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Comparing Cannabis sativa with Cannabis indica and their hybrids

I.M. Boggled

Certified Bloomin' Idiot
Veteran
[Medical Cannabis users, whom this information is intended for,
are currently, by sheer dumb luck default, at the very forefront of modern Cannabis research. They have the answers to various questions such as...
What strains are the most effective medically?
What are the best ways to ingest for different ailments? etc...
IMB ]

"Comparing Cannabis sativa with Cannabis indica and their hybrids
By James H. Freire Jr.

In comparing varieties within a genus one must establish representative examples as benchmarks for each variety. In doing so the examples must represent all of the hallmarks of each variety.
To this end I have chosen generic afghani as my benchmark indica and a Oaxaca/ Colombian cross as my benchmark sativa.
From these two varieties we can make most of the important differences and similarities apparent.
When trying to choose a medical strain one must first make a list of desired benefit from the use of cannabis, for instance if you have chronic fatigue with fibromyalgia you may wish for the following benefits
1) increased energy
2) pain relief
3) immunological support

A person would then research which variety has shown efficacy in these areas and choose one or more varieties to achieve the desired results.It may well be a single hybrid can produce all desired effect( In this case possibly a sativa dominant hybrid for reasons we'll get into).
One must remember that most of the information on this is anecdotal and some what subjective so any specific application is greatly dependent on ones own response to the variety.
With these things said lets talk about the plants, in general Cannabis sativa is the taller lankier variety that under optimal conditions can reach 5-6 m, it is usually characterized by narrow serrated leaves and a loose spear-like flower cluster that can be extremely resinous.

The cannabinoids present in Cannabis sativa are characterised by an elevated cannabidiol level and a more stimulating psychological effect (although certain african and hawaiian types can be quite sedative in a somewhat unique way). Sativas also seem to have greater immune enhancing abilities than indica varieties.

Tinctures made from sativa cannabis are very effective on strep throat, and the variety seems to be prefered by immune comprimised patients.

Cannabis indica is characterised by a shorter stockier growth pattern (1-2m) with wide deeply serrated leaves and a much more compact and dense flower cluster.
The cannabinoids found in indicas generaly have an elevated cannabinol level and a much more narcotic type psychological effect.

Indicas make very good pain "relievers" and sedatives.

Tinctures made from indicas are effective on muscle spasm and various types of myalgia and neuralgia.
These varieties seem to be preferred for nausea also.
Now with that said one should know that there are probably 500 plus different "hybrids" of sativas and indicas each with its own unique cannbinoid profile.

By using the general guidlines for the benchmark varieties one can experiment with different hybridizations to fine tune the effect desired.
Keep in mind that you are the best judge of what works for you and it will be up to you to determine what that will be.


Strain recomendations to benefit specific body systems

1) Neurological problems should be treated on a case by case basis with sativa dominant hybrids being used as stimulating agents (such as in tension headache) only where a stimulating effect is desired. In general neurological problems respond well to the soothing effects of the indica profile .As an aside I personally know a young man who was able to eliminate haldol and control his Tourette's syndrome using indica dominant strains.

2) Musculoskeletal problems can present a dual problem,the pain associated with these ailments can often be acompanied by depression and fatigue. So the easy solution of recomending a strongly analgesic indica could compound the secondary ailments of fatigue and depression. In these cases a hybrid variety could be the answer,look for pain relief of an afghani crossed with a stimulating sativa to help keep you active, if you could benefit from it. In some instances simply using a very potent hawaiian or african sativa can give a balance between pain relief and energy level (these types seem to slow the body but leave the mind very active)

3) Immunological problems create special needsfor the patient as far as product purity and method of cure. AIDS patient cannot be exposed to molds or fungi so great care must be used in curing the product to absolute dryness. Also immunological problems can also be quite painfull so choosing a product to give maximum benefit with minimal negative impact on the immune system. The feed back I have recieved indicates that sativa varieties are prefered by immune compromised patients for their uplifting effects(could this be whats behind the immune enhacing effect (?) and the energy boost the can provide.

4) Gastrointestinal effects are what really sparked the rennesance of cannabis medicine. Cannabis' powerful antiemetic and appetite enhancing properties have been known by cancer patients for years. For this system I will make one broad recomendation; indicas seem to be broadly effective for most GI complaints ,the exception being motion sickness which respondes to the stimulating effects of a sativa variety.

