they must the answer.

Thanks for these gracious thoughtful responses, and thanks in advance for anyone else in the community who might chime in with theories and opinions.

Jeff, formerly Oldsterone

 

[Mr.Tortoise]

I hope that breeders are becoming more aware of the value of high levels of CBD for certain medical conditions. My wife and I favorite strain right now is cannatonic that is suppose to have equal levels of THC and CBD. I personally do not like getting "high" all the time form my meds. There is a time and place for recreational smoking where the goal is to get stoned, but for daily use I want something that controls my symptoms and let me lead a productive life. I find that cannatonic does this nicely. I make a tea out of it that I consume throughout the day that just makes me feel good and relieves my symptoms. I tried Hashberry and I couldn't remember anything! Would not want to be like that on a regular basis as I wouldn't be able to get anything done! There was a thread on here discussing strains high in CBD but I am still actively looking for strain that have tested high in CBD.

 

[sac beh]

???
doesn't THC degrade into CBD (with oxidative indication apparent in amber trichomes), so harvest timing and light intensity are variables?
Later harvesting allows THC to begin oxidation, light intensity increases oxidation.
or have I confused the chemical process?

This is something of a myth carried over from times when we didn't have good information about the cannabinoids in cannabis. We now know that it is CBN that is a product of THC degredation. CBD and THC content is mostly determined by genetics.

OP, read through this thread:

https://www.icmag.com/ic/showthread.php?t=60763

where a lot of knowledgeable folks have commented on the issue of CBD content in modern strains. The best advice that I can give is that while 1,2 or 3% CBD may sound like a small amount, it actually goes a long way to inhibiting some of the undesirable effects people experience. Such strains are available in most places.

peace

 

[dagon420]

CBD is not present is large enough levels in drug-type cannabis to have any CNS effects. It would have to be present at a ratio of around 1:1.

Also, CBD is just an antagonist of CB1 receptors, so adding a lot of CBD to THC is the same as having low amounts of THC.

 

[sac beh]

Also, CBD is just an antagonist of CB1 receptors, so adding a lot of CBD to THC is the same as having low amounts of THC.

Except for the fact that CBD is a CB2 agonist, which plays a significant role in immune system regulation. And it has been demonstrated in studies that CBD has an effect apart from THC also, mainly due to this role as agonist not merely CB1 antagonist.

 

[dagon420]

Except for the fact that CBD is a CB2 agonist, which plays a significant role in immune system regulation. And it has been demonstrated in studies that CBD has an effect apart from THC also, mainly due to this role as agonist not merely CB1 antagonist.

CB2 receptors are not present in the brain so that is irrelevant.

 

[sac beh]

CB2 receptors are not present in the brain so that is irrelevant.

Well I don't want to argue about this here. But its absolutely relevant as you gave incorrect information. You said, "Also, CBD is just an antagonist of CB1 receptors, so adding a lot of CBD to THC is the same as having low amounts of THC."

CBD is NOT just an antagonist of CB1 receptors. It may only serve this function in the brain, but it serves other functions also.

Adding a lot of CBD to THC is NOT the same as having low amounts of THC. Ratio and amount will have different effects.

Oh, and they're finding CB2 receptors in the brain:
http://onlinelibrary.wiley.com/doi/10.1002/syn.20050/abstract
http://onlinelibrary.wiley.com/doi/10.1196/annals.1369.052/abstract

The effect of direct CB2 antisense oligonucleotide injection into the brain and treatment with JWH015 in motor function and plus-maze tests also demonstrated the functional presence of CB2 cannabinoid receptors in the central nervous system (CNS). Thus, contrary to the prevailing view that CB2 CBrs are restricted to peripheral tissues and predominantly in immune cells, we demonstrated that CB2 CBrs and their gene transcripts are widely distributed in the brain.

 

[dagon420]

CBD is not present in large enough quantities in drug-type cannabis to make a difference. That's why ratios of THC: CBD in studies is usually 1:1.

http://www.ncbi.nlm.nih.gov/pubmed/15118485

With the concomitant administration of the drugs (5 mg THC and 5 mg CBD to 15 mg THC and 15 mg CBD), there was a decrease in stage 3 sleep, and with the higher dose combination, wakefulness was increased. The next day, with 15 mg THC, memory was impaired, sleep latency was reduced, and the subjects reported increased sleepiness and changes in mood. With the lower dose combination, reaction time was faster on the digit recall task, and with the higher dose combination, subjects reported increased sleepiness and changes in mood. Fifteen milligrams THC would appear to be sedative, while 15 mg CBD appears to have alerting properties as it increased awake activity during sleep and counteracted the residual sedative activity of 15 mg THC

 

[sac beh]

I really love the chart you keep posting, but its just a distraction. Its not proof that CBD must be present in an equal ratio with THC for it to have an effect. The fact that they use this ratio often in studies is a scientific strategy for producing the most obvious results with limited treatments.

The study that the OP is talking about showed that smoking non-clinical street cannabis with at least .75% CBD was enough to eliminate memory impairment effects. This is positive evidence for my original claim that although 1-2% CBD doesn't sound like much, it does go a long way to inhibiting undesirable effects.

 

[sac beh]

By the way, the reason this point is important is because if people were to believe your claim without investigating it, they would be naturally led to the assumption that it is hopeless to try to eliminate the negative effects that this and other studies associate with low CBD, since 1:1 cannabis is virtually non-existent in the current market. But this isn't true, its not what the study is saying, and the situation is certainly not hopeless for those who need a noticeable CBD effect in their cannabis.

 

[dagon420]

CBD has is unlikely to have any pharmacodynamic activity at those quantities since it does not display high affinity for CB1 or CB2 receptors. I haven't read the data on pharmacokinetics of cannabinoids, but as of right now, its safe to say that CBD probably doesn't do much at the low levels present in drug-type cannabis.