6 new Cannabinoids

[Sam_Skunkman]

6 new Cannabinoids have been found.

(±)-6,7-trans-epoxycannabigerolic acid,
(±)-6,7-cis-epoxycannabigerolic acid,
(±)-6,7-cis-epoxycannabigerol,
(±)-6,7-trans-epoxycannabigerol,
5?-methyl-4-pentylbiphenyl-2,2?,6-triol,
7-methoxycannabispirone,

http://www.thieme-connect.com/ejournals/abstract/plantamedica/doi/10.1055/s-2008-1034311

Isolation and Characterization of New Cannabis Constituents from a High Potency Variety

Mohamed M. Radwan1, Samir A. Ross1,2, Desmond Slade1, Safwat A. Ahmed1, Fazila Zulfiqar1, Mahmoud A. ElSohly1,3
1 National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA
2 Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, USA
3 Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
Abstract

Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, (±)-6,7-trans-epoxycannabigerolic acid (2), (±)-6,7-cis-epoxycannabigerolic acid (3), (±)-6,7-cis-epoxycannabigerol (4), (±)-6,7-trans-epoxycannabigerol (5), 5?-methyl-4-pentylbiphenyl-2,2?,6-triol (7), and 7-methoxycannabispirone (8), along with seven known compounds namely, cannabigerolic acid (1), 5?-methoxycannabigerolic acid (6), cannabispirone (9), ?-cannabispiranol (10), dehydrocannabifuran (11), cannflavin B (12) and cannabigerol (13). The antimicrobial as well as the antileishmanial activities were investigated.

-SamS

 

[Mr.Botanical]

Noice!

Though it doesn't really make a difference because I've been smoking those 6 cannabinoids for decades now anyways :wink:

Sam, do you know whether or not the +,- have to do with the molecule's chirality? Thats what I' assuming, but you never know.

 

[Sam_Skunkman]

Are you sure about that? Cannabis has upto 72 Cannabinoids found in it, but the 72 are not in each and every variety. Most western varieties have only THC with little to none of the other 71 Cannabinoids.

-SamS

 

[guineapig]

This is fantastic news.....i will read the article in its entirety......

I wonder how they got a hold of "a High Potency Variety"......very intriguing!!!

Thanks Sam for the abstract....

kind regards from guineapig

 

[Guest]

Does it even matter?

 

[Guest]

Does it even matter?

SEEDS!

 

[coop]

JACKFROST SEEdS!

 

[Mr.Botanical]

Are you sure about that? Cannabis has upto 72 Cannabinoids found in it, but the 72 are not in each and every variety. Most western varieties have only THC with little to none of the other 71 Cannabinoids.

-SamS

You don't say? Hmmm, quite interesting.

 

[guineapig]

Was the varietal they used "Jack Frost" from Goldenseeds?

Or were you just giving that strain a shout out?

kind regards from guineapig

 

[Guest]

Hi Sam, so if western cannabis only has pretty much 1 of the 72 cannabinoids, is it the terpenoids that largely account for the variety variety of effects you can get from different strains?

Are the other 71 cannabinoids psychoactive? I remember you posting on OG that THCV on it's own wasn't psychoactive, is it the case that some of these other 71 cannabinoids have a synergistic effect with THC, modulating it's effect and psychoactivity? If so, is it reasonable to assume that there are unique and quite distinct effects to be had from unselected landrace populations that still contain other cannabinoids? Or are the other 71 only of use in medicinal applications?

 

[Sam_Skunkman]

The only way to know if a Cannabinoid is active is to try it.
The only way to know if a Cannabinoid modifies THC when smoked with THC is to try them together.
Most are not active and don't modify THC.
I am sure they will find new Cannabinoids if they look hard enough.
I would be surprised if they are important for recreational smoking.
There may be medical uses for the new 6 I have no idea, to be honest.
The other 71 as you say are being researched now and uses have been found for some already, like THCV, CBD, as well as THCA which is not psychoactive.

-SamS

 

[XyZ]

interesting info man - thanks for sharing

 

[Guest]

Thanks Sam, so I guess we better stick to our THC varieties and leave the research into the others to the folks with huge greenhouses and analysis labs!

I've often wondered why different varieties can have such varied and different effects if THc is the only substance that is creating those effects, due to the lack of easily digested written material on the different cannabinoids, I supposed it was these mysterious other substances that accounted for the range of effects. I guess our knowledge of cannabis is far from complete!

I know you make dry sift that is greater than 50% THC, do you also make dry sift from other varieties that are high in other cannabinoids in order to evaluate their potential psychoactivity? Is an experienced 'head' a reasonably accurate way to determine whetehr a cannabinoids is psychoactive or do you need to scientifically analyse it?

Sorry for all the questions, but this is new and fascinating knowledge and when it comes to cannabis, I crave knowledge!

 

[Sam_Skunkman]

It is best to use pure Cannabinoids to determine if they are psychoactive or not.

-SamS

 

[DoobieDuck]

interesting info man - thanks for sharing

DITTO....DUCK

 

[Kendo The Green]

I have always been interested in canabinoids.
but seriously, Ananamides and the plethora of complex compounds are about as interesting as you canget. The Harm reduction, cell regeneration that takes place in a subject with higher levels of Canabinoids is amazing.

Here is alink to my site where I have some info on Harm reduction
http://playbud.com/marijuana_as_medicine.htm

and here is the link to Dr Bob's," Dr Robert Melamede" a leading cannabinoid researcher and top notch stoner.
http://www.uccs.edu/~rmelamed/Homepage/

 

[bopper]

Hi Kendo,

Much thanks for the links. I'll be busy exploring Dr. Melamede's pages and links for some time. This work makes me wish I were a couple of decades younger and had the time for a thorough explore. The study of medicine never before seemed so alluring.

Best,

bopper

 

[geminibud]

I'd sure like to have some High cannibanoid cannabis that was bred to a high thc strain and see what grows out of those seeds.
Can you even HAVE the best of two worlds???

 

[Guest]

I'm wondering Sam, have you studied the modifying effects of THCV? It is said that Malawi Gold, some Thais and Zamal from La Reunion all contain significant levels of THCV and that this perhaps accounts for the psychedelic nature of their effects.

 

[Sam_Skunkman]

You need to check my old posts on THCV. Then ask me again, if you need to.
Hint: THCV is a THC antagonist.
-SamS