Originally posted by paddyod11
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update: CHS is caused by cannabinoids and pesticides. you become sensitive to them through the same mechanism. there is an enzyme called beta glucuronidase that is produced by e. coli bacteria (there's tons of these in your intestines that don't cause disease) the function of it is to deconjugate molecules that are coming out of your liver, such as nutrients that you need to absorb (your liver bonds molecules with glucaric acid to make them water soluble so you can excrete them) if your gut flora is imbalanced and you have too much beta glucuronidase, it starts deconjugating other things. high levels of beta glucuronidase have been linked to breast, prostate and colon cancer, because excess hormones that are being deconjugated and kept in the body are causing the cancer. so CHS sufferers are not removing cannabinoids from their body. you know how you can get sick from eating too many edibles or doing too many dabs, or how doing dabs can make you sweat? these are the main symptoms of CHS, profuse sweating and vomiting. it is possible to reach a level of cannbinoids in your intestine that makes you sick, or makes your body try to sweat out the excess toxins. a person in the prodromal phase of CHS gets sick occasionally because their body keeps running into times when the level of cannabinoids in their intestines is too high. then hyperemesis occurs when the level of cannabinoids in the fat cells becomes too high and none of it is being removed. after that, all/most of the cannabinoids in your system have been removed so you go back to normal for a while. there is only one youtube video discussing the link between beta glucuronidase, but there is plenty of reading you can do on the internet about the other effects of beta glucuronidase. this is a perfect explanation for CHS as it shows how and why it progresses, takes all the mystery out. it shouldnt even be called CHS. doctors just call it this because they only see people who are puking their guts out, not people like me who don't puke. there is a supplement you can take called calcium d glucarate that inhibits beta glucuronidase so your body can properly remove toxins. of course there's no research on using it for this purpose, but it's been shown to be effective for other applications. I've been taking it for a couple weeks and pretty quickly I noticed that i could smoke more in a day with less discomfort. I've also started taking probiotics every day. maybe I'll talk to my doctor about it as well as you can have your stool tested to see your beta glucuronidase level. I'm out of weed so I'm just going to keep taking the calcium d glucarate and smoking small amounts with friends when I get the chance. Im not good at formatting my thoughts, but I hope this information is helpful.
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