5) Dermatological problems can take on several forms, plain itching or lesions of some kind.Systemic anti-inflamitory cannabinoids can be of benefit. look into low doses of indica type cannabis (excess use can actually make you itch much like the effect opiates have on some people) and perhaps a topical preparation of resinous sativa (disolved in an emolient of some kind ) can provide topical anti-inflamatory effect.

6) Cardiopulmonary issues and cannabis are a contraversial subject as mainstream medicine views the inhalation of any smoke as anathema. But patients with lung and heart problems find benefit from the use of Cannabis in spite of negative medical bias.
Cardiac patients can get benefit from sedative indicas for relaxation and stress relief but care should be exercised as Cannabis use can slightly raise heartrate but without an increase in blood pressure ( I used cannabis before my post bypass exercise sessions and can sustain 45 min hard aerobic exercise without problems less than 1 year after surgery)
Pulmonary ailments generally shouldn't be treated with smoked product with the exception being conditions which respond to an expectorant product smoked Cannabis of any variety is an excellent expectorant.

7) Psychological therapy using Cannabis is as old as man's association with it. Cannabis is effective in substance withdrawl and various mental perturbations.One way it works is by changing the mood of the user, usually in a positive direction, although it can cause paranoia and agitation in some cases.Strain selection for psychological problems should hinge on wether the condition causes agitation and unrest or depression and angst and appropriate stimulating or sedative qualities should be chosen

8)Endocrine conditions are as a rule not primarily affected by Cannabis and its use is primarily pallative .Strain selection should focus on immune enhancement and easing distressful sensations.

9) Chemotherapy and radiation therapy cause great stress to the body, indeed these treatments literaly bring the body close to death to destroy the less hardy cancer.
As a result a whole range of physical and psychological symptoms accompany these drastic treatments. The most well known being the wracking nausea and vomiting associated with chemotherapy but the list of secondary effects of treatment is much longer.
Again treatment with Cannabis should be of a supportive nature, sustaining the appetite, easing discomfort, and raising the spirits of the patient, sativas seem good for this effect as well as sustaining the immune system.

10) Opthalmological uses range from easing glaucoma to slowing macular degeneration.
I believe indicas to be most efective in eye conditions because of what I believe to be a higher concentration of calcium channel blocking cannabinoids. These substances work in a similar manner to calcium channel medications for blood pressure except the eye has nerve receptors specific to endocannabinoids (substances created in the body)

11) Gynecological problems treated with Cannabis were made famous by Queen Elizabeth's use for pre-menstrual symptoms. As her Cannabis probably came from India at the time it was probably an indica or indica dominant hybrid.


This guideline is by no means complete and as more research is done and more longtime medical users come forward with new aplications I will update as applicable.

'm sure that as more research is done the potential for this amazing medicine will become apparent.
To date most research is done wth smoked Cannabis or synthetic derivitives, leaving out the effects of altenative ingestion modes (tincture, food, transdermal, vaporizers,inhalers...)
All of these modes will change the effect of the same Cannabis.

We who this information is for, are at present the forefront of Cannabis research.

It is we who will not be denied this wonderful remedy and we who will pioneer its re-establiment of it's rightful place in modern man's medicine chest."

:)
 
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I.M. Boggled

Certified Bloomin' Idiot
Veteran
"Differential effects of medical marijuana...

"Differential effects of medical marijuana...

www.wamm.org
"A collective of patients and caregivers, creating community, building hope, dissolving barriers, providing support and free medical marijuana since 1993."

"Differential effects of medical marijuana based on strain and route of administration: A three-year observational study

Abstract:

Cannabis displays substantial effectiveness to affect a variety of medical symptoms. Seventy-seven patients took part in a study in California to assess the efficacy of organically grown Cannabis sativa and indica strains in treatment of various medical conditions via smoking or ingestion. HIV/AIDS was the most frequent condition reported, at 51%. Standardized rating forms provided 1,892 records that were statistically analyzed. Results demonstrated that in the case of nausea and spasm, changes in symptom expression are definitely affected by method of cannabis administration. However, while Cannabis indica strains increased energy and appetite, it is useful to note that in treating nausea in HIV/AIDS and orthopedic diagnosis groups, Cannabis sativa and C. indica strains proved equivalent.

Keywords: cannabis, medical marijuana, Cannabis sativa, Cannabis indica, AIDS, HIV "

http://www.ukcia.org/research/DifferentialEffects/
 
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I.M. Boggled

Certified Bloomin' Idiot
Veteran
(from the above posted link)

Marijuana, whether Cannabis sativa and Cannabis indica, produces its medical and other effects by virtue of the concentration and balance of various active ingredients, especially the cannabinoids, which are unique to marijuana, but including also a wide range of terpenoids and flavonoids (McPartland and Mediavilla 2001; McPartland and Pruitt 1999).

Terpenoids are cannabis constituents that provide the characteristic strong odor of marijuana and hashish.

Flavonoids are any of the flavone derivatives.
The concentration and relative proportions of these ingredients depend on the plant's genetic structure and applied hybridization techniques, and as such, allow for a substantially varied outcome.

Little is known about how differences in constituent profiles translate into differences in therapeutic effectiveness.
A range of differentiable effects has been ascribed to THC (tetrahydrocannabinol is the primary psychoactive component of marijuana) and CBD (cannabidiol, a compound related to THC) when administered in purified form (Iversen 2000).
Studies are lacking on the differential clinical effects produced when varying "menus" of constituents are taken together.

Another factor bearing on the effects and the effectiveness of marijuana is the route of administration.
Orally administered marijuana is absorbed more slowly than when delivered systemically (e.g., smoking, vaporizers).
Moreover, the liver metabolizes orally ingested marijuana.
This produces a potent and long-acting cannabinoid (11-hydroxy-THC), which induces varied reactions in medical marijuana patients and is not often well tolerated (Grotenhermen 2001).
However, once more, there is little information available concerning the differential clinical effects of oral vs. smoked forms of marijuana.

:)

This thread is would be an excellent place for Med users to post specific strain recommendations for other med users reference sake...so...

What works for you?

is the essay question at hand, one hundred words or less.
I'm teasing now, whatever length you want it, but lets make this a master reference thread on the "best of the best" of the various medical appropriate strains that are readily available.

I will start with Bog's "Lifesaver", which comes highly recommended as a painkilling medicine.
Dr. Jay was quite fond of Lifesaver. Quoting him now, he said:

BOG calls this his "medical" stain and most who have tried it heartily agree.
Lifesaver is a hearty plant with good yield and a fast flowering time of 40-50 days.
Often described as an Indica dominant "couchlock" strain, I find Lifesaver to be relaxing but not paralyzing like some stronger Indicas such as Black Domina or Snowbud. Our Lifesaver had a "Sativa" pheno and was very special. With trifolate leaves the Jacks Cleaner (a Haze) comes through producing a very balanced smoke."...

...I believe Lifesaver is best used as fresh as possible (within the first 4-6 weeks). This is when the cannabidiol (CBD) is highest. CBD and Lifesaver have powerful anti-inflammatory effects, and Lifesaver is superb for muscle relaxation and back pain.
Lifesaver isn't overpowering like Train Wreck but is strong enough.

Dr. Jay ICMAG Trainwreck thread

Bogbubble and Hog was mentioned by the good Dr. as other good painkiller strains.

Blue Moon Rocks are very popular in my household, particularly by my wife for its muscle relaxant, pain killing & antidepressant/euphoric ways. Now that the B.M.R. just celebrated its first birthday, she is noticably more potent than when she was as a much younger gal.

I've heard a rumor that NurseNancy, Dr. Jays wife, occasionally lurks around here...She's quite knowledgeable on the subject of Medical Cannabis dosing, I've heard,...if she sees this someday, heh, it would be a great honor for us all if she were to register and post and share her wealth of knowledge with us. :)

Let us all "Please" strive to make this thread a classic reference material for the benefit of current and future Medical Marijuana patients.
I Thank You. IMB :)
 
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I.M. Boggled

Certified Bloomin' Idiot
Veteran
What works for you?

What works for you?

This thread is would be an excellent place for Med users to post specific strain recommendations for other med users reference sake...

Please:
lets make this a master reference thread on the "best of the best" of the various medical appropriate strains that are readily available.

Any strain recommendations?

"Common Medical Uses for Cannabis (Marijuana)"
link is to "The American Alliance For Medical Cannabis" website.
http://www.letfreedomgrow.com/cmu/index.htm

Clinical Studies and Case Reports(Link)
On this site you will find clinical studies with cannabis or single cannabinoids in different diseases and case reports on the use of cannabis by patients.
You may search for diseases (indications), authors, medication, study design (controlled study, open trial, case report etc.) and other criteria.
http://www.cannabis-med.org/studies/study.php



Dr. Jay and Nurse Nancy surrounded by Cali-O, Sierra Foothills variety.
This is where Jay and Nancy learned to trim, make butter, and experimented with candy recipes.

This is outdoor organic cannabis that is pest and mold free.

Cali-O is not the strongest cannabis but an excellent treatment for muscle spasm including those involved with MS and Hepatitis C.

Cali-O is a Sativa/Indica hybrid (40/60) grown for decades in the forests of the Sierra Nevada.

:cool:
 
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guineapig

Active member
Veteran
ch. 18 medical cannabis (Mel Frank)

ch. 18 medical cannabis (Mel Frank)

reprinted for educational purposes......apologies to Mel but this is important...

Medical Cannabis

Cannabis has no potential for overdose; however, inexperienced or chronic users can experience acute, adverse reactions to large doses. Anxiety and paranoia are the most common; others include panic, agoraphobia, depression, dysphoria, depersonalization, delusions, illusions and hallucinations. The reactions don't last long, yet 17% of surveyed marijuana smokers reported experience of a least one of these symptoms. Cannabis use can also cause rapid heart beat (tachycardia) in humans, 20 to 100% above normal. The increase in heart rate is highest in the first 20 minutes after smoking then decreases rapidly, depending on dose. In contrast, chronic oral ingestion of cannabis reduces the heart rate in humans. A change in heart rate and blood pressure can present serious problems for some patients, but cannabis has no proven long-term health risks associated with its use and has no serious potential for dependency. However, withdrawal symptoms have been observed. In one study, subjects were given very high doses of oral THC: 180 to 210 mg per day for 10 to 20 days, (equivalent to smoking 9 to 10, 2% THC cigarettes per day). Once cannabis use stopped, the subjects were irritable and suffered mild insomnia, runny nose, sweating and decreased appetite. The withdrawal symptoms lasted for around four days yet there was no associated craving for the drug, unlike cocaine, opiates, alcohol and tobacco. Cannabis users should avoid joints due to the caricinogenic effect tobacco has on the human body. In addition tobacco smoke contains many other harmful additives including sulphur and ammonia. Those who like to smoke joints should use a cigarette filter instead of a roach and medicl users are advised to use vaporizers or cook with it.

to be continued by gp......
 

I.M. Boggled

Certified Bloomin' Idiot
Veteran
Thank you for your kind words...I'm guessing that guineapig thanks you also

Thank you for your kind words...I'm guessing that guineapig thanks you also

Those who like to smoke joints should use a cigarette filter instead of a roach and medicl users are advised to use vaporizers or cook with it.
Is that common smoking cannabis with a filter? I've never done or seen that, but hey, I don't get out and about much.

I know that "Bugler" brand tobacco products puts out a line of empty "regular" and "light" cigerette filter tubes along with a little machine for packing/making the filtered smokes. Pretty cheap too, less than 10 dollars U.S. out the door with no tobacco, okay, okay a little pouch if you must. :D

Cannabis users should avoid joints due to the caricinogenic effect tobacco has on the human body.

Cannabis users/writers should avoid joints before composing lines like that ;D [from mels book] :D
 
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Wrecked

Active member
You always come up with somegreat info imboggled! you have some very informative post for sure. Trainwreck is a great medicinal strain as you mentioned but even i will admit it is no good for sleep or getting to sleep.It is my alltime favorite allday smoke. I normally cant fall asleep for a couple hours from smoking the trainwreck. Thats where i use some good indicas. g13 and sour bubble are some current favorites especially when its in form of hash or oil than i can go to sleep with no problems most of the time. Im sure i will find some new favorites son as i have a bunch of strains going now that i havent smoked before. PeAcE
 

Sleepy

Active member
Veteran
Wow, you are always an unending supply of information, thank you, I.M Boggled!

>>i have found BOG's Strain Grape Punch to be great if you have trouble sleeping. it is a creeper stone, but will put your lights out!! :bat:

easy to grow, too!
 
any reccomendations for seizure disorders????
esp. temporal lobe (right)
complex partial seizures? (language based w/ some automatism [not mynoclonic though])
 
G

Guest

^^yeah something for seizures.


a nice indica with muscle relaxant qualities, with no para or racy thoughts and good for meditation. Something euforicaly mind numbing and creativelly up lifting.

a nicely balanced buzz basically with muscle relaxant qualities.
 

guineapig

Active member
Veteran
hey EsoMan and PeaceSeek I will type up some information on neurological therapies of Cannabis......it deserves its own thread and discussion format.....-gp neurosci
 
